Click here to switch to the map view.

The map label for this gene is glmU [H]

Identifier: 197103668

GI number: 197103668

Start: 199420

End: 200136

Strand: Reverse

Name: glmU [H]

Synonym: PHZ_c0202

Alternate gene names: 197103668

Gene position: 200136-199420 (Counterclockwise)

Preceding gene: 197103669

Following gene: 197103667

Centisome position: 5.01

GC content: 72.66

Gene sequence:

>717_bases
GTGAGCCAGGCGCCCACGACGGCGATGGTGCTGGCGGCGGGGCTCGGCACCCGCATGCGGCCGCTGACGGACACCACGCC
CAAGTGCCTGGTCCCGGTGGCGGGCCGGCCGCTGATCGACCACGTGCTGGACGAGTTGGTCGCCGCCGGCGTCACCCGCG
CCGTGGTCAACGTCCACCACTTCGCCGACCAGGTGGAGGCGCACCTGGCGCGCCGCACGGACCTCGAGATCCGCATCTCC
GACGAGCGGGCCGAGCTGCTGGATTCCGGCGGCGGCATCCAGCACGCCCGGCCGCTGCTGGGCGATGAGCCGATCTTCGT
CGCCAACATCGACTCGCTGTGGATCACCGAGGGCGAGCCGCCGCTGGAGACCCTGAAGCGGGTCTGGGACCCGGCGGCCA
TGGACATCCTCCTGCTGCTGGTCCGCCGCGGCCACGGCCTGGGCTTCGAGGGGCCCAACGGCTTCTTCATGGACGCGCAG
GGCCGACTGACCCATTCGGTCGCGCCCAAGCCGCCGACGCCCTACGCCAACACCGGCTTCGGCATCCTCAAGCCCCAGGT
CCTCGACGCCTCGCCCAGGACGGGCCCGTTCTCGATCCTGCCGGTCTGGCATGAGCTGCAGGCCGCAGGCCGGCTCCGCG
GCGTGGCCATGGACGCTTTCTGGATGCACGTGGGCGACCCCGCCGCGCGCGAGGCGGCGGAGCAGAGGCTGTCGTGA

Upstream 100 bases:

>100_bases
TGCCGCGCACCTGGCGCTACCTGGAGCGCAACCTGCAGGATCCCGAGCTCGCCGGCCTGAAGGCCTGGTTCGACCGCCAC
GTTCCGCCCGAGGCCCGCGC

Downstream 100 bases:

>100_bases
CCCGCTTCTTCGAGCGGCCGGGTCCTCGCTGGTTCAACATCCCGGCGCACCGGCCGTTCGCCGAAGACCTCGCCCGCGGG
CTCTACGAGGCCCTGGCCGA

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSQAPTTAMVLAAGLGTRMRPLTDTTPKCLVPVAGRPLIDHVLDELVAAGVTRAVVNVHHFADQVEAHLARRTDLEIRIS
DERAELLDSGGGIQHARPLLGDEPIFVANIDSLWITEGEPPLETLKRVWDPAAMDILLLLVRRGHGLGFEGPNGFFMDAQ
GRLTHSVAPKPPTPYANTGFGILKPQVLDASPRTGPFSILPVWHELQAAGRLRGVAMDAFWMHVGDPAAREAAEQRLS

Sequences:

>Translated_238_residues
MSQAPTTAMVLAAGLGTRMRPLTDTTPKCLVPVAGRPLIDHVLDELVAAGVTRAVVNVHHFADQVEAHLARRTDLEIRIS
DERAELLDSGGGIQHARPLLGDEPIFVANIDSLWITEGEPPLETLKRVWDPAAMDILLLLVRRGHGLGFEGPNGFFMDAQ
GRLTHSVAPKPPTPYANTGFGILKPQVLDASPRTGPFSILPVWHELQAAGRLRGVAMDAFWMHVGDPAAREAAEQRLS
>Mature_237_residues
SQAPTTAMVLAAGLGTRMRPLTDTTPKCLVPVAGRPLIDHVLDELVAAGVTRAVVNVHHFADQVEAHLARRTDLEIRISD
ERAELLDSGGGIQHARPLLGDEPIFVANIDSLWITEGEPPLETLKRVWDPAAMDILLLLVRRGHGLGFEGPNGFFMDAQG
RLTHSVAPKPPTPYANTGFGILKPQVLDASPRTGPFSILPVWHELQAAGRLRGVAMDAFWMHVGDPAAREAAEQRLS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=233, Percent_Identity=28.3261802575107, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI11761619, Length=233, Percent_Identity=28.3261802575107, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1787488, Length=123, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=233, Percent_Identity=29.6137339055794, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355443, Length=232, Percent_Identity=29.7413793103448, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644084, Length=232, Percent_Identity=29.7413793103448, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 25769; Mature: 25638

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAPTTAMVLAAGLGTRMRPLTDTTPKCLVPVAGRPLIDHVLDELVAAGVTRAVVNVHH
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
FADQVEAHLARRTDLEIRISDERAELLDSGGGIQHARPLLGDEPIFVANIDSLWITEGEP
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCEEEEECCCC
PLETLKRVWDPAAMDILLLLVRRGHGLGFEGPNGFFMDAQGRLTHSVAPKPPTPYANTGF
HHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCC
GILKPQVLDASPRTGPFSILPVWHELQAAGRLRGVAMDAFWMHVGDPAAREAAEQRLS
CCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHEEHHHHHEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQAPTTAMVLAAGLGTRMRPLTDTTPKCLVPVAGRPLIDHVLDELVAAGVTRAVVNVHH
CCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
FADQVEAHLARRTDLEIRISDERAELLDSGGGIQHARPLLGDEPIFVANIDSLWITEGEP
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCEEEEECCCC
PLETLKRVWDPAAMDILLLLVRRGHGLGFEGPNGFFMDAQGRLTHSVAPKPPTPYANTGF
HHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCC
GILKPQVLDASPRTGPFSILPVWHELQAAGRLRGVAMDAFWMHVGDPAAREAAEQRLS
CCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHEEHHHHHEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA