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The map label for this gene is prs [H]

Identifier: 197104112

GI number: 197104112

Start: 694237

End: 695226

Strand: Reverse

Name: prs [H]

Synonym: PHZ_c0646

Alternate gene names: 197104112

Gene position: 695226-694237 (Counterclockwise)

Preceding gene: 197104113

Following gene: 197104110

Centisome position: 17.4

GC content: 75.15

Gene sequence:

>990_bases
ATGAGCGGCCTTCCGTCGACCGTGCGCCTGTTCGCGCTGAACGCCACGGCCGAGCTCGGCGCGGCGATCGCCAGCGCCGC
GGGCCGGCCCCTCACGCCGCACGAGGAGCGCGAATTCGAGGACGGCGAACACAAGGCCCGGCCGCTGGAGTCCGTCGCCG
GCGCCGACTGCTACGTGATCCAGAGCCTGCACGGCGGCCCGGACCAGAGCGCCAACGACAAGCTCTGCCGCCTGCTGTTC
TTCATCGGCGCTCTGAAGGACGCGGGCGCGGCGCGGGTGACCGCCGTCGCGCCCTACCTCTGCTATGCGCGCAAGGACGT
GCGCACCAAGCCGTTCGACCCCGTCACCGTCCGCTATGTGGCGTCGCTGTTCGAGGCGGTGGGGACCGATGCGGTCGTCG
CGCTGGAGGTCCACAACCCGGCCGCGTTCGAGAACGCCTTCCGCCGGCGGGCGATCGCGCTGTCGGCCGCGCCGCTGTTC
CTGGATCTGGCGGCCGGCCTCGCCGACGGCCCGGTCTGCGTGCTCTCGCCCGACCCGGGCGGGGCCAAGCGCGCCGAGCT
GTTCCGCCAGGCGCTGGAGGCCCGCCTCGGCCGCCCGGTCGGCAAGGCATTCGCCGACAAGCACCGCAGCGGCGGCGTGG
TCACCGGCGACCTGCTGGTGGGCGACGTCCGGGACGCCGCCGTCTTCGTCGTGGACGACCTGATCAGCACCGGCGGCACC
ATCGCCCGCGCCGCCCGCTCGGCCCGGGCCGCGGGCGCCCGGCGCGTCGTGGCGCTGGCCGCCCACGGCCTCTTCATGCC
GGGCGCCGCCGAGGTCCTGGCCGACCCGGCGGTGGAGCGCATCGTGGTCGCCGACGCCGCGCCGCCGTCCCGCATCGCCG
GATCGCCGCTGCAGGCCAAGGTCGAGGCGCTCGCCAGCGCGCCGCTGCTGGCCGAGGCGATCCGGCGGCTGGCCTGCGAT
GAGGCGCTTACCGACCTGATGGTGTTCTGA

Upstream 100 bases:

>100_bases
ACGCCTGCCGGGCCCTCGACGTGGACGGCTCCGAGGCCGAGGCGCGGCGGCGGCTGGGCGAGGCCGACGTGCGGTTCTCA
CGCGCTGAAGAGCTCAGGCC

Downstream 100 bases:

>100_bases
GCCGCCGCTCCAACTGGCGGGCGTCGCGGGCCGCGAGCGCCAGGTAGGCCCTCGCCTGCCGCGGCCATTTCTCGGGGGTG
CGCGGGTTCGGCTCCAGCAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSGLPSTVRLFALNATAELGAAIASAAGRPLTPHEEREFEDGEHKARPLESVAGADCYVIQSLHGGPDQSANDKLCRLLF
FIGALKDAGAARVTAVAPYLCYARKDVRTKPFDPVTVRYVASLFEAVGTDAVVALEVHNPAAFENAFRRRAIALSAAPLF
LDLAAGLADGPVCVLSPDPGGAKRAELFRQALEARLGRPVGKAFADKHRSGGVVTGDLLVGDVRDAAVFVVDDLISTGGT
IARAARSARAAGARRVVALAAHGLFMPGAAEVLADPAVERIVVADAAPPSRIAGSPLQAKVEALASAPLLAEAIRRLACD
EALTDLMVF

Sequences:

>Translated_329_residues
MSGLPSTVRLFALNATAELGAAIASAAGRPLTPHEEREFEDGEHKARPLESVAGADCYVIQSLHGGPDQSANDKLCRLLF
FIGALKDAGAARVTAVAPYLCYARKDVRTKPFDPVTVRYVASLFEAVGTDAVVALEVHNPAAFENAFRRRAIALSAAPLF
LDLAAGLADGPVCVLSPDPGGAKRAELFRQALEARLGRPVGKAFADKHRSGGVVTGDLLVGDVRDAAVFVVDDLISTGGT
IARAARSARAAGARRVVALAAHGLFMPGAAEVLADPAVERIVVADAAPPSRIAGSPLQAKVEALASAPLLAEAIRRLACD
EALTDLMVF
>Mature_328_residues
SGLPSTVRLFALNATAELGAAIASAAGRPLTPHEEREFEDGEHKARPLESVAGADCYVIQSLHGGPDQSANDKLCRLLFF
IGALKDAGAARVTAVAPYLCYARKDVRTKPFDPVTVRYVASLFEAVGTDAVVALEVHNPAAFENAFRRRAIALSAAPLFL
DLAAGLADGPVCVLSPDPGGAKRAELFRQALEARLGRPVGKAFADKHRSGGVVTGDLLVGDVRDAAVFVVDDLISTGGTI
ARAARSARAAGARRVVALAAHGLFMPGAAEVLADPAVERIVVADAAPPSRIAGSPLQAKVEALASAPLLAEAIRRLACDE
ALTDLMVF

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=326, Percent_Identity=32.8220858895706, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4506127, Length=323, Percent_Identity=32.1981424148607, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI84875539, Length=329, Percent_Identity=32.5227963525836, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI28557709, Length=323, Percent_Identity=31.5789473684211, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1787458, Length=321, Percent_Identity=34.8909657320872, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25149168, Length=322, Percent_Identity=29.5031055900621, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17554702, Length=322, Percent_Identity=29.5031055900621, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71989924, Length=323, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17554704, Length=292, Percent_Identity=31.5068493150685, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17570245, Length=308, Percent_Identity=24.3506493506494, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320946, Length=326, Percent_Identity=30.9815950920245, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319403, Length=324, Percent_Identity=31.1728395061728, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321776, Length=326, Percent_Identity=29.4478527607362, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324511, Length=116, Percent_Identity=31.8965517241379, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322667, Length=190, Percent_Identity=28.4210526315789, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355239, Length=328, Percent_Identity=29.8780487804878, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45551540, Length=351, Percent_Identity=28.2051282051282, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34187; Mature: 34055

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLPSTVRLFALNATAELGAAIASAAGRPLTPHEEREFEDGEHKARPLESVAGADCYVI
CCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEE
QSLHGGPDQSANDKLCRLLFFIGALKDAGAARVTAVAPYLCYARKDVRTKPFDPVTVRYV
ECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ASLFEAVGTDAVVALEVHNPAAFENAFRRRAIALSAAPLFLDLAAGLADGPVCVLSPDPG
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
GAKRAELFRQALEARLGRPVGKAFADKHRSGGVVTGDLLVGDVRDAAVFVVDDLISTGGT
CHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCEEEECCHHHHHHHHHHHHHCCCH
IARAARSARAAGARRVVALAAHGLFMPGAAEVLADPAVERIVVADAAPPSRIAGSPLQAK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHEEEEECCCCCHHHCCCCHHHH
VEALASAPLLAEAIRRLACDEALTDLMVF
HHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGLPSTVRLFALNATAELGAAIASAAGRPLTPHEEREFEDGEHKARPLESVAGADCYVI
CCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEE
QSLHGGPDQSANDKLCRLLFFIGALKDAGAARVTAVAPYLCYARKDVRTKPFDPVTVRYV
ECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ASLFEAVGTDAVVALEVHNPAAFENAFRRRAIALSAAPLFLDLAAGLADGPVCVLSPDPG
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
GAKRAELFRQALEARLGRPVGKAFADKHRSGGVVTGDLLVGDVRDAAVFVVDDLISTGGT
CHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCEEEECCHHHHHHHHHHHHHCCCH
IARAARSARAAGARRVVALAAHGLFMPGAAEVLADPAVERIVVADAAPPSRIAGSPLQAK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHEEEEECCCCCHHHCCCCHHHH
VEALASAPLLAEAIRRLACDEALTDLMVF
HHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]