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The map label for this gene is gyaR [H]

Identifier: 197103497

GI number: 197103497

Start: 26435

End: 27418

Strand: Direct

Name: gyaR [H]

Synonym: PHZ_c0031

Alternate gene names: 197103497

Gene position: 26435-27418 (Clockwise)

Preceding gene: 197103491

Following gene: 197103499

Centisome position: 0.66

GC content: 69.21

Gene sequence:

>984_bases
ATGCCTCGCAAGCCAAAAGTCATCGTGACGCGCAAACTGCCAGACTCCGTGGAGACGCGGATGCGGGAGCTGTTCGACAC
CGAGCTGAATGTGACCGACGCGCCGATGAGCCGCGAGGCGCTGATCGACGCAGTCGGCCGCTGCGACGTGCTGGCGCCGA
CCATCACGGACGAGATCGACGCGGCCCTGCTGGAGAAGGCGGGCGAGCGGCTGAAGCTGATCGCCAACTTCGGGGCGGGG
GTCGATCACATCGACGTGGCCGCGGCGACCGAGCGCGGGATCACCGTCACCAACACCCCCGGCGTGCTCACCGAGGACAC
GGCCGACCTGACCATGGCCCTGATGATGGCGGTGGCGCGACGCATCGTGGAGGGGGCGAACGTCGTCCAGGCGGGCGGCT
TCCAGGGCTGGGCCCCCACCTGGATGCTGGGCCGCCGGGTGACCGGCAAGCGGCTGGGGATCATTGGCCTGGGCCGCATC
GGCTCGGCCGTCGCCCGCCGGGCCAAGGCCTTCGGCCTGCAGATCCACTACCACAACCGCAAGCGCGTCAGCCCCCGCAT
CGAGGAGGAGCTGGAGGCCACCTACTGGGACAGCCTGGACCAGATGCTGGCCCGGATGGACATCATCAGCGTGCACTCGC
CGCACACGCCGGCCACCTACCACCTGCTGTCGGCCCGCCGGCTGAAGCTGCTGCAGCCGCACGCGATCATCATCAACACC
GCCCGCGGCGAGATCATCGACGAGGACGCCCTGGCCGAGCTGCTGCGCGACGGCAAGGTCGCCGGCGCGGGCCTCGACGT
TTTCGAGTTCGAGCCGCAGGTGAACCCCAAGCTGCTGAACCTGCCCAACGCGGTGCTGCTGCCGCACCTGGGTTCGGCGA
CGGTCGAGGCCCGCGTCGACATGGGCGAGAAGGTGATCATCAACATCAAGACCTGGATGGACGGCCACCGCCCGCCCGAC
CGCGTCCTGCCGCAGATGCTCTAG

Upstream 100 bases:

>100_bases
GGTGACCCCTTTGGTAAGGGTCTCGTCTGATCGATCCGCCTGCGCCGGCCGCGGCGCAGGGCATGCCCCCTTTTCAAGTC
GCACCCCGCTTTTTGCAAGA

Downstream 100 bases:

>100_bases
GCGGCCCCCTCCCCATCAAGGAGAGGGAGGGCCCCCGCACACCGGACAGCCGGGATCGCCCGCCACCTTCACGGTCCGCG
TCTCGGCGGCCAGGGCGTCG

Product: D-isomer specific 2-hydroxyacid dehydrogenases family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPRKPKVIVTRKLPDSVETRMRELFDTELNVTDAPMSREALIDAVGRCDVLAPTITDEIDAALLEKAGERLKLIANFGAG
VDHIDVAAATERGITVTNTPGVLTEDTADLTMALMMAVARRIVEGANVVQAGGFQGWAPTWMLGRRVTGKRLGIIGLGRI
GSAVARRAKAFGLQIHYHNRKRVSPRIEEELEATYWDSLDQMLARMDIISVHSPHTPATYHLLSARRLKLLQPHAIIINT
ARGEIIDEDALAELLRDGKVAGAGLDVFEFEPQVNPKLLNLPNAVLLPHLGSATVEARVDMGEKVIINIKTWMDGHRPPD
RVLPQML

Sequences:

>Translated_327_residues
MPRKPKVIVTRKLPDSVETRMRELFDTELNVTDAPMSREALIDAVGRCDVLAPTITDEIDAALLEKAGERLKLIANFGAG
VDHIDVAAATERGITVTNTPGVLTEDTADLTMALMMAVARRIVEGANVVQAGGFQGWAPTWMLGRRVTGKRLGIIGLGRI
GSAVARRAKAFGLQIHYHNRKRVSPRIEEELEATYWDSLDQMLARMDIISVHSPHTPATYHLLSARRLKLLQPHAIIINT
ARGEIIDEDALAELLRDGKVAGAGLDVFEFEPQVNPKLLNLPNAVLLPHLGSATVEARVDMGEKVIINIKTWMDGHRPPD
RVLPQML
>Mature_326_residues
PRKPKVIVTRKLPDSVETRMRELFDTELNVTDAPMSREALIDAVGRCDVLAPTITDEIDAALLEKAGERLKLIANFGAGV
DHIDVAAATERGITVTNTPGVLTEDTADLTMALMMAVARRIVEGANVVQAGGFQGWAPTWMLGRRVTGKRLGIIGLGRIG
SAVARRAKAFGLQIHYHNRKRVSPRIEEELEATYWDSLDQMLARMDIISVHSPHTPATYHLLSARRLKLLQPHAIIINTA
RGEIIDEDALAELLRDGKVAGAGLDVFEFEPQVNPKLLNLPNAVLLPHLGSATVEARVDMGEKVIINIKTWMDGHRPPDR
VLPQML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=320, Percent_Identity=35.625, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI23308577, Length=308, Percent_Identity=33.1168831168831, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=33.7164750957854, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=33.7164750957854, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=33.0739299610895, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=33.0739299610895, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=33.0739299610895, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=38.0368098159509, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=31.1284046692607, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787645, Length=335, Percent_Identity=27.1641791044776, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788660, Length=315, Percent_Identity=24.7619047619048, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=291, Percent_Identity=28.5223367697594, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=36.0153256704981, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=263, Percent_Identity=32.6996197718631, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=302, Percent_Identity=34.7682119205298, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=29.1525423728814, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=259, Percent_Identity=30.1158301158301, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321253, Length=178, Percent_Identity=33.7078651685393, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=215, Percent_Identity=28.3720930232558, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=181, Percent_Identity=30.3867403314917, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571528, Length=323, Percent_Identity=39.0092879256966, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI45552429, Length=277, Percent_Identity=35.0180505415162, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45551003, Length=276, Percent_Identity=35.1449275362319, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI28574284, Length=276, Percent_Identity=35.1449275362319, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24585514, Length=276, Percent_Identity=35.1449275362319, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI28574282, Length=276, Percent_Identity=35.1449275362319, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=33.5640138408304, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24585516, Length=283, Percent_Identity=29.6819787985866, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=35.4330708661417, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=35.4330708661417, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=35.4330708661417, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=35.4330708661417, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=35.4330708661417, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI19921140, Length=251, Percent_Identity=36.6533864541833, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35934; Mature: 35803

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKPKVIVTRKLPDSVETRMRELFDTELNVTDAPMSREALIDAVGRCDVLAPTITDEID
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEECCCHHHHHH
AALLEKAGERLKLIANFGAGVDHIDVAAATERGITVTNTPGVLTEDTADLTMALMMAVAR
HHHHHHCCHHEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
RIVEGANVVQAGGFQGWAPTWMLGRRVTGKRLGIIGLGRIGSAVARRAKAFGLQIHYHNR
HHHCCCCEEECCCCCCCCCHHHHCCCCCCCEECEEEECHHHHHHHHHHHHHEEEEEECCC
KRVSPRIEEELEATYWDSLDQMLARMDIISVHSPHTPATYHLLSARRLKLLQPHAIIINT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEC
ARGEIIDEDALAELLRDGKVAGAGLDVFEFEPQVNPKLLNLPNAVLLPHLGSATVEARVD
CCCCEECHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEECCCCCEECCCCCCCEEEEEEC
MGEKVIINIKTWMDGHRPPDRVLPQML
CCCEEEEEEEECCCCCCCHHHHHHCCC
>Mature Secondary Structure 
PRKPKVIVTRKLPDSVETRMRELFDTELNVTDAPMSREALIDAVGRCDVLAPTITDEID
CCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEECCCHHHHHH
AALLEKAGERLKLIANFGAGVDHIDVAAATERGITVTNTPGVLTEDTADLTMALMMAVAR
HHHHHHCCHHEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
RIVEGANVVQAGGFQGWAPTWMLGRRVTGKRLGIIGLGRIGSAVARRAKAFGLQIHYHNR
HHHCCCCEEECCCCCCCCCHHHHCCCCCCCEECEEEECHHHHHHHHHHHHHEEEEEECCC
KRVSPRIEEELEATYWDSLDQMLARMDIISVHSPHTPATYHLLSARRLKLLQPHAIIINT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEC
ARGEIIDEDALAELLRDGKVAGAGLDVFEFEPQVNPKLLNLPNAVLLPHLGSATVEARVD
CCCCEECHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEECCCCCEECCCCCCCEEEEEEC
MGEKVIINIKTWMDGHRPPDRVLPQML
CCCEEEEEEEECCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA