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The map label for this gene is fadE12 [H]

Identifier: 197104637

GI number: 197104637

Start: 1344074

End: 1345243

Strand: Direct

Name: fadE12 [H]

Synonym: PHZ_c1171

Alternate gene names: 197104637

Gene position: 1344074-1345243 (Clockwise)

Preceding gene: 197104636

Following gene: 197104639

Centisome position: 33.63

GC content: 70.6

Gene sequence:

>1170_bases
ATGAACGGTTTCTGGCTCACGGACGAGCAGCAGGCGATCCGCGACGGGGTCCTGCGCCTGTGCGAACGCTTCGACGCCGA
GTATTGGCGCCGCACAGACGAGACCGGCGAGTTCCCCGAGGCCTTCGTCGCGGCCATGGCCGAGGCAGGCTGGCTGGGCG
CGGCCATGCCCGTCGAGCTGGGCGGCTCGGGCCTGGGCCTGACCGAGGCCGCCATCGCCATGCAGGCGGTGGCCGAGAGC
GGAGCCGGCTTCTCCGGCGCCAGCGCGCTGCACCTGAACATCTTCGGCCCCATGCCGCTCGCGAAGTTCGGCACGGACGA
CCAGAAGCGCAAGCTGATCCCGCGCCTGATCGCGGGCCAGGACCGGATGTGCTTCGGCGTGACCGAACCCGACGCCGGGC
TCGACACCACCCGCGTGGCGACCCGCGCAGTGCGGAGCAACGACGGCTACGTCATCTCGGGCCGGAAGATGTGGACGACC
ATGGCCCAGCGCGCGACCAAGATGCTGATCGTGGCGCGCACCACGCCGCGGGAAGAGGTGAAGAAGCCGCACGAGGGCCT
CAGCCTGTTCTACGTCGACTTCGACCGCGAGCGGATCCACGCCCGGCCGATCCCGAAGATGGGCCGCAAGGCGATCGAGT
CGAACGCCGTCTTCATCGACGACCTTCACGTGCCCGCGGAGGCCCTGGTGGGCGAGGAGGGGCAGGGCTTTCGCTACCTG
CTGGAGGGGCTGAACCCGGAGCGGGTGCTGATCGCCGCCGAGGCTGTGGGGCTGGGCCGGGCGGCGCTGAGGAAGGCCGC
GGCCTATGCGAAGGAACGGGTCGTGTTCGGCCGGCCGATCGGCCAGAACCAGGGGGTCGCCCATCCGCTGGCCAGGTCCT
GGGCCGAGCTGGAGGCTGCCAACCTGATGGCCTTCAAGGCCGCCGCGCTCTACGACGCCGGCCGCGAGTGCGGGGCCGAG
GCGAACGCGGCCAAGTACCTGGCGGGCGAAGCCGGCTTCAACGCCTGCGAGGCGGCGGTGCTGGCGCACGGCGGCATGGG
CTACGCCAGGGAGTACGACGTCGAGCGCTACTTCCGCGAGGCGATGATCCCGCGCATCGCCCCCGTCAGCCGCGAGATGA
TCTTCAACTACATCGCCGAGCGCGTGCTGGGCCTGCCGAAGAGCTACTGA

Upstream 100 bases:

>100_bases
CCCAGGTCGTCGCGGCCTGCGTGACGGGGCGCGATCCCGGCGCGTACGGTCCGCGCTTCGATCCGGCGCGCTTCAGGAAG
CCGGGCCTTAGAGGGACGGC

Downstream 100 bases:

>100_bases
AGGCCTACCCCAGCCGGAAGCGGATCGGGATGCGCACCTCGCCGCCCTCGACCGGCCGGCCGTCCACGGTCTTGGGGACC
ATGCGGAAGTAGCGGGACAG

Product: acyl-CoA dehydrogenase family protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNGFWLTDEQQAIRDGVLRLCERFDAEYWRRTDETGEFPEAFVAAMAEAGWLGAAMPVELGGSGLGLTEAAIAMQAVAES
GAGFSGASALHLNIFGPMPLAKFGTDDQKRKLIPRLIAGQDRMCFGVTEPDAGLDTTRVATRAVRSNDGYVISGRKMWTT
MAQRATKMLIVARTTPREEVKKPHEGLSLFYVDFDRERIHARPIPKMGRKAIESNAVFIDDLHVPAEALVGEEGQGFRYL
LEGLNPERVLIAAEAVGLGRAALRKAAAYAKERVVFGRPIGQNQGVAHPLARSWAELEAANLMAFKAAALYDAGRECGAE
ANAAKYLAGEAGFNACEAAVLAHGGMGYAREYDVERYFREAMIPRIAPVSREMIFNYIAERVLGLPKSY

Sequences:

>Translated_389_residues
MNGFWLTDEQQAIRDGVLRLCERFDAEYWRRTDETGEFPEAFVAAMAEAGWLGAAMPVELGGSGLGLTEAAIAMQAVAES
GAGFSGASALHLNIFGPMPLAKFGTDDQKRKLIPRLIAGQDRMCFGVTEPDAGLDTTRVATRAVRSNDGYVISGRKMWTT
MAQRATKMLIVARTTPREEVKKPHEGLSLFYVDFDRERIHARPIPKMGRKAIESNAVFIDDLHVPAEALVGEEGQGFRYL
LEGLNPERVLIAAEAVGLGRAALRKAAAYAKERVVFGRPIGQNQGVAHPLARSWAELEAANLMAFKAAALYDAGRECGAE
ANAAKYLAGEAGFNACEAAVLAHGGMGYAREYDVERYFREAMIPRIAPVSREMIFNYIAERVLGLPKSY
>Mature_389_residues
MNGFWLTDEQQAIRDGVLRLCERFDAEYWRRTDETGEFPEAFVAAMAEAGWLGAAMPVELGGSGLGLTEAAIAMQAVAES
GAGFSGASALHLNIFGPMPLAKFGTDDQKRKLIPRLIAGQDRMCFGVTEPDAGLDTTRVATRAVRSNDGYVISGRKMWTT
MAQRATKMLIVARTTPREEVKKPHEGLSLFYVDFDRERIHARPIPKMGRKAIESNAVFIDDLHVPAEALVGEEGQGFRYL
LEGLNPERVLIAAEAVGLGRAALRKAAAYAKERVVFGRPIGQNQGVAHPLARSWAELEAANLMAFKAAALYDAGRECGAE
ANAAKYLAGEAGFNACEAAVLAHGGMGYAREYDVERYFREAMIPRIAPVSREMIFNYIAERVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=29.1005291005291, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI187960098, Length=344, Percent_Identity=32.8488372093023, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI4557231, Length=344, Percent_Identity=32.8488372093023, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4557233, Length=358, Percent_Identity=31.2849162011173, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=28.2722513089005, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=24.7340425531915, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI7656849, Length=386, Percent_Identity=27.4611398963731, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=29.9212598425197, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=29.9212598425197, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI226958414, Length=362, Percent_Identity=24.0331491712707, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=26.1971830985915, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38505218, Length=298, Percent_Identity=28.5234899328859, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI48976061, Length=277, Percent_Identity=29.9638989169675, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI211971008, Length=277, Percent_Identity=29.9638989169675, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4503943, Length=364, Percent_Identity=25.5494505494505, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=25.5494505494505, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=29.0909090909091, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786223, Length=374, Percent_Identity=27.2727272727273, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI87081702, Length=309, Percent_Identity=27.5080906148867, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=301, Percent_Identity=29.2358803986711, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=369, Percent_Identity=31.7073170731707, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=28.3068783068783, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=387, Percent_Identity=30.749354005168, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=27.2486772486773, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=380, Percent_Identity=31.0526315789474, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=29.9212598425197, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=26.2734584450402, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=297, Percent_Identity=28.2828282828283, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=326, Percent_Identity=30.0613496932515, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=26.7806267806268, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=27.0655270655271, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=29.8245614035088, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533517, Length=353, Percent_Identity=24.3626062322946, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=25.9259259259259, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=329, Percent_Identity=24.3161094224924, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=23.7226277372263, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=166, Percent_Identity=26.5060240963855, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666513, Length=381, Percent_Identity=30.7086614173228, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21356377, Length=366, Percent_Identity=31.9672131147541, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=30.0261096605744, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24660351, Length=364, Percent_Identity=29.9450549450549, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646207, Length=358, Percent_Identity=29.8882681564246, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=28.2321899736148, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19920834, Length=300, Percent_Identity=24.6666666666667, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42451; Mature: 42451

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGFWLTDEQQAIRDGVLRLCERFDAEYWRRTDETGEFPEAFVAAMAEAGWLGAAMPVEL
CCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEE
GGSGLGLTEAAIAMQAVAESGAGFSGASALHLNIFGPMPLAKFGTDDQKRKLIPRLIAGQ
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHCCC
DRMCFGVTEPDAGLDTTRVATRAVRSNDGYVISGRKMWTTMAQRATKMLIVARTTPREEV
CCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHEEEEEEECCCHHHH
KKPHEGLSLFYVDFDRERIHARPIPKMGRKAIESNAVFIDDLHVPAEALVGEEGQGFRYL
CCCCCCCEEEEEECCHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHCCCCCCCHHHH
LEGLNPERVLIAAEAVGLGRAALRKAAAYAKERVVFGRPIGQNQGVAHPLARSWAELEAA
HCCCCCCEEEEEEHHHCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHH
NLMAFKAAALYDAGRECGAEANAAKYLAGEAGFNACEAAVLAHGGMGYAREYDVERYFRE
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
AMIPRIAPVSREMIFNYIAERVLGLPKSY
HHCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNGFWLTDEQQAIRDGVLRLCERFDAEYWRRTDETGEFPEAFVAAMAEAGWLGAAMPVEL
CCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEE
GGSGLGLTEAAIAMQAVAESGAGFSGASALHLNIFGPMPLAKFGTDDQKRKLIPRLIAGQ
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHCCC
DRMCFGVTEPDAGLDTTRVATRAVRSNDGYVISGRKMWTTMAQRATKMLIVARTTPREEV
CCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHEEEEEEECCCHHHH
KKPHEGLSLFYVDFDRERIHARPIPKMGRKAIESNAVFIDDLHVPAEALVGEEGQGFRYL
CCCCCCCEEEEEECCHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHCCCCCCCHHHH
LEGLNPERVLIAAEAVGLGRAALRKAAAYAKERVVFGRPIGQNQGVAHPLARSWAELEAA
HCCCCCCEEEEEEHHHCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHH
NLMAFKAAALYDAGRECGAEANAAKYLAGEAGFNACEAAVLAHGGMGYAREYDVERYFRE
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
AMIPRIAPVSREMIFNYIAERVLGLPKSY
HHCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]