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The map label for this gene is lrp [H]

Identifier: 197103804

GI number: 197103804

Start: 337534

End: 338004

Strand: Reverse

Name: lrp [H]

Synonym: PHZ_c0338

Alternate gene names: 197103804

Gene position: 338004-337534 (Counterclockwise)

Preceding gene: 197103809

Following gene: 197103801

Centisome position: 8.46

GC content: 70.91

Gene sequence:

>471_bases
ATGGCGAACAATCTGCGACTGGACGAGACCGACCGGCGGCTGCTGCGGGCGCTGCAGGCGGACGGGCGGATCAGCAACGC
CGAGCTCGCCGAGCGGTGCCATCTGTCCCCCTCCGCCTGCTCCGAGCGGGTGCGGCGGCTGCGCGAGGGCGGCTACATCA
CCGGCTTCACCGCCCTGGTGGACCCCGAGAAGGTCGAGCGCGGGGTGCTGATCTTCGTCGAGGTGGTGCTGGACCGCACG
ACGCCCGAGGTGTTCGAGACCTTCGCCGCCGCGGCCCGCCGCTCGCCCGACGTGCTGGAGTGCCACATGGTGGCGGGAGG
CTTCGACTACCTCATCAAGTCGCGGGTGCGCGACCTGGCCGCCTGGCGGACGTTCCTGGAGGACGTGCTGGTGCGCATCC
CCGGCGTGCGCGAGACGCGCACCTACGCCGTGCTGGAAGAGGTGAAGAGCACGACCCAGCTGCCGGTTTGA

Upstream 100 bases:

>100_bases
GAGCCTCCTGCTGCGACAGCATTCGGGATATGGTACTTAGCGCCGAATGTATCACGGTTCGGCGGCGAGGTCGCCGCAGC
TTCCACGGCGGAAACGGGCG

Downstream 100 bases:

>100_bases
TCTCCAGCCGCGAGCGAACGCCCGCCTTCCCCAAAAGCAAAGGGCCCGGCGTTTCCGCCGGGCCCTCGCCTAGTGTCCGA
CCGAAGCCGGCGATCGAGAT

Product: leucine-responsive transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MANNLRLDETDRRLLRALQADGRISNAELAERCHLSPSACSERVRRLREGGYITGFTALVDPEKVERGVLIFVEVVLDRT
TPEVFETFAAAARRSPDVLECHMVAGGFDYLIKSRVRDLAAWRTFLEDVLVRIPGVRETRTYAVLEEVKSTTQLPV

Sequences:

>Translated_156_residues
MANNLRLDETDRRLLRALQADGRISNAELAERCHLSPSACSERVRRLREGGYITGFTALVDPEKVERGVLIFVEVVLDRT
TPEVFETFAAAARRSPDVLECHMVAGGFDYLIKSRVRDLAAWRTFLEDVLVRIPGVRETRTYAVLEEVKSTTQLPV
>Mature_155_residues
ANNLRLDETDRRLLRALQADGRISNAELAERCHLSPSACSERVRRLREGGYITGFTALVDPEKVERGVLIFVEVVLDRTT
PEVFETFAAAARRSPDVLECHMVAGGFDYLIKSRVRDLAAWRTFLEDVLVRIPGVRETRTYAVLEEVKSTTQLPV

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=50.6666666666667, Blast_Score=170, Evalue=3e-44,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790182, Length=144, Percent_Identity=27.0833333333333, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17617; Mature: 17486

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNLRLDETDRRLLRALQADGRISNAELAERCHLSPSACSERVRRLREGGYITGFTALV
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHC
DPEKVERGVLIFVEVVLDRTTPEVFETFAAAARRSPDVLECHMVAGGFDYLIKSRVRDLA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHH
AWRTFLEDVLVRIPGVRETRTYAVLEEVKSTTQLPV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANNLRLDETDRRLLRALQADGRISNAELAERCHLSPSACSERVRRLREGGYITGFTALV
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHC
DPEKVERGVLIFVEVVLDRTTPEVFETFAAAARRSPDVLECHMVAGGFDYLIKSRVRDLA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHH
AWRTFLEDVLVRIPGVRETRTYAVLEEVKSTTQLPV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]