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The map label for this gene is nrdZ [H]

Identifier: 197104105

GI number: 197104105

Start: 688478

End: 690190

Strand: Direct

Name: nrdZ [H]

Synonym: PHZ_c0639

Alternate gene names: 197104105

Gene position: 688478-690190 (Clockwise)

Preceding gene: 197104104

Following gene: 197104108

Centisome position: 17.23

GC content: 77.41

Gene sequence:

>1713_bases
TTGGCCGCTGAGCTCTCCGGCGCCGAGCTCTCCCGCCTGGTGTGGGAGGCCAAGTACCGGGCCCCCGGAGAGGCCGCGGT
CGCCGACACCTGGGCCCGCATCGCCGCCGCGACCGCCGCAGTGGAGCGCGAACCGGGGCTCTGGCGAGGACGGTTTCGGG
CCTTGCTGGAGGACTTCCGCTTCCTCCCCGGCGGGCGGATCCAGGCGGGGGCGGGCGATCCCGCCGCGGTGCTGTTCAAC
TGCTTCGTCCTGCCCGCATTCGGGCCTGGACCCGGGGCCGAGGCCGACCGGGCGCTGGACGCCCTGCGGGAGGCGGTGGC
GACCCTCCGGGCGGGCGGCGGCGTCGGCTGCGACGTCTCGGGGGCGCCGCCGGCCGGCGCGGCCGCGGAGCGGGGGCCGC
CGGCGCCGGGGCCCGTCGGCTACCTGCACCTGTGGGACGCCGCGTGCCGCGTGTTCCTGGCCGGCGCGACGCGTCAGGGC
GCGCTGATGGGCGCGCTCCGCTGCGACCACCCGGACGTGGAGGCCTTCGCCGCGGCCAAGACCGCGCCCGGCGCGCTCAG
CCGGTTCAACCTCTCTGTGGCGGTGACCGAGGCCTTCATGGCGGCGGTCGCGGCGGACGCCGACTGGCCGCTGAGGTTCC
CCGTGGAGACGGGCCCCGTGGTGCGCACGGTCCGCGCCCGGGGCCTCTGGACCCGCATCCTGCGCTGCGCCTACGAGACC
GGCGATCCGGGGGTGCTGTTTATCGACCGGATCAACGCGGAGAACCCGCTGGCCTGGCGCGAGCGGCTGGCGGCGACCAA
CCCCTGCGGCGAGGTCCCGCTGCCCGACTACGGCGCCTGCGACCTGGGCTCGCTGAACCTGACGCGCTTCGTCGCCGCGC
CCTTCACGCCCGAGGCGCGCCTGGACCTGGCCGGCCTGGCAGAGGCGGCGGCGGCGGCGGTGCGCCTGCTGGACGACGTC
ATCGACATCTCGGCCTTCCCGCTCGCCGCCCAGGCCGACGAGGCGCGGGCCACGCGCCGGATCGGCCTCGGGATCACCGG
CCTGGCCGACGCCCTGGTGATGCTGGGGCTGCGGTACGGCGAGGCGGCGTCGCTGCGGGCGGCCGGTGAAGCGATGCGCA
CGATCCGCGACGCGGCCTACGGCGCCTCGGCCGGGCTGGCGCGGGAGAAGGGCGCCTTCCCCGCCTGCGAGGCGGAGCGG
CTGCTGGCCGGGCCGTTCGCGCGGCGCCTGCCGGAACCGCTGCGCGCGGCCATCGCGCGGCACGGGCTGCGCAATAGCCA
CCTGCTCGCCGTCGCGCCCGCCGGATCGATCAGCCTGCTGGCGGGCGGGATCTCGCCCGGGCTGGAGCCGATCTTCGCCG
CCGTGCAGGAACGGACCCTGCGCACGAGCCCCGGGGAGACCCGCGCCGTCCGCTGGACGGCCGCCTCGGTGGCGCTGTGG
CGGCGCGCGACGGGCGAGGCCGCCGGCCTTCCGCCGGCGTTCGCGGCGGCCCACGACATCCCCGCGGACGCGCACCTCGA
CATGCAGGCGGCGCTGCAGCCTTACGTGGACCAGGCGATCTCGAAGACCGTCAACGTCCCGGTCGAGACCCCCTTCGAGG
ACTTCGCGCGGATCTACGCCGGGGCGCACGCGCGGGGGCTGAAGGGCTGCACCGCCTTCCGGCCGGCGCGCGCGCAGGTG
ATCGCCGCGGCGCCCGGCGGGTGTCCGGGCTAG

Upstream 100 bases:

>100_bases
CCGGGGAGCGGGACACGCTCGCCCGCGGAGGCCGCCATGACCGCCCTCGCCGCACGCCCGCCATGCCCCAGCGCCCGCCG
GCTCCCGCGCGAGGCGCGCC

Downstream 100 bases:

>100_bases
GCCTGGGCGGCGCCCTTCACGAGGTGGACGGTCGAGGCCTGGGGCCCCTTCACGCCTTCGCTCTCGGCGAAGCGGACCCG
GTCGCCGACGGCGAGGTGCT

Product: ribonucleoside-diphosphate reductase alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MAAELSGAELSRLVWEAKYRAPGEAAVADTWARIAAATAAVEREPGLWRGRFRALLEDFRFLPGGRIQAGAGDPAAVLFN
CFVLPAFGPGPGAEADRALDALREAVATLRAGGGVGCDVSGAPPAGAAAERGPPAPGPVGYLHLWDAACRVFLAGATRQG
ALMGALRCDHPDVEAFAAAKTAPGALSRFNLSVAVTEAFMAAVAADADWPLRFPVETGPVVRTVRARGLWTRILRCAYET
GDPGVLFIDRINAENPLAWRERLAATNPCGEVPLPDYGACDLGSLNLTRFVAAPFTPEARLDLAGLAEAAAAAVRLLDDV
IDISAFPLAAQADEARATRRIGLGITGLADALVMLGLRYGEAASLRAAGEAMRTIRDAAYGASAGLAREKGAFPACEAER
LLAGPFARRLPEPLRAAIARHGLRNSHLLAVAPAGSISLLAGGISPGLEPIFAAVQERTLRTSPGETRAVRWTAASVALW
RRATGEAAGLPPAFAAAHDIPADAHLDMQAALQPYVDQAISKTVNVPVETPFEDFARIYAGAHARGLKGCTAFRPARAQV
IAAAPGGCPG

Sequences:

>Translated_570_residues
MAAELSGAELSRLVWEAKYRAPGEAAVADTWARIAAATAAVEREPGLWRGRFRALLEDFRFLPGGRIQAGAGDPAAVLFN
CFVLPAFGPGPGAEADRALDALREAVATLRAGGGVGCDVSGAPPAGAAAERGPPAPGPVGYLHLWDAACRVFLAGATRQG
ALMGALRCDHPDVEAFAAAKTAPGALSRFNLSVAVTEAFMAAVAADADWPLRFPVETGPVVRTVRARGLWTRILRCAYET
GDPGVLFIDRINAENPLAWRERLAATNPCGEVPLPDYGACDLGSLNLTRFVAAPFTPEARLDLAGLAEAAAAAVRLLDDV
IDISAFPLAAQADEARATRRIGLGITGLADALVMLGLRYGEAASLRAAGEAMRTIRDAAYGASAGLAREKGAFPACEAER
LLAGPFARRLPEPLRAAIARHGLRNSHLLAVAPAGSISLLAGGISPGLEPIFAAVQERTLRTSPGETRAVRWTAASVALW
RRATGEAAGLPPAFAAAHDIPADAHLDMQAALQPYVDQAISKTVNVPVETPFEDFARIYAGAHARGLKGCTAFRPARAQV
IAAAPGGCPG
>Mature_569_residues
AAELSGAELSRLVWEAKYRAPGEAAVADTWARIAAATAAVEREPGLWRGRFRALLEDFRFLPGGRIQAGAGDPAAVLFNC
FVLPAFGPGPGAEADRALDALREAVATLRAGGGVGCDVSGAPPAGAAAERGPPAPGPVGYLHLWDAACRVFLAGATRQGA
LMGALRCDHPDVEAFAAAKTAPGALSRFNLSVAVTEAFMAAVAADADWPLRFPVETGPVVRTVRARGLWTRILRCAYETG
DPGVLFIDRINAENPLAWRERLAATNPCGEVPLPDYGACDLGSLNLTRFVAAPFTPEARLDLAGLAEAAAAAVRLLDDVI
DISAFPLAAQADEARATRRIGLGITGLADALVMLGLRYGEAASLRAAGEAMRTIRDAAYGASAGLAREKGAFPACEAERL
LAGPFARRLPEPLRAAIARHGLRNSHLLAVAPAGSISLLAGGISPGLEPIFAAVQERTLRTSPGETRAVRWTAASVALWR
RATGEAAGLPPAFAAAHDIPADAHLDMQAALQPYVDQAISKTVNVPVETPFEDFARIYAGAHARGLKGCTAFRPARAQVI
AAAPGGCPG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=543, Percent_Identity=24.1252302025783, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI2367133, Length=350, Percent_Identity=24.2857142857143, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17555242, Length=511, Percent_Identity=25.0489236790607, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322123, Length=522, Percent_Identity=24.3295019157088, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320914, Length=522, Percent_Identity=22.9885057471264, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17352481, Length=532, Percent_Identity=24.4360902255639, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 59201; Mature: 59070

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAELSGAELSRLVWEAKYRAPGEAAVADTWARIAAATAAVEREPGLWRGRFRALLEDFR
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FLPGGRIQAGAGDPAAVLFNCFVLPAFGPGPGAEADRALDALREAVATLRAGGGVGCDVS
CCCCCEEECCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GAPPAGAAAERGPPAPGPVGYLHLWDAACRVFLAGATRQGALMGALRCDHPDVEAFAAAK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEHHCCCCCCHHHHHHHC
TAPGALSRFNLSVAVTEAFMAAVAADADWPLRFPVETGPVVRTVRARGLWTRILRCAYET
CCCCCHHHEEEHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
GDPGVLFIDRINAENPLAWRERLAATNPCGEVPLPDYGACDLGSLNLTRFVAAPFTPEAR
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCC
LDLAGLAEAAAAAVRLLDDVIDISAFPLAAQADEARATRRIGLGITGLADALVMLGLRYG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
EAASLRAAGEAMRTIRDAAYGASAGLAREKGAFPACEAERLLAGPFARRLPEPLRAAIAR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHCCHHHHHCCHHHHHHHHH
HGLRNSHLLAVAPAGSISLLAGGISPGLEPIFAAVQERTLRTSPGETRAVRWTAASVALW
CCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
RRATGEAAGLPPAFAAAHDIPADAHLDMQAALQPYVDQAISKTVNVPVETPFEDFARIYA
HHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GAHARGLKGCTAFRPARAQVIAAAPGGCPG
CCCCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
AAELSGAELSRLVWEAKYRAPGEAAVADTWARIAAATAAVEREPGLWRGRFRALLEDFR
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FLPGGRIQAGAGDPAAVLFNCFVLPAFGPGPGAEADRALDALREAVATLRAGGGVGCDVS
CCCCCEEECCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GAPPAGAAAERGPPAPGPVGYLHLWDAACRVFLAGATRQGALMGALRCDHPDVEAFAAAK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEHHCCCCCCHHHHHHHC
TAPGALSRFNLSVAVTEAFMAAVAADADWPLRFPVETGPVVRTVRARGLWTRILRCAYET
CCCCCHHHEEEHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
GDPGVLFIDRINAENPLAWRERLAATNPCGEVPLPDYGACDLGSLNLTRFVAAPFTPEAR
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCC
LDLAGLAEAAAAAVRLLDDVIDISAFPLAAQADEARATRRIGLGITGLADALVMLGLRYG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
EAASLRAAGEAMRTIRDAAYGASAGLAREKGAFPACEAERLLAGPFARRLPEPLRAAIAR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHCCHHHHHCCHHHHHHHHH
HGLRNSHLLAVAPAGSISLLAGGISPGLEPIFAAVQERTLRTSPGETRAVRWTAASVALW
CCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
RRATGEAAGLPPAFAAAHDIPADAHLDMQAALQPYVDQAISKTVNVPVETPFEDFARIYA
HHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GAHARGLKGCTAFRPARAQVIAAAPGGCPG
CCCCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]