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The map label for this gene is lpxK

Identifier: 197103977

GI number: 197103977

Start: 536581

End: 537567

Strand: Reverse

Name: lpxK

Synonym: PHZ_c0511

Alternate gene names: 197103977

Gene position: 537567-536581 (Counterclockwise)

Preceding gene: 197103978

Following gene: 197103975

Centisome position: 13.45

GC content: 76.8

Gene sequence:

>987_bases
ATGAAACTGGCGACCCCCCGCTGGTGGTACGAGCGCGACCGGCGCTCCATGCCGATGACCCGGGCGCTGCTCACGCCGCT
GTCCTGGGCCTGGGCCGGCGTGACGGCCCGGCGGATCGCCCGCGCCCGGCCGCTGGACGCGGGCGCGCCGGTGATCTGCG
TGGGCAACCTGACCATGGGCGGCGCGGGCAAGACCCCGGTCGTGCGCGAGATCGCCCGCCGGCTCGGCGGACACGTCCTG
TCGCGCGGCTACGGCGGCTCGCTGGCGGGTCCGGTGCGGGTCGATCCCGCCGTCCACGCCAGCGGCGAGGTGGGCGACGA
GCCCCTGATGCTGGCCCGCGACCTGCCCGTCTGGGTCTCCCGCGACCGTCTGGCCGGCGCGCGGGCCGCGGCCGCCGCGG
GCGCCCGCGTGGTGGTGATGGACGACGGCCACCAGAACCCCTCCGTGAAGAAGGCCCTGTCGCTGGTGGTCGTGGACGGC
GAGACGCGGAACGGCGAGTGGCCCTTCGGGGACGGGCGGGTGTTTCCCGCCGGGCCCATGCGCGAGCCGCTCGCGGCGGG
GCTGGCGCGGGCGGACGCCGCGGTCATCCTGCTGCCCGCCGATCTCGCGGCGCCCGATCCCGAGCTGGTCCGCGTGCTGT
CGAAGGTCCCGGTGCTGATCGCCCGGCTCGAGCCCGAGGGGCCGCCGCCGGTCGGACCGCAGGTCGCCTTCGCCGGCATC
GGCAAGCCGTGGAAGTTCGAGCGCGCCCTGAAGGCGGCCGGCTGCGAGCTGGTGGAGTTCGCCCCCTTCCCGGACCACTA
CGCCTACGACGCCGCTGCGCTCGCCCTGCTGGCGGATCGCGCGGCCCAGGACGGCGCCGGCCTCCTCACCACCGAGAAGG
ACTGGATCCGCCTGCCCCCCGCCTGGCGCGAGCGGGTGCGGCCCTGGCCGGTCCGGGCCGTCTTCCAGGACGAGGCGGCC
TTGGACGCCGTGGTGGGCGGCCTCTAG

Upstream 100 bases:

>100_bases
CGACCCGCGAAGCCCTGGGACGGGCCGCCCTCGCCTACGCCGAGCGGCAGGGCGCCCAGCTCGACGCCGCCTTCGCCGTC
CTCGATCCCCTGCTGCCCGC

Downstream 100 bases:

>100_bases
CCGGCGCCGGCCTTCTTCGCGAACTCCCAGCTGGTCTGGGCCAGCGCCAGGACCCGCGGGCCCATGCTGGCCGCGTCCGG
GTGGTTGGCGGTGCCGTCGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMGGAGKTPVVREIARRLGGHVL
SRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVSRDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDG
ETRNGEWPFGDGRVFPAGPMREPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGI
GKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPPAWRERVRPWPVRAVFQDEAA
LDAVVGGL

Sequences:

>Translated_328_residues
MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMGGAGKTPVVREIARRLGGHVL
SRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVSRDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDG
ETRNGEWPFGDGRVFPAGPMREPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGI
GKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPPAWRERVRPWPVRAVFQDEAA
LDAVVGGL
>Mature_328_residues
MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMGGAGKTPVVREIARRLGGHVL
SRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVSRDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDG
ETRNGEWPFGDGRVFPAGPMREPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGI
GKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPPAWRERVRPWPVRAVFQDEAA
LDAVVGGL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=297, Percent_Identity=32.996632996633, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PHEZH (B4REI3)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129354.1
- GeneID:   6790002
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0511
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   CLSK889830
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34961; Mature: 34961

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMG
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEC
GAGKTPVVREIARRLGGHVLSRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVS
CCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCEEE
RDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDGETRNGEWPFGDGRVFPAGPM
CHHHCCHHHHHHCCCEEEEEECCCCCCCHHHEEEEEEEECCCCCCCCCCCCCEECCCCCC
REPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGI
CCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCEEEECC
GKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPP
CCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCH
AWRERVRPWPVRAVFQDEAALDAVVGGL
HHHHCCCCCCCCEECCCHHHHHHHHCCC
>Mature Secondary Structure
MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMG
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEC
GAGKTPVVREIARRLGGHVLSRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVS
CCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCEEE
RDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDGETRNGEWPFGDGRVFPAGPM
CHHHCCHHHHHHCCCEEEEEECCCCCCCHHHEEEEEEEECCCCCCCCCCCCCEECCCCCC
REPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGI
CCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCEEEECC
GKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPP
CCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCH
AWRERVRPWPVRAVFQDEAALDAVVGGL
HHHHCCCCCCCCEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA