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The map label for this gene is lhgO [H]

Identifier: 197104076

GI number: 197104076

Start: 653594

End: 654733

Strand: Direct

Name: lhgO [H]

Synonym: PHZ_c0610

Alternate gene names: 197104076

Gene position: 653594-654733 (Clockwise)

Preceding gene: 197104075

Following gene: 197104080

Centisome position: 16.36

GC content: 73.95

Gene sequence:

>1140_bases
ATGGCCGAGTTCGATTTCGATGCGGTGGTCGTGGGCGCGGGCGCCGTGGGGCTGGCGTGCGGCTACGCGCTGGCCCGGCG
GGGCCTGACGGCGGCGGTGCTGGAGCAGGACGCGGCCATCGGCCAGGGCGTCTCCTCGCGCAACTCCGAGGTGATCCACG
GCGGGCTCTACTATCCGACGGGGTCGCTGAAGGCGCGGCTGTGCGTGGCCGGCCGGCGGATGCTGTACGCCTTCCTCGAC
GCCCACCACGTGGCCTACGACCGCTGCGGCAAGCTGGTGGTGGCCACCGCGCCCGAGGAGGTGGAGCGGCTGGACGCCAT
CCTCGAGCAGGCGCGGACCAACGAGGTGGAGGGGATGGCGCGGCTCTCGAAGGCCGAGGCCCTGGCCCTGGAGCCCGAAC
TGGCCTGCGAGGCGGCGCTTCTGTCGCCGGAAAGCGGGGTGTTCGACAGCCACGGCTACATGCTGGCCCTGCAGGGCGAG
ATCGAGGCGGCCGGCGGAGCGGTGGCGCTCTCGACGCCGTTCGAGGCGGCGAGGCCCCTCGAGGGCGGCGGCTTCGAGGT
GCGGGCCGGCGGCGCCGAGCCGACCAGGCTGACCTGTCGATACCTGGTGACCGCGCCGGGGCTCTCGGCCCAGGGCGTGG
CGGCGCACATCGAGGGCTTTCCCGCCGAGGTGATCCCCGAGGCGCACTTCGGCAAGGGCATGTACTTCCGGCTGCAGGGC
AAGGCGCCGTTCGCCCGCCTGATCTATCCGCCGCCGATCCCCGGCGCGCTCGGCACCCACTACCGGCGGGACCTGGGCGG
CCAGGCGGTGTTCGGGCCGGACCTGACGTTCGTGGACGCGCCGGACTACACGGTGGACCCCGCGGCGGCCGAGGGCTTCT
ACCGCTACATCCGCAAGTTCTGGCCGGCCCTGCCCGACGGGGCGCTGAGCCCCGACTACGCCGGCGTGCGGCCCAAGCTG
CACGGCCCCGGCGAGCCGCAACCGGACTTCCGCATCGACGGGCAGGACGTCCACGGCCTTCCGGGGCTGGTGACCCTGTT
CGGCATCGAGAGCCCGGGCCTGACCTCCTCGCTGGCGATCGGCGAGGAGGCCGCGGCGAGGCTGGGGCTCTCGGCCGCCC
CCTCCGGCTCTACCGCTTAG

Upstream 100 bases:

>100_bases
CCATCGCCCGCCAGACCCTGATGTACCGCGAGACGGTGCGGCTCTACTTCCTGGGGACGTGACGGTTTCCAACGGCTGCG
CCGCGCGTTAGGCCAGCCGT

Downstream 100 bases:

>100_bases
GCGTGACCTTCAGGACCCGGCCGTCCTCGTTGTCGGTGGCGACGTAGAGGGCGCCGTCGGGGCCGACGACGACGTCGCGG
AGGCGCTCGCCCACCTCGGT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MAEFDFDAVVVGAGAVGLACGYALARRGLTAAVLEQDAAIGQGVSSRNSEVIHGGLYYPTGSLKARLCVAGRRMLYAFLD
AHHVAYDRCGKLVVATAPEEVERLDAILEQARTNEVEGMARLSKAEALALEPELACEAALLSPESGVFDSHGYMLALQGE
IEAAGGAVALSTPFEAARPLEGGGFEVRAGGAEPTRLTCRYLVTAPGLSAQGVAAHIEGFPAEVIPEAHFGKGMYFRLQG
KAPFARLIYPPPIPGALGTHYRRDLGGQAVFGPDLTFVDAPDYTVDPAAAEGFYRYIRKFWPALPDGALSPDYAGVRPKL
HGPGEPQPDFRIDGQDVHGLPGLVTLFGIESPGLTSSLAIGEEAAARLGLSAAPSGSTA

Sequences:

>Translated_379_residues
MAEFDFDAVVVGAGAVGLACGYALARRGLTAAVLEQDAAIGQGVSSRNSEVIHGGLYYPTGSLKARLCVAGRRMLYAFLD
AHHVAYDRCGKLVVATAPEEVERLDAILEQARTNEVEGMARLSKAEALALEPELACEAALLSPESGVFDSHGYMLALQGE
IEAAGGAVALSTPFEAARPLEGGGFEVRAGGAEPTRLTCRYLVTAPGLSAQGVAAHIEGFPAEVIPEAHFGKGMYFRLQG
KAPFARLIYPPPIPGALGTHYRRDLGGQAVFGPDLTFVDAPDYTVDPAAAEGFYRYIRKFWPALPDGALSPDYAGVRPKL
HGPGEPQPDFRIDGQDVHGLPGLVTLFGIESPGLTSSLAIGEEAAARLGLSAAPSGSTA
>Mature_378_residues
AEFDFDAVVVGAGAVGLACGYALARRGLTAAVLEQDAAIGQGVSSRNSEVIHGGLYYPTGSLKARLCVAGRRMLYAFLDA
HHVAYDRCGKLVVATAPEEVERLDAILEQARTNEVEGMARLSKAEALALEPELACEAALLSPESGVFDSHGYMLALQGEI
EAAGGAVALSTPFEAARPLEGGGFEVRAGGAEPTRLTCRYLVTAPGLSAQGVAAHIEGFPAEVIPEAHFGKGMYFRLQGK
APFARLIYPPPIPGALGTHYRRDLGGQAVFGPDLTFVDAPDYTVDPAAAEGFYRYIRKFWPALPDGALSPDYAGVRPKLH
GPGEPQPDFRIDGQDVHGLPGLVTLFGIESPGLTSSLAIGEEAAARLGLSAAPSGSTA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=407, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI87082148, Length=377, Percent_Identity=27.0557029177719, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17565764, Length=410, Percent_Identity=29.7560975609756, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24585081, Length=254, Percent_Identity=30.3149606299213, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39616; Mature: 39485

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFDFDAVVVGAGAVGLACGYALARRGLTAAVLEQDAAIGQGVSSRNSEVIHGGLYYPT
CCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCEECCC
GSLKARLCVAGRRMLYAFLDAHHVAYDRCGKLVVATAPEEVERLDAILEQARTNEVEGMA
CCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHH
RLSKAEALALEPELACEAALLSPESGVFDSHGYMLALQGEIEAAGGAVALSTPFEAARPL
HHHHHHHEECCCHHHHHHHEECCCCCCCCCCCEEEEEECCEECCCCEEEEECCHHHCCCC
EGGGFEVRAGGAEPTRLTCRYLVTAPGLSAQGVAAHIEGFPAEVIPEAHFGKGMYFRLQG
CCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCEECCCCCCHHHCCCCCCCCCEEEEEEC
KAPFARLIYPPPIPGALGTHYRRDLGGQAVFGPDLTFVDAPDYTVDPAAAEGFYRYIRKF
CCCEEEEECCCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCCCCCCHHHHHHHHHHHHH
WPALPDGALSPDYAGVRPKLHGPGEPQPDFRIDGQDVHGLPGLVTLFGIESPGLTSSLAI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHC
GEEAAARLGLSAAPSGSTA
CHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AEFDFDAVVVGAGAVGLACGYALARRGLTAAVLEQDAAIGQGVSSRNSEVIHGGLYYPT
CCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCEECCC
GSLKARLCVAGRRMLYAFLDAHHVAYDRCGKLVVATAPEEVERLDAILEQARTNEVEGMA
CCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHH
RLSKAEALALEPELACEAALLSPESGVFDSHGYMLALQGEIEAAGGAVALSTPFEAARPL
HHHHHHHEECCCHHHHHHHEECCCCCCCCCCCEEEEEECCEECCCCEEEEECCHHHCCCC
EGGGFEVRAGGAEPTRLTCRYLVTAPGLSAQGVAAHIEGFPAEVIPEAHFGKGMYFRLQG
CCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCEECCCCCCHHHCCCCCCCCCEEEEEEC
KAPFARLIYPPPIPGALGTHYRRDLGGQAVFGPDLTFVDAPDYTVDPAAAEGFYRYIRKF
CCCEEEEECCCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCCCCCCHHHHHHHHHHHHH
WPALPDGALSPDYAGVRPKLHGPGEPQPDFRIDGQDVHGLPGLVTLFGIESPGLTSSLAI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHC
GEEAAARLGLSAAPSGSTA
CHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]