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The map label for this gene is hlyU [H]

Identifier: 197103530

GI number: 197103530

Start: 58759

End: 59109

Strand: Reverse

Name: hlyU [H]

Synonym: PHZ_c0064

Alternate gene names: 197103530

Gene position: 59109-58759 (Counterclockwise)

Preceding gene: 197103531

Following gene: 197103527

Centisome position: 1.48

GC content: 74.07

Gene sequence:

>351_bases
ATGACCAAAGTCCCCGCCGCCGTCGCCCGGGAGCTGCCCAAGCCCGCCGAGCTCGAGGAGCTGGAGCGGCACGCCTCGGC
CGCCGCGCGGCTGATGAAGCTGATGGCCAACGAGCAGCGGCTGATCCTGATGTGCCGCCTGGGCGAGGGCGAGTGCTCGG
TGGGCGACCTGGCCGCCCACGTGGGCCTGGCCCAGTCCGCCGCCTCGCAGCACCTGGCCAAGCTGCGGGCCGAGGGCGTG
GTCGCCACCCGCCGGGACGGCCAGACGATCTACTACCGCCTCGAGGACCCCGCCGCGGCCCGGGTGATCGACACCCTCTG
CGAGATCTACCGCGGCAAGCCGGCCGGCTAG

Upstream 100 bases:

>100_bases
CTGGTGATCCCGGCGATCTACGTGGTGCTGCGCGACGACGGCCGCCCGGCGAGCGGACCGACCCCTGGCGCGCAACATTA
GGGATCCCTAAAATAAGGCC

Downstream 100 bases:

>100_bases
ACCTTCCGCCGGCGCACGTCGCGCAGGATCTCGGCGGCGGCGTTGTGGCCCGGCGCGCCGGTGACCCCGCCGCCCGGGTG
GGTTCCCGAACCGCACTGGT

Product: transcriptional regulator, ArsR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MTKVPAAVARELPKPAELEELERHASAAARLMKLMANEQRLILMCRLGEGECSVGDLAAHVGLAQSAASQHLAKLRAEGV
VATRRDGQTIYYRLEDPAAARVIDTLCEIYRGKPAG

Sequences:

>Translated_116_residues
MTKVPAAVARELPKPAELEELERHASAAARLMKLMANEQRLILMCRLGEGECSVGDLAAHVGLAQSAASQHLAKLRAEGV
VATRRDGQTIYYRLEDPAAARVIDTLCEIYRGKPAG
>Mature_115_residues
TKVPAAVARELPKPAELEELERHASAAARLMKLMANEQRLILMCRLGEGECSVGDLAAHVGLAQSAASQHLAKLRAEGVV
ATRRDGQTIYYRLEDPAAARVIDTLCEIYRGKPAG

Specific function: Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=95, Percent_Identity=41.0526315789474, Blast_Score=73, Evalue=5e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 12538; Mature: 12406

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVPAAVARELPKPAELEELERHASAAARLMKLMANEQRLILMCRLGEGECSVGDLAAH
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHH
VGLAQSAASQHLAKLRAEGVVATRRDGQTIYYRLEDPAAARVIDTLCEIYRGKPAG
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKVPAAVARELPKPAELEELERHASAAARLMKLMANEQRLILMCRLGEGECSVGDLAAH
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHH
VGLAQSAASQHLAKLRAEGVVATRRDGQTIYYRLEDPAAARVIDTLCEIYRGKPAG
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]