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The map label for this gene is pepA [H]

Identifier: 197103824

GI number: 197103824

Start: 362941

End: 364332

Strand: Direct

Name: pepA [H]

Synonym: PHZ_c0358

Alternate gene names: 197103824

Gene position: 362941-364332 (Clockwise)

Preceding gene: 197103823

Following gene: 197103825

Centisome position: 9.08

GC content: 74.64

Gene sequence:

>1392_bases
ATGTCCGACGTGATCCTCGAGGCCTGGGACGGGCCCGTCGTCCCCGTGCACGCCCTGACCGAGGGCGAGGCGCAGGCGCT
GTTCGAGGCCGAGCCCTTCGTGGGCGCGCTGGCGCGGACCGCCGAGTTCAAGGGCAAGGCCGGCCAGGCGCTGGCCGTGC
CCGCCGCCGACGGGAGCCTGGACCGGGTGCTGTTCGGCCTGGGCGCCGAGCCCGCCTGGACCGCCCTGCGCGCCCTGCCG
GCCAAGCTGCCGGCGGGCGTGGTCTGCCGCATCGCCCAGGCGCCGGACTCGATCACTCCCGCCCAGGCGGCCCTGGCCTT
CGCCCTGGGGAGCTACCGGTTCGACCGCTACAAGGCCCGCGAGGGCGAGCGGCCGCGGCTGCTGGCCGAGGGGGACGAAG
GAGCGGCCGAGGCGCGCCAGGTGGCCCACGCCTGCGCCCTGGCCCGCGACATGGTCAACACCCCGGCCAACGACATGGGC
CCGCAGCAGATCGAGACCATCGCCCGCGAGATCGCCGAACAGCACGGCGCCCAGGTGACGGTGCTGGAGGGCGAGGGCCT
GCTGGAGGCCGGCTATCCGGCCGTCCACGCGGTGGGCCGCGCCGCCCATCCCGAGCGCGCGCCTCGGATGATCGAGCTGT
GCTGGGCGCCCCCCGGGGGAGAGGACCGGCCGCTGGTGGCCATCGTCGGCAAGGGCGTGGTGTTCGACACCGGCGGCCTC
GACATCAAGCCCTCGGCCGGCATGCGGCTGATGAAGAAGGACATGGGCGGGGCCGCCCACGCCCTGGCTCTGGGCCGGAT
GGTCATGGCCGCCAAGCTGCCGGTGCGGCTGGTCGTGCTGGTCCCGGCGGTGGAGAACGCCATTTCCGGCGACGCCATGC
GGCCCGGCGACGTGCTGGCGACCCGCAAGGGGCTGAGCGTCGAGGTGGGCAACACCGACGCCGAGGGGCGGCTGATCCTC
GCCGACGCCCTGGCCCGCGCGGCCGAGCTGGAGCCGGCGCTGACCATCGACCTGGCCACCCTGACCGGGGCGGCGCGCAT
CGCCCTGGGGCCGCAGGTGATCCCGTTCTACACCGACGACGACGAGCTGGCCGGCCAGATCGAGGCGGCGGCGAAGGCCG
AGGCCGACGCCGTCTGGCGGATGCCGCTGTGGAAGCCCTACGCCGAGGCGCTGGAGTCCGAGGTCGCCGACCTGAAGAAC
GACCCCGACGCCTGGGCCCAGGCCGGCTCGGTGACCGCGGCGCTGTTCCTGCAGAAGTTCGCGCCGCGCGGGCCGTGGGT
CCATTTCGACATCTTCGCCTGGAACCCTCGCGGGAAACCGGGCCAGCCCGCGGGCGCCGAGGTCCAGGCGATCCGCGGCC
TCTACCGCATGATCCGGGAGCGATTCGCATGA

Upstream 100 bases:

>100_bases
CGCGGCCGGCGCCCTGGCGGCCTTCCCCCTCTCGCCGTTCCCCACAGTGTTCGGAGCGCTCTAGGTTGCGGCGCCTTCGG
ACATGCGCGACAGGTGGATC

Downstream 100 bases:

>100_bases
ACCTCGATCCTCGGGTGACGCCGATCCGCGACGGGATCGCCGCCCGCAGCCTGGAGGGGATCGTGGCGGCCGAGGTCTAT
CTGGACCCGACGCCGATGAC

Product: cytosol aminopeptidase family protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSDVILEAWDGPVVPVHALTEGEAQALFEAEPFVGALARTAEFKGKAGQALAVPAADGSLDRVLFGLGAEPAWTALRALP
AKLPAGVVCRIAQAPDSITPAQAALAFALGSYRFDRYKAREGERPRLLAEGDEGAAEARQVAHACALARDMVNTPANDMG
PQQIETIAREIAEQHGAQVTVLEGEGLLEAGYPAVHAVGRAAHPERAPRMIELCWAPPGGEDRPLVAIVGKGVVFDTGGL
DIKPSAGMRLMKKDMGGAAHALALGRMVMAAKLPVRLVVLVPAVENAISGDAMRPGDVLATRKGLSVEVGNTDAEGRLIL
ADALARAAELEPALTIDLATLTGAARIALGPQVIPFYTDDDELAGQIEAAAKAEADAVWRMPLWKPYAEALESEVADLKN
DPDAWAQAGSVTAALFLQKFAPRGPWVHFDIFAWNPRGKPGQPAGAEVQAIRGLYRMIRERFA

Sequences:

>Translated_463_residues
MSDVILEAWDGPVVPVHALTEGEAQALFEAEPFVGALARTAEFKGKAGQALAVPAADGSLDRVLFGLGAEPAWTALRALP
AKLPAGVVCRIAQAPDSITPAQAALAFALGSYRFDRYKAREGERPRLLAEGDEGAAEARQVAHACALARDMVNTPANDMG
PQQIETIAREIAEQHGAQVTVLEGEGLLEAGYPAVHAVGRAAHPERAPRMIELCWAPPGGEDRPLVAIVGKGVVFDTGGL
DIKPSAGMRLMKKDMGGAAHALALGRMVMAAKLPVRLVVLVPAVENAISGDAMRPGDVLATRKGLSVEVGNTDAEGRLIL
ADALARAAELEPALTIDLATLTGAARIALGPQVIPFYTDDDELAGQIEAAAKAEADAVWRMPLWKPYAEALESEVADLKN
DPDAWAQAGSVTAALFLQKFAPRGPWVHFDIFAWNPRGKPGQPAGAEVQAIRGLYRMIRERFA
>Mature_462_residues
SDVILEAWDGPVVPVHALTEGEAQALFEAEPFVGALARTAEFKGKAGQALAVPAADGSLDRVLFGLGAEPAWTALRALPA
KLPAGVVCRIAQAPDSITPAQAALAFALGSYRFDRYKAREGERPRLLAEGDEGAAEARQVAHACALARDMVNTPANDMGP
QQIETIAREIAEQHGAQVTVLEGEGLLEAGYPAVHAVGRAAHPERAPRMIELCWAPPGGEDRPLVAIVGKGVVFDTGGLD
IKPSAGMRLMKKDMGGAAHALALGRMVMAAKLPVRLVVLVPAVENAISGDAMRPGDVLATRKGLSVEVGNTDAEGRLILA
DALARAAELEPALTIDLATLTGAARIALGPQVIPFYTDDDELAGQIEAAAKAEADAVWRMPLWKPYAEALESEVADLKND
PDAWAQAGSVTAALFLQKFAPRGPWVHFDIFAWNPRGKPGQPAGAEVQAIRGLYRMIRERFA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=331, Percent_Identity=35.6495468277946, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI47155554, Length=294, Percent_Identity=34.6938775510204, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1790710, Length=452, Percent_Identity=33.4070796460177, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI87082123, Length=326, Percent_Identity=39.2638036809816, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17556903, Length=289, Percent_Identity=38.0622837370242, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=181, Percent_Identity=33.1491712707182, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355725, Length=332, Percent_Identity=33.1325301204819, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24661038, Length=301, Percent_Identity=35.2159468438538, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221379063, Length=291, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI221379062, Length=291, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI21357381, Length=291, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24662227, Length=291, Percent_Identity=29.553264604811, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI20129969, Length=291, Percent_Identity=29.553264604811, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21355645, Length=338, Percent_Identity=27.2189349112426, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662223, Length=338, Percent_Identity=27.2189349112426, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20129963, Length=420, Percent_Identity=28.3333333333333, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161077148, Length=339, Percent_Identity=28.9085545722714, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20130057, Length=339, Percent_Identity=28.9085545722714, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19922386, Length=361, Percent_Identity=26.5927977839335, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646701, Length=216, Percent_Identity=37.037037037037, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646703, Length=216, Percent_Identity=37.037037037037, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21358201, Length=216, Percent_Identity=37.037037037037, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48852; Mature: 48721

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVILEAWDGPVVPVHALTEGEAQALFEAEPFVGALARTAEFKGKAGQALAVPAADGSL
CCCCEEECCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCH
DRVLFGLGAEPAWTALRALPAKLPAGVVCRIAQAPDSITPAQAALAFALGSYRFDRYKAR
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
EGERPRLLAEGDEGAAEARQVAHACALARDMVNTPANDMGPQQIETIAREIAEQHGAQVT
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
VLEGEGLLEAGYPAVHAVGRAAHPERAPRMIELCWAPPGGEDRPLVAIVGKGVVFDTGGL
EEECCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEEECCCC
DIKPSAGMRLMKKDMGGAAHALALGRMVMAAKLPVRLVVLVPAVENAISGDAMRPGDVLA
EECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCCCCCCCCHHE
TRKGLSVEVGNTDAEGRLILADALARAAELEPALTIDLATLTGAARIALGPQVIPFYTDD
ECCCCEEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEEHHHCCCEEEEECCEEEEEECCC
DELAGQIEAAAKAEADAVWRMPLWKPYAEALESEVADLKNDPDAWAQAGSVTAALFLQKF
HHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
APRGPWVHFDIFAWNPRGKPGQPAGAEVQAIRGLYRMIRERFA
CCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDVILEAWDGPVVPVHALTEGEAQALFEAEPFVGALARTAEFKGKAGQALAVPAADGSL
CCCEEECCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCH
DRVLFGLGAEPAWTALRALPAKLPAGVVCRIAQAPDSITPAQAALAFALGSYRFDRYKAR
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
EGERPRLLAEGDEGAAEARQVAHACALARDMVNTPANDMGPQQIETIAREIAEQHGAQVT
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
VLEGEGLLEAGYPAVHAVGRAAHPERAPRMIELCWAPPGGEDRPLVAIVGKGVVFDTGGL
EEECCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEEECCCC
DIKPSAGMRLMKKDMGGAAHALALGRMVMAAKLPVRLVVLVPAVENAISGDAMRPGDVLA
EECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCCCCCCCCHHE
TRKGLSVEVGNTDAEGRLILADALARAAELEPALTIDLATLTGAARIALGPQVIPFYTDD
ECCCCEEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEEHHHCCCEEEEECCEEEEEECCC
DELAGQIEAAAKAEADAVWRMPLWKPYAEALESEVADLKNDPDAWAQAGSVTAALFLQKF
HHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
APRGPWVHFDIFAWNPRGKPGQPAGAEVQAIRGLYRMIRERFA
CCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA