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The map label for this gene is sdhA [H]

Identifier: 197103678

GI number: 197103678

Start: 209080

End: 210867

Strand: Direct

Name: sdhA [H]

Synonym: PHZ_c0212

Alternate gene names: 197103678

Gene position: 209080-210867 (Clockwise)

Preceding gene: 197103677

Following gene: 197103679

Centisome position: 5.23

GC content: 68.79

Gene sequence:

>1788_bases
ATGGCCGCTTACGAATTCATCGACCACAAGTTCGACGTCGTCGTCGTCGGCGCCGGCGGCTCGGGCCTGCGGGCCGCGCT
CGGCTGCGCCCAGGCGGGCCTGAAGACCGCCTGCATCACCAAGGTGTTCCCGACCCGCTCGCACACGGTCGCCGCCCAGG
GCGGGATCTCCGCTTCGCTGGGCAACATGGGCGAGGACGACTGGCGCTGGCACATGTACGACACCGTCAAGGGGTCGGAC
TGGCTTGGCGACCAGGACGCCATCGAATACCTCTGCCGCAACGCGCCGGCGGCGGTGTACGAGCTCGAGCACTGGGGCGT
CCCGTTCAGCCGCACGGCCGACGGCAAGATCTACCAGCGCGCCTTCGGCGGCATGACCCGCAACTTCGGCGAGGCCCCGA
TCCAGCGCACCTGCGCGGCGGCCGACCGGACCGGCCACGCCATGCTGCACACCATGTACGGCCAGTCGCTGGCCCACGAC
ACCGAGTTCTTCATCGAGTTCTTCGCCCTCGACCTGATCATGGACGAGGGCGTCTGCCGGGGCGTCACCGCCTGGAAGCT
GGACGACGGCACCCTGCACCGGTTCCAGGCCCAGATGGTCATCCTGGCCACCGGCGGCTACGGCCGGGCCTACTTCTCCT
GCACCAGCGCCCACACCTGCACCGGCGACGGCGGCGGCATGGCGCTGCGCGCCGGCCTGCCGCTGCAGGACATGGAGTTC
GTCCAGTTTCACCCCACGGGGATCTACGGCGCCGGCTGCCTGATCACCGAAGGCGCGAGAGGCGAGGGCGGCTACCTGAC
CAACTCCGAGGGCGAGCGGTTCATGGAGCGCTATGCGCCGACCGTGAAGGACCTCGCGCCGCGGGACATGGTCAGCCGGG
CCATGACCATCGAGATCCGCGAGGGCCGCGGCGTCGGTCCGAACAAGGACCACATCTTCCTGCACCTGGATCACCTGGAT
CCGAAGATCCTGGCCGAACGTCTTCCGGGGATCTCGGAAAGCGCCAAGATCTTCGCAGGCGTCGACGTGACCAAGGAGCC
GATCCCGGTCCTGCCGACCGTCCACTACAACATGGGCGGCATCCCGACGAACTTCTACTCGGAGGTGGTGACCAAGGCCG
GCAAGAATCCGGACCAGGTGGTGCCGGGGCTGATGGCGGTGGGCGAGGCGGCCTGCGTCTCGGTGCACGGCGCCAACCGG
CTCGGCTCGAACAGCCTGATCGACCTCGTGGTGTTCGGCCGCTCGGCGGCCCTTCGCGCGGCCGACGTCCTGACCCCGGG
CGCCAGCCAGCCCGAGCTGAAGGACCACATGACCGACGGCCACCTGGCCCGGTTCGACCGCTTCCGCCACGCGGCGGGCG
AGGTTCCGACCGCCGAGCTGCGGCTCGAGATGCAGCGGGCCATGCAGGAGGACGCCGCCGTCTTCCGCACCGGCGAGAGC
CTGACGTCGGGCGTCAAGCGCCTGCAGGCGGTGCACGACAAGCGCAAGCACATCCGCGTCACCGACCGCAGCATGATCTG
GAACTCGGACCTCATGGAGACCCTGGAGTTCGACAACCTGGTCGGCCAGGCGGCGGTGACGGTGAACGGGGCGGCCAACC
GCACCGAGAGCCGCGGCGCCCACGCCCGCGAGGATTTCCCCGACCGCGACGACAAGAAGTGGATGAAGCACACCCTGGCC
TGGTTCGACGACAAGACCGGGAAGGTGAAGCTGGACGACCGTCCGGTGCACAACTTCACCATGTCCAACGACATCGCCTA
CATCCCGCCGAAGGCGCGGGTGTACTAA

Upstream 100 bases:

>100_bases
CCGCGCTCCTGCTCCTCAACTTCTTCGTCTGCGGACTGGCCGGCGCGCTCGCCGTCTTCTCCGTGCTGAAGGTCGCGCTG
GGAGGCGCGTGAGACACCCC

Downstream 100 bases:

>100_bases
GGCCAGCCCCAGGAAGACCCGCCCGATGGCCGAGATCCGCCTGCCCAAGAACTCCCGCGTCACCCAGGGCCGCCACCACC
CGGCGCCCGCCGGCGCGGCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MAAYEFIDHKFDVVVVGAGGSGLRAALGCAQAGLKTACITKVFPTRSHTVAAQGGISASLGNMGEDDWRWHMYDTVKGSD
WLGDQDAIEYLCRNAPAAVYELEHWGVPFSRTADGKIYQRAFGGMTRNFGEAPIQRTCAAADRTGHAMLHTMYGQSLAHD
TEFFIEFFALDLIMDEGVCRGVTAWKLDDGTLHRFQAQMVILATGGYGRAYFSCTSAHTCTGDGGGMALRAGLPLQDMEF
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTVKDLAPRDMVSRAMTIEIREGRGVGPNKDHIFLHLDHLD
PKILAERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFYSEVVTKAGKNPDQVVPGLMAVGEAACVSVHGANR
LGSNSLIDLVVFGRSAALRAADVLTPGASQPELKDHMTDGHLARFDRFRHAAGEVPTAELRLEMQRAMQEDAAVFRTGES
LTSGVKRLQAVHDKRKHIRVTDRSMIWNSDLMETLEFDNLVGQAAVTVNGAANRTESRGAHAREDFPDRDDKKWMKHTLA
WFDDKTGKVKLDDRPVHNFTMSNDIAYIPPKARVY

Sequences:

>Translated_595_residues
MAAYEFIDHKFDVVVVGAGGSGLRAALGCAQAGLKTACITKVFPTRSHTVAAQGGISASLGNMGEDDWRWHMYDTVKGSD
WLGDQDAIEYLCRNAPAAVYELEHWGVPFSRTADGKIYQRAFGGMTRNFGEAPIQRTCAAADRTGHAMLHTMYGQSLAHD
TEFFIEFFALDLIMDEGVCRGVTAWKLDDGTLHRFQAQMVILATGGYGRAYFSCTSAHTCTGDGGGMALRAGLPLQDMEF
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTVKDLAPRDMVSRAMTIEIREGRGVGPNKDHIFLHLDHLD
PKILAERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFYSEVVTKAGKNPDQVVPGLMAVGEAACVSVHGANR
LGSNSLIDLVVFGRSAALRAADVLTPGASQPELKDHMTDGHLARFDRFRHAAGEVPTAELRLEMQRAMQEDAAVFRTGES
LTSGVKRLQAVHDKRKHIRVTDRSMIWNSDLMETLEFDNLVGQAAVTVNGAANRTESRGAHAREDFPDRDDKKWMKHTLA
WFDDKTGKVKLDDRPVHNFTMSNDIAYIPPKARVY
>Mature_594_residues
AAYEFIDHKFDVVVVGAGGSGLRAALGCAQAGLKTACITKVFPTRSHTVAAQGGISASLGNMGEDDWRWHMYDTVKGSDW
LGDQDAIEYLCRNAPAAVYELEHWGVPFSRTADGKIYQRAFGGMTRNFGEAPIQRTCAAADRTGHAMLHTMYGQSLAHDT
EFFIEFFALDLIMDEGVCRGVTAWKLDDGTLHRFQAQMVILATGGYGRAYFSCTSAHTCTGDGGGMALRAGLPLQDMEFV
QFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTVKDLAPRDMVSRAMTIEIREGRGVGPNKDHIFLHLDHLDP
KILAERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFYSEVVTKAGKNPDQVVPGLMAVGEAACVSVHGANRL
GSNSLIDLVVFGRSAALRAADVLTPGASQPELKDHMTDGHLARFDRFRHAAGEVPTAELRLEMQRAMQEDAAVFRTGESL
TSGVKRLQAVHDKRKHIRVTDRSMIWNSDLMETLEFDNLVGQAAVTVNGAANRTESRGAHAREDFPDRDDKKWMKHTLAW
FDDKTGKVKLDDRPVHNFTMSNDIAYIPPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=613, Percent_Identity=61.1745513866232, Blast_Score=746, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=592, Percent_Identity=53.8851351351351, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=42.6343154246101, Blast_Score=414, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=30.2491103202847, Blast_Score=209, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=60.4234527687296, Blast_Score=746, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=612, Percent_Identity=58.6601307189542, Blast_Score=718, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=64.7058823529412, Blast_Score=790, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=63.3165829145729, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=25.4098360655738, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137288, Length=610, Percent_Identity=62.1311475409836, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=610, Percent_Identity=62.1311475409836, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=610, Percent_Identity=62.1311475409836, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=55.5555555555556, Blast_Score=692, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65142; Mature: 65010

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYEFIDHKFDVVVVGAGGSGLRAALGCAQAGLKTACITKVFPTRSHTVAAQGGISASL
CCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCEECC
GNMGEDDWRWHMYDTVKGSDWLGDQDAIEYLCRNAPAAVYELEHWGVPFSRTADGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCHHHHH
AFGGMTRNFGEAPIQRTCAAADRTGHAMLHTMYGQSLAHDTEFFIEFFALDLIMDEGVCR
HHCCHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVTAWKLDDGTLHRFQAQMVILATGGYGRAYFSCTSAHTCTGDGGGMALRAGLPLQDMEF
CCEEEEECCCHHEEEEEEEEEEEECCCCCEEEEECCCCEECCCCCCEEEECCCCCCCCCE
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTVKDLAPRDMVSRAMTIEIR
EEECCCCEEECCEEEECCCCCCCCEEECCHHHHHHHHHCCHHHHCCHHHHHCCEEEEEEE
EGRGVGPNKDHIFLHLDHLDPKILAERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGG
CCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCC
IPTNFYSEVVTKAGKNPDQVVPGLMAVGEAACVSVHGANRLGSNSLIDLVVFGRSAALRA
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHH
ADVLTPGASQPELKDHMTDGHLARFDRFRHAAGEVPTAELRLEMQRAMQEDAAVFRTGES
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHH
LTSGVKRLQAVHDKRKHIRVTDRSMIWNSDLMETLEFDNLVGQAAVTVNGAANRTESRGA
HHHHHHHHHHHHHHHHEEEEECCCEEECHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
HAREDFPDRDDKKWMKHTLAWFDDKTGKVKLDDRPVHNFTMSNDIAYIPPKARVY
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCEEECCCCCCCC
>Mature Secondary Structure 
AAYEFIDHKFDVVVVGAGGSGLRAALGCAQAGLKTACITKVFPTRSHTVAAQGGISASL
CCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCEECC
GNMGEDDWRWHMYDTVKGSDWLGDQDAIEYLCRNAPAAVYELEHWGVPFSRTADGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCHHHHH
AFGGMTRNFGEAPIQRTCAAADRTGHAMLHTMYGQSLAHDTEFFIEFFALDLIMDEGVCR
HHCCHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVTAWKLDDGTLHRFQAQMVILATGGYGRAYFSCTSAHTCTGDGGGMALRAGLPLQDMEF
CCEEEEECCCHHEEEEEEEEEEEECCCCCEEEEECCCCEECCCCCCEEEECCCCCCCCCE
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTVKDLAPRDMVSRAMTIEIR
EEECCCCEEECCEEEECCCCCCCCEEECCHHHHHHHHHCCHHHHCCHHHHHCCEEEEEEE
EGRGVGPNKDHIFLHLDHLDPKILAERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGG
CCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCC
IPTNFYSEVVTKAGKNPDQVVPGLMAVGEAACVSVHGANRLGSNSLIDLVVFGRSAALRA
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHH
ADVLTPGASQPELKDHMTDGHLARFDRFRHAAGEVPTAELRLEMQRAMQEDAAVFRTGES
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHH
LTSGVKRLQAVHDKRKHIRVTDRSMIWNSDLMETLEFDNLVGQAAVTVNGAANRTESRGA
HHHHHHHHHHHHHHHHEEEEECCCEEECHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
HAREDFPDRDDKKWMKHTLAWFDDKTGKVKLDDRPVHNFTMSNDIAYIPPKARVY
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA