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The map label for this gene is tetA [H]

Identifier: 197104522

GI number: 197104522

Start: 1191076

End: 1192338

Strand: Reverse

Name: tetA [H]

Synonym: PHZ_c1056

Alternate gene names: 197104522

Gene position: 1192338-1191076 (Counterclockwise)

Preceding gene: 197104523

Following gene: 197104520

Centisome position: 29.84

GC content: 75.93

Gene sequence:

>1263_bases
ATGACCCAGCCGCCCGAACCCACGCAGGCCCCGGCGCCCCCCCCGGCGCCCCGCGGCGCCCTGCCGGTCATGCTGCTGCT
GGTGTTCCTCAGCCTGATCGGCTTCGGCGTCGTCATCCCGCTCCTTCCGTTCTTCGCCATCGTGTTCGAGGCGAAGGCCT
GGCAGGTCACCCTGCTCTTCTCGGTGTTCTCGGCCGGCCAGTTCCTGGGCGAGCTGACCTGGGGTCGGCTCTCGGACCGC
ATCGGCCGGCGGCCGGTCCTGCTGATGACCATCGTCGCCTCGGCCCTGGGGTACGTCGCCCTCGCCTTCGCGCCGAACAT
CTGGTTCGCGGTGGCCGCCCGCGCCGTCGCCGGCTTCTTCTCGGGCAACATGTCGGCGATCCAGGGCTACATCGTCGACG
TCTCCCCGCCCGAGCGCCTGGCCGGCCGCCTCGGCCTCGTGGGCTCGGCGTTCGGGGTCGGCTTCGTGGTCGGCCCGGCC
CTGGGCGGCCTCCTGGCCCGGCCCGAGCTGGGCGCCGCCGGCTTCCGCCCGCCCCTGCTCGTCGCCGCCGGGCTCTGCCT
GGTGGCCGTGGCGGGGCTGCTGATCTTCGTGCGCGACCACCGCAGGGTCGCGCCCGCCGCCGCCTCCGCCGCCGCCCGCG
TCCGGCGCAATCCGCTGGCGGGCCTGCGCGAGGTCGCCGGCCACCCGGTCCTGGCGCTGGTGTTCGCCACCATCTTCTTC
GGCTTCTTCTCCAGCGCCGGGCTCTGGTCGGTGCTCGGCCTGTGGATGGACGCCCGCTTCGCCTGGGGCCCGCGCGAGGT
GGGCTTCGTGATGGCGCTGACCGGCGTCGCCGCCGCCCTCACCCAGGGGATCCTGTCGGGCGCCATGGTCCGGCGGATCG
GCGCCGGCGCCACCATCTCCATCGGCTTCGTGGTCTCGGCCATCGCCACGGTCGCCATGGCGGGGGCGCCCTTCGGCTGG
CTCGCCGCGATCCTCCTGCTGGCCTCGGTCACCGGCCACGCGGCCTGGCAGCCCGCGGCCATGTCCATCGCCTCGCGCTC
GGCCGGCGCCGACCGCCAGGGCGCGGTCCTGGGCGCGGCCACGGCGTCCGGCTCCCTGTCGCGGGTGCTGGCGCCCCTGA
TCTCGGGGCCGCTGTTCTCGGGGATCGGGCCCTGGGCGCCGGTGGCGCTCTCGGGGCTCGTCATGCTGCCCGCCGCCTGG
CTCGGCTGGCGGGCCGCCCGGGCGCTGCGGACCTGGATCGAGACCGGCCCGCAGCGCGTCTAG

Upstream 100 bases:

>100_bases
GTGGACGTGGCGAGGCCCCGGCTCCGGCTGGGGCCTCGTTTCGTTCGGGGTCCGGTTTTAGGTGTGGAGGCGCCGCCCGG
ACGCCGCTAAGCCCGGGGGC

Downstream 100 bases:

>100_bases
GGGGCCTACTTCGGCTGCGGCGCCGGCGCGGCCGCGCCGTCCGTGGTCGTCATGCCGCTCGAGTCCGACGGCGGCGTCAC
CACTACCGCGGTGTTCGAGC

Product: multidrug resistance protein

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTQPPEPTQAPAPPPAPRGALPVMLLLVFLSLIGFGVVIPLLPFFAIVFEAKAWQVTLLFSVFSAGQFLGELTWGRLSDR
IGRRPVLLMTIVASALGYVALAFAPNIWFAVAARAVAGFFSGNMSAIQGYIVDVSPPERLAGRLGLVGSAFGVGFVVGPA
LGGLLARPELGAAGFRPPLLVAAGLCLVAVAGLLIFVRDHRRVAPAAASAAARVRRNPLAGLREVAGHPVLALVFATIFF
GFFSSAGLWSVLGLWMDARFAWGPREVGFVMALTGVAAALTQGILSGAMVRRIGAGATISIGFVVSAIATVAMAGAPFGW
LAAILLLASVTGHAAWQPAAMSIASRSAGADRQGAVLGAATASGSLSRVLAPLISGPLFSGIGPWAPVALSGLVMLPAAW
LGWRAARALRTWIETGPQRV

Sequences:

>Translated_420_residues
MTQPPEPTQAPAPPPAPRGALPVMLLLVFLSLIGFGVVIPLLPFFAIVFEAKAWQVTLLFSVFSAGQFLGELTWGRLSDR
IGRRPVLLMTIVASALGYVALAFAPNIWFAVAARAVAGFFSGNMSAIQGYIVDVSPPERLAGRLGLVGSAFGVGFVVGPA
LGGLLARPELGAAGFRPPLLVAAGLCLVAVAGLLIFVRDHRRVAPAAASAAARVRRNPLAGLREVAGHPVLALVFATIFF
GFFSSAGLWSVLGLWMDARFAWGPREVGFVMALTGVAAALTQGILSGAMVRRIGAGATISIGFVVSAIATVAMAGAPFGW
LAAILLLASVTGHAAWQPAAMSIASRSAGADRQGAVLGAATASGSLSRVLAPLISGPLFSGIGPWAPVALSGLVMLPAAW
LGWRAARALRTWIETGPQRV
>Mature_419_residues
TQPPEPTQAPAPPPAPRGALPVMLLLVFLSLIGFGVVIPLLPFFAIVFEAKAWQVTLLFSVFSAGQFLGELTWGRLSDRI
GRRPVLLMTIVASALGYVALAFAPNIWFAVAARAVAGFFSGNMSAIQGYIVDVSPPERLAGRLGLVGSAFGVGFVVGPAL
GGLLARPELGAAGFRPPLLVAAGLCLVAVAGLLIFVRDHRRVAPAAASAAARVRRNPLAGLREVAGHPVLALVFATIFFG
FFSSAGLWSVLGLWMDARFAWGPREVGFVMALTGVAAALTQGILSGAMVRRIGAGATISIGFVVSAIATVAMAGAPFGWL
AAILLLASVTGHAAWQPAAMSIASRSAGADRQGAVLGAATASGSLSRVLAPLISGPLFSGIGPWAPVALSGLVMLPAAWL
GWRAARALRTWIETGPQRV

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=312, Percent_Identity=26.9230769230769, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI94721311, Length=366, Percent_Identity=23.7704918032787, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI217416366, Length=442, Percent_Identity=24.6606334841629, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI225703104, Length=356, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI225703102, Length=356, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=380, Percent_Identity=23.1578947368421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17738085, Length=364, Percent_Identity=28.8461538461538, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357569, Length=364, Percent_Identity=23.6263736263736, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656463, Length=364, Percent_Identity=23.6263736263736, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656468, Length=364, Percent_Identity=23.6263736263736, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161080926, Length=364, Percent_Identity=23.6263736263736, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161080924, Length=364, Percent_Identity=23.6263736263736, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43235; Mature: 43104

Theoretical pI: Translated: 12.31; Mature: 12.31

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPPEPTQAPAPPPAPRGALPVMLLLVFLSLIGFGVVIPLLPFFAIVFEAKAWQVTLLF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SVFSAGQFLGELTWGRLSDRIGRRPVLLMTIVASALGYVALAFAPNIWFAVAARAVAGFF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
SGNMSAIQGYIVDVSPPERLAGRLGLVGSAFGVGFVVGPALGGLLARPELGAAGFRPPLL
CCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VAAGLCLVAVAGLLIFVRDHRRVAPAAASAAARVRRNPLAGLREVAGHPVLALVFATIFF
HHHHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHH
GFFSSAGLWSVLGLWMDARFAWGPREVGFVMALTGVAAALTQGILSGAMVRRIGAGATIS
HHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEH
IGFVVSAIATVAMAGAPFGWLAAILLLASVTGHAAWQPAAMSIASRSAGADRQGAVLGAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEC
TASGSLSRVLAPLISGPLFSGIGPWAPVALSGLVMLPAAWLGWRAARALRTWIETGPQRV
CCCCHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQPPEPTQAPAPPPAPRGALPVMLLLVFLSLIGFGVVIPLLPFFAIVFEAKAWQVTLLF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SVFSAGQFLGELTWGRLSDRIGRRPVLLMTIVASALGYVALAFAPNIWFAVAARAVAGFF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
SGNMSAIQGYIVDVSPPERLAGRLGLVGSAFGVGFVVGPALGGLLARPELGAAGFRPPLL
CCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VAAGLCLVAVAGLLIFVRDHRRVAPAAASAAARVRRNPLAGLREVAGHPVLALVFATIFF
HHHHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHH
GFFSSAGLWSVLGLWMDARFAWGPREVGFVMALTGVAAALTQGILSGAMVRRIGAGATIS
HHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEH
IGFVVSAIATVAMAGAPFGWLAAILLLASVTGHAAWQPAAMSIASRSAGADRQGAVLGAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEC
TASGSLSRVLAPLISGPLFSGIGPWAPVALSGLVMLPAAWLGWRAARALRTWIETGPQRV
CCCCHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]