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The map label for this gene is phoR [H]

Identifier: 197103968

GI number: 197103968

Start: 527082

End: 528515

Strand: Direct

Name: phoR [H]

Synonym: PHZ_c0502

Alternate gene names: 197103968

Gene position: 527082-528515 (Clockwise)

Preceding gene: 197103964

Following gene: 197103969

Centisome position: 13.19

GC content: 73.85

Gene sequence:

>1434_bases
TTGCCGCTTCTGCAGCCGCCTTCGCCGCTGGCGCCGCCGCGCAGGCGCGAAAGCCCCTTCTGGCCCATCGTGGCGGCCGG
GGCGGCGGGGCTCGTGGCGATCGGCGCCCTGGCGGCCCTGCAGCGGGTCGACGCCGCGGGCGCCGTCGCGGCGCTGATCT
TCGTGGCGGCCGCCACCGCGCTGGTGCTGATCCAGGCCGACCGCCGGGCCGAAGCCGACGCCGAGGCCCTGGCTCCCGAG
CGCGACCGGGCCTCGGGCGAGGCGCCGCCGTACGCCGCGCTCATCAACGCCCTGCCGGATCCCATCCTGGTGGTCTCGGC
GGCCGAGCCCGACGACCTGACCGGTCGCCGGTACGTCTTCGCCAACAGCGCCGCGCGCACCCTGTTCCGCATCGAGCGGA
GCGAGGGCGTGCTGGTCAGCGTGTTGCGCGATCCCCAGCTGCTGGAGACGGTGGACGAGGCGCTGTTCGCCGCCCGCGAC
GGCGAGTCGGTCTACGAGACGGGCGGCGTCCAGTCGCGCGTGCTCCGCGCCATCGTCCGCCCCATGGGCCTGTCGCTGGA
CGGCTCGCACCTGGCGCTGGTGTCGTTCCGGGACGAGACCGAGCTGCGGCAGGTGGAGCGGACCCGGGCCGATTTCCTGG
CCAACGCCAGCCACGAGCTGCGCACGCCCCTGGCGTCCCTCTCGGGGTTCATCGAGACCCTCCGCGGCCACGCCCGCAGC
GACCCGGGGGCGCAGGAGCGGTTCCTGACCATCATGCAGGCCCAGGCCGAGCGGATGCGCCGGCTGATCGACGACCTGAT
GTCGCTGAGCCGCATCGAGCTGAACGAGCATATCGCCCCGAGCCAGGCCGTGGAGCTGGCGGACGCCGTCGCCGACGTGA
TGGACGCCGTCGGGCCCATCGCCCGTGAGAAGGGCGTGAAGCTGGAGGTTTCGGGCCCGCCCGCGGACGCCGCGCCGGTC
ACGGGCGACCGTGACCAGATCGTCCAGGTGATCCAGAACCTCGTGGACAACGCCCTGAAATACTCCGCGCCGGGCGGGAC
GGTGCGCGTGGCCATCGAGGCCGGCCGGACCGCCGAGGCCGCCGCCGCCGGCGTGCGTCCCGAGGCCTCGCGCCTGTCGC
TGCTGACGCCCGACCACACCGGCGAGACCTACGGCGTCGTCCGCGTGACCGACCAGGGCCCGGGAATCGCGCGCGAGCAC
CTGCCGCGCCTCACCGAGCGGTTCTACCGGGTCGAGGGGCAGAAGAGCGGCGAGCGTCTCGGGACCGGCCTTGGTCTCGC
GATCGTGAAGCACATCGTCAACCGGCACCGGGGCGGCTTGGCGGTGGAAAGCGCCCTCGGCGCGGGCACGACGTTCACCG
CCTATCTGCCGGAACGGGTCGCCGCGGCGGCGCCCGCGGCCGGGGACCGTCGTGAAACTGTCATCAAAATGTAG

Upstream 100 bases:

>100_bases
CGACGGCGGCTTTGGCTGATAACGCGCGAGGCGCAGCTAGGCTGTCATGGCCGTGACACACGCTTGCGGATGCTGAAGAG
TCCTTCCACGGAGATTCGCC

Downstream 100 bases:

>100_bases
CAATGGGGCAGCGCGGCGCGGGCAGTCTCGCCCACGCTGAACCGGCAAGCGCCGTGGCGCGGCTTTGTAAGAGCGATCCA
TGATCACCTGGGCCGTCCTG

Product: phosphate regulon sensor histidine kinase PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MPLLQPPSPLAPPRRRESPFWPIVAAGAAGLVAIGALAALQRVDAAGAVAALIFVAAATALVLIQADRRAEADAEALAPE
RDRASGEAPPYAALINALPDPILVVSAAEPDDLTGRRYVFANSAARTLFRIERSEGVLVSVLRDPQLLETVDEALFAARD
GESVYETGGVQSRVLRAIVRPMGLSLDGSHLALVSFRDETELRQVERTRADFLANASHELRTPLASLSGFIETLRGHARS
DPGAQERFLTIMQAQAERMRRLIDDLMSLSRIELNEHIAPSQAVELADAVADVMDAVGPIAREKGVKLEVSGPPADAAPV
TGDRDQIVQVIQNLVDNALKYSAPGGTVRVAIEAGRTAEAAAAGVRPEASRLSLLTPDHTGETYGVVRVTDQGPGIAREH
LPRLTERFYRVEGQKSGERLGTGLGLAIVKHIVNRHRGGLAVESALGAGTTFTAYLPERVAAAAPAAGDRRETVIKM

Sequences:

>Translated_477_residues
MPLLQPPSPLAPPRRRESPFWPIVAAGAAGLVAIGALAALQRVDAAGAVAALIFVAAATALVLIQADRRAEADAEALAPE
RDRASGEAPPYAALINALPDPILVVSAAEPDDLTGRRYVFANSAARTLFRIERSEGVLVSVLRDPQLLETVDEALFAARD
GESVYETGGVQSRVLRAIVRPMGLSLDGSHLALVSFRDETELRQVERTRADFLANASHELRTPLASLSGFIETLRGHARS
DPGAQERFLTIMQAQAERMRRLIDDLMSLSRIELNEHIAPSQAVELADAVADVMDAVGPIAREKGVKLEVSGPPADAAPV
TGDRDQIVQVIQNLVDNALKYSAPGGTVRVAIEAGRTAEAAAAGVRPEASRLSLLTPDHTGETYGVVRVTDQGPGIAREH
LPRLTERFYRVEGQKSGERLGTGLGLAIVKHIVNRHRGGLAVESALGAGTTFTAYLPERVAAAAPAAGDRRETVIKM
>Mature_476_residues
PLLQPPSPLAPPRRRESPFWPIVAAGAAGLVAIGALAALQRVDAAGAVAALIFVAAATALVLIQADRRAEADAEALAPER
DRASGEAPPYAALINALPDPILVVSAAEPDDLTGRRYVFANSAARTLFRIERSEGVLVSVLRDPQLLETVDEALFAARDG
ESVYETGGVQSRVLRAIVRPMGLSLDGSHLALVSFRDETELRQVERTRADFLANASHELRTPLASLSGFIETLRGHARSD
PGAQERFLTIMQAQAERMRRLIDDLMSLSRIELNEHIAPSQAVELADAVADVMDAVGPIAREKGVKLEVSGPPADAAPVT
GDRDQIVQVIQNLVDNALKYSAPGGTVRVAIEAGRTAEAAAAGVRPEASRLSLLTPDHTGETYGVVRVTDQGPGIAREHL
PRLTERFYRVEGQKSGERLGTGLGLAIVKHIVNRHRGGLAVESALGAGTTFTAYLPERVAAAAPAAGDRRETVIKM

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=305, Percent_Identity=34.7540983606557, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=31.6981132075472, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788713, Length=393, Percent_Identity=24.1730279898219, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=31.3131313131313, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790436, Length=324, Percent_Identity=27.1604938271605, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=27.1653543307087, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=27.0916334661355, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=276, Percent_Identity=25.3623188405797, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=275, Percent_Identity=25.8181818181818, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788279, Length=281, Percent_Identity=26.3345195729537, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=396, Percent_Identity=28.030303030303, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=27.5555555555556, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50677; Mature: 50546

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLQPPSPLAPPRRRESPFWPIVAAGAAGLVAIGALAALQRVDAAGAVAALIFVAAATA
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLIQADRRAEADAEALAPERDRASGEAPPYAALINALPDPILVVSAAEPDDLTGRRYVF
HHHEECCCCCCCCHHHCCCCHHCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEEE
ANSAARTLFRIERSEGVLVSVLRDPQLLETVDEALFAARDGESVYETGGVQSRVLRAIVR
ECHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
PMGLSLDGSHLALVSFRDETELRQVERTRADFLANASHELRTPLASLSGFIETLRGHARS
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DPGAQERFLTIMQAQAERMRRLIDDLMSLSRIELNEHIAPSQAVELADAVADVMDAVGPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AREKGVKLEVSGPPADAAPVTGDRDQIVQVIQNLVDNALKYSAPGGTVRVAIEAGRTAEA
HHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCHHH
AAAGVRPEASRLSLLTPDHTGETYGVVRVTDQGPGIAREHLPRLTERFYRVEGQKSGERL
HHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
GTGLGLAIVKHIVNRHRGGLAVESALGAGTTFTAYLPERVAAAAPAAGDRRETVIKM
HCHHHHHHHHHHHHHCCCCEEHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PLLQPPSPLAPPRRRESPFWPIVAAGAAGLVAIGALAALQRVDAAGAVAALIFVAAATA
CCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLIQADRRAEADAEALAPERDRASGEAPPYAALINALPDPILVVSAAEPDDLTGRRYVF
HHHEECCCCCCCCHHHCCCCHHCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEEE
ANSAARTLFRIERSEGVLVSVLRDPQLLETVDEALFAARDGESVYETGGVQSRVLRAIVR
ECHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
PMGLSLDGSHLALVSFRDETELRQVERTRADFLANASHELRTPLASLSGFIETLRGHARS
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DPGAQERFLTIMQAQAERMRRLIDDLMSLSRIELNEHIAPSQAVELADAVADVMDAVGPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AREKGVKLEVSGPPADAAPVTGDRDQIVQVIQNLVDNALKYSAPGGTVRVAIEAGRTAEA
HHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCHHH
AAAGVRPEASRLSLLTPDHTGETYGVVRVTDQGPGIAREHLPRLTERFYRVEGQKSGERL
HHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
GTGLGLAIVKHIVNRHRGGLAVESALGAGTTFTAYLPERVAAAAPAAGDRRETVIKM
HCHHHHHHHHHHHHHCCCCEEHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]