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The map label for this gene is mfnA [H]

Identifier: 197104164

GI number: 197104164

Start: 764220

End: 765977

Strand: Reverse

Name: mfnA [H]

Synonym: PHZ_c0698

Alternate gene names: 197104164

Gene position: 765977-764220 (Counterclockwise)

Preceding gene: 197104168

Following gene: 197104149

Centisome position: 19.17

GC content: 74.8

Gene sequence:

>1758_bases
ATGCGATCCTCTCCCGTCCCGCCCGGCTGCTTCCTGGGCCCCAAGTCCGAGAACGCCGCCTGGCTTCGCGATCAGCTGGA
CGTCGTGTTCGACGCCTGGTTCGAGGGCCGCCGCCGGCGCTTCCCCGGCGACGACGCCCAGCTCGCCGCCACCGACGCCG
GGACCTGCCGCCGCACCGCGGAAAGCCTGCACGCGCTGCTGGCGGCGCTGGACCAGGAGGTGCCCACCTACACCCCGCGA
TATCTCGGCCACATGGTGTCGGACCCCGCCCTGCCGGCCCTGCTCGGCCATGTGGCGGCCCTGCTGCACAATCCGAACAA
CACCTCGCGCGAGGCCGCCAAGGTCGGCACGGCGATCGAGGCCGAGGCCATCGCCATGCTGGCGCGGATGATCGGCTACG
ACCCGAGCGCGGCGCGCGGCCACTTCACCTCGGGCGGCACGGTCGCCAACCTTGAGGCCGTCTGGCGGGCGCGCTTCCGG
CTGGACCACCGGCTGGCGCTGGGCCTGGCGCTTGCCGAGGCGGAGGGCCGGCCGCTGGACGTCTTCGCGGCGGCGCACAT
GACCGAGGCCCGGTTCCAGGAACGGCTGGCGGCGCTCGGCGAGGAAGCCGCCATGCGGGCGTGCAGCGGGGTGCTGAACA
ATCCCTACGAGATCGCCGAACGGCTGCGGCGCGCGAGCGGGCGCCCCTATCGCGGTCCGGTCATCATCGCCCCCGGCCAC
CGGCACTATTCCTGGATCAAGGCGGCCAACGTGTTCGGCCTGGGCGAGGCGGCCTGCTGGACGGCGCCGCTCGATGCGGA
CGGGCGGCTGGACGCCGAGGGCCTCATGGCCTGCATCCGCCGCGCGCGGGCCGAGCATCGGCCGATCCTGATGGTGGTCG
GCGTGGCCGGCACCACCGAGCTTGGCGCGATCGACCCGGTGGACAAGGTGGCCGGGCGGCTCGAAGCGCTTCGCGAGGCT
GAAGACCTCGACATCTGGCTCCACGTGGACGCGGCCTACGGCGGCTTCTTCTGCACCCTGGCGGCCGACGAGCCGCGGCT
GGCGCCCGAGCGCCGCCGCGCCCTCGCCGCCATCCGGCGCGCCGACAGCGTGACGGTGGACCCGCACAAGCTGGGCTACG
TGCCCTACGCCTGCGGGGCGCTCCTGGTCCGGGACTCCAGCCGCGATGCCGTGTCGAGCTTCGCCGCGCCCTACGTGGAA
CGCGCCGAACTCGGCGAGGCCCCTTGGACCCGGACGCTGGAGGGCTCGCGGCCGGCGACGGGCGCGGCGGCGGTCTGGAT
GATGGGCCGCTCGGTCGGCTTCGGGCCCGAGGGCCTGGGCGCGGTGCTGCGCGGCGCCATCGAGGGCCGCGCGGCGATCG
CCGAGGCGCTGGCGCAGCTTCCGGACGTGCGCCTGCTGGAGCCCGCCGACACCAACATCCTGTGCTTCTCGATCGCGGCG
GAGGGCGAGGCGCTCAGCGCCGCCAACGCCCGGACGAGCGCCGCCCACGCCTGGTTCGCGGCCTCTCCGAACCTCTCGCT
GTCGCGGACCGTGCTCGGGACCGAAAGCGCCCCCGATCTCGTCCGCCGGCACGTGCGCAGCTTCCGCGGGCGGATGGAGT
CGGACCGGCTGGTGCTGCTCCGCTGCGTGGTGATGAACCCGCTGTGGGGCGAGGCCGACGCGCGGGCGCGGCTCCTGCCG
CAGCTCGTCTCCGAGCTCCGGTCCGCCATCGACGCCGGCGCGGAAGCAGCGGGTCGACGGGCCGCGGCGCCGGCCTAG

Upstream 100 bases:

>100_bases
CCGGCCGTCAAGCCGCGCCTTGACCCGCGCTTGGCCGCCGCCCCGCCTACGCTTGATGTCGCTCAATCGGCCCGCGCGCG
TGCTGGGGCAGTGTCGACCG

Downstream 100 bases:

>100_bases
AGCGTCAGGCCTTCCCGCGAGGCGAACTCCGTCGCGAGCGCGGCCGCAACGGCGGCTTCGAGCGTGGCGGCGGTGAACGG
CTTGTGCAGCACCATGACGT

Product: glutamate decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MRSSPVPPGCFLGPKSENAAWLRDQLDVVFDAWFEGRRRRFPGDDAQLAATDAGTCRRTAESLHALLAALDQEVPTYTPR
YLGHMVSDPALPALLGHVAALLHNPNNTSREAAKVGTAIEAEAIAMLARMIGYDPSAARGHFTSGGTVANLEAVWRARFR
LDHRLALGLALAEAEGRPLDVFAAAHMTEARFQERLAALGEEAAMRACSGVLNNPYEIAERLRRASGRPYRGPVIIAPGH
RHYSWIKAANVFGLGEAACWTAPLDADGRLDAEGLMACIRRARAEHRPILMVVGVAGTTELGAIDPVDKVAGRLEALREA
EDLDIWLHVDAAYGGFFCTLAADEPRLAPERRRALAAIRRADSVTVDPHKLGYVPYACGALLVRDSSRDAVSSFAAPYVE
RAELGEAPWTRTLEGSRPATGAAAVWMMGRSVGFGPEGLGAVLRGAIEGRAAIAEALAQLPDVRLLEPADTNILCFSIAA
EGEALSAANARTSAAHAWFAASPNLSLSRTVLGTESAPDLVRRHVRSFRGRMESDRLVLLRCVVMNPLWGEADARARLLP
QLVSELRSAIDAGAEAAGRRAAAPA

Sequences:

>Translated_585_residues
MRSSPVPPGCFLGPKSENAAWLRDQLDVVFDAWFEGRRRRFPGDDAQLAATDAGTCRRTAESLHALLAALDQEVPTYTPR
YLGHMVSDPALPALLGHVAALLHNPNNTSREAAKVGTAIEAEAIAMLARMIGYDPSAARGHFTSGGTVANLEAVWRARFR
LDHRLALGLALAEAEGRPLDVFAAAHMTEARFQERLAALGEEAAMRACSGVLNNPYEIAERLRRASGRPYRGPVIIAPGH
RHYSWIKAANVFGLGEAACWTAPLDADGRLDAEGLMACIRRARAEHRPILMVVGVAGTTELGAIDPVDKVAGRLEALREA
EDLDIWLHVDAAYGGFFCTLAADEPRLAPERRRALAAIRRADSVTVDPHKLGYVPYACGALLVRDSSRDAVSSFAAPYVE
RAELGEAPWTRTLEGSRPATGAAAVWMMGRSVGFGPEGLGAVLRGAIEGRAAIAEALAQLPDVRLLEPADTNILCFSIAA
EGEALSAANARTSAAHAWFAASPNLSLSRTVLGTESAPDLVRRHVRSFRGRMESDRLVLLRCVVMNPLWGEADARARLLP
QLVSELRSAIDAGAEAAGRRAAAPA
>Mature_585_residues
MRSSPVPPGCFLGPKSENAAWLRDQLDVVFDAWFEGRRRRFPGDDAQLAATDAGTCRRTAESLHALLAALDQEVPTYTPR
YLGHMVSDPALPALLGHVAALLHNPNNTSREAAKVGTAIEAEAIAMLARMIGYDPSAARGHFTSGGTVANLEAVWRARFR
LDHRLALGLALAEAEGRPLDVFAAAHMTEARFQERLAALGEEAAMRACSGVLNNPYEIAERLRRASGRPYRGPVIIAPGH
RHYSWIKAANVFGLGEAACWTAPLDADGRLDAEGLMACIRRARAEHRPILMVVGVAGTTELGAIDPVDKVAGRLEALREA
EDLDIWLHVDAAYGGFFCTLAADEPRLAPERRRALAAIRRADSVTVDPHKLGYVPYACGALLVRDSSRDAVSSFAAPYVE
RAELGEAPWTRTLEGSRPATGAAAVWMMGRSVGFGPEGLGAVLRGAIEGRAAIAEALAQLPDVRLLEPADTNILCFSIAA
EGEALSAANARTSAAHAWFAASPNLSLSRTVLGTESAPDLVRRHVRSFRGRMESDRLVLLRCVVMNPLWGEADARARLLP
QLVSELRSAIDAGAEAAGRRAAAPA

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=431, Percent_Identity=24.1299303944316, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI194294551, Length=146, Percent_Identity=36.986301369863, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI197276620, Length=146, Percent_Identity=33.5616438356164, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4503875, Length=146, Percent_Identity=33.5616438356164, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI58331246, Length=153, Percent_Identity=31.3725490196078, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555682, Length=199, Percent_Identity=31.6582914572864, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993058, Length=199, Percent_Identity=31.6582914572864, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993062, Length=199, Percent_Identity=31.6582914572864, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356415, Length=394, Percent_Identity=24.3654822335025, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 62656; Mature: 62656

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSPVPPGCFLGPKSENAAWLRDQLDVVFDAWFEGRRRRFPGDDAQLAATDAGTCRRTA
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHH
ESLHALLAALDQEVPTYTPRYLGHMVSDPALPALLGHVAALLHNPNNTSREAAKVGTAIE
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHH
AEAIAMLARMIGYDPSAARGHFTSGGTVANLEAVWRARFRLDHRLALGLALAEAEGRPLD
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
VFAAAHMTEARFQERLAALGEEAAMRACSGVLNNPYEIAERLRRASGRPYRGPVIIAPGH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
RHYSWIKAANVFGLGEAACWTAPLDADGRLDAEGLMACIRRARAEHRPILMVVGVAGTTE
CCHHHHHHHCCCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
LGAIDPVDKVAGRLEALREAEDLDIWLHVDAAYGGFFCTLAADEPRLAPERRRALAAIRR
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHH
ADSVTVDPHKLGYVPYACGALLVRDSSRDAVSSFAAPYVERAELGEAPWTRTLEGSRPAT
CCCCEECHHHCCCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GAAAVWMMGRSVGFGPEGLGAVLRGAIEGRAAIAEALAQLPDVRLLEPADTNILCFSIAA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEC
EGEALSAANARTSAAHAWFAASPNLSLSRTVLGTESAPDLVRRHVRSFRGRMESDRLVLL
CCCHHHHCCCCCHHHCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
RCVVMNPLWGEADARARLLPQLVSELRSAIDAGAEAAGRRAAAPA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure
MRSSPVPPGCFLGPKSENAAWLRDQLDVVFDAWFEGRRRRFPGDDAQLAATDAGTCRRTA
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHH
ESLHALLAALDQEVPTYTPRYLGHMVSDPALPALLGHVAALLHNPNNTSREAAKVGTAIE
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHH
AEAIAMLARMIGYDPSAARGHFTSGGTVANLEAVWRARFRLDHRLALGLALAEAEGRPLD
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
VFAAAHMTEARFQERLAALGEEAAMRACSGVLNNPYEIAERLRRASGRPYRGPVIIAPGH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
RHYSWIKAANVFGLGEAACWTAPLDADGRLDAEGLMACIRRARAEHRPILMVVGVAGTTE
CCHHHHHHHCCCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
LGAIDPVDKVAGRLEALREAEDLDIWLHVDAAYGGFFCTLAADEPRLAPERRRALAAIRR
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHH
ADSVTVDPHKLGYVPYACGALLVRDSSRDAVSSFAAPYVERAELGEAPWTRTLEGSRPAT
CCCCEECHHHCCCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GAAAVWMMGRSVGFGPEGLGAVLRGAIEGRAAIAEALAQLPDVRLLEPADTNILCFSIAA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEC
EGEALSAANARTSAAHAWFAASPNLSLSRTVLGTESAPDLVRRHVRSFRGRMESDRLVLL
CCCHHHHCCCCCHHHCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
RCVVMNPLWGEADARARLLPQLVSELRSAIDAGAEAAGRRAAAPA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]