| Definition | Phenylobacterium zucineum HLK1, complete genome. |
|---|---|
| Accession | NC_011144 |
| Length | 3,996,255 |
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The map label for this gene is topA [H]
Identifier: 197104783
GI number: 197104783
Start: 1494464
End: 1497100
Strand: Reverse
Name: topA [H]
Synonym: PHZ_c1317
Alternate gene names: 197104783
Gene position: 1497100-1494464 (Counterclockwise)
Preceding gene: 197104784
Following gene: 197104782
Centisome position: 37.46
GC content: 70.53
Gene sequence:
>2637_bases ATGAACGTCGTCATCGTCGAGAGCCCGGCCAAGGCCAAGACCATCAACAAGTACCTGGGCTCGGACTACAAGGTGCTCGC CTCCTACGGCCACGTCCGCGACCTGCCCGCGAAGGACGGTTCGGTGCGCCCCGACGAGGACTTCGCCATGTCCTGGGACG TGGACGCCAAGGCCGCCAAGCGCCTGTCCGAGATCGCCGAGGCCGCCAAGGGCGCCGACCGCGTGATCCTGGCCACCGAC CCCGACCGCGAGGGCGAGGCCATCAGCTGGCACGTGCTGGAGGTGCTGCAGAAGAAGCGCGCGCTGAAGGACGCCAAGGT CCAGCGCGTGGTGTTCAACGCCATCACCAAGTCGGCCGTCACCGAGGCCATGGCCAACCCGCGCGAGCTCGACATGGAGC TGGTGGAGGCCTACCTGGCCCGCCGCGCCCTCGACTACCTGGTGGGCTTCACGCTCTCGCCGGTGCTGTGGCGCAAGCTG CCGGGCGCCAAGTCGGCCGGCCGGGTGCAGTCGGTCGCCCTGCGGCTGATCGTCGACCGCGAGCTCGAGATCGAGCGGTT CAGGACGCAGGAATACTGGACCGTCGAAGCCGAGGTGGCCGCCGGCGGCGATCCCTTCACCGCCCGGCTGGTGAAGCACG AGGGCAAGCGGCTCTCGAAGTTCGACCTCGGCAACGAGGCCAGCGCCTTCGCCGCCCGCGACGCCGTCAAGGCCGCGACG TTCAAGGTCGCCGCCGTCGAGCGCAAGCCCGGCCGGCGCTCGCCCCCGCCCCCGTTCACCACCTCGACCCTGCAGCAGGA GGCCGCCCGCAAGCTCGGCTTCTCGGCCCAGCGGACCATGCAGGCCGCCCAGAAGCTGTACGAAGGCGTCGACATCGGGG GCGAGACGGTCGGCCTCATCACCTACATGCGGACCGACGGCGTGCAGACCGCGCCCGAGGCGCTGGACGAGGCGCGCGCC GTGATCGGCGGGCTCTACGGCAAGGACTACGTCCCCGAGAAGCCGCGCTTCTACTCCACCAAGGCCAAGAACGCGCAGGA GGCCCACGAGGCGATCCGCCCGACCAGCCTCGGCCGCAATCCCGGCAAGCTGCGCCTGGAGGGCGACCTCGGCCGGCTCT ACGAGCTGATCTGGAAGCGGATGATCGCCTCGCAGATGGAGTCCGCCCGCATCGAGCGCACCACCATCGACTTGGAGAGC GCCGACGGCCGCACCGGCCTGCGCGCCACCGGCCAGGTGGTGACGTTCCCCGGCTACCTCGCCGTCTACGAAGAGGGCCG CGACGATCCTGAGGATGAAGAAGGCGGGCGCCTGCCGCAGGTGGCGGAGGGCGCCCAGGCGACCGTCCGCCAGGCGAAGG CCGACCAGCACTTCACCGAGCCGCCGCCGCGCTACTCGGAAGCCAGCCTGGTGAAGAAGATGGAGGAGCTGGGCATCGGC CGGCCCTCCACCTACGCCTCGATCCTGGAGCGTCTGCGCGACCGGTCCTACGTGCGGATGGAGAAGCAGCGGTTCGTGCC CGAGGACCAGGGCCGGATCGTCACGATCTTCCTCGAGGAGTTCTTCGGCAAGTACGTCGAGTACGACTTCACGGCGGACC TCGAGGACCAGCTGGACCAGGTGTCGGCCGGCGACCTCGACTGGAAGGTGCTGCTCAAGAACTTCTGGGCCGATTTCAAC GCCAAGGTCGGCGAGTTGGGCCAGATCGGCACCCGCGAGGTCATCGACGCCCTCGACGAGAGCCTGGCCTCGACGCTGTT CCCGCCAATGGCCGACGGTTCGGACCCCCGCGTCTGCCCGCGCTGCGGCAGCGGCCGGCTCAGCCTGAAGCCCAGCCGGA CCGGCGCCTTCATCGGCTGCTCGAACTATCCCGAGTGCCGCTTCACCCGCCCCTTCGGCCCGCCGGACGCCGAGGGCGCC GAGGCCAGCGGCGACCGCGACCTGGGGACCGATCCCCAGACGGGCGAGACCGTCTGGCTGAAGGCCGGCCGCTTCGGCCC CTACGTGCAGCTCGGCGAGGGCGAGAAGCCCAAGCGGTCCAGCCTGCCTAAGGGCTGGAGCGTGGCCGACATGGACCTGG AAAAGGCGCTTCGCCTGCTGCGCCTGCCGCGCGAGATCGGCCCGCACCCGGAGGACGGCAAGCCGATCCTGGCCGGCATC GGCCGGTACGGCCCCTTCGTCCAGCACAACGGCACCTACGCGAACCTGCCCAGCGTGGACGAGGTGTTCGAGGTGGGCCT CAACCGCGCCGTCGACCTGATCGCCACCAAGCGCGCCGGCGGCAAGCGCGGCGGCGAGGCCGAGGCGCTGAAGGACCTGG GCGCCCACCCCGCCGACGGACAGCCGGTGCGCGTGCTGGCCGGCCGCTACGGCCCGTATGTGAAGCATGGCTCCACCAAC GCCACGATCCCGAAGGGCGCCGATCCCAAGGCGCTGACCCTGGACGAGGCGGTGAAGCTGCTGGCCGAGCGCGAGGCCAA GGGCGGCGGCAAGAAGAAGCCCGCCCGCAAGGCCAAGGCGGAGCCGAAGGCCAAGAAGGCGCCGGCGAAGAAAGCTCCGG CGAAGAAGGCGGCTGCGAAGACGCCCGCCAAGGCGACGCCGGCTGGCGATATCGACGACGACGAGTCGCCGTTCTGA
Upstream 100 bases:
>100_bases CCCCTTAAGGGGCTCGGCGGAGCCGCGGCCTCGCGCCCGTTGACAGCGCCTAGCGGGCACCCCCACCTTCCGCGCTCTTT TCGGATCAGACCCAGAACAA
Downstream 100 bases:
>100_bases GCTACGTCCGGCATCTCATATAAAGATATCTTTATGTCTTTATATGGCTGAGCTATAGGGAGCGCATGTCGGATGCGCTG CCATTCACCTTGGCGGCTGT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 878; Mature: 878
Protein sequence:
>878_residues MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATD PDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKL PGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAAT FKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARA VIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLES ADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIG RPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFN AKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGA EASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGI GRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTN ATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF
Sequences:
>Translated_878_residues MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATD PDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKL PGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAAT FKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARA VIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLES ADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIG RPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFN AKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGA EASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGI GRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTN ATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF >Mature_878_residues MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATD PDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKL PGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAAT FKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARA VIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLES ADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIG RPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFN AKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGA EASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGI GRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTN ATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=590, Percent_Identity=26.9491525423729, Blast_Score=136, Evalue=8e-32, Organism=Homo sapiens, GI4507635, Length=657, Percent_Identity=25.4185692541857, Blast_Score=131, Evalue=4e-30, Organism=Escherichia coli, GI1787529, Length=658, Percent_Identity=40.4255319148936, Blast_Score=454, Evalue=1e-128, Organism=Escherichia coli, GI1788061, Length=520, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-32, Organism=Caenorhabditis elegans, GI32563869, Length=561, Percent_Identity=27.2727272727273, Blast_Score=148, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17555378, Length=464, Percent_Identity=27.5862068965517, Blast_Score=129, Evalue=5e-30, Organism=Saccharomyces cerevisiae, GI6323263, Length=487, Percent_Identity=27.3100616016427, Blast_Score=132, Evalue=2e-31, Organism=Drosophila melanogaster, GI24585251, Length=605, Percent_Identity=25.9504132231405, Blast_Score=142, Evalue=1e-33, Organism=Drosophila melanogaster, GI24640096, Length=605, Percent_Identity=24.4628099173554, Blast_Score=118, Evalue=2e-26,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 95953; Mature: 95953
Theoretical pI: Translated: 8.79; Mature: 8.79
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAK CCEEEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHH RLSEIAEAAKGADRVILATDPDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAV HHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDR HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC ELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAAT CHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHH FKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLI EEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEE TYMRTDGVQTAPEALDEARAVIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRN EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC PGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLESADGRTGLRATGQVVTFPGYL CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEECCCEE AVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIG EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC RPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQ CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHHH VSAGDLDWKVLLKNFWADFNAKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCP HCCCCCHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC RCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGAEASGDRDLGTDPQTGETVWL CCCCCCEEECCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE KAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGI ECCCCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH GRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADG HCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC QPVRVLAGRYGPYVKHGSTNATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKA CCEEEEECCCCCCEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHCC EPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF CCCHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAK CCEEEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHH RLSEIAEAAKGADRVILATDPDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAV HHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDR HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC ELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAAT CHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHH FKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLI EEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEE TYMRTDGVQTAPEALDEARAVIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRN EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC PGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLESADGRTGLRATGQVVTFPGYL CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEECCCEE AVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIG EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC RPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQ CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHHH VSAGDLDWKVLLKNFWADFNAKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCP HCCCCCHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC RCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGAEASGDRDLGTDPQTGETVWL CCCCCCEEECCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE KAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGI ECCCCCCEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH GRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADG HCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC QPVRVLAGRYGPYVKHGSTNATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKA CCEEEEECCCCCCEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHCC EPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF CCCHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA