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The map label for this gene is hisE [H]

Identifier: 197103510

GI number: 197103510

Start: 36784

End: 37113

Strand: Direct

Name: hisE [H]

Synonym: PHZ_c0044

Alternate gene names: 197103510

Gene position: 36784-37113 (Clockwise)

Preceding gene: 197103509

Following gene: 197103513

Centisome position: 0.92

GC content: 74.55

Gene sequence:

>330_bases
ATGCCGCACCAGCGCTTCGCCGAGGTGATCGGCCGCCTCGCCGCCACGATCGAGAGCCGCCGGGGCGGGGACGCCTCGGC
CTCGTATACGGCCCAGCTGCTCTGCGACCTCGACCGCGCGGCCAAGAAGCTGGGCGAGGAGGCGGTGGAGGCGGTGATCG
CCGCCGCCCAAGGCGACCGCGAGGGGCTCACCGCCGAGAGCGCCGACCTGATCTACCACTGGCTGGTGGTGCTGGCGGCG
GCGGGGGTGAGCCTGGACGACGTCGCCGCGCGCCTGGAGGCCCGCGAAGGGACGTCGGGGCTCGCCGAGAAGGCCTCGCG
CAAGGTCTAG

Upstream 100 bases:

>100_bases
CGGCCTCGATCTTCCACTTCGGCGAGGTGTCCATCGGCGAGGTCAAGGCCGCCATGGCCGCCGAGGGCATTCCCGTCCGC
CTGACCGAGAGGGCCGCCTG

Downstream 100 bases:

>100_bases
CTGCTCGCAGCATCGGGACGCGAAGGAGCGCCAGCCGCAGGTGCTGCGGCTGGCGCCGAGTTCGCGCTCGGCCCTTCGCT
GACGTCTAGCGGGGCTCGGG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MPHQRFAEVIGRLAATIESRRGGDASASYTAQLLCDLDRAAKKLGEEAVEAVIAAAQGDREGLTAESADLIYHWLVVLAA
AGVSLDDVAARLEAREGTSGLAEKASRKV

Sequences:

>Translated_109_residues
MPHQRFAEVIGRLAATIESRRGGDASASYTAQLLCDLDRAAKKLGEEAVEAVIAAAQGDREGLTAESADLIYHWLVVLAA
AGVSLDDVAARLEAREGTSGLAEKASRKV
>Mature_108_residues
PHQRFAEVIGRLAATIESRRGGDASASYTAQLLCDLDRAAKKLGEEAVEAVIAAAQGDREGLTAESADLIYHWLVVLAAA
GVSLDDVAARLEAREGTSGLAEKASRKV

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=39.7727272727273, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 11449; Mature: 11318

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHQRFAEVIGRLAATIESRRGGDASASYTAQLLCDLDRAAKKLGEEAVEAVIAAAQGDR
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EGLTAESADLIYHWLVVLAAAGVSLDDVAARLEAREGTSGLAEKASRKV
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
PHQRFAEVIGRLAATIESRRGGDASASYTAQLLCDLDRAAKKLGEEAVEAVIAAAQGDR
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EGLTAESADLIYHWLVVLAAAGVSLDDVAARLEAREGTSGLAEKASRKV
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA