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The map label for this gene is gcvT [H]

Identifier: 197104058

GI number: 197104058

Start: 626494

End: 627636

Strand: Reverse

Name: gcvT [H]

Synonym: PHZ_c0592

Alternate gene names: 197104058

Gene position: 627636-626494 (Counterclockwise)

Preceding gene: 197104059

Following gene: 197104057

Centisome position: 15.71

GC content: 71.22

Gene sequence:

>1143_bases
GTGTCCGACCATCCCGAAACGGTCCTGAAGACCACCCCGCTCACTGAGGCGCACGTGGCGCTGGGGGCGAAGATGGTCCC
CTTCGCCGGCTACTCCATGCCCGTGCAGTACGCCGAGGGCGTGCTGAAGGAGCACCTGTGGGTGCGCGAGCACGCGGGCC
TGTTCGACGTCTCCCACATGGGCCAGGCGCGCCTGACCGGCGTCTCGCCGCTCTCGGCCATCGAGGAGATCGTCCCCGGC
GACTTCATCGGCCTGAAGCCCGGCAAGCAGAAGTATTCCCTGCTGCTGAACAGGAAGGGCGGGATCATCGACGACCTGAT
GGCCGGCCGCCCGACCGGCCCGGGCGGGGCGCCCGATCCGGGCCTCTTCCTGGTGGTCAACGGCGCCTGCAAGGAGAACG
ACTTCAAGGTCATCGACGACGAGCTGGCCGGCCAGGTGGACGTCGAGCGCCTGGAGGACCGCGCGCTGCTGGCCCTGCAG
GGCCCCAAGGCGGCCGAGGCCCTGAAGGTCCATGCGCCCGAGGTCGCGACCATGGCCTTCATGGACATCCGCCGCATCGA
GGCGTTCGGCGTCGACTGCATCGTCTCGCGCTCGGGCTACACCGGGGAGGACGGCTTCGAGATCTCGGTCCCCGCCCATG
CCGCGACCTTCGTCTGGAACACCCTGCTGGCCGACGAGCGGGTCAAGCCCATCGGCCTGGGCGCCCGCGATTCCCTGCGG
CTGGAGGCCGGCCTGCCGCTCTACGGCCACGACCTCGACGAGACCGTCAGCCCGGTCGAGGCGGGCCTGACCTTCGCCAT
CAACAGGAACCGCCGCGAGCAGCGCGACTTCCCGGGCGCGGCCCGGATCGTCAAGGAGCTGTCCGAGGGCCCCGCCCGCG
TCCGCGTCGGCCTGAGGGTGCTGGAAGGCGCCCCGGCCCGCGAGGGCGCGGAAGTGGCCGACGAGGCCGGCCAGGTGATC
GGCGTCGTCACCTCGGGCGGCTTCTCCCCCACCCTGCGCGCCGGCATCGCCCTGGCCTTCGTGCCCCCGCTGCATTCGGA
AGCCGGCACGAAGCTGAAGGTCATCGTCCGCGGCAAGCCCCAGGCCTGCGAGGTCGTGAAGACCCCCTTCGTCCCCCACC
GCTACGTCCGCAAGGCGTCGTGA

Upstream 100 bases:

>100_bases
CCGGACGGCTCGAAATCTCTCAGGCCAAGGGACAGCGGGGGCGCGGACGGTGCGGGGCGGGCCCCGGCCGCTCGCCGCAT
CGTCAGCCGGAGTCCCTCTC

Downstream 100 bases:

>100_bases
TGGGCTCGGCGGCGACATCGATATCCACCCTCCTCCCCCGTCGGGGGAGGGGGACCGCGACAGCGGTGGAGGGGGCCAGC
CCCGTCCGCCGCGCTCGCCC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSDHPETVLKTTPLTEAHVALGAKMVPFAGYSMPVQYAEGVLKEHLWVREHAGLFDVSHMGQARLTGVSPLSAIEEIVPG
DFIGLKPGKQKYSLLLNRKGGIIDDLMAGRPTGPGGAPDPGLFLVVNGACKENDFKVIDDELAGQVDVERLEDRALLALQ
GPKAAEALKVHAPEVATMAFMDIRRIEAFGVDCIVSRSGYTGEDGFEISVPAHAATFVWNTLLADERVKPIGLGARDSLR
LEAGLPLYGHDLDETVSPVEAGLTFAINRNRREQRDFPGAARIVKELSEGPARVRVGLRVLEGAPAREGAEVADEAGQVI
GVVTSGGFSPTLRAGIALAFVPPLHSEAGTKLKVIVRGKPQACEVVKTPFVPHRYVRKAS

Sequences:

>Translated_380_residues
MSDHPETVLKTTPLTEAHVALGAKMVPFAGYSMPVQYAEGVLKEHLWVREHAGLFDVSHMGQARLTGVSPLSAIEEIVPG
DFIGLKPGKQKYSLLLNRKGGIIDDLMAGRPTGPGGAPDPGLFLVVNGACKENDFKVIDDELAGQVDVERLEDRALLALQ
GPKAAEALKVHAPEVATMAFMDIRRIEAFGVDCIVSRSGYTGEDGFEISVPAHAATFVWNTLLADERVKPIGLGARDSLR
LEAGLPLYGHDLDETVSPVEAGLTFAINRNRREQRDFPGAARIVKELSEGPARVRVGLRVLEGAPAREGAEVADEAGQVI
GVVTSGGFSPTLRAGIALAFVPPLHSEAGTKLKVIVRGKPQACEVVKTPFVPHRYVRKAS
>Mature_379_residues
SDHPETVLKTTPLTEAHVALGAKMVPFAGYSMPVQYAEGVLKEHLWVREHAGLFDVSHMGQARLTGVSPLSAIEEIVPGD
FIGLKPGKQKYSLLLNRKGGIIDDLMAGRPTGPGGAPDPGLFLVVNGACKENDFKVIDDELAGQVDVERLEDRALLALQG
PKAAEALKVHAPEVATMAFMDIRRIEAFGVDCIVSRSGYTGEDGFEISVPAHAATFVWNTLLADERVKPIGLGARDSLRL
EAGLPLYGHDLDETVSPVEAGLTFAINRNRREQRDFPGAARIVKELSEGPARVRVGLRVLEGAPAREGAEVADEAGQVIG
VVTSGGFSPTLRAGIALAFVPPLHSEAGTKLKVIVRGKPQACEVVKTPFVPHRYVRKAS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=44.973544973545, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=44.5378151260504, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=41.6666666666667, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=43.4782608695652, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI24797151, Length=348, Percent_Identity=24.4252873563218, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI197927446, Length=323, Percent_Identity=25.6965944272446, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21361378, Length=323, Percent_Identity=25.6965944272446, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789272, Length=376, Percent_Identity=37.5, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560118, Length=389, Percent_Identity=43.1876606683805, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6320222, Length=396, Percent_Identity=41.1616161616162, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=38.4816753926702, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20130091, Length=327, Percent_Identity=25.0764525993884, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40636; Mature: 40505

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHPETVLKTTPLTEAHVALGAKMVPFAGYSMPVQYAEGVLKEHLWVREHAGLFDVSHM
CCCCCCCCEECCCCCHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHC
GQARLTGVSPLSAIEEIVPGDFIGLKPGKQKYSLLLNRKGGIIDDLMAGRPTGPGGAPDP
CCEEECCCCHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCC
GLFLVVNGACKENDFKVIDDELAGQVDVERLEDRALLALQGPKAAEALKVHAPEVATMAF
CEEEEEECCCCCCCCEEECHHHCCCCCHHHHCCCEEEEECCCCHHHHEEECCCHHHHHHH
MDIRRIEAFGVDCIVSRSGYTGEDGFEISVPAHAATFVWNTLLADERVKPIGLGARDSLR
HHHHHHHHCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LEAGLPLYGHDLDETVSPVEAGLTFAINRNRREQRDFPGAARIVKELSEGPARVRVGLRV
EECCCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCCEEEEEEHE
LEGAPAREGAEVADEAGQVIGVVTSGGFSPTLRAGIALAFVPPLHSEAGTKLKVIVRGKP
ECCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCEEEEEECCCCCCCCCEEEEEECCCC
QACEVVKTPFVPHRYVRKAS
CHHHHCCCCCCCHHHHHCCC
>Mature Secondary Structure 
SDHPETVLKTTPLTEAHVALGAKMVPFAGYSMPVQYAEGVLKEHLWVREHAGLFDVSHM
CCCCCCCEECCCCCHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHC
GQARLTGVSPLSAIEEIVPGDFIGLKPGKQKYSLLLNRKGGIIDDLMAGRPTGPGGAPDP
CCEEECCCCHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCC
GLFLVVNGACKENDFKVIDDELAGQVDVERLEDRALLALQGPKAAEALKVHAPEVATMAF
CEEEEEECCCCCCCCEEECHHHCCCCCHHHHCCCEEEEECCCCHHHHEEECCCHHHHHHH
MDIRRIEAFGVDCIVSRSGYTGEDGFEISVPAHAATFVWNTLLADERVKPIGLGARDSLR
HHHHHHHHCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LEAGLPLYGHDLDETVSPVEAGLTFAINRNRREQRDFPGAARIVKELSEGPARVRVGLRV
EECCCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCCEEEEEEHE
LEGAPAREGAEVADEAGQVIGVVTSGGFSPTLRAGIALAFVPPLHSEAGTKLKVIVRGKP
ECCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCEEEEEECCCCCCCCCEEEEEECCCC
QACEVVKTPFVPHRYVRKAS
CHHHHCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA