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The map label for this gene is trxA [H]

Identifier: 197103665

GI number: 197103665

Start: 192563

End: 192892

Strand: Reverse

Name: trxA [H]

Synonym: PHZ_c0199

Alternate gene names: 197103665

Gene position: 192892-192563 (Counterclockwise)

Preceding gene: 197103666

Following gene: 197103659

Centisome position: 4.83

GC content: 66.67

Gene sequence:

>330_bases
ATGAGCACCGTGAAGGTCACCGACGAATCCTTCGAGACCGACGTCCTGCAGGCCGAGCGCCCTGTGCTCGTCGACTTCTG
GGCGGAGTGGTGCGGCCCCTGCAAGCAGATCGCCCCGGCCCTCGAGCAGCTCTCGGACGAACTCGCCGACAAGGTGACCA
TCGCCAAGCTGAACATCGAGGAGAGCCCGACGACGCCCTCGCGCTACGGCGTGCGCGGCATCCCGACGATGATGCTGTTC
AAGGGCGGCCAGATGGCCTCGATGAAGGTGGGCGCCATGCCCAAGCAGAAGATCCTGGAGTGGCTCACCGAGGCCGGCGT
CGCCGCCTGA

Upstream 100 bases:

>100_bases
CGCCGTTCTGGTTGATACCGCCCTAACACCCGCCTACATGGGCGGATCAGACAGGCGCCGGCCCGCGTTCCATCCGGCCG
TGCGCGAAAGGAGCTTTCCT

Downstream 100 bases:

>100_bases
GGCGGCCGCCGAAGCGCGTTACTCCACAGGGCCGCCTTCGGGCGGCCCTTCTTCTTTCGGCCCTGGCCGTTCCGCCCTCT
TCGGGGGCCGCCGCAGCACG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSTVKVTDESFETDVLQAERPVLVDFWAEWCGPCKQIAPALEQLSDELADKVTIAKLNIEESPTTPSRYGVRGIPTMMLF
KGGQMASMKVGAMPKQKILEWLTEAGVAA

Sequences:

>Translated_109_residues
MSTVKVTDESFETDVLQAERPVLVDFWAEWCGPCKQIAPALEQLSDELADKVTIAKLNIEESPTTPSRYGVRGIPTMMLF
KGGQMASMKVGAMPKQKILEWLTEAGVAA
>Mature_108_residues
STVKVTDESFETDVLQAERPVLVDFWAEWCGPCKQIAPALEQLSDELADKVTIAKLNIEESPTTPSRYGVRGIPTMMLFK
GGQMASMKVGAMPKQKILEWLTEAGVAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=103, Percent_Identity=33.0097087378641, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=109, Percent_Identity=33.0275229357798, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=56.5656565656566, Blast_Score=135, Evalue=6e-34,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=42.156862745098, Blast_Score=99, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=41.8918918918919, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=43.0555555555556, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=40.5405405405405, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=89, Percent_Identity=40.4494382022472, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=37.3333333333333, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=31.25, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=85, Percent_Identity=35.2941176470588, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=34.5238095238095, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=37.2340425531915, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=95, Percent_Identity=36.8421052631579, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573567, Length=99, Percent_Identity=34.3434343434343, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=35.2272727272727, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=35.2272727272727, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921434, Length=109, Percent_Identity=30.2752293577982, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358065, Length=97, Percent_Identity=32.9896907216495, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11959; Mature: 11828

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVKVTDESFETDVLQAERPVLVDFWAEWCGPCKQIAPALEQLSDELADKVTIAKLNIE
CCCEECCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEECC
ESPTTPSRYGVRGIPTMMLFKGGQMASMKVGAMPKQKILEWLTEAGVAA
CCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STVKVTDESFETDVLQAERPVLVDFWAEWCGPCKQIAPALEQLSDELADKVTIAKLNIE
CCEECCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEECC
ESPTTPSRYGVRGIPTMMLFKGGQMASMKVGAMPKQKILEWLTEAGVAA
CCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]