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The map label for this gene is map [H]

Identifier: 197104536

GI number: 197104536

Start: 1207060

End: 1207878

Strand: Reverse

Name: map [H]

Synonym: PHZ_c1070

Alternate gene names: 197104536

Gene position: 1207878-1207060 (Counterclockwise)

Preceding gene: 197104538

Following gene: 197104535

Centisome position: 30.23

GC content: 69.96

Gene sequence:

>819_bases
ATGACCGACATCCTCGACGCCGAGCACCGCACCGGCCAGATCAAGCTGCACAAGCCCGAAGACTTCGAGGGCATGCGCAA
GGCCGGCCGGCTGGCCGCCGAGTGCCTCGACATGCTGACGCCCCACGTGGTCCCCGGCGTGCTCACCGAGACGCTGGACG
ACCTGGCCCGCGAGTTCATCCTCGACCACGGCGCGATCCCGGCCTGCCTCGGCTACCGCGGCTACACGCGGACCACCTGC
ATCAGCCCCAACCACATCGTCTGCCACGGCATCCCGGGCGAGCGGGTGCTGCGCGAGGGCGACATCGCCAACATCGACGT
CACCGTCATTGTGGACGGCTGGCACGGCGACACCTCGCGCATGTACGGCGTCGGCGAGGTGGCCCCGCGGGCCAAGCGGC
TGGTGGACGTCACCTACGAGGCGCTCGAGCGCGGCCTGGCGGCCGTGAAGCCCGGCGCCACGACCGGCGACATCGGCCAC
GCCATCCAGTCCTACGTCGAGAGCATGCGCTGCTCGGTCGTGCGCGACTTCTGCGGCCACGGCCTGGGCCGCGTGTTCCA
CGACGCGCCCAACATCCTGCACTTCGGCCGCCCGGGCGAAGGCGCGGTGCTGAAGCCCGGCATGTTCTTCACGATCGAGC
CGATGGTGAACCTCGGCAAGCATCCGGTGAAGCTGCTCTCCGACGGCTGGACCGCGGTCACCCGCGACAAGTCGCTGTCG
GCCCAGTGCGAGCATTCGGTGGGCGTCACCGAGGACGGCGTCGAGATCTTCACCCTCTCGCCGGCGGGCATCTTCAAGCC
GCCGATCCAGGGCGCCTAG

Upstream 100 bases:

>100_bases
CGAGAGGCGGCGGACGCTGGCATGCGTTCCTTCGTCCCGCAAGCCGCCGCGCCGGTTGAATTCCCGTGCTACGATTGCGA
CATAGGCCGCGGAGTTCATG

Downstream 100 bases:

>100_bases
GGCCCCATGATCCTCAGGGCGTGGACCGGCCGGATCCGGACCGCGGACGAGGCGGAGTACGCCGCCTACATCGAGGCGAC
CGGCGGGCGCGAGTACCTGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTDILDAEHRTGQIKLHKPEDFEGMRKAGRLAAECLDMLTPHVVPGVLTETLDDLAREFILDHGAIPACLGYRGYTRTTC
ISPNHIVCHGIPGERVLREGDIANIDVTVIVDGWHGDTSRMYGVGEVAPRAKRLVDVTYEALERGLAAVKPGATTGDIGH
AIQSYVESMRCSVVRDFCGHGLGRVFHDAPNILHFGRPGEGAVLKPGMFFTIEPMVNLGKHPVKLLSDGWTAVTRDKSLS
AQCEHSVGVTEDGVEIFTLSPAGIFKPPIQGA

Sequences:

>Translated_272_residues
MTDILDAEHRTGQIKLHKPEDFEGMRKAGRLAAECLDMLTPHVVPGVLTETLDDLAREFILDHGAIPACLGYRGYTRTTC
ISPNHIVCHGIPGERVLREGDIANIDVTVIVDGWHGDTSRMYGVGEVAPRAKRLVDVTYEALERGLAAVKPGATTGDIGH
AIQSYVESMRCSVVRDFCGHGLGRVFHDAPNILHFGRPGEGAVLKPGMFFTIEPMVNLGKHPVKLLSDGWTAVTRDKSLS
AQCEHSVGVTEDGVEIFTLSPAGIFKPPIQGA
>Mature_271_residues
TDILDAEHRTGQIKLHKPEDFEGMRKAGRLAAECLDMLTPHVVPGVLTETLDDLAREFILDHGAIPACLGYRGYTRTTCI
SPNHIVCHGIPGERVLREGDIANIDVTVIVDGWHGDTSRMYGVGEVAPRAKRLVDVTYEALERGLAAVKPGATTGDIGHA
IQSYVESMRCSVVRDFCGHGLGRVFHDAPNILHFGRPGEGAVLKPGMFFTIEPMVNLGKHPVKLLSDGWTAVTRDKSLSA
QCEHSVGVTEDGVEIFTLSPAGIFKPPIQGA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=258, Percent_Identity=43.4108527131783, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=37.9032258064516, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=53.2258064516129, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71996291, Length=246, Percent_Identity=41.869918699187, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=40.8, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=44.9799196787149, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=40.5622489959839, Blast_Score=189, Evalue=1e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29425; Mature: 29294

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILDAEHRTGQIKLHKPEDFEGMRKAGRLAAECLDMLTPHVVPGVLTETLDDLAREFI
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LDHGAIPACLGYRGYTRTTCISPNHIVCHGIPGERVLREGDIANIDVTVIVDGWHGDTSR
HHCCCCHHHHCCCCCCCEEECCCCCEEEECCCHHHHHHCCCCCEEEEEEEEECCCCCCHH
MYGVGEVAPRAKRLVDVTYEALERGLAAVKPGATTGDIGHAIQSYVESMRCSVVRDFCGH
CCCCHHHCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GLGRVFHDAPNILHFGRPGEGAVLKPGMFFTIEPMVNLGKHPVKLLSDGWTAVTRDKSLS
CHHHHHHCCCCEEECCCCCCCCEECCCCEEEECHHHCCCCCHHHHHHCCCEEEECCCCCC
AQCEHSVGVTEDGVEIFTLSPAGIFKPPIQGA
CHHHCCCCCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TDILDAEHRTGQIKLHKPEDFEGMRKAGRLAAECLDMLTPHVVPGVLTETLDDLAREFI
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LDHGAIPACLGYRGYTRTTCISPNHIVCHGIPGERVLREGDIANIDVTVIVDGWHGDTSR
HHCCCCHHHHCCCCCCCEEECCCCCEEEECCCHHHHHHCCCCCEEEEEEEEECCCCCCHH
MYGVGEVAPRAKRLVDVTYEALERGLAAVKPGATTGDIGHAIQSYVESMRCSVVRDFCGH
CCCCHHHCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GLGRVFHDAPNILHFGRPGEGAVLKPGMFFTIEPMVNLGKHPVKLLSDGWTAVTRDKSLS
CHHHHHHCCCCEEECCCCCCCCEECCCCEEEECHHHCCCCCHHHHHHCCCEEEECCCCCC
AQCEHSVGVTEDGVEIFTLSPAGIFKPPIQGA
CHHHCCCCCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]