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The map label for this gene is ctaB [H]

Identifier: 197104010

GI number: 197104010

Start: 576108

End: 577094

Strand: Direct

Name: ctaB [H]

Synonym: PHZ_c0544

Alternate gene names: 197104010

Gene position: 576108-577094 (Clockwise)

Preceding gene: 197104009

Following gene: 197104011

Centisome position: 14.42

GC content: 71.43

Gene sequence:

>987_bases
ATGCTCATGGCCATGTCGCCGGCCCTCAGCTCGACCCGCGCGCCCGCCCGCTGGCAGGACTACTTCCAGCTGCTGAAGCC
GCGCGTCATGTCGCTGGTGGTGTTCACCGCCCTGACCGGCCTGGTCTGCGCCGACCGGGCGATCCATCCTGTGCTGGCCG
GCGTCGCGGTGCTGTGCATCGCGGTGGGCGCGGGCGCCTCCGGCGCGCTGAACATGTGGTGGGACGCCGACATCGACGCA
AAGATGCGCCGCACCCGCGGCCGTCCGGTGCCCGCCGGCCGGGTGCAGGGCGCCGACGCCCTGGCCCTCGGCGTCGTCCT
GTCGCTGTTCTCGGTGATGCTGATGGGCATGGCGCTGAACTGGTTCGCCGCCGGCCTGCTCGCCTTCACCATCCTGTTCT
ACGCGGTCGTCTACACGATGTGGCTGAAGCGCTGGACGGCGCAGAACATCGTGATCGGCGGCCTGGCCGGCGCGCTGCCG
CCGGTGATCGGCTGGGCCGCGGCCACGGGTTCGGCCCCGCTGAACGCCTGGCTGCTGTGCGCCATCATCTTCATGTGGAC
CCCGCCGCACTTCTGGGCGCTGTCGCTCTACACCAGCGAGGACTACGCCAAGGCGGGCGTGCCGATGCTGCCGGTGGTGC
GCGGCGCGGCCTCCACCCGCCGGCAGATCCTGATCTACAGCCTGCTGCTGATCCCGGTGTGCATCGCCCCGGCGTTCACC
GGCCTCGGCGGCCTGCCCTATCTGGCGGTGTCGAGCCTCGGCGGCCTGGTGTTCCTGCTGCTCGCCTGGCGCCTGTACCG
CTCGAAAGCGGGCGAGGCGGCCGATCCGCGCAACGACCCGGAAGCCAACGGGGGCCTCTACGACGTGCGCGCCGCCGCCC
GCGACGCGCGCAACCTGTTCGCCTTCTCCATCCTGTACCTGGCCCTGCTGTTCGCGACCCTGCTCGCCGAGCACCTGGCG
GGCCTGAAGCCTCTGGAGCTCGTCTAG

Upstream 100 bases:

>100_bases
CCGGTGGTCAAGCCGGACGCCCACTAGCGTCAGGCTCCTCCGGGACCATCTATGAGGGGCGCGCTCCGACGGGGCGCGCC
CCTCGGACATTGTAGAGTAT

Downstream 100 bases:

>100_bases
ATGAGCGACCCCACCCGTGAGAACGAGACCGAAGCCAAGGCGCGGCGCGGCCGCAACATCGCCCTGGCCGTCGGCCTCGT
GCTGTTCGTGATCCTCGTCT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLMAMSPALSSTRAPARWQDYFQLLKPRVMSLVVFTALTGLVCADRAIHPVLAGVAVLCIAVGAGASGALNMWWDADIDA
KMRRTRGRPVPAGRVQGADALALGVVLSLFSVMLMGMALNWFAAGLLAFTILFYAVVYTMWLKRWTAQNIVIGGLAGALP
PVIGWAAATGSAPLNAWLLCAIIFMWTPPHFWALSLYTSEDYAKAGVPMLPVVRGAASTRRQILIYSLLLIPVCIAPAFT
GLGGLPYLAVSSLGGLVFLLLAWRLYRSKAGEAADPRNDPEANGGLYDVRAAARDARNLFAFSILYLALLFATLLAEHLA
GLKPLELV

Sequences:

>Translated_328_residues
MLMAMSPALSSTRAPARWQDYFQLLKPRVMSLVVFTALTGLVCADRAIHPVLAGVAVLCIAVGAGASGALNMWWDADIDA
KMRRTRGRPVPAGRVQGADALALGVVLSLFSVMLMGMALNWFAAGLLAFTILFYAVVYTMWLKRWTAQNIVIGGLAGALP
PVIGWAAATGSAPLNAWLLCAIIFMWTPPHFWALSLYTSEDYAKAGVPMLPVVRGAASTRRQILIYSLLLIPVCIAPAFT
GLGGLPYLAVSSLGGLVFLLLAWRLYRSKAGEAADPRNDPEANGGLYDVRAAARDARNLFAFSILYLALLFATLLAEHLA
GLKPLELV
>Mature_328_residues
MLMAMSPALSSTRAPARWQDYFQLLKPRVMSLVVFTALTGLVCADRAIHPVLAGVAVLCIAVGAGASGALNMWWDADIDA
KMRRTRGRPVPAGRVQGADALALGVVLSLFSVMLMGMALNWFAAGLLAFTILFYAVVYTMWLKRWTAQNIVIGGLAGALP
PVIGWAAATGSAPLNAWLLCAIIFMWTPPHFWALSLYTSEDYAKAGVPMLPVVRGAASTRRQILIYSLLLIPVCIAPAFT
GLGGLPYLAVSSLGGLVFLLLAWRLYRSKAGEAADPRNDPEANGGLYDVRAAARDARNLFAFSILYLALLFATLLAEHLA
GLKPLELV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=216, Percent_Identity=31.4814814814815, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786631, Length=289, Percent_Identity=28.719723183391, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=266, Percent_Identity=33.8345864661654, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=298, Percent_Identity=30.5369127516779, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19921064, Length=213, Percent_Identity=29.5774647887324, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 35160; Mature: 35160

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMAMSPALSSTRAPARWQDYFQLLKPRVMSLVVFTALTGLVCADRAIHPVLAGVAVLCI
CCEECCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGAGASGALNMWWDADIDAKMRRTRGRPVPAGRVQGADALALGVVLSLFSVMLMGMALN
HHCCCCCCCEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFAAGLLAFTILFYAVVYTMWLKRWTAQNIVIGGLAGALPPVIGWAAATGSAPLNAWLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIIFMWTPPHFWALSLYTSEDYAKAGVPMLPVVRGAASTRRQILIYSLLLIPVCIAPAFT
HHHHHHCCCCCEEEEEECCCHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GLGGLPYLAVSSLGGLVFLLLAWRLYRSKAGEAADPRNDPEANGGLYDVRAAARDARNLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFSILYLALLFATLLAEHLAGLKPLELV
HHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLMAMSPALSSTRAPARWQDYFQLLKPRVMSLVVFTALTGLVCADRAIHPVLAGVAVLCI
CCEECCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGAGASGALNMWWDADIDAKMRRTRGRPVPAGRVQGADALALGVVLSLFSVMLMGMALN
HHCCCCCCCEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFAAGLLAFTILFYAVVYTMWLKRWTAQNIVIGGLAGALPPVIGWAAATGSAPLNAWLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIIFMWTPPHFWALSLYTSEDYAKAGVPMLPVVRGAASTRRQILIYSLLLIPVCIAPAFT
HHHHHHCCCCCEEEEEECCCHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GLGGLPYLAVSSLGGLVFLLLAWRLYRSKAGEAADPRNDPEANGGLYDVRAAARDARNLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFSILYLALLFATLLAEHLAGLKPLELV
HHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]