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The map label for this gene is pepA [H]

Identifier: 197103990

GI number: 197103990

Start: 550346

End: 551881

Strand: Direct

Name: pepA [H]

Synonym: PHZ_c0524

Alternate gene names: 197103990

Gene position: 550346-551881 (Clockwise)

Preceding gene: 197103982

Following gene: 197103991

Centisome position: 13.77

GC content: 74.15

Gene sequence:

>1536_bases
ATGCGAGCCGTCGTCGCCGCCCTGAGCCTGGCGCTGTGCGCCACCGCCGCCGAAGCGCGGCCCATCCAGTTCGCCGCCGA
GGCGCCCCAGACGGGCGCGCTGGTGCTGCCGCTGGCGTCCGAAGCCGACCTGGCGGCCCGCGGAACCATGCTGGACGAAG
GCGTGCGCGCCGCCGTCTCCCGCGCCCTGGCGGCCGCCAAGTTCGACTACAAGGCCGGCGAGACCCTGAGCCTGCGCGGC
CCGGGCCCCTGGGATCAGATCGTCGTCCTGGGCGCCCGGCCCGAGGGCGCCGCGCTCACCGCCGTCGAGCTGCAGGACCT
CGGCGCGGCGGCCGCCAAGGCCACGGCCAAGGCGCCGGCCGCGCTGGTGGCGACGGGCCTCTCCGATCCGTCCCAGGCGG
CCCTGGGCGCGGCCCTGGGTTCGTACCGCTTCTCCAACAGCTACAAGTCCCGCAAGGCCGACGAGCCGGCGACCGAGCCC
GCGCTGACCGTCGTGGCGTCCGACGCCGCGGCGGCGCGGCAGGCCTACGCCCGGCGCGGCGAGGCCCTGGCCGAGGCCGT
GGCCTTCACCCGCGACCTGATCACCGAGCCCGCCAACGTGATCTATCCCGAGACCTTCGTGGAGCGCACCCGCGCGGCCT
TCAAGGGCGTGGGCGGCGTGACCATCGAGGCGTTCGACGAGGCGGCGCTGCAGAAGATGGGCATGAACGCCATCCTCAGC
GTGGGCATGGGGTCCAAGCGTCCGCCGCGCCTGCTGGTGGTCGAGTACAAGGGTCCCGGCGCGTCCGGCAAGCCGGTGGT
GCTGACCGGCAAGGGGATCACCTTCGATTCCGGCGGCATCTCGCTGAAGCCGGGCTCGAACATGTGGAAGATGAAGGACG
ACATGTCCGGTGCGGCCGCGGTCGTCGGCGCGACCCTGTCGCTGGCCAAGTCGAAGGCCCCGGTGCACGTGGTGGCGATC
GCCGCCCTGGCCGAGAACATGCCGGACGGCGGGGCCGCGCGCCCGGGCGACGTGATCCGCGCCTATGGCGGCAAGACCAT
CGAGCGGCTGAACACCGACGCCGAGGGCCGCATCGTGCTGGCCGACGCCACCGCCTACGCCGACCAGCGCTACGACGCGG
CGGCCATCGTCAACCTCGCCACCCTGACCGGTGCGGTCGTGGGCGCCCTGGGCGACGACTACGCCGGCCTCTTCAGCCGT
CACGACGGCCTGGCCGAACAGGTCGAGGCGGCGGCCAAGGCCAGCGGCGAGGGCGTGTGGCGCCTGCCGATGCATCCCAG
CTATGCCAAGGCGGTGGACTCGCCGATCGCCGACATCCGCGACATCGGCTCGGGCGAGCCGGGCGCCGGCGTGGGCGCCC
AGGTGATCGGCTTCTTCGCCGACCCCGAGACCCCGTGGGCGCACGTCGACATCGCCGGCGTCGCCTGGGACGACCAGGGC
ACGCCCACCGCGCCGAAGGGCGCCCGCGGCTACGGCGTCCGCCTGCTGGACGAGCTGGTTCGCGGATTCGACGCCGCCAA
GGCCGCCCGCAAGTAG

Upstream 100 bases:

>100_bases
GGGCAGATGACGGAGTGTTAGCGAAGCTGGGGCGGCCGGCCTAGCCAGGGCTCAGTTTAGCTGCTTAACAGGCGTTACAG
TGTAACGGGGGAAATCCTGC

Downstream 100 bases:

>100_bases
TCCCCGCTCGGGAGCGGCGTCTTTACGGCGCCGCTCCGCCGGGCGCAGGATGGCGCATGGCGATAGAGACGCTCGAGGAC
CTGGAGGCGATCTACGGCGT

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MRAVVAALSLALCATAAEARPIQFAAEAPQTGALVLPLASEADLAARGTMLDEGVRAAVSRALAAAKFDYKAGETLSLRG
PGPWDQIVVLGARPEGAALTAVELQDLGAAAAKATAKAPAALVATGLSDPSQAALGAALGSYRFSNSYKSRKADEPATEP
ALTVVASDAAAARQAYARRGEALAEAVAFTRDLITEPANVIYPETFVERTRAAFKGVGGVTIEAFDEAALQKMGMNAILS
VGMGSKRPPRLLVVEYKGPGASGKPVVLTGKGITFDSGGISLKPGSNMWKMKDDMSGAAAVVGATLSLAKSKAPVHVVAI
AALAENMPDGGAARPGDVIRAYGGKTIERLNTDAEGRIVLADATAYADQRYDAAAIVNLATLTGAVVGALGDDYAGLFSR
HDGLAEQVEAAAKASGEGVWRLPMHPSYAKAVDSPIADIRDIGSGEPGAGVGAQVIGFFADPETPWAHVDIAGVAWDDQG
TPTAPKGARGYGVRLLDELVRGFDAAKAARK

Sequences:

>Translated_511_residues
MRAVVAALSLALCATAAEARPIQFAAEAPQTGALVLPLASEADLAARGTMLDEGVRAAVSRALAAAKFDYKAGETLSLRG
PGPWDQIVVLGARPEGAALTAVELQDLGAAAAKATAKAPAALVATGLSDPSQAALGAALGSYRFSNSYKSRKADEPATEP
ALTVVASDAAAARQAYARRGEALAEAVAFTRDLITEPANVIYPETFVERTRAAFKGVGGVTIEAFDEAALQKMGMNAILS
VGMGSKRPPRLLVVEYKGPGASGKPVVLTGKGITFDSGGISLKPGSNMWKMKDDMSGAAAVVGATLSLAKSKAPVHVVAI
AALAENMPDGGAARPGDVIRAYGGKTIERLNTDAEGRIVLADATAYADQRYDAAAIVNLATLTGAVVGALGDDYAGLFSR
HDGLAEQVEAAAKASGEGVWRLPMHPSYAKAVDSPIADIRDIGSGEPGAGVGAQVIGFFADPETPWAHVDIAGVAWDDQG
TPTAPKGARGYGVRLLDELVRGFDAAKAARK
>Mature_511_residues
MRAVVAALSLALCATAAEARPIQFAAEAPQTGALVLPLASEADLAARGTMLDEGVRAAVSRALAAAKFDYKAGETLSLRG
PGPWDQIVVLGARPEGAALTAVELQDLGAAAAKATAKAPAALVATGLSDPSQAALGAALGSYRFSNSYKSRKADEPATEP
ALTVVASDAAAARQAYARRGEALAEAVAFTRDLITEPANVIYPETFVERTRAAFKGVGGVTIEAFDEAALQKMGMNAILS
VGMGSKRPPRLLVVEYKGPGASGKPVVLTGKGITFDSGGISLKPGSNMWKMKDDMSGAAAVVGATLSLAKSKAPVHVVAI
AALAENMPDGGAARPGDVIRAYGGKTIERLNTDAEGRIVLADATAYADQRYDAAAIVNLATLTGAVVGALGDDYAGLFSR
HDGLAEQVEAAAKASGEGVWRLPMHPSYAKAVDSPIADIRDIGSGEPGAGVGAQVIGFFADPETPWAHVDIAGVAWDDQG
TPTAPKGARGYGVRLLDELVRGFDAAKAARK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=385, Percent_Identity=37.9220779220779, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI47155554, Length=311, Percent_Identity=34.0836012861736, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1790710, Length=283, Percent_Identity=43.1095406360424, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082123, Length=368, Percent_Identity=34.5108695652174, Blast_Score=162, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17556903, Length=328, Percent_Identity=32.6219512195122, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=254, Percent_Identity=28.3464566929134, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129969, Length=437, Percent_Identity=29.2906178489703, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21355725, Length=346, Percent_Identity=32.6589595375723, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661038, Length=479, Percent_Identity=28.39248434238, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI20129963, Length=453, Percent_Identity=31.1258278145695, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24662227, Length=397, Percent_Identity=30.4785894206549, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355645, Length=441, Percent_Identity=28.1179138321995, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24662223, Length=441, Percent_Identity=28.1179138321995, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI161077148, Length=402, Percent_Identity=30.5970149253731, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20130057, Length=402, Percent_Identity=30.5970149253731, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19922386, Length=398, Percent_Identity=30.1507537688442, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI221379063, Length=331, Percent_Identity=31.4199395770393, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221379062, Length=331, Percent_Identity=31.4199395770393, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357381, Length=331, Percent_Identity=31.4199395770393, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=309, Percent_Identity=26.537216828479, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646703, Length=309, Percent_Identity=26.537216828479, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358201, Length=309, Percent_Identity=26.537216828479, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52184; Mature: 52184

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVAALSLALCATAAEARPIQFAAEAPQTGALVLPLASEADLAARGTMLDEGVRAAVS
CHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHH
RALAAAKFDYKAGETLSLRGPGPWDQIVVLGARPEGAALTAVELQDLGAAAAKATAKAPA
HHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEEEEEHHHCCHHHHHHHHCCCH
ALVATGLSDPSQAALGAALGSYRFSNSYKSRKADEPATEPALTVVASDAAAARQAYARRG
HEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
EALAEAVAFTRDLITEPANVIYPETFVERTRAAFKGVGGVTIEAFDEAALQKMGMNAILS
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHHHC
VGMGSKRPPRLLVVEYKGPGASGKPVVLTGKGITFDSGGISLKPGSNMWKMKDDMSGAAA
CCCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEECCCCEEECCCCCCEEECCCCCCHHH
VVGATLSLAKSKAPVHVVAIAALAENMPDGGAARPGDVIRAYGGKTIERLNTDAEGRIVL
HHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHCCCCCCCEEEE
ADATAYADQRYDAAAIVNLATLTGAVVGALGDDYAGLFSRHDGLAEQVEAAAKASGEGVW
EECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEE
RLPMHPSYAKAVDSPIADIRDIGSGEPGAGVGAQVIGFFADPETPWAHVDIAGVAWDDQG
ECCCCCHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCC
TPTAPKGARGYGVRLLDELVRGFDAAKAARK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRAVVAALSLALCATAAEARPIQFAAEAPQTGALVLPLASEADLAARGTMLDEGVRAAVS
CHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHHH
RALAAAKFDYKAGETLSLRGPGPWDQIVVLGARPEGAALTAVELQDLGAAAAKATAKAPA
HHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEEEEEHHHCCHHHHHHHHCCCH
ALVATGLSDPSQAALGAALGSYRFSNSYKSRKADEPATEPALTVVASDAAAARQAYARRG
HEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
EALAEAVAFTRDLITEPANVIYPETFVERTRAAFKGVGGVTIEAFDEAALQKMGMNAILS
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHHHC
VGMGSKRPPRLLVVEYKGPGASGKPVVLTGKGITFDSGGISLKPGSNMWKMKDDMSGAAA
CCCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEECCCCEEECCCCCCEEECCCCCCHHH
VVGATLSLAKSKAPVHVVAIAALAENMPDGGAARPGDVIRAYGGKTIERLNTDAEGRIVL
HHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHCCCCCCCEEEE
ADATAYADQRYDAAAIVNLATLTGAVVGALGDDYAGLFSRHDGLAEQVEAAAKASGEGVW
EECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEE
RLPMHPSYAKAVDSPIADIRDIGSGEPGAGVGAQVIGFFADPETPWAHVDIAGVAWDDQG
ECCCCCHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCC
TPTAPKGARGYGVRLLDELVRGFDAAKAARK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA