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The map label for this gene is hisG [H]

Identifier: 197103800

GI number: 197103800

Start: 331606

End: 332556

Strand: Direct

Name: hisG [H]

Synonym: PHZ_c0334

Alternate gene names: 197103800

Gene position: 331606-332556 (Clockwise)

Preceding gene: 197103799

Following gene: 197103802

Centisome position: 8.3

GC content: 74.87

Gene sequence:

>951_bases
ATGAGCGAGCTGGTCATCGCGGTCCCGTCCAAGGGCCGCCTGAAGGAGCAGGTGGAGGCCTGGCTGGCCGACGCCGGCCT
CGACCTTTCCGTCACCGGCGGGGCGCGCGGCTACATGGCGGGCCTCAAGGGGCTGCCGGGCGCCCAGGTGCGCCTCCTGT
CGGCCGGCGACATCGCCGAGGCCCTGGACGCCGGCGAGGTCCACCTCGGGATCACCGGCGAAGACCTGCTGCGCGAGCGC
GGCGAGGACCTCGACTCCCGCGTCCTGCTGTTGCGGCCGCTGGGCTTCGGCCGCGCCGACCTCGTCGTCGCCGCACCGAA
GAGCTGGCTCGACGTCGAGACCATGGCCGACCTCGAGGAGGTCGCCGCCGAGCACCTGGCCCGCACCGGCCGGCGCATGC
GCGTGGCGACCAAGTACCTCTCCCAGACCCGGGCCTTCTTCGCCCGCCACGGCATCGCCGATTACCGCATCGCCGAGTCG
GGCGGGGCGACCGAGGGCGCGCCGGCGGCCGGCGCGGCCGAGCTGGTGGTGGACATCACCACCACCGGGGCGACCCTGGC
CGCCAACGGCCTGAAGGTGCTGGCCGACGGGGTGATCCTGAAGAGCCAGGCGCAGCTCGCCGCCAGCCTGCGGGCCGAGT
GGGGCGAATCGGCCCTCGCGGCGGCCGAGCGCCTGCTGCGGGCGGTGGAGGCCCGGGCCGCGGCCCGGCGCAGCGCGACC
CTGATCTGGCCATCCCGTGGCGACGCCGCCGAGGCCGAGGCGGTGGACCGTCTCGTCGCCGCCGGCGCCTCGCGCCGACC
CAACGGCCTGCTGGTCGAGATGGGGCAGGTGGCCGAGGCCGCTCAGGCGCTTACCGCCGCGGGCCTCGGGCCGGTCACAG
CCGCCCAGCCCGAGTTCGTCTTTGACGTGAGCTGCCCAGCGCTTACAACCCTCAAGTCCCGGTTGTTTTGA

Upstream 100 bases:

>100_bases
ACGGCCTGCTGGCCCGCCTTGGGGCTGGCCTCGGGGGCGGCGAAGGGAGGGCGGTGGGCTGCATGGTCCGGCCCTGGCGC
GCATGGGACGGAGGCGAGCA

Downstream 100 bases:

>100_bases
CGACAGCGTCAAAAATTTGAGGCAAATCGCAATTTTATGAACTGACTTTGCCGGGAACCCCGTTTGGGCCCGTTGACTCG
GCCAGAAAATTGCCGTTCTG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSELVIAVPSKGRLKEQVEAWLADAGLDLSVTGGARGYMAGLKGLPGAQVRLLSAGDIAEALDAGEVHLGITGEDLLRER
GEDLDSRVLLLRPLGFGRADLVVAAPKSWLDVETMADLEEVAAEHLARTGRRMRVATKYLSQTRAFFARHGIADYRIAES
GGATEGAPAAGAAELVVDITTTGATLAANGLKVLADGVILKSQAQLAASLRAEWGESALAAAERLLRAVEARAAARRSAT
LIWPSRGDAAEAEAVDRLVAAGASRRPNGLLVEMGQVAEAAQALTAAGLGPVTAAQPEFVFDVSCPALTTLKSRLF

Sequences:

>Translated_316_residues
MSELVIAVPSKGRLKEQVEAWLADAGLDLSVTGGARGYMAGLKGLPGAQVRLLSAGDIAEALDAGEVHLGITGEDLLRER
GEDLDSRVLLLRPLGFGRADLVVAAPKSWLDVETMADLEEVAAEHLARTGRRMRVATKYLSQTRAFFARHGIADYRIAES
GGATEGAPAAGAAELVVDITTTGATLAANGLKVLADGVILKSQAQLAASLRAEWGESALAAAERLLRAVEARAAARRSAT
LIWPSRGDAAEAEAVDRLVAAGASRRPNGLLVEMGQVAEAAQALTAAGLGPVTAAQPEFVFDVSCPALTTLKSRLF
>Mature_315_residues
SELVIAVPSKGRLKEQVEAWLADAGLDLSVTGGARGYMAGLKGLPGAQVRLLSAGDIAEALDAGEVHLGITGEDLLRERG
EDLDSRVLLLRPLGFGRADLVVAAPKSWLDVETMADLEEVAAEHLARTGRRMRVATKYLSQTRAFFARHGIADYRIAESG
GATEGAPAAGAAELVVDITTTGATLAANGLKVLADGVILKSQAQLAASLRAEWGESALAAAERLLRAVEARAAARRSATL
IWPSRGDAAEAEAVDRLVAAGASRRPNGLLVEMGQVAEAAQALTAAGLGPVTAAQPEFVFDVSCPALTTLKSRLF

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=271, Percent_Identity=29.520295202952, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32852; Mature: 32721

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELVIAVPSKGRLKEQVEAWLADAGLDLSVTGGARGYMAGLKGLPGAQVRLLSAGDIAE
CCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCEEEEEECCCHHH
ALDAGEVHLGITGEDLLRERGEDLDSRVLLLRPLGFGRADLVVAAPKSWLDVETMADLEE
HHCCCCEEEECCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHH
VAAEHLARTGRRMRVATKYLSQTRAFFARHGIADYRIAESGGATEGAPAAGAAELVVDIT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEEEE
TTGATLAANGLKVLADGVILKSQAQLAASLRAEWGESALAAAERLLRAVEARAAARRSAT
CCCCHHHHCCHHHHHCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEE
LIWPSRGDAAEAEAVDRLVAAGASRRPNGLLVEMGQVAEAAQALTAAGLGPVTAAQPEFV
EEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCEE
FDVSCPALTTLKSRLF
EECCCCHHHHHHHHCC
>Mature Secondary Structure 
SELVIAVPSKGRLKEQVEAWLADAGLDLSVTGGARGYMAGLKGLPGAQVRLLSAGDIAE
CCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCEEEEEECCCHHH
ALDAGEVHLGITGEDLLRERGEDLDSRVLLLRPLGFGRADLVVAAPKSWLDVETMADLEE
HHCCCCEEEECCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHH
VAAEHLARTGRRMRVATKYLSQTRAFFARHGIADYRIAESGGATEGAPAAGAAELVVDIT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEEEE
TTGATLAANGLKVLADGVILKSQAQLAASLRAEWGESALAAAERLLRAVEARAAARRSAT
CCCCHHHHCCHHHHHCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEE
LIWPSRGDAAEAEAVDRLVAAGASRRPNGLLVEMGQVAEAAQALTAAGLGPVTAAQPEFV
EEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCEE
FDVSCPALTTLKSRLF
EECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA