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The map label for this gene is 197103811

Identifier: 197103811

GI number: 197103811

Start: 348568

End: 349413

Strand: Reverse

Name: 197103811

Synonym: PHZ_c0345

Alternate gene names: NA

Gene position: 349413-348568 (Counterclockwise)

Preceding gene: 197103813

Following gene: 197103809

Centisome position: 8.74

GC content: 74.94

Gene sequence:

>846_bases
ATGCGAAACCTTTTCTTGGCCTTGGCCCTGGCGACGGCGACCGCCGCCCCGTCCGTGTCGATCGCCCAGGACGCGGCCCA
GCGCGCCGAGTGGAACCGGCCCGCCGCGCCGTTCCGGATCGCTGGCCCGGTCTACTACGTCGGGACCGAGGGCCTGGGCG
CCTACCTCGTCGCCGACCCCGGCGGGCACGCGCTGATCGACGGCGGCCTGCCCGAGAGCGCGCCGCTGATCGCCGCCAAC
ATCGAGGCGCTGGGCTTCAAGCTGGAGGACGTGCGCTACCTGCTGGTCAACCACGCCCACTTCGACCACGCGGGCGGCCT
CGCCGAGCTGAAGCGCCGCACGGGCGCGGCGCTGGTCGCCAGCGCCGGCGATGCGCCCGACCTCGGGGCGGGCCGCACCC
TCGGCCGCCCCGAGCTGGACGGCTTCCCCGCGGTCGCGGTGGATCAGGTCGTGGCCGACGGCGACACCCTGCGGCTCGGC
CAGGCGTCGCTGACCGCCCACGTGACCCCCGGCCACACCCGCGGCTGCACCAGCTGGTCGCTGGCCGGCCCGTCCGGAAC
GGTGCTGTTCGCCTGCAGCCTGACGGTGGCCGGCCAGAAGCTGCACGGCGATCCGGCCTATCCCGACGCCGCCGCCGACT
TCCGGCGCACCTTCGCCCGCCTGCGGACGCTGCACGCCGACTACTTCCTCAACTTCCACCCCGAGTTCTTCGACATGGCC
GGCAAGCGGGCCAGGCGCGCGGCGGGCGAGCCCGATCCCTTCCGCGACCCCGCCGAGCTGGCCCGCCAGGTCGACCGCGC
CGAAGCCATGTTCGAACGCGAACTCGCCCGCCAGGCCGCCCGCTGA

Upstream 100 bases:

>100_bases
TCCCGCCAGGAAAGGTCCTTTGCACTGCGCCCGGCGCCTGCGCCATCAAAGGGCGGCCGTCGGCCCGGCGCGCCGCCCGG
CTGACGCGGGAGGGACCCTG

Downstream 100 bases:

>100_bases
CGCCCCCTCTCCCCTTCCCGCTCTCCCCCGTGAAGCGGGGAGGGTCCGGGCGCACGGCATGCCCGGCTCGGCGCCCAGCT
GGCGCAGCGAGGCGCCGTCG

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: Beta-lactamase type II; Penicillinase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRNLFLALALATATAAPSVSIAQDAAQRAEWNRPAAPFRIAGPVYYVGTEGLGAYLVADPGGHALIDGGLPESAPLIAAN
IEALGFKLEDVRYLLVNHAHFDHAGGLAELKRRTGAALVASAGDAPDLGAGRTLGRPELDGFPAVAVDQVVADGDTLRLG
QASLTAHVTPGHTRGCTSWSLAGPSGTVLFACSLTVAGQKLHGDPAYPDAAADFRRTFARLRTLHADYFLNFHPEFFDMA
GKRARRAAGEPDPFRDPAELARQVDRAEAMFERELARQAAR

Sequences:

>Translated_281_residues
MRNLFLALALATATAAPSVSIAQDAAQRAEWNRPAAPFRIAGPVYYVGTEGLGAYLVADPGGHALIDGGLPESAPLIAAN
IEALGFKLEDVRYLLVNHAHFDHAGGLAELKRRTGAALVASAGDAPDLGAGRTLGRPELDGFPAVAVDQVVADGDTLRLG
QASLTAHVTPGHTRGCTSWSLAGPSGTVLFACSLTVAGQKLHGDPAYPDAAADFRRTFARLRTLHADYFLNFHPEFFDMA
GKRARRAAGEPDPFRDPAELARQVDRAEAMFERELARQAAR
>Mature_281_residues
MRNLFLALALATATAAPSVSIAQDAAQRAEWNRPAAPFRIAGPVYYVGTEGLGAYLVADPGGHALIDGGLPESAPLIAAN
IEALGFKLEDVRYLLVNHAHFDHAGGLAELKRRTGAALVASAGDAPDLGAGRTLGRPELDGFPAVAVDQVVADGDTLRLG
QASLTAHVTPGHTRGCTSWSLAGPSGTVLFACSLTVAGQKLHGDPAYPDAAADFRRTFARLRTLHADYFLNFHPEFFDMA
GKRARRAAGEPDPFRDPAELARQVDRAEAMFERELARQAAR

Specific function: Has a high activity against imipenem [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 29745; Mature: 29745

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLFLALALATATAAPSVSIAQDAAQRAEWNRPAAPFRIAGPVYYVGTEGLGAYLVADP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCEEEEECC
GGHALIDGGLPESAPLIAANIEALGFKLEDVRYLLVNHAHFDHAGGLAELKRRTGAALVA
CCCEEEECCCCCCCCEEEECHHHHCEEHHHHHEEEHCCCCCCCCCCHHHHHHHCCCEEEE
SAGDAPDLGAGRTLGRPELDGFPAVAVDQVVADGDTLRLGQASLTAHVTPGHTRGCTSWS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCCEE
LAGPSGTVLFACSLTVAGQKLHGDPAYPDAAADFRRTFARLRTLHADYFLNFHPEFFDMA
ECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
GKRARRAAGEPDPFRDPAELARQVDRAEAMFERELARQAAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRNLFLALALATATAAPSVSIAQDAAQRAEWNRPAAPFRIAGPVYYVGTEGLGAYLVADP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCEEEEECC
GGHALIDGGLPESAPLIAANIEALGFKLEDVRYLLVNHAHFDHAGGLAELKRRTGAALVA
CCCEEEECCCCCCCCEEEECHHHHCEEHHHHHEEEHCCCCCCCCCCHHHHHHHCCCEEEE
SAGDAPDLGAGRTLGRPELDGFPAVAVDQVVADGDTLRLGQASLTAHVTPGHTRGCTSWS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCCEE
LAGPSGTVLFACSLTVAGQKLHGDPAYPDAAADFRRTFARLRTLHADYFLNFHPEFFDMA
ECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
GKRARRAAGEPDPFRDPAELARQVDRAEAMFERELARQAAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8018721; 3931629; 9811546 [H]