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The map label for this gene is icd [H]

Identifier: 197104455

GI number: 197104455

Start: 1097569

End: 1098783

Strand: Reverse

Name: icd [H]

Synonym: PHZ_c0989

Alternate gene names: 197104455

Gene position: 1098783-1097569 (Counterclockwise)

Preceding gene: 197104456

Following gene: 197104454

Centisome position: 27.5

GC content: 65.35

Gene sequence:

>1215_bases
ATGGCCAAGATCAAAGTCGCCAACCCTGTCGTCGACCTCGACGGGGACGAGATGACCCGCATCATCTGGAAGCTCATCAA
GGACAAGCTGATCTTCCCGTTCGTCGACCTGCCGATCGAGTACTACGACCTCGGCATCGAGCATCGCGATGCGACGGACG
ACAAGGTGACGGTCGAGGCGGCCGAGGCCATCAAGAAGCACGGCGTCGGCATCAAGTGCGCGACCATCACCCCGGACGAG
GCCCGGGTGGAGGAATTCAAGCTCAAGAAGATGTGGAAGTCGCCGAACGGCACGATCCGCAACATCCTGGGCGGGGTCGT
CTTCCGCGAGCCGATCATCTGCCGCAACGTGCCGCGCCTGATCCCCGGCTGGACCCAGCCGATCATCGTCGGCCGCCACG
CCTTCGGCGACCAGTACAAGGCCACCGACTTCGTCGTGCCCGGCAAGGGCAAGCTGAAGATCAGCTGGGAAGGCGAGGAC
GGCCAGAGGATCGAGCACGACGTGTTCGATTTCCCCGGCGGCGGCGTCGCCATGGGCATGTACAACCTGGATTCCTCGAT
CCGCGAGTTCGCCCACGCCTGCTTCGCCTACGGCCTGAACCGCAAGTATCCGGTCTACCTGTCGACGAAGAACACCATCC
TCAAGGCCTACGACGGGCGCTTCAAGGACATCTTCGCCGAGATCTTCGAGGCCGAGTACGCCGCGAAGTACAAGGAAGCC
GGTCTCGTCTACGAGCACCGCCTGATCGACGACATGGTCGCCTCGGCCCTGAAGTGGTCGGGCGCCTTCATCTGGGCCTG
CAAGAACTACGACGGCGACGTGCAGTCGGACCAGGTCGCCCAGGGCTTCGGCTCGCTGGGCCTGATGACCTCGGTGCTGG
TGACGCCGGACGGCCGGACGCTGGAGGCCGAGGCCGCCCACGGCACGGTCACCCGCCACTACCGCCAGCACCAGCGCGGC
GAGAGCACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTGGAGCACCGGGCCAAGCTGGACGGCAA
CGAGGACCTGGCGCGCTTCGCCAAGACCCTGGAGCAGGTCTGCGTCTCCACCGTCGAGAGCGGTTCGATGACCAAGGACC
TGGCGCTGCTGGTCGGCGACACCCAGGGCTGGCTGACCACCGAGGGCTTCATCGACAAGGTGGCGGCGAACCTCGAGAAG
GCGCTGGCGGCCTAA

Upstream 100 bases:

>100_bases
GCGGGGTCGGATAGTCGCGCCCCACGGCCTTTGCGTCGGCGTCGCTCGGCGGCTATACGGCCCCCTCAACGACGTACACC
GCCCGGAGCGCTTCCCCCTC

Downstream 100 bases:

>100_bases
ACCACAGCCACCATGGCACGTCGAGACGCCCGCCCGGCCCCGCCGCGGCGGGCGTCTTGCTGTTCGGCTATTGTTGTTCC
CTATTTGTTCGGTAACATCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVDLDGDEMTRIIWKLIKDKLIFPFVDLPIEYYDLGIEHRDATDDKVTVEAAEAIKKHGVGIKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVVFREPIICRNVPRLIPGWTQPIIVGRHAFGDQYKATDFVVPGKGKLKISWEGED
GQRIEHDVFDFPGGGVAMGMYNLDSSIREFAHACFAYGLNRKYPVYLSTKNTILKAYDGRFKDIFAEIFEAEYAAKYKEA
GLVYEHRLIDDMVASALKWSGAFIWACKNYDGDVQSDQVAQGFGSLGLMTSVLVTPDGRTLEAEAAHGTVTRHYRQHQRG
ESTSTNSIASIFAWTRGLEHRAKLDGNEDLARFAKTLEQVCVSTVESGSMTKDLALLVGDTQGWLTTEGFIDKVAANLEK
ALAA

Sequences:

>Translated_404_residues
MAKIKVANPVVDLDGDEMTRIIWKLIKDKLIFPFVDLPIEYYDLGIEHRDATDDKVTVEAAEAIKKHGVGIKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVVFREPIICRNVPRLIPGWTQPIIVGRHAFGDQYKATDFVVPGKGKLKISWEGED
GQRIEHDVFDFPGGGVAMGMYNLDSSIREFAHACFAYGLNRKYPVYLSTKNTILKAYDGRFKDIFAEIFEAEYAAKYKEA
GLVYEHRLIDDMVASALKWSGAFIWACKNYDGDVQSDQVAQGFGSLGLMTSVLVTPDGRTLEAEAAHGTVTRHYRQHQRG
ESTSTNSIASIFAWTRGLEHRAKLDGNEDLARFAKTLEQVCVSTVESGSMTKDLALLVGDTQGWLTTEGFIDKVAANLEK
ALAA
>Mature_403_residues
AKIKVANPVVDLDGDEMTRIIWKLIKDKLIFPFVDLPIEYYDLGIEHRDATDDKVTVEAAEAIKKHGVGIKCATITPDEA
RVEEFKLKKMWKSPNGTIRNILGGVVFREPIICRNVPRLIPGWTQPIIVGRHAFGDQYKATDFVVPGKGKLKISWEGEDG
QRIEHDVFDFPGGGVAMGMYNLDSSIREFAHACFAYGLNRKYPVYLSTKNTILKAYDGRFKDIFAEIFEAEYAAKYKEAG
LVYEHRLIDDMVASALKWSGAFIWACKNYDGDVQSDQVAQGFGSLGLMTSVLVTPDGRTLEAEAAHGTVTRHYRQHQRGE
STSTNSIASIFAWTRGLEHRAKLDGNEDLARFAKTLEQVCVSTVESGSMTKDLALLVGDTQGWLTTEGFIDKVAANLEKA
LAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=67.0761670761671, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=65.609756097561, Blast_Score=566, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=68.6567164179104, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=65.1105651105651, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=62.6829268292683, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=62.1026894865526, Blast_Score=534, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=59.6577017114914, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=66.5036674816626, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=66.5036674816626, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=66.5036674816626, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=66.5036674816626, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=66.5036674816626, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=66.5036674816626, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=66.5036674816626, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=66.5036674816626, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=66.5036674816626, Blast_Score=573, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 44921; Mature: 44789

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVDLDGDEMTRIIWKLIKDKLIFPFVDLPIEYYDLGIEHRDATDDKVTVEA
CCEEEECCCEEECCCHHHHHHHHHHHHHHHCCCHHCCCCEEHHCCCCCCCCCCCEEEHHH
AEAIKKHGVGIKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVVFREPIICRNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
IPGWTQPIIVGRHAFGDQYKATDFVVPGKGKLKISWEGEDGQRIEHDVFDFPGGGVAMGM
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCCCEEEEE
YNLDSSIREFAHACFAYGLNRKYPVYLSTKNTILKAYDGRFKDIFAEIFEAEYAAKYKEA
EHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHC
GLVYEHRLIDDMVASALKWSGAFIWACKNYDGDVQSDQVAQGFGSLGLMTSVLVTPDGRT
CCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCE
LEAEAAHGTVTRHYRQHQRGESTSTNSIASIFAWTRGLEHRAKLDGNEDLARFAKTLEQV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHH
CVSTVESGSMTKDLALLVGDTQGWLTTEGFIDKVAANLEKALAA
HHHHHCCCCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVDLDGDEMTRIIWKLIKDKLIFPFVDLPIEYYDLGIEHRDATDDKVTVEA
CEEEECCCEEECCCHHHHHHHHHHHHHHHCCCHHCCCCEEHHCCCCCCCCCCCEEEHHH
AEAIKKHGVGIKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVVFREPIICRNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
IPGWTQPIIVGRHAFGDQYKATDFVVPGKGKLKISWEGEDGQRIEHDVFDFPGGGVAMGM
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCCCEEEEE
YNLDSSIREFAHACFAYGLNRKYPVYLSTKNTILKAYDGRFKDIFAEIFEAEYAAKYKEA
EHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHC
GLVYEHRLIDDMVASALKWSGAFIWACKNYDGDVQSDQVAQGFGSLGLMTSVLVTPDGRT
CCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCE
LEAEAAHGTVTRHYRQHQRGESTSTNSIASIFAWTRGLEHRAKLDGNEDLARFAKTLEQV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHH
CVSTVESGSMTKDLALLVGDTQGWLTTEGFIDKVAANLEKALAA
HHHHHCCCCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]