Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 197103854

GI number: 197103854

Start: 391220

End: 392362

Strand: Reverse

Name: acdA [H]

Synonym: PHZ_c0388

Alternate gene names: 197103854

Gene position: 392362-391220 (Counterclockwise)

Preceding gene: 197103855

Following gene: 197103852

Centisome position: 9.82

GC content: 68.33

Gene sequence:

>1143_bases
ATGCTGCAGACCGACACCCGCACCGTCTACGACGAGGACCTGAACGTCTTCCGCGACCAGGTCCGGAAATTCTTCGAGCG
GGCGCTGACGCCCAACCTCGACCGGTGGGAGGAGGAAGGCCTCGTCGACCGCGCCTTCTGGCTGGCCTGCGGCGAGGCGG
GCCTGCTGTGCCCCACCGTGCCCGCCGAGTACGGCGGCCTCGGCCTCGACTTCCGCTACAACGCCGTGATCGACGAGGAG
CTGTCCTACGCGGGCTCGTCGGCCGGCATCACCCTGCAGTCGGACATCGTCGCCGACTACCTCGTCAACTACGGCTCGGA
AGAGCAGAAGCGGCAGTGGCTGCCCAAGATGGTCTCGGGCGAGGCGATCACCGCCATCGCCATGACCGAGCCCGGCACCG
GCTCCGACCTGCAGGGCGTGCGCACCACGGCCAGGAAGGACGGCGACCACTATGTGGTGAACGGGTCCAAGACCTACATC
ACCAACGGCCAGAACGCCGACCTGATCATCGTGGTCGCCAAGACCGACCCCAACGCCGGGTCGAAGGGCATCTCGCTGAT
CCTGGTCGAGGCGACCCGCGAGGGCTTCAAGCGCGGCCGCAACCTCGACAAGATCGGCCAGAACTCGGCGGACACCTCCG
AGCTGTTCTTCGAGGACGTGCGCGTGCCCCTGGCCAACTGCCTGGGCGAGGAAGGCAAGGGCTTCGTCTACCTGATGAGC
CAGCTGCCGCAGGAGCGCCTCGGCATCGCCGTCTCGGGACAGGCGGGCGCCCAGCGCGCCTTCGACGAGGCCGCGAAGTT
CACCAAGGAGCGCCGCGCCTTCGGCCAGGCGGTGTTCGAATTCCAGAACACCCGCTTCACCATGGCCGGGCTGAAGGCCA
AGCTGCAGGCCGGCTGGGCGCACCTGGACTGGTGCATCGCCCGCCATCTGGAGGGCAAGCTGACCGCGGCCGAGGCCTCG
GCGGCCAAGCTGTTCCACACCGAGCTGCAGTGGGAGGTGTGCGACGCCGCCCTCCAGCTGCACGGCGGCGCGGGCTACAT
GAACGAGTATCCCATCGCCCGCCTGTGGCGCGACGCCCGCGTCCAGCGGATCTACGGCGGCACGTCCGAGATCATGAAGG
AAGTGGTGGCGCGGACGATCTAG

Upstream 100 bases:

>100_bases
GCTGCGCGCCGAGATCCTCGCGGCCTGTTTCGCGTAACGGCCCTCTTCCCCGACGCGGCGTCAGCCCGCTAACTCGGGAC
GGAAACGCCCGGAGACCGCG

Downstream 100 bases:

>100_bases
CGGCCCTGGCTGCCTCCCCTGGCGCGTCATCCCGCCGTTCGCGTCAGCGCACCCGGGATGACGACCTGCGAGGCTACTGG
CGCTTCACCACCTCGCCGCC

Product: long-chain acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MLQTDTRTVYDEDLNVFRDQVRKFFERALTPNLDRWEEEGLVDRAFWLACGEAGLLCPTVPAEYGGLGLDFRYNAVIDEE
LSYAGSSAGITLQSDIVADYLVNYGSEEQKRQWLPKMVSGEAITAIAMTEPGTGSDLQGVRTTARKDGDHYVVNGSKTYI
TNGQNADLIIVVAKTDPNAGSKGISLILVEATREGFKRGRNLDKIGQNSADTSELFFEDVRVPLANCLGEEGKGFVYLMS
QLPQERLGIAVSGQAGAQRAFDEAAKFTKERRAFGQAVFEFQNTRFTMAGLKAKLQAGWAHLDWCIARHLEGKLTAAEAS
AAKLFHTELQWEVCDAALQLHGGAGYMNEYPIARLWRDARVQRIYGGTSEIMKEVVARTI

Sequences:

>Translated_380_residues
MLQTDTRTVYDEDLNVFRDQVRKFFERALTPNLDRWEEEGLVDRAFWLACGEAGLLCPTVPAEYGGLGLDFRYNAVIDEE
LSYAGSSAGITLQSDIVADYLVNYGSEEQKRQWLPKMVSGEAITAIAMTEPGTGSDLQGVRTTARKDGDHYVVNGSKTYI
TNGQNADLIIVVAKTDPNAGSKGISLILVEATREGFKRGRNLDKIGQNSADTSELFFEDVRVPLANCLGEEGKGFVYLMS
QLPQERLGIAVSGQAGAQRAFDEAAKFTKERRAFGQAVFEFQNTRFTMAGLKAKLQAGWAHLDWCIARHLEGKLTAAEAS
AAKLFHTELQWEVCDAALQLHGGAGYMNEYPIARLWRDARVQRIYGGTSEIMKEVVARTI
>Mature_380_residues
MLQTDTRTVYDEDLNVFRDQVRKFFERALTPNLDRWEEEGLVDRAFWLACGEAGLLCPTVPAEYGGLGLDFRYNAVIDEE
LSYAGSSAGITLQSDIVADYLVNYGSEEQKRQWLPKMVSGEAITAIAMTEPGTGSDLQGVRTTARKDGDHYVVNGSKTYI
TNGQNADLIIVVAKTDPNAGSKGISLILVEATREGFKRGRNLDKIGQNSADTSELFFEDVRVPLANCLGEEGKGFVYLMS
QLPQERLGIAVSGQAGAQRAFDEAAKFTKERRAFGQAVFEFQNTRFTMAGLKAKLQAGWAHLDWCIARHLEGKLTAAEAS
AAKLFHTELQWEVCDAALQLHGGAGYMNEYPIARLWRDARVQRIYGGTSEIMKEVVARTI

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=46.1538461538462, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=37.7659574468085, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=39.0532544378698, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=33.42175066313, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=36.8563685636856, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=32.8042328042328, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=32.8042328042328, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=30.952380952381, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI21361497, Length=378, Percent_Identity=32.5396825396825, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI76496475, Length=396, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI4557235, Length=395, Percent_Identity=32.6582278481013, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=26.2599469496021, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=30.3448275862069, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=30.3448275862069, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI7669494, Length=351, Percent_Identity=26.4957264957265, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI38505218, Length=361, Percent_Identity=27.4238227146814, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI87081958, Length=350, Percent_Identity=32.5714285714286, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786223, Length=336, Percent_Identity=29.1666666666667, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87082384, Length=338, Percent_Identity=24.5562130177515, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=36.7021276595745, Blast_Score=247, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=34.5945945945946, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17551932, Length=382, Percent_Identity=33.7696335078534, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17570075, Length=368, Percent_Identity=33.9673913043478, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17508101, Length=363, Percent_Identity=32.7823691460055, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17534899, Length=367, Percent_Identity=34.8773841961853, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=33.0666666666667, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=367, Percent_Identity=31.6076294277929, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=35.472972972973, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=30.6179775280899, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=34.2222222222222, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=265, Percent_Identity=29.4339622641509, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=272, Percent_Identity=30.5147058823529, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.790450928382, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.553264604811, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=28.2157676348548, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=27.3722627737226, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=27.3722627737226, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=35.4330708661417, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=32.8083989501312, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=32.7127659574468, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=31.1170212765957, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=31.7829457364341, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.989247311828, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19920834, Length=371, Percent_Identity=26.9541778975741, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42000; Mature: 42000

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQTDTRTVYDEDLNVFRDQVRKFFERALTPNLDRWEEEGLVDRAFWLACGEAGLLCPTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCC
PAEYGGLGLDFRYNAVIDEELSYAGSSAGITLQSDIVADYLVNYGSEEQKRQWLPKMVSG
CCCCCCCCCCEEECEEECHHHHHCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCC
EAITAIAMTEPGTGSDLQGVRTTARKDGDHYVVNGSKTYITNGQNADLIIVVAKTDPNAG
CEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCC
SKGISLILVEATREGFKRGRNLDKIGQNSADTSELFFEDVRVPLANCLGEEGKGFVYLMS
CCCEEEEEEHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
QLPQERLGIAVSGQAGAQRAFDEAAKFTKERRAFGQAVFEFQNTRFTMAGLKAKLQAGWA
HCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCHH
HLDWCIARHLEGKLTAAEASAAKLFHTELQWEVCDAALQLHGGAGYMNEYPIARLWRDAR
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VQRIYGGTSEIMKEVVARTI
HHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLQTDTRTVYDEDLNVFRDQVRKFFERALTPNLDRWEEEGLVDRAFWLACGEAGLLCPTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCC
PAEYGGLGLDFRYNAVIDEELSYAGSSAGITLQSDIVADYLVNYGSEEQKRQWLPKMVSG
CCCCCCCCCCEEECEEECHHHHHCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCC
EAITAIAMTEPGTGSDLQGVRTTARKDGDHYVVNGSKTYITNGQNADLIIVVAKTDPNAG
CEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCC
SKGISLILVEATREGFKRGRNLDKIGQNSADTSELFFEDVRVPLANCLGEEGKGFVYLMS
CCCEEEEEEHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
QLPQERLGIAVSGQAGAQRAFDEAAKFTKERRAFGQAVFEFQNTRFTMAGLKAKLQAGWA
HCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCHH
HLDWCIARHLEGKLTAAEASAAKLFHTELQWEVCDAALQLHGGAGYMNEYPIARLWRDAR
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VQRIYGGTSEIMKEVVARTI
HHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]