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The map label for this gene is moaB [H]

Identifier: 197104148

GI number: 197104148

Start: 739989

End: 740564

Strand: Reverse

Name: moaB [H]

Synonym: PHZ_c0682

Alternate gene names: 197104148

Gene position: 740564-739989 (Counterclockwise)

Preceding gene: 197104149

Following gene: 197104147

Centisome position: 18.53

GC content: 74.65

Gene sequence:

>576_bases
GTGACCGCGACCCTGCAGGCGCGCCGGCCCGAGGCCGGCAAGGCGCGCATCGACCCCGACCTGCCGTTCCATCCCCTCGG
GATCGCCGTGCTGACGGTGTCCGACACCCGCGACGAGGCCACCGACACCTCGGGCGGCCTGCTCGCCCAGCGGCTGACGG
GCGCCGGCCATGTCCTCGCCGGCAAGGCCATCGTGCCCGACGAGGTCGAGGCGATCCGCGCGCGGGTGCTGGCCTGGGCG
GCCGATCCCGATGTGGACGTGATCCTGGTCACCGGCGGGACGGGCTTTTCCCCGCGGGACGTCACGCCCGAGGCGGTGCG
CCCCCTGCTGCGCCGGGAGATGGACGGCTTCGCGGTGGTCTTCCACCAGGCGAGCTACGGGACCGTCGGCGTCTCCACCC
TCCAGTCGCGGGCGCTCGCCGGCCAGGTCGAGGACACCTTCGTCTTCTGCGTGCCCGGCTCGACGGGCGCCTGCCGCGAC
GCCTGGGACCTGGTGCTGGCGCAGGAGCTGGACAGCCGTTTCCGCCCCTGCTCGCTGGTCGGCCAGGTGCCGCGCTACCG
CGGCGTCTGTCCCTGA

Upstream 100 bases:

>100_bases
AAGATCGTCGGCTGACCGCCGCCGCCCGGGGGCTTGATGTCGGACAACCGCGATCGCCCGCGGCCGCGGTAGTCAGGCTG
GGCAACTGGGAGCCCCTTCC

Downstream 100 bases:

>100_bases
TCCGCCCTCCTGATCCGCTCGCTGGCCAGCCGGCGACGCCCATCAAGCCTGGCCTTGACGCGCGACAAGCGGATCCGCCG
CCGATGAGTCTATCCAGGCC

Product: molybdopterin biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MTATLQARRPEAGKARIDPDLPFHPLGIAVLTVSDTRDEATDTSGGLLAQRLTGAGHVLAGKAIVPDEVEAIRARVLAWA
ADPDVDVILVTGGTGFSPRDVTPEAVRPLLRREMDGFAVVFHQASYGTVGVSTLQSRALAGQVEDTFVFCVPGSTGACRD
AWDLVLAQELDSRFRPCSLVGQVPRYRGVCP

Sequences:

>Translated_191_residues
MTATLQARRPEAGKARIDPDLPFHPLGIAVLTVSDTRDEATDTSGGLLAQRLTGAGHVLAGKAIVPDEVEAIRARVLAWA
ADPDVDVILVTGGTGFSPRDVTPEAVRPLLRREMDGFAVVFHQASYGTVGVSTLQSRALAGQVEDTFVFCVPGSTGACRD
AWDLVLAQELDSRFRPCSLVGQVPRYRGVCP
>Mature_190_residues
TATLQARRPEAGKARIDPDLPFHPLGIAVLTVSDTRDEATDTSGGLLAQRLTGAGHVLAGKAIVPDEVEAIRARVLAWAA
DPDVDVILVTGGTGFSPRDVTPEAVRPLLRREMDGFAVVFHQASYGTVGVSTLQSRALAGQVEDTFVFCVPGSTGACRDA
WDLVLAQELDSRFRPCSLVGQVPRYRGVCP

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=35.8108108108108, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=35.8108108108108, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1787000, Length=157, Percent_Identity=50.9554140127389, Blast_Score=157, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17564954, Length=143, Percent_Identity=37.7622377622378, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136978, Length=143, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24638841, Length=143, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 20308; Mature: 20177

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLQARRPEAGKARIDPDLPFHPLGIAVLTVSDTRDEATDTSGGLLAQRLTGAGHVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCEEE
GKAIVPDEVEAIRARVLAWAADPDVDVILVTGGTGFSPRDVTPEAVRPLLRREMDGFAVV
CCCCCCHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEE
FHQASYGTVGVSTLQSRALAGQVEDTFVFCVPGSTGACRDAWDLVLAQELDSRFRPCSLV
EECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
GQVPRYRGVCP
HCCCCCCCCCC
>Mature Secondary Structure 
TATLQARRPEAGKARIDPDLPFHPLGIAVLTVSDTRDEATDTSGGLLAQRLTGAGHVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCEEE
GKAIVPDEVEAIRARVLAWAADPDVDVILVTGGTGFSPRDVTPEAVRPLLRREMDGFAVV
CCCCCCHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEE
FHQASYGTVGVSTLQSRALAGQVEDTFVFCVPGSTGACRDAWDLVLAQELDSRFRPCSLV
EECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
GQVPRYRGVCP
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]