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The map label for this gene is ptrB [C]

Identifier: 197104797

GI number: 197104797

Start: 1509100

End: 1511184

Strand: Direct

Name: ptrB [C]

Synonym: PHZ_c1331

Alternate gene names: 197104797

Gene position: 1509100-1511184 (Clockwise)

Preceding gene: 197104796

Following gene: 197104798

Centisome position: 37.76

GC content: 68.87

Gene sequence:

>2085_bases
ATGACGTTGCGCCTGCTGGCCACGCTTTTCGCCGGAGTGTTCCTGATGGGGGCCGCCCCCGATGACGACCCCTACGCCTG
GATGGAGGAGATCGAGGGCTCGCGCCCGCTGGAGTGGGCCAGGGCCGAGAACGCCAGTTCGCTGCCCAGGCTGCAGAACG
ATCCCCGCTACGCCGCCCTCTACGCCGACGCCCTGAAGATCGCGACGGCCAAGGACCGCATCCCCGCCGTGCGCTTCGCC
GGCGATGGAAGCCTGCGCGACTTCTGGCAGGACGCCGACCACGTGCGGGGGATCTGGCGCACGACGAGCCTCGACAGCTA
CCGGTCGGGCAAGCCCCAGTGGCGGACCATCCTCGACCTCGACGCCCTGGCCAAGAGCGAGGGCGCCAACTGGGTCTGGC
ACGGCGCCGCCTGCCTGGCGCCCGAGGACCGCCTCTGCCTCGTGGAGCTGTCGAACGGCGGCAAGGACGCCGCGGTGGTG
CGCGAGTTCGACGCCGTCGCCGGCGCGTTCGTGGAGGGCGGCTTCGTCATCCCCGAGGCCAAGGCCAACTACGCCTGGCT
CGATCGCGACACGCTCGTGGTCGCCACCGAGTGGACGGAGGGCGACCTCACCGCCTCGGGCTACCCCTACATCGTCAAGA
CCCTGAAGCGGGGCCAGCCGCTGGACCAGGCGCAGGAGGTCTTCCGCGGACAGAAAGCCGACGTATCGGTCCAGCCGATG
GTGCTGCGTGAGCCCGACGGCCAGGTGGCCGCGGTGATCGCCGGGCGCGGCCTCGACTTCTTCAACAGCGAATATCACCT
GCTGACGCCGAACGGCCCGGCCAAGCTCGACCTGCCCACCAAGGCCACGATCCAGGGCTATGTCGCCGGCCGGCTGGTCG
TCAGCCTGGAGCAGGACTGGGCCGAGAAGGGCTTCAAGGAAGGCGACCTGATCGACTTCGACCTCGCCGCAGTGAAGGCC
GATCCCGCCCGTCTGGCCGGGACCCTCGTGCTGCGGCCGACGCAGAGCCAGGCGATCGAACAGGTGGCGACGACGCGTAA
CCGGCTGGTCGTCGCGCTCTACGACAACGTGAAGGGCCAGGTGCTGAGTTACGCCCGTCAGGGCGAGGCCTGGACCTCGA
GCCGGCTCGACCTGCCCAAGGATTCCAGCATCGGGATCAGTTCCGCGTCCGACCGGGACGACCGGCTGATCCTCAACGTC
ACCGGCTTCCTGACCCCCTCCAGCCAGTGGCTGGCCGACGCCGCCTCGGGCGCGCCCGAGCGCCTGGCGGTGATGCCCGA
GCGTTTCGACGCCTCGGACATGAAGGTCGAGCAGCTCTGGGCGACCTCGAAGGACGGAACCCGGGTCCCGTACTTCGTCG
TCTCGAAGAAGGACCTGAAGCTGGACGGCTCGAACCCGACGCTGCTCTACGCCTATGGCGGCTTCCTGGTCAGCCAGACG
CCGGCCTACGCCCAGACGGCGGGCAAGCTGTGGCTGGAGAAGGGCGGCGTCTACGTCGTCGCCAACATCCGCGGGGGAGG
CGAGTTCGGCCCGCGCTGGCACAACGCGGGCCTCAAGCTGAACCGGATGCGGGTCTACGAGGACTTCTTCGCCGTCTCCG
AGGACCTGATCGCCCGCAAGATCACCAGTCCCCGGCGCCTGGGTATCATGGGCGGCTCCAACGGCGGCCTCCTGATGGGC
GTGGCGCTGACGAAGCGGCCCGAGCTCTACAACGCCGTGGTCATCCAGGTGCCGCTGTTCGACATGATCGGCTACACCCA
CATCGGGGCCGGGGCTTCCTGGGTCGGCGAGTACGGCGACCCGGCGATCCCCGCGGAGCGGGCGATGCTGATGAGCTATT
CGCCCTACCAGAACCTGAAGCCCGGCCAGAAGTACCCGCGCGTGTTCCTGGAGACCTCCACCAAGGACGACCGGGTGCAT
CCGGCCCACGCCCGCAAGGCCGCCGCGCGGCTGAAGGAATACGGCTACGACTACCTCTATTACGAGAACATCGACGGCGG
GCACGCCGCGGCGGCCAACCTGAACGAGCGGGCCATGCGCCAGGCGCTCGAATACACCTACCTCCACCAGCAGCTGATGG
ACTGA

Upstream 100 bases:

>100_bases
GCCGGAGCCGGTGACGAGCGGCGTTCGGCGAGAAACGCCTTGAGCTTGGCCGATCCCTCCGAACTATCTGGGGGCGCGTT
CAAGTTCGGGGTGTTTCCAC

Downstream 100 bases:

>100_bases
GGATGGCGCCGGGGCCGGTCAGCGCGGGAGTGCTCGCCTGGCGGGCCCGGCCGGAGGGGCCGCAGTTCCTGCTGGTGCAT
CCAGGCGGTCCCTACTGGCG

Product: prolyl oligopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MTLRLLATLFAGVFLMGAAPDDDPYAWMEEIEGSRPLEWARAENASSLPRLQNDPRYAALYADALKIATAKDRIPAVRFA
GDGSLRDFWQDADHVRGIWRTTSLDSYRSGKPQWRTILDLDALAKSEGANWVWHGAACLAPEDRLCLVELSNGGKDAAVV
REFDAVAGAFVEGGFVIPEAKANYAWLDRDTLVVATEWTEGDLTASGYPYIVKTLKRGQPLDQAQEVFRGQKADVSVQPM
VLREPDGQVAAVIAGRGLDFFNSEYHLLTPNGPAKLDLPTKATIQGYVAGRLVVSLEQDWAEKGFKEGDLIDFDLAAVKA
DPARLAGTLVLRPTQSQAIEQVATTRNRLVVALYDNVKGQVLSYARQGEAWTSSRLDLPKDSSIGISSASDRDDRLILNV
TGFLTPSSQWLADAASGAPERLAVMPERFDASDMKVEQLWATSKDGTRVPYFVVSKKDLKLDGSNPTLLYAYGGFLVSQT
PAYAQTAGKLWLEKGGVYVVANIRGGGEFGPRWHNAGLKLNRMRVYEDFFAVSEDLIARKITSPRRLGIMGGSNGGLLMG
VALTKRPELYNAVVIQVPLFDMIGYTHIGAGASWVGEYGDPAIPAERAMLMSYSPYQNLKPGQKYPRVFLETSTKDDRVH
PAHARKAAARLKEYGYDYLYYENIDGGHAAAANLNERAMRQALEYTYLHQQLMD

Sequences:

>Translated_694_residues
MTLRLLATLFAGVFLMGAAPDDDPYAWMEEIEGSRPLEWARAENASSLPRLQNDPRYAALYADALKIATAKDRIPAVRFA
GDGSLRDFWQDADHVRGIWRTTSLDSYRSGKPQWRTILDLDALAKSEGANWVWHGAACLAPEDRLCLVELSNGGKDAAVV
REFDAVAGAFVEGGFVIPEAKANYAWLDRDTLVVATEWTEGDLTASGYPYIVKTLKRGQPLDQAQEVFRGQKADVSVQPM
VLREPDGQVAAVIAGRGLDFFNSEYHLLTPNGPAKLDLPTKATIQGYVAGRLVVSLEQDWAEKGFKEGDLIDFDLAAVKA
DPARLAGTLVLRPTQSQAIEQVATTRNRLVVALYDNVKGQVLSYARQGEAWTSSRLDLPKDSSIGISSASDRDDRLILNV
TGFLTPSSQWLADAASGAPERLAVMPERFDASDMKVEQLWATSKDGTRVPYFVVSKKDLKLDGSNPTLLYAYGGFLVSQT
PAYAQTAGKLWLEKGGVYVVANIRGGGEFGPRWHNAGLKLNRMRVYEDFFAVSEDLIARKITSPRRLGIMGGSNGGLLMG
VALTKRPELYNAVVIQVPLFDMIGYTHIGAGASWVGEYGDPAIPAERAMLMSYSPYQNLKPGQKYPRVFLETSTKDDRVH
PAHARKAAARLKEYGYDYLYYENIDGGHAAAANLNERAMRQALEYTYLHQQLMD
>Mature_693_residues
TLRLLATLFAGVFLMGAAPDDDPYAWMEEIEGSRPLEWARAENASSLPRLQNDPRYAALYADALKIATAKDRIPAVRFAG
DGSLRDFWQDADHVRGIWRTTSLDSYRSGKPQWRTILDLDALAKSEGANWVWHGAACLAPEDRLCLVELSNGGKDAAVVR
EFDAVAGAFVEGGFVIPEAKANYAWLDRDTLVVATEWTEGDLTASGYPYIVKTLKRGQPLDQAQEVFRGQKADVSVQPMV
LREPDGQVAAVIAGRGLDFFNSEYHLLTPNGPAKLDLPTKATIQGYVAGRLVVSLEQDWAEKGFKEGDLIDFDLAAVKAD
PARLAGTLVLRPTQSQAIEQVATTRNRLVVALYDNVKGQVLSYARQGEAWTSSRLDLPKDSSIGISSASDRDDRLILNVT
GFLTPSSQWLADAASGAPERLAVMPERFDASDMKVEQLWATSKDGTRVPYFVVSKKDLKLDGSNPTLLYAYGGFLVSQTP
AYAQTAGKLWLEKGGVYVVANIRGGGEFGPRWHNAGLKLNRMRVYEDFFAVSEDLIARKITSPRRLGIMGGSNGGLLMGV
ALTKRPELYNAVVIQVPLFDMIGYTHIGAGASWVGEYGDPAIPAERAMLMSYSPYQNLKPGQKYPRVFLETSTKDDRVHP
AHARKAAARLKEYGYDYLYYENIDGGHAAAANLNERAMRQALEYTYLHQQLMD

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=339, Percent_Identity=34.5132743362832, Blast_Score=206, Evalue=8e-53,
Organism=Homo sapiens, GI284172438, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI284172431, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI284172420, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI284172413, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI70778815, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI108860686, Length=223, Percent_Identity=27.8026905829596, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI108860692, Length=214, Percent_Identity=27.1028037383178, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788150, Length=303, Percent_Identity=31.023102310231, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583414, Length=376, Percent_Identity=32.4468085106383, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI221510989, Length=319, Percent_Identity=34.1692789968652, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 76392; Mature: 76261

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLLATLFAGVFLMGAAPDDDPYAWMEEIEGSRPLEWARAENASSLPRLQNDPRYAAL
CHHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCEEEE
YADALKIATAKDRIPAVRFAGDGSLRDFWQDADHVRGIWRTTSLDSYRSGKPQWRTILDL
EHHHHHEEECCCCCCEEEEECCCCHHHHHCCHHHHHHEEEECCCCHHCCCCCCCEEEEEH
DALAKSEGANWVWHGAACLAPEDRLCLVELSNGGKDAAVVREFDAVAGAFVEGGFVIPEA
HHHHHCCCCCEEEECEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECC
KANYAWLDRDTLVVATEWTEGDLTASGYPYIVKTLKRGQPLDQAQEVFRGQKADVSVQPM
CCCEEEECCCEEEEEEECCCCCEECCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEECEE
VLREPDGQVAAVIAGRGLDFFNSEYHLLTPNGPAKLDLPTKATIQGYVAGRLVVSLEQDW
EEECCCCCEEEEEEECCCHHCCCCEEEECCCCCCEEECCCCHHEEEEEEEEEEEEECHHH
AEKGFKEGDLIDFDLAAVKADPARLAGTLVLRPTQSQAIEQVATTRNRLVVALYDNVKGQ
HHCCCCCCCEEEEEHHEECCCHHHHEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHH
VLSYARQGEAWTSSRLDLPKDSSIGISSASDRDDRLILNVTGFLTPSSQWLADAASGAPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCC
RLAVMPERFDASDMKVEQLWATSKDGTRVPYFVVSKKDLKLDGSNPTLLYAYGGFLVSQT
CEEECCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECCEEEECCCCCEEEEEECCEEEECC
PAYAQTAGKLWLEKGGVYVVANIRGGGEFGPRWHNAGLKLNRMRVYEDFFAVSEDLIARK
CHHHHHHHHHEEECCCEEEEEEECCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHH
ITSPRRLGIMGGSNGGLLMGVALTKRPELYNAVVIQVPLFDMIGYTHIGAGASWVGEYGD
CCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEHHHHHCCCCCCCCCHHHCCCCC
PAIPAERAMLMSYSPYQNLKPGQKYPRVFLETSTKDDRVHPAHARKAAARLKEYGYDYLY
CCCCHHHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
YENIDGGHAAAANLNERAMRQALEYTYLHQQLMD
EECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLRLLATLFAGVFLMGAAPDDDPYAWMEEIEGSRPLEWARAENASSLPRLQNDPRYAAL
HHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCEEEE
YADALKIATAKDRIPAVRFAGDGSLRDFWQDADHVRGIWRTTSLDSYRSGKPQWRTILDL
EHHHHHEEECCCCCCEEEEECCCCHHHHHCCHHHHHHEEEECCCCHHCCCCCCCEEEEEH
DALAKSEGANWVWHGAACLAPEDRLCLVELSNGGKDAAVVREFDAVAGAFVEGGFVIPEA
HHHHHCCCCCEEEECEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECC
KANYAWLDRDTLVVATEWTEGDLTASGYPYIVKTLKRGQPLDQAQEVFRGQKADVSVQPM
CCCEEEECCCEEEEEEECCCCCEECCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEECEE
VLREPDGQVAAVIAGRGLDFFNSEYHLLTPNGPAKLDLPTKATIQGYVAGRLVVSLEQDW
EEECCCCCEEEEEEECCCHHCCCCEEEECCCCCCEEECCCCHHEEEEEEEEEEEEECHHH
AEKGFKEGDLIDFDLAAVKADPARLAGTLVLRPTQSQAIEQVATTRNRLVVALYDNVKGQ
HHCCCCCCCEEEEEHHEECCCHHHHEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHH
VLSYARQGEAWTSSRLDLPKDSSIGISSASDRDDRLILNVTGFLTPSSQWLADAASGAPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCC
RLAVMPERFDASDMKVEQLWATSKDGTRVPYFVVSKKDLKLDGSNPTLLYAYGGFLVSQT
CEEECCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECCEEEECCCCCEEEEEECCEEEECC
PAYAQTAGKLWLEKGGVYVVANIRGGGEFGPRWHNAGLKLNRMRVYEDFFAVSEDLIARK
CHHHHHHHHHEEECCCEEEEEEECCCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHH
ITSPRRLGIMGGSNGGLLMGVALTKRPELYNAVVIQVPLFDMIGYTHIGAGASWVGEYGD
CCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEHHHHHCCCCCCCCCHHHCCCCC
PAIPAERAMLMSYSPYQNLKPGQKYPRVFLETSTKDDRVHPAHARKAAARLKEYGYDYLY
CCCCHHHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
YENIDGGHAAAANLNERAMRQALEYTYLHQQLMD
EECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.47 {tosyl-Lys-methyl} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]