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The map label for this gene is moeB [H]

Identifier: 197103498

GI number: 197103498

Start: 27434

End: 28183

Strand: Reverse

Name: moeB [H]

Synonym: PHZ_c0032

Alternate gene names: 197103498

Gene position: 28183-27434 (Counterclockwise)

Preceding gene: 197103503

Following gene: 197103496

Centisome position: 0.71

GC content: 72.8

Gene sequence:

>750_bases
GTGACGTTCACCGACGACGAGATCGAGCGCTACGCCCGGCACCTGGTCCTGCGCGAACTGGGCGGGCCGGGGCAGCAGAA
GCTGAAGGCCGCCAGCGTGCTGATCGTGGGCGCGGGCGGCCTCGGCGCGCCGGCCTCGCTGTACCTGGCCGCCGCCGGCG
TCGGGACGATCATCCTGGCCGATCCCGACGAGGTGGACCGCTCGAACCTGCAGCGGCAGGTGATCTTCGCCGAGGACGAC
CTCGGCCGGCCCAAGGTGGACGCCGCCGCCGACCGGCTGCACGCGCTCAACCCCCACGTCTTCGTCGCCGGCTTCAACGG
CGCCTTCGAGGCCGCCACGGCCGACGAGCTGGTGGAGGGCGTGGACCTGGTGCTCGACGGCACCGACGATTTCGGGGTCC
GATTCTGCGTCAACGAGGCCTGCGTACGGCACGGCAAGACCCTGGTGTCGGGAGCGATCGGCCGCTGGACGGGGCAGGTG
GGGGTGTTCGGCCGCCAGCCCTGCTACCGCTGCCTCGTCCCCGAGATCCCTCCCGACGCCGAGACCTGCGTCGCCGTGGG
CGTCGTGGGCGCCCTGCCGGGCGTCATCGGCTCGATGATGGCCATGGAGGCGATCAAGCTGATCACCGGCGCCGGCGAGC
CGCTGGCCGGCCGCCTCCTGATCTACGACGCCCTGGCCGCCGAGACGCGGACCGTGAAGGTGGCGGGCGATCCCGGCTGT
CCGGTGTGCGGGGGCCCTCCCTCTCCTTGA

Upstream 100 bases:

>100_bases
TTGCGCACCGCGAGGATGGTGGTGCCGTGCCAGTCGGGGAAGGTTGAGGTATTCGACATCGGCGCGATGAAGGGCGGGGC
AGGCCACAAGGTCAAGTGAC

Downstream 100 bases:

>100_bases
TGGGGAGGGGGCCGCCTAGAGCATCTGCGGCAGGACGCGGTCGGGCGGGCGGTGGCCGTCCATCCAGGTCTTGATGTTGA
TGATCACCTTCTCGCCCATG

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTFTDDEIERYARHLVLRELGGPGQQKLKAASVLIVGAGGLGAPASLYLAAAGVGTIILADPDEVDRSNLQRQVIFAEDD
LGRPKVDAAADRLHALNPHVFVAGFNGAFEAATADELVEGVDLVLDGTDDFGVRFCVNEACVRHGKTLVSGAIGRWTGQV
GVFGRQPCYRCLVPEIPPDAETCVAVGVVGALPGVIGSMMAMEAIKLITGAGEPLAGRLLIYDALAAETRTVKVAGDPGC
PVCGGPPSP

Sequences:

>Translated_249_residues
MTFTDDEIERYARHLVLRELGGPGQQKLKAASVLIVGAGGLGAPASLYLAAAGVGTIILADPDEVDRSNLQRQVIFAEDD
LGRPKVDAAADRLHALNPHVFVAGFNGAFEAATADELVEGVDLVLDGTDDFGVRFCVNEACVRHGKTLVSGAIGRWTGQV
GVFGRQPCYRCLVPEIPPDAETCVAVGVVGALPGVIGSMMAMEAIKLITGAGEPLAGRLLIYDALAAETRTVKVAGDPGC
PVCGGPPSP
>Mature_248_residues
TFTDDEIERYARHLVLRELGGPGQQKLKAASVLIVGAGGLGAPASLYLAAAGVGTIILADPDEVDRSNLQRQVIFAEDDL
GRPKVDAAADRLHALNPHVFVAGFNGAFEAATADELVEGVDLVLDGTDDFGVRFCVNEACVRHGKTLVSGAIGRWTGQVG
VFGRQPCYRCLVPEIPPDAETCVAVGVVGALPGVIGSMMAMEAIKLITGAGEPLAGRLLIYDALAAETRTVKVAGDPGCP
VCGGPPSP

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=252, Percent_Identity=43.6507936507937, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI13376212, Length=254, Percent_Identity=28.3464566929134, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI38045948, Length=154, Percent_Identity=33.1168831168831, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI38327032, Length=238, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI23510338, Length=145, Percent_Identity=30.3448275862069, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI23510340, Length=145, Percent_Identity=30.3448275862069, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=46.1224489795918, Blast_Score=211, Evalue=3e-56,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=41.0569105691057, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17540406, Length=246, Percent_Identity=41.4634146341463, Blast_Score=193, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=28.476821192053, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=249, Percent_Identity=38.1526104417671, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320598, Length=168, Percent_Identity=25.5952380952381, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322639, Length=142, Percent_Identity=30.2816901408451, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582879, Length=251, Percent_Identity=44.6215139442231, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24660640, Length=150, Percent_Identity=29.3333333333333, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25772; Mature: 25641

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTDDEIERYARHLVLRELGGPGQQKLKAASVLIVGAGGLGAPASLYLAAAGVGTIILA
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCHHHHEEECCCCEEEEE
DPDEVDRSNLQRQVIFAEDDLGRPKVDAAADRLHALNPHVFVAGFNGAFEAATADELVEG
CCCCCCHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCC
VDLVLDGTDDFGVRFCVNEACVRHGKTLVSGAIGRWTGQVGVFGRQPCYRCLVPEIPPDA
CEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCHHHCCCCCCCCCCCCHHHHCCCCCCCCH
ETCVAVGVVGALPGVIGSMMAMEAIKLITGAGEPLAGRLLIYDALAAETRTVKVAGDPGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCEEEEEECCCCC
PVCGGPPSP
CCCCCCCCC
>Mature Secondary Structure 
TFTDDEIERYARHLVLRELGGPGQQKLKAASVLIVGAGGLGAPASLYLAAAGVGTIILA
CCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCHHHHEEECCCCEEEEE
DPDEVDRSNLQRQVIFAEDDLGRPKVDAAADRLHALNPHVFVAGFNGAFEAATADELVEG
CCCCCCHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCC
VDLVLDGTDDFGVRFCVNEACVRHGKTLVSGAIGRWTGQVGVFGRQPCYRCLVPEIPPDA
CEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCHHHCCCCCCCCCCCCHHHHCCCCCCCCH
ETCVAVGVVGALPGVIGSMMAMEAIKLITGAGEPLAGRLLIYDALAAETRTVKVAGDPGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCEEEEEECCCCC
PVCGGPPSP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]