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The map label for this gene is hisB

Identifier: 197103506

GI number: 197103506

Start: 34062

End: 34652

Strand: Direct

Name: hisB

Synonym: PHZ_c0040

Alternate gene names: 197103506

Gene position: 34062-34652 (Clockwise)

Preceding gene: 197103505

Following gene: 197103507

Centisome position: 0.85

GC content: 67.01

Gene sequence:

>591_bases
ATGAGCCGCACGGCCGAAGTCCGCCGCGACACCAAGGAGACCCAGATCCGGGTTTGGGTGGATCTGGACGGGACCGGCGC
GTCCGAAGTCTCGACGGGCGTCGGCTTCTTCGACCACATGCTGGACAGCTTCGCCCGCCACGGCGGCTTCGACCTGAAGG
TCGAGACGAAGGGCGACCTGCACATCGACATGCACCACACCGTCGAGGACACCGGCATCGTCCTCGGCCAGGCGATCAAG
GAGTCCCTGGACGGGTTCAAGGGGATCCGCCGGTTCGGCCACGCCTACATCCCGATGGACGAGACCCTGTCGCGCTGCGC
CATCGACCTGTCGAACCGGCCCTACCTGATCTGGAAGACGGACTTCCGCACGCCCAAGGTCGGCGACATGGACACCGAGC
TCTTCAAGGAGTTCCACCACGCCTTCGCGATGAACGCGGGCGCGTGCGTGCACCTGGAGTGCCTCTACGGGACCAACTCG
CACCACATCGCCGAGAGCGGGTTCAAGGCGCTGGCCCGGGCCCTGCGGCAGGCGGTCGAGCTCGATCCCAAGACCCACGG
CCACGCCCCCTCCACCAAGGGCGTCCTCTAG

Upstream 100 bases:

>100_bases
GGCCGCGGCCGAGGTGATCTCGCACTACGGCCCCCGGCCGCAGGTCTCGCTGCAGGACCTGGCGGCGTCCCGGGGCTACT
AGGACGCAGGGATACTGACG

Downstream 100 bases:

>100_bases
GATCATCGCGATGCAGAGGGTGGCCCTGATCGACTACGGGTCGGGCAACCTGCGCTCGGCCGAAAAGGCCCTCGTCCGCG
CCGCGGACGGGCGGGCGGAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSRTAEVRRDTKETQIRVWVDLDGTGASEVSTGVGFFDHMLDSFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIK
ESLDGFKGIRRFGHAYIPMDETLSRCAIDLSNRPYLIWKTDFRTPKVGDMDTELFKEFHHAFAMNAGACVHLECLYGTNS
HHIAESGFKALARALRQAVELDPKTHGHAPSTKGVL

Sequences:

>Translated_196_residues
MSRTAEVRRDTKETQIRVWVDLDGTGASEVSTGVGFFDHMLDSFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIK
ESLDGFKGIRRFGHAYIPMDETLSRCAIDLSNRPYLIWKTDFRTPKVGDMDTELFKEFHHAFAMNAGACVHLECLYGTNS
HHIAESGFKALARALRQAVELDPKTHGHAPSTKGVL
>Mature_195_residues
SRTAEVRRDTKETQIRVWVDLDGTGASEVSTGVGFFDHMLDSFARHGGFDLKVETKGDLHIDMHHTVEDTGIVLGQAIKE
SLDGFKGIRRFGHAYIPMDETLSRCAIDLSNRPYLIWKTDFRTPKVGDMDTELFKEFHHAFAMNAGACVHLECLYGTNSH
HIAESGFKALARALRQAVELDPKTHGHAPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=52.0618556701031, Blast_Score=193, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=42.6605504587156, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PHEZH (B4RBJ4)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002128883.1
- ProteinModelPortal:   B4RBJ4
- GeneID:   6789527
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0040
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21836; Mature: 21705

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTAEVRRDTKETQIRVWVDLDGTGASEVSTGVGFFDHMLDSFARHGGFDLKVETKGDL
CCCCHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
HIDMHHTVEDTGIVLGQAIKESLDGFKGIRRFGHAYIPMDETLSRCAIDLSNRPYLIWKT
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCEEEEEC
DFRTPKVGDMDTELFKEFHHAFAMNAGACVHLECLYGTNSHHIAESGFKALARALRQAVE
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LDPKTHGHAPSTKGVL
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRTAEVRRDTKETQIRVWVDLDGTGASEVSTGVGFFDHMLDSFARHGGFDLKVETKGDL
CCCHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
HIDMHHTVEDTGIVLGQAIKESLDGFKGIRRFGHAYIPMDETLSRCAIDLSNRPYLIWKT
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCEEEEEC
DFRTPKVGDMDTELFKEFHHAFAMNAGACVHLECLYGTNSHHIAESGFKALARALRQAVE
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LDPKTHGHAPSTKGVL
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA