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The map label for this gene is mltA [H]

Identifier: 197103474

GI number: 197103474

Start: 5457

End: 6113

Strand: Direct

Name: mltA [H]

Synonym: PHZ_c0008

Alternate gene names: 197103474

Gene position: 5457-6113 (Clockwise)

Preceding gene: 197103473

Following gene: 197103475

Centisome position: 0.14

GC content: 75.65

Gene sequence:

>657_bases
GTGCGGCCGAAGCCCGCCGACCTGGTGAACGGCGCCCCCTACGCCGACCGCGCCGCCATCGAGGCGCGTCCGGCCGACGA
CGCCATCGCCTGGATGCGGCCCGAGGAGCTGTTCTTCCTGCAGGTGCAGGGCTCGGGCGTGCTGACCTTCGAGGACGGCC
GGCGGATGAAGGCGCTCTACGCCGCCAACAACGGCCAGCCCTTCGTCGGCATCGCCAATCCCATGCGCGACCGAGGCCTG
CTGGCGCGGGACGCCACCTCGGGCGAGGCGATCCGCCTGTGGCTGGCGGCCAACCGGGGCCCGGCCGCCGACGAGATCAT
GCGGCTCAATCCGCGCTACGCCTTCTTCCGCCTCGCCCCGGGCGACGGCCGCCCGCCCGCCGGCGCGGCGAACGTGCCCC
TGCCCGCCGGCCGGGCCATCGCGGTGGACCCGGCGCACCACGCCTACGGCGGCTTCTACTGGATCGACGCCGAGGCGCCG
CTGCTGAAGGGCGCCTTCCCGACCTACCGCCGCCTTGTCGCCGCCCTGGACACCGGCGGGGCGATCAAGGGGCCGGTGCG
GGCCGACCTCTACCTCGGCGAAGGCGGCGCGGCCGGAGCCGAGGCGGGGCGGGTGCGCCACACCCTGCGCATGTTCCGCC
TGGTCCCCTACCGGTGA

Upstream 100 bases:

>100_bases
GCCGAGCCGCTGCCGGGCGAGGGGGTGCTCACCGCCTATTTCCTATTTCGCTCCCGTCTACGAAGCGCGCCGCCGGCCCG
ACGCCGAGTTCAGCGCCCCC

Downstream 100 bases:

>100_bases
AACGGCCGCTGAAGCCCGAGGAGCTGCGGATCTGGTCGCTGGTGGCCGCGACCGTCCACCCGCTCCCGGGGAGGGCGACG
CCGAAGCAGCCCGCCCCCCA

Product: transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRPKPADLVNGAPYADRAAIEARPADDAIAWMRPEELFFLQVQGSGVLTFEDGRRMKALYAANNGQPFVGIANPMRDRGL
LARDATSGEAIRLWLAANRGPAADEIMRLNPRYAFFRLAPGDGRPPAGAANVPLPAGRAIAVDPAHHAYGGFYWIDAEAP
LLKGAFPTYRRLVAALDTGGAIKGPVRADLYLGEGGAAGAEAGRVRHTLRMFRLVPYR

Sequences:

>Translated_218_residues
MRPKPADLVNGAPYADRAAIEARPADDAIAWMRPEELFFLQVQGSGVLTFEDGRRMKALYAANNGQPFVGIANPMRDRGL
LARDATSGEAIRLWLAANRGPAADEIMRLNPRYAFFRLAPGDGRPPAGAANVPLPAGRAIAVDPAHHAYGGFYWIDAEAP
LLKGAFPTYRRLVAALDTGGAIKGPVRADLYLGEGGAAGAEAGRVRHTLRMFRLVPYR
>Mature_218_residues
MRPKPADLVNGAPYADRAAIEARPADDAIAWMRPEELFFLQVQGSGVLTFEDGRRMKALYAANNGQPFVGIANPMRDRGL
LARDATSGEAIRLWLAANRGPAADEIMRLNPRYAFFRLAPGDGRPPAGAANVPLPAGRAIAVDPAHHAYGGFYWIDAEAP
LLKGAFPTYRRLVAALDTGGAIKGPVRADLYLGEGGAAGAEAGRVRHTLRMFRLVPYR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=182, Percent_Identity=36.8131868131868, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 23476; Mature: 23476

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPKPADLVNGAPYADRAAIEARPADDAIAWMRPEELFFLQVQGSGVLTFEDGRRMKALY
CCCCCCCCCCCCCCCCCCEEECCCCCCCEEEECCCEEEEEEECCCEEEEECCCCEEEEEE
AANNGQPFVGIANPMRDRGLLARDATSGEAIRLWLAANRGPAADEIMRLNPRYAFFRLAP
EECCCCEEEEECCCCCCCCEEEECCCCCCEEEEEEEECCCCCHHHHEECCCCEEEEEECC
GDGRPPAGAANVPLPAGRAIAVDPAHHAYGGFYWIDAEAPLLKGAFPTYRRLVAALDTGG
CCCCCCCCCCCCCCCCCCEEEECCCHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCC
AIKGPVRADLYLGEGGAAGAEAGRVRHTLRMFRLVPYR
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPKPADLVNGAPYADRAAIEARPADDAIAWMRPEELFFLQVQGSGVLTFEDGRRMKALY
CCCCCCCCCCCCCCCCCCEEECCCCCCCEEEECCCEEEEEEECCCEEEEECCCCEEEEEE
AANNGQPFVGIANPMRDRGLLARDATSGEAIRLWLAANRGPAADEIMRLNPRYAFFRLAP
EECCCCEEEEECCCCCCCCEEEECCCCCCEEEEEEEECCCCCHHHHEECCCCEEEEEECC
GDGRPPAGAANVPLPAGRAIAVDPAHHAYGGFYWIDAEAPLLKGAFPTYRRLVAALDTGG
CCCCCCCCCCCCCCCCCCEEEECCCHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCC
AIKGPVRADLYLGEGGAAGAEAGRVRHTLRMFRLVPYR
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]