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The map label for this gene is nrdZ [H]

Identifier: 197104081

GI number: 197104081

Start: 660224

End: 662461

Strand: Reverse

Name: nrdZ [H]

Synonym: PHZ_c0615

Alternate gene names: 197104081

Gene position: 662461-660224 (Counterclockwise)

Preceding gene: 197104084

Following gene: 197104079

Centisome position: 16.58

GC content: 73.01

Gene sequence:

>2238_bases
ATGGCGTTCGACAATCCGCTCGCGGCCGAGATCTGGTCCGGCAAGTACCGCTTCGCCCAGCCCGACGGCGCGGGCGACGG
CAGCGTGGAGGCCACCTGGGCCCGCGTGGCCGAGGCCATCGCGCGGGCCGAATCGCCCAAGCTGCGGCGCGCCTGGCGCG
AGCGGTTCGAGGACGCCCTGGGCGACTTCCAGTTCCTGCCCGCCGGCCGCATCCTGGCGGGCGCCGGCACGGCCCGCACG
GTCACCCTCTTCAACTGCTTCGTCATGGGCGCCATCCCGGACGACCTGGAGGGGATCTTCCGCCACGTGCAGGAGGCCGC
GGTCACCATGCAGCAGGGCGGCGGGGTGGGCATGGACTTCTCCACCATCCGCCCCTCGGGCGCCCCGGTGCGCGGCGTCG
GCGCCGACGCCTCCGGCCCTCTGAGCTTCATGGACGTGTGGGATTCGATGTGCCGCACCATCCTCTCGGCCGGCCAGCGG
CGCGGGGCGATGATGGGCTGCCTGCGCATCGACCACCCCGACATCGAGGCCTTCATCGACGCCAAGCGCGACGGGGCGCG
GCTGCGCAACTTCAACCTCTCGGTCCTGGTCACCGACGCCTTCCTCGAGACGCTGGAGCGCGACGGCGAGTGGCCCCTGG
TGTTCGATGGCGTGGTCCACCGCACGGTCCGCGCCGCCGACCTCTGGCGGCGGCTGATGCAGGGCACCTACGACTGCGCC
GAGCCCGGCGTGATCTTCATCGACCGGGTCAACGCCCGGAACAACCTCGCCCACTGCGAGACCATCACCGCCTCCAACCC
CTGCGGCGAGCAGATGCTGCCGCCCTACGGCGCCTGCCTGCTGGGCTCGATCAACCTGGCCCGGCTGGTCCCCGCCCCGT
TCGAGCCGGGCGCCGAGTTGGACGAGGACCGGCTCGCCGCCCTCACCCGCACCGCGGTGCGGTTCCTCGACAACGTGATC
GACGTTTCGCGCTATCCGCTGCCGGCCCAGGAGGCCGAGGCCAAGGCCAAGCGCCGCATCGGCCTCGGCGTCACCGGCCT
CGCCGACGCCCTGATCTTCTGCGGCGTGCCCTACGGCGGCGAGCGGTCGGCCGAGCTCACCCGCCGCTGGCTCGAGGTCA
TCAAGCGCGAGGCCTACCGCGCCTCGGCCGAGCTGGCGGCCGAGAAGGGCGCCTTCCCCCTCTACGACCCGGTCATGCTC
GAGACGCCCAACCTGAAGGGCCTCGATCCCGAGACCCGCGAGCTGATCGCCCGCCACGGCCTGCGCAACGGCTGCCTCAC
CTCGATCGCGCCCACCGGCACCACCTCGCTGCTGGCCGGCAACGTCTCGTCGGGCATCGAGCCGGTGTTCGCCTTCGCCT
ACACCCGCAAGGTCCGCCAGCCCGACGGCTCCTCCCGCGAGGAGGCGGTGGAGGACTACGCCTTGGCGGTGTGGAAGCGC
CTGCACGGACAGGCCGAGCCGCCGGCCGACATCTTCGTCACCGCCCAGACGCTCACCCCCGCCGACCACCTGCGCATCCA
GGCCGCCGCCCAGGAGGTGGTCGACAGCTCGATCTCCAAGACCGTCAACTGCCCCGAGGACATCGCCTTCGACGCGTTCT
CCGACGTCTACCTCGACGGCTGGCGGCGCGGCTGCAAGGGGCTGACCACCTACCGGCCGAACGCGGTGACCGGCTCGGTC
CTGTCGGTGGCGCCGGCCAAGCCGGAGCCGCCGGCGCCGACGCCCGCCCCCCTGCCGCCCCGCCCCGAGTCGCTGGAGGG
GGCGACCTACAAGGTGCGCTGGCCGCACAGCGCCCACGCCGTCTACGTCACCATCAACGACGAGGGGGAAGGCGACGAGC
GGCGGCCGTTCGAGATCTTCGTGAACTCCAAGAACATGGAGCACTACGCCTGGACCCTGGCCCTGACCCGCATGATCTCG
GCGGTCTTCCGGCGCGGCGGCGACGTCTCGTTCGTGGCCGAGGAGCTGAAGGCGGTGTTCGATCCCCAGGGCGGCGCCTG
GCTCGCCGGCCGCTACGTGCCCTCTCTGCCGGCGGCGATCGGCGGGATCCTCGAGCGGCACCTTGGCCGCGCCGGCCCGG
TCTGCGATCCGGTCGAGGCGCCGCCGGCGGCGCCCCCCGCGACCGCCGAGGCCGCCGCCGCGCCCCGCGCCGTCTGCCCC
CGCTGCGGCGGGACCGGCCTGGTGCGCAAGGAGGGCTGCGACACCTGCTTCGACTGCGGCTACTCCAAGTGCGGCTGA

Upstream 100 bases:

>100_bases
CCTCATCTAGTCCGCCGAGTCCCGCCCGATCTTTGCGGCCCGACAAATTCGCCTGCGCGGGAATCGCCCAGCCTCGCCTG
TCCCACCAAGGAGACAGCAC

Downstream 100 bases:

>100_bases
GCCGCCGCCCCGCTCTTCAGCCATGAAAAAAGGCCCGCCGGAAACGGCGGGCCTTCCTCTTTTGCGGATGGGCGGACGGC
TAGTGGCCGTGATCCTGGTT

Product: Ribonucleotide reductase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MAFDNPLAAEIWSGKYRFAQPDGAGDGSVEATWARVAEAIARAESPKLRRAWRERFEDALGDFQFLPAGRILAGAGTART
VTLFNCFVMGAIPDDLEGIFRHVQEAAVTMQQGGGVGMDFSTIRPSGAPVRGVGADASGPLSFMDVWDSMCRTILSAGQR
RGAMMGCLRIDHPDIEAFIDAKRDGARLRNFNLSVLVTDAFLETLERDGEWPLVFDGVVHRTVRAADLWRRLMQGTYDCA
EPGVIFIDRVNARNNLAHCETITASNPCGEQMLPPYGACLLGSINLARLVPAPFEPGAELDEDRLAALTRTAVRFLDNVI
DVSRYPLPAQEAEAKAKRRIGLGVTGLADALIFCGVPYGGERSAELTRRWLEVIKREAYRASAELAAEKGAFPLYDPVML
ETPNLKGLDPETRELIARHGLRNGCLTSIAPTGTTSLLAGNVSSGIEPVFAFAYTRKVRQPDGSSREEAVEDYALAVWKR
LHGQAEPPADIFVTAQTLTPADHLRIQAAAQEVVDSSISKTVNCPEDIAFDAFSDVYLDGWRRGCKGLTTYRPNAVTGSV
LSVAPAKPEPPAPTPAPLPPRPESLEGATYKVRWPHSAHAVYVTINDEGEGDERRPFEIFVNSKNMEHYAWTLALTRMIS
AVFRRGGDVSFVAEELKAVFDPQGGAWLAGRYVPSLPAAIGGILERHLGRAGPVCDPVEAPPAAPPATAEAAAAPRAVCP
RCGGTGLVRKEGCDTCFDCGYSKCG

Sequences:

>Translated_745_residues
MAFDNPLAAEIWSGKYRFAQPDGAGDGSVEATWARVAEAIARAESPKLRRAWRERFEDALGDFQFLPAGRILAGAGTART
VTLFNCFVMGAIPDDLEGIFRHVQEAAVTMQQGGGVGMDFSTIRPSGAPVRGVGADASGPLSFMDVWDSMCRTILSAGQR
RGAMMGCLRIDHPDIEAFIDAKRDGARLRNFNLSVLVTDAFLETLERDGEWPLVFDGVVHRTVRAADLWRRLMQGTYDCA
EPGVIFIDRVNARNNLAHCETITASNPCGEQMLPPYGACLLGSINLARLVPAPFEPGAELDEDRLAALTRTAVRFLDNVI
DVSRYPLPAQEAEAKAKRRIGLGVTGLADALIFCGVPYGGERSAELTRRWLEVIKREAYRASAELAAEKGAFPLYDPVML
ETPNLKGLDPETRELIARHGLRNGCLTSIAPTGTTSLLAGNVSSGIEPVFAFAYTRKVRQPDGSSREEAVEDYALAVWKR
LHGQAEPPADIFVTAQTLTPADHLRIQAAAQEVVDSSISKTVNCPEDIAFDAFSDVYLDGWRRGCKGLTTYRPNAVTGSV
LSVAPAKPEPPAPTPAPLPPRPESLEGATYKVRWPHSAHAVYVTINDEGEGDERRPFEIFVNSKNMEHYAWTLALTRMIS
AVFRRGGDVSFVAEELKAVFDPQGGAWLAGRYVPSLPAAIGGILERHLGRAGPVCDPVEAPPAAPPATAEAAAAPRAVCP
RCGGTGLVRKEGCDTCFDCGYSKCG
>Mature_744_residues
AFDNPLAAEIWSGKYRFAQPDGAGDGSVEATWARVAEAIARAESPKLRRAWRERFEDALGDFQFLPAGRILAGAGTARTV
TLFNCFVMGAIPDDLEGIFRHVQEAAVTMQQGGGVGMDFSTIRPSGAPVRGVGADASGPLSFMDVWDSMCRTILSAGQRR
GAMMGCLRIDHPDIEAFIDAKRDGARLRNFNLSVLVTDAFLETLERDGEWPLVFDGVVHRTVRAADLWRRLMQGTYDCAE
PGVIFIDRVNARNNLAHCETITASNPCGEQMLPPYGACLLGSINLARLVPAPFEPGAELDEDRLAALTRTAVRFLDNVID
VSRYPLPAQEAEAKAKRRIGLGVTGLADALIFCGVPYGGERSAELTRRWLEVIKREAYRASAELAAEKGAFPLYDPVMLE
TPNLKGLDPETRELIARHGLRNGCLTSIAPTGTTSLLAGNVSSGIEPVFAFAYTRKVRQPDGSSREEAVEDYALAVWKRL
HGQAEPPADIFVTAQTLTPADHLRIQAAAQEVVDSSISKTVNCPEDIAFDAFSDVYLDGWRRGCKGLTTYRPNAVTGSVL
SVAPAKPEPPAPTPAPLPPRPESLEGATYKVRWPHSAHAVYVTINDEGEGDERRPFEIFVNSKNMEHYAWTLALTRMISA
VFRRGGDVSFVAEELKAVFDPQGGAWLAGRYVPSLPAAIGGILERHLGRAGPVCDPVEAPPAAPPATAEAAAAPRAVCPR
CGGTGLVRKEGCDTCFDCGYSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=550, Percent_Identity=26.3636363636364, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI2367133, Length=563, Percent_Identity=25.7548845470693, Blast_Score=126, Evalue=6e-30,
Organism=Escherichia coli, GI1789030, Length=584, Percent_Identity=24.3150684931507, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17555242, Length=575, Percent_Identity=26.0869565217391, Blast_Score=180, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322123, Length=564, Percent_Identity=24.822695035461, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320914, Length=567, Percent_Identity=23.8095238095238, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17352481, Length=447, Percent_Identity=28.1879194630872, Blast_Score=176, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 80464; Mature: 80333

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDNPLAAEIWSGKYRFAQPDGAGDGSVEATWARVAEAIARAESPKLRRAWRERFEDAL
CCCCCCCHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GDFQFLPAGRILAGAGTARTVTLFNCFVMGAIPDDLEGIFRHVQEAAVTMQQGGGVGMDF
CCEEECCCCCEEECCCCCCEEHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
STIRPSGAPVRGVGADASGPLSFMDVWDSMCRTILSAGQRRGAMMGCLRIDHPDIEAFID
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCEEEEEECCCCCHHHHHC
AKRDGARLRNFNLSVLVTDAFLETLERDGEWPLVFDGVVHRTVRAADLWRRLMQGTYDCA
CCCCCCCEECCCEEEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCC
EPGVIFIDRVNARNNLAHCETITASNPCGEQMLPPYGACLLGSINLARLVPAPFEPGAEL
CCCEEEEEECCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCC
DEDRLAALTRTAVRFLDNVIDVSRYPLPAQEAEAKAKRRIGLGVTGLADALIFCGVPYGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
ERSAELTRRWLEVIKREAYRASAELAAEKGAFPLYDPVMLETPNLKGLDPETRELIARHG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCC
LRNGCLTSIAPTGTTSLLAGNVSSGIEPVFAFAYTRKVRQPDGSSREEAVEDYALAVWKR
CCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LHGQAEPPADIFVTAQTLTPADHLRIQAAAQEVVDSSISKTVNCPEDIAFDAFSDVYLDG
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
WRRGCKGLTTYRPNAVTGSVLSVAPAKPEPPAPTPAPLPPRPESLEGATYKVRWPHSAHA
HHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCE
VYVTINDEGEGDERRPFEIFVNSKNMEHYAWTLALTRMISAVFRRGGDVSFVAEELKAVF
EEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DPQGGAWLAGRYVPSLPAAIGGILERHLGRAGPVCDPVEAPPAAPPATAEAAAAPRAVCP
CCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCC
RCGGTGLVRKEGCDTCFDCGYSKCG
CCCCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
AFDNPLAAEIWSGKYRFAQPDGAGDGSVEATWARVAEAIARAESPKLRRAWRERFEDAL
CCCCCCHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GDFQFLPAGRILAGAGTARTVTLFNCFVMGAIPDDLEGIFRHVQEAAVTMQQGGGVGMDF
CCEEECCCCCEEECCCCCCEEHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
STIRPSGAPVRGVGADASGPLSFMDVWDSMCRTILSAGQRRGAMMGCLRIDHPDIEAFID
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCEEEEEECCCCCHHHHHC
AKRDGARLRNFNLSVLVTDAFLETLERDGEWPLVFDGVVHRTVRAADLWRRLMQGTYDCA
CCCCCCCEECCCEEEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCC
EPGVIFIDRVNARNNLAHCETITASNPCGEQMLPPYGACLLGSINLARLVPAPFEPGAEL
CCCEEEEEECCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCC
DEDRLAALTRTAVRFLDNVIDVSRYPLPAQEAEAKAKRRIGLGVTGLADALIFCGVPYGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
ERSAELTRRWLEVIKREAYRASAELAAEKGAFPLYDPVMLETPNLKGLDPETRELIARHG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCC
LRNGCLTSIAPTGTTSLLAGNVSSGIEPVFAFAYTRKVRQPDGSSREEAVEDYALAVWKR
CCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LHGQAEPPADIFVTAQTLTPADHLRIQAAAQEVVDSSISKTVNCPEDIAFDAFSDVYLDG
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
WRRGCKGLTTYRPNAVTGSVLSVAPAKPEPPAPTPAPLPPRPESLEGATYKVRWPHSAHA
HHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCE
VYVTINDEGEGDERRPFEIFVNSKNMEHYAWTLALTRMISAVFRRGGDVSFVAEELKAVF
EEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DPQGGAWLAGRYVPSLPAAIGGILERHLGRAGPVCDPVEAPPAAPPATAEAAAAPRAVCP
CCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCC
RCGGTGLVRKEGCDTCFDCGYSKCG
CCCCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]