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The map label for this gene is galM [H]

Identifier: 195978840

GI number: 195978840

Start: 1801288

End: 1802331

Strand: Direct

Name: galM [H]

Synonym: Sez_1744

Alternate gene names: 195978840

Gene position: 1801288-1802331 (Clockwise)

Preceding gene: 195978839

Following gene: 195978843

Centisome position: 88.99

GC content: 43.97

Gene sequence:

>1044_bases
GTGAACATTTATCAAGACATCATTGAATACATCGATCAAGTACCAGTCACCCAGCTAAGACTGATTAATGCTAACGGTGT
TGAGGCTCACCTGCTGACACTAGGAGCGACCCTACAGGCCTTTCTAGTGCCAAATGAAAAGCAGCCAAAAAATATCATTT
TGGGACATAACCGACCAAGTGACTATCTAAAAAACCCCCTTTGTGCAGGGCAAACCATTGGCCGAGTAGCAGGTCGTATA
AAGAGAGGAAGCTTTCAGCTAGAGCAGCAAAGGGTTTGTGTTGACACCAATGAAAATGGGCATTGCCTGCATGGAGGCTT
CAAGGGCTTTCATAAGCTTCATTGGCCTTATGATACCCGTCAAACAGCTGATTACCTTGAAGTAACCTTTAAAAAGGATA
TTTTAGAAGCAGATGACCATTTCCCAGGTGATCTGACCGTAAGCATTACCTACCGTCTAGACAACCATAATCGCTTAAGC
ATTCACTTTAAGGCTCATAGCATGAGAGGCACTAGCCTATTCAATCCAACTAACCATGTTTATTTTAATTTAGGTCAAAC
ACAAGACCTAACCAATCACAACCTACACATCGCAGCATCACATAGGATTGAAACAGATAATGAGCTAATCCCAACAGGTC
AAAAGCTAGCAGTTGACCAGACGGTCTATGATTTTAGATCAATAAAGCCCCTCTATCCTGCTATTGTCGAAAATAATGGC
TTTGATACCGCCTTTGAAATTGATCAGCAGGCTATTGGAACAACCCAACCCATTGCTGTCTTACAAGACAGCGTCAGCCA
TGACCAAATCAGCATCTACTCTGACCGAAACGCACTCGTCATTTATACCATGGACAGTATCCAAGATGGCTTGTATTTTG
GAAGAGATCAGGGCAAGGAGGGACTGGCTCGTGAGGGGATCGCTATGGAAGCGCAAACCCTGCCTGATGCTATCCACCAC
AACCAATTTGGTGACATTATCCTCAAAGAAGGAGACACCAAAAGCTACACTATCTGCCTGGCCTATGAACATCTACCAGA
CTAG

Upstream 100 bases:

>100_bases
GACGATAAAACAAGTGGCAGCTAGTCCCTCAAGGCAGCTACCACAGCAAGTACTCAGCCTCTCTTAATTCATACACCTAT
ACTAATAGGAGAAATAAACT

Downstream 100 bases:

>100_bases
ATAAGTAGCAGCCAAGCTTTAATAAAGTAACAAGACCTTGATTTTTTTGAATTGCACCCCAACCGTTAGCCAAAAACTCT
AACAAGCTGGGGTCAGTTCA

Product: aldose 1-epimerase GalM

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNIYQDIIEYIDQVPVTQLRLINANGVEAHLLTLGATLQAFLVPNEKQPKNIILGHNRPSDYLKNPLCAGQTIGRVAGRI
KRGSFQLEQQRVCVDTNENGHCLHGGFKGFHKLHWPYDTRQTADYLEVTFKKDILEADDHFPGDLTVSITYRLDNHNRLS
IHFKAHSMRGTSLFNPTNHVYFNLGQTQDLTNHNLHIAASHRIETDNELIPTGQKLAVDQTVYDFRSIKPLYPAIVENNG
FDTAFEIDQQAIGTTQPIAVLQDSVSHDQISIYSDRNALVIYTMDSIQDGLYFGRDQGKEGLAREGIAMEAQTLPDAIHH
NQFGDIILKEGDTKSYTICLAYEHLPD

Sequences:

>Translated_347_residues
MNIYQDIIEYIDQVPVTQLRLINANGVEAHLLTLGATLQAFLVPNEKQPKNIILGHNRPSDYLKNPLCAGQTIGRVAGRI
KRGSFQLEQQRVCVDTNENGHCLHGGFKGFHKLHWPYDTRQTADYLEVTFKKDILEADDHFPGDLTVSITYRLDNHNRLS
IHFKAHSMRGTSLFNPTNHVYFNLGQTQDLTNHNLHIAASHRIETDNELIPTGQKLAVDQTVYDFRSIKPLYPAIVENNG
FDTAFEIDQQAIGTTQPIAVLQDSVSHDQISIYSDRNALVIYTMDSIQDGLYFGRDQGKEGLAREGIAMEAQTLPDAIHH
NQFGDIILKEGDTKSYTICLAYEHLPD
>Mature_347_residues
MNIYQDIIEYIDQVPVTQLRLINANGVEAHLLTLGATLQAFLVPNEKQPKNIILGHNRPSDYLKNPLCAGQTIGRVAGRI
KRGSFQLEQQRVCVDTNENGHCLHGGFKGFHKLHWPYDTRQTADYLEVTFKKDILEADDHFPGDLTVSITYRLDNHNRLS
IHFKAHSMRGTSLFNPTNHVYFNLGQTQDLTNHNLHIAASHRIETDNELIPTGQKLAVDQTVYDFRSIKPLYPAIVENNG
FDTAFEIDQQAIGTTQPIAVLQDSVSHDQISIYSDRNALVIYTMDSIQDGLYFGRDQGKEGLAREGIAMEAQTLPDAIHH
NQFGDIILKEGDTKSYTICLAYEHLPD

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=317, Percent_Identity=27.7602523659306, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=30.4733727810651, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17557428, Length=337, Percent_Identity=27.5964391691395, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI115533334, Length=337, Percent_Identity=27.5964391691395, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319493, Length=363, Percent_Identity=27.8236914600551, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=329, Percent_Identity=27.0516717325228, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324399, Length=332, Percent_Identity=25.9036144578313, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583720, Length=352, Percent_Identity=31.5340909090909, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24668278, Length=335, Percent_Identity=28.0597014925373, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24659048, Length=351, Percent_Identity=29.6296296296296, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24668282, Length=348, Percent_Identity=28.1609195402299, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24641876, Length=338, Percent_Identity=26.3313609467456, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39149; Mature: 39149

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYQDIIEYIDQVPVTQLRLINANGVEAHLLTLGATLQAFLVPNEKQPKNIILGHNRPS
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCEEEEECCCCH
DYLKNPLCAGQTIGRVAGRIKRGSFQLEQQRVCVDTNENGHCLHGGFKGFHKLHWPYDTR
HHHCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEECCCCCCEEECCCCCCC
QTADYLEVTFKKDILEADDHFPGDLTVSITYRLDNHNRLSIHFKAHSMRGTSLFNPTNHV
CCCHHHHEEEHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCEECCCCCEE
YFNLGQTQDLTNHNLHIAASHRIETDNELIPTGQKLAVDQTVYDFRSIKPLYPAIVENNG
EEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCHHEECCCC
FDTAFEIDQQAIGTTQPIAVLQDSVSHDQISIYSDRNALVIYTMDSIQDGLYFGRDQGKE
CCCEEECCHHHCCCCCCHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCEECCCCCCC
GLAREGIAMEAQTLPDAIHHNQFGDIILKEGDTKSYTICLAYEHLPD
CHHHCCCEEEHHHCCHHHHCCCCCCEEEECCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MNIYQDIIEYIDQVPVTQLRLINANGVEAHLLTLGATLQAFLVPNEKQPKNIILGHNRPS
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCEEEEECCCCH
DYLKNPLCAGQTIGRVAGRIKRGSFQLEQQRVCVDTNENGHCLHGGFKGFHKLHWPYDTR
HHHCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEECCCCCCEEECCCCCCC
QTADYLEVTFKKDILEADDHFPGDLTVSITYRLDNHNRLSIHFKAHSMRGTSLFNPTNHV
CCCHHHHEEEHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCEECCCCCEE
YFNLGQTQDLTNHNLHIAASHRIETDNELIPTGQKLAVDQTVYDFRSIKPLYPAIVENNG
EEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCHHEECCCC
FDTAFEIDQQAIGTTQPIAVLQDSVSHDQISIYSDRNALVIYTMDSIQDGLYFGRDQGKE
CCCEEECCHHHCCCCCCHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCEECCCCCCC
GLAREGIAMEAQTLPDAIHHNQFGDIILKEGDTKSYTICLAYEHLPD
CHHHCCCEEEHHHCCHHHHCCCCCCEEEECCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1694527 [H]