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The map label for this gene is purC

Identifier: 197104482

GI number: 197104482

Start: 1130605

End: 1131360

Strand: Reverse

Name: purC

Synonym: PHZ_c1016

Alternate gene names: 197104482

Gene position: 1131360-1130605 (Counterclockwise)

Preceding gene: 197104484

Following gene: 197104481

Centisome position: 28.31

GC content: 61.24

Gene sequence:

>756_bases
ATGACCCGCCGTAAGAAGATCTACGAGGGCAAGGCCAAGATCCTCTACGAAGGTCCGGAGCCCGGCACGCTCATTCAGTA
CTTCAAGGACGACACCACCGCATTCGACGCGACGAAGAAGGCCGTGCTCGAGGGCAAGGGCGTTATCAACAATCGCATCA
GCGAATACATCATGACGAAGCTGAACTCGATCGGGGTTCAGAACCACTTCATCAAGCGCCTGAACCTGCGCGAGCAGCTG
ATCCGGGAAGTCGAGATCATCCCGCTGGAGGTGGTGTGCCGCAACGTGGCCGCCGGCTCACTGTCCAAGCGCTTCGGCCT
GCCCGAGGGCCAGGCCCTTCCCCGCTCGATCATCGAGTTCTACCTGAAGGACGACAAGCTCCACGACCCGATGGTCGCCG
AGGAGCACATCACCGCCTTCAACTGGGCCTCGACCCAGGAGATCGACGACATGATGGCGCTCACCCTGCGGGTGAACGAC
TTCCTCACTGGCCTGTTCTCGGGCGTCGGGATCACCCTGGTGGACTTCAAGATCGAGTTCGGCCGCATCTGGGAGAACGA
CTTCTCGCGGATCATCCTGGCCGACGAGATCAGCCCCGACAGCTGCCGGCTGTGGGACTCCCAGACCAACGAGAAGCTCG
ACAAGGACCGTTTCCGCCGCGACCTGGGCAATGTCATCGAGAGCTACACCGAGGTTGCCAGGCGGCTCGGCATCATGAAG
GAGATGCCCACCGTGATTCAGGGGGGACTCCACTAG

Upstream 100 bases:

>100_bases
GGCGAGAACCCCGAGTCGGACCCCGCGCGCGAGGAATCAGCCGCGCGCGTTTTTCGTTTCACCGACCGGCGCCAACCCTC
GCCATGGAGAAGGCTGTTAG

Downstream 100 bases:

>100_bases
TGAAGGCGAAGGTCCACGTTTTCCTGAAGCCCGGCGTCCTCGACGTGCAGGGCAAGGCGGTCGAGCAGGCGCTGCATGGC
CTGGGCTGGGGCGGCGTCGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTKLNSIGVQNHFIKRLNLREQL
IREVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEFYLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVND
FLTGLFSGVGITLVDFKIEFGRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMK
EMPTVIQGGLH

Sequences:

>Translated_251_residues
MTRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTKLNSIGVQNHFIKRLNLREQL
IREVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEFYLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVND
FLTGLFSGVGITLVDFKIEFGRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMK
EMPTVIQGGLH
>Mature_250_residues
TRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTKLNSIGVQNHFIKRLNLREQLI
REVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEFYLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVNDF
LTGLFSGVGITLVDFKIEFGRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMKE
MPTVIQGGLH

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=239, Percent_Identity=33.8912133891213, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI5453539, Length=239, Percent_Identity=33.8912133891213, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI119220559, Length=246, Percent_Identity=32.9268292682927, Blast_Score=110, Evalue=9e-25,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=42.436974789916, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=243, Percent_Identity=32.9218106995885, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=33.4728033472803, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583917, Length=209, Percent_Identity=30.622009569378, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PHEZH (B4RHH0)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129859.1
- ProteinModelPortal:   B4RHH0
- GeneID:   6790509
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1016
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28757; Mature: 28625

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTK
CCCCCCHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LNSIGVQNHFIKRLNLREQLIREVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEF
HHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
YLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVNDFLTGLFSGVGITLVDFKIEF
HHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHH
GRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMK
HHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMPTVIQGGLH
HCHHHHCCCCC
>Mature Secondary Structure 
TRRKKIYEGKAKILYEGPEPGTLIQYFKDDTTAFDATKKAVLEGKGVINNRISEYIMTK
CCCCCHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LNSIGVQNHFIKRLNLREQLIREVEIIPLEVVCRNVAAGSLSKRFGLPEGQALPRSIIEF
HHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
YLKDDKLHDPMVAEEHITAFNWASTQEIDDMMALTLRVNDFLTGLFSGVGITLVDFKIEF
HHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHH
GRIWENDFSRIILADEISPDSCRLWDSQTNEKLDKDRFRRDLGNVIESYTEVARRLGIMK
HHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMPTVIQGGLH
HCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA