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The map label for this gene is hisA [H]

Identifier: 197103508

GI number: 197103508

Start: 35286

End: 36017

Strand: Direct

Name: hisA [H]

Synonym: PHZ_c0042

Alternate gene names: 197103508

Gene position: 35286-36017 (Clockwise)

Preceding gene: 197103507

Following gene: 197103509

Centisome position: 0.88

GC content: 71.58

Gene sequence:

>732_bases
GTGGCGCCCTTGATCCTCTATCCCGCCATCGACCTGAAGGACGGACAGTGCGTCCGGGTGCTTCACGGCGATCTTTCCAC
GGCCACGGTGTTCAACACCGACCCCGGCGCCCAGGCGAGGAGCTTCGCCGAGGCCGGCTTCCACTGGGTGCACGTGGTCG
ACCTGAACGGGGCGGTGGAGGGCCACGCGGTGAACGCCGCCGCGGTCGAGGCCATCCTCTCGTCGGTGTCGATCCCGGTG
CAGCTGGGCGGCGGCATCCGCACGCTGGCCGACATCGAGCGTTGGATCGAGGCCGGTGTCAGCCGGGTCATCCTGGGCAC
CGTCGCGGTGAAGGAGCCCGAGGTGGTGATCGAAGCCGCGCGGCTCTTCCCCGAGCAGATCGCCGTCAGCGTCGACGTGC
GCGCCGGCAAGGTGGCGGTGCAGGGCTGGACGGCCGACAGCGATCTGGATGCGATCACCGTGGCCAGGCGGTTCGAGGAC
GCCGGCGTCGGCGCCCTGATCGTCACCGACATCGACCGCGACGGCACCGTCATGGGCTTCAACGTCGAGGCCTTCGGCGC
CATGGCGGACGCGGTGAGCATCCCCGTGATCGCGGCCGGCGGCCTCGCCTCGGTGGACGACCTCGTGCGGCTGAAGGCCC
GCAAGGGCGCGCCGATCGCCGGCGCGGTGCTGGGCCGGGCGCTCTACAACGGCGCCATCGACCCGGCCGAGGCGCTGAAG
GTGGCCGCCTGA

Upstream 100 bases:

>100_bases
GCTTCCCGGCGGCCGTCGCGCGCGGCAACATGGCCGGCGTCCAGTTCCACCCGGAGAAGTCGCAAGGCGCCGGCCTCTCC
CTCCTCGCCGATTTCCTGGA

Downstream 100 bases:

>100_bases
TGCTGAACGTGCGCGTCATCCCCTGCCTGGACGTGAAGGACGGGCGCGTGGTGAAGGGCGTGCAGTTCGTCTCGCTGCGG
GACGCGGGCGATCCGGTCGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MAPLILYPAIDLKDGQCVRVLHGDLSTATVFNTDPGAQARSFAEAGFHWVHVVDLNGAVEGHAVNAAAVEAILSSVSIPV
QLGGGIRTLADIERWIEAGVSRVILGTVAVKEPEVVIEAARLFPEQIAVSVDVRAGKVAVQGWTADSDLDAITVARRFED
AGVGALIVTDIDRDGTVMGFNVEAFGAMADAVSIPVIAAGGLASVDDLVRLKARKGAPIAGAVLGRALYNGAIDPAEALK
VAA

Sequences:

>Translated_243_residues
MAPLILYPAIDLKDGQCVRVLHGDLSTATVFNTDPGAQARSFAEAGFHWVHVVDLNGAVEGHAVNAAAVEAILSSVSIPV
QLGGGIRTLADIERWIEAGVSRVILGTVAVKEPEVVIEAARLFPEQIAVSVDVRAGKVAVQGWTADSDLDAITVARRFED
AGVGALIVTDIDRDGTVMGFNVEAFGAMADAVSIPVIAAGGLASVDDLVRLKARKGAPIAGAVLGRALYNGAIDPAEALK
VAA
>Mature_242_residues
APLILYPAIDLKDGQCVRVLHGDLSTATVFNTDPGAQARSFAEAGFHWVHVVDLNGAVEGHAVNAAAVEAILSSVSIPVQ
LGGGIRTLADIERWIEAGVSRVILGTVAVKEPEVVIEAARLFPEQIAVSVDVRAGKVAVQGWTADSDLDAITVARRFEDA
GVGALIVTDIDRDGTVMGFNVEAFGAMADAVSIPVIAAGGLASVDDLVRLKARKGAPIAGAVLGRALYNGAIDPAEALKV
AA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=31.404958677686, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788336, Length=241, Percent_Identity=22.4066390041494, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25036; Mature: 24905

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLILYPAIDLKDGQCVRVLHGDLSTATVFNTDPGAQARSFAEAGFHWVHVVDLNGAVE
CCCEEEEECEECCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCC
GHAVNAAAVEAILSSVSIPVQLGGGIRTLADIERWIEAGVSRVILGTVAVKEPEVVIEAA
CCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCHHHEEEEEEEECCCHHHHHHH
RLFPEQIAVSVDVRAGKVAVQGWTADSDLDAITVARRFEDAGVGALIVTDIDRDGTVMGF
HHCHHHEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
NVEAFGAMADAVSIPVIAAGGLASVDDLVRLKARKGAPIAGAVLGRALYNGAIDPAEALK
EHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHE
VAA
ECC
>Mature Secondary Structure 
APLILYPAIDLKDGQCVRVLHGDLSTATVFNTDPGAQARSFAEAGFHWVHVVDLNGAVE
CCEEEEECEECCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCC
GHAVNAAAVEAILSSVSIPVQLGGGIRTLADIERWIEAGVSRVILGTVAVKEPEVVIEAA
CCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCHHHEEEEEEEECCCHHHHHHH
RLFPEQIAVSVDVRAGKVAVQGWTADSDLDAITVARRFEDAGVGALIVTDIDRDGTVMGF
HHCHHHEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
NVEAFGAMADAVSIPVIAAGGLASVDDLVRLKARKGAPIAGAVLGRALYNGAIDPAEALK
EHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHE
VAA
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]