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The map label for this gene is ponA [H]

Identifier: 195978673

GI number: 195978673

Start: 1618525

End: 1620615

Strand: Direct

Name: ponA [H]

Synonym: Sez_1571

Alternate gene names: 195978673

Gene position: 1618525-1620615 (Clockwise)

Preceding gene: 195978672

Following gene: 195978683

Centisome position: 79.96

GC content: 45.58

Gene sequence:

>2091_bases
GTGACAATTACCTTAGGTGGCCTTTTGTTTGCTTACTATATCAGCAGTGCCCCTAAGCTTTCTGAGGCCCAGCTCAAATC
GACCAATTCCAGCCTTGTTTATGACGGTAATAATCATTTGATTGCTGACTTGGGCTCTGAAAAGCGTGAAAATGTTACAG
CAGACAGCATTCCTATCAATCTGGTCAATGCTATCATTTCTATAGAAGACAAGCGCTTTTTTAATCATCGAGGTGTTGAT
CTCTATCGTATCTTAGGTGCAGCCTTTCACAATTTAACAAGCAAAACAACCCAAGGGGGGTCTACACTTGATCAGCAGCT
GATTAAGCTAGCCTACTTCTCGACAAACGAGTCTGACCAGACCTTGAAGCGAAAAGCTCAGGAGGTTTGGCTGGCCCTTC
AAATGGAGCGAAAATATACCAAGCAAGAAATCCTGACCTTCTACATCAACAAGGTTTATATGGGAAATGGTAATTATGGT
ATGCTGACAGCAGCCAAGGCCTATTATGGCAAGGATTTGAAAGACTTGTCCTATGCTCAGCTAGCCTTGCTGGCAGGGAT
TCCACAGGCGCCAAGCCAATATGACCCCTACACACAGCCTGAGACAGCTCAAAGCCGCCGAAATATTGTCCTTCAGCAAA
TGTATGCTGAAAAGAACATTACCAAGGCTGAGTACGAGGCAGCTATCGCCACACCTATATCAGAAGGCCTACAGCCTCTC
CAGCAACGCGCCAGCTATCCAAAATACATGGATAATTACTTAAAGCAAGTGATCGAGCAGGTAAAGGCTGAGACCAACAA
GGATATTTTTACCTCTGGTCTAAAGGTTTACACAAACATCATTCCAGAGGCCCAAAAAAGACTTTATGACATCTACAATT
CTGAGGACTATGTGTATTACCCTGATGCTGACTTTCAGGTGGCCTCAACCGTTATTGATGTCACTAATGGACACGTTATC
GCCCAATTAGGAGGACGCAATCAGGATACCAACGTTTCCTTTGGAACCAATCAGGCTGTCTTAACCGATCGTGACTGGGG
ATCCACCATGAAGCCGATCACAGACTATGGACCTGCTATTGAATCTGGTGCTTACAACTCTACAGCTCAAACAACTAACG
ACTCTGTCTACTATTGGCCAGGGACACACACTCAGCTCTATAACTGGGACCGTAGATACTATGGCTGGATGACCATTCAA
GCTGCTCTCATGCAATCACGAAACGTCCCTGCAGTTAGGGCTCTAGAGGCGGCAGGACTTAGCTATGCACAATCCTTCCT
CAGTGATCTGGGCATTAACTATCCAGAGATGCATTATTCAAATGCCATCTCAAGTAACAATAGCAGCTCTGATTCAAAAT
ACGGTGCAAGCAGTGAAAAAATGGCTGCTGCCTATGCGGCTTTTGCCAACGGTGGACTCTATTATAAGCCACAATACGTC
AACAAAATTGAATTCAGCGACGGCACCAGCAAGGTTATCGAAAACAAGGGCAAGCGTGCCATGAAGGAAACAACAGCCTA
TATGATGACTGATATGCTAAAAACGGTACTAACCTACGGTACAGGTACTGCTGCGGCTATCCCAGGAGTTGCACAGGCTG
GTAAAACTGGTACCTCAAACTATACCGATGAGGAGCTGGCACAAATTGTTGAGACACATGGACTATCCCCTGATTATGTG
GGAACAATGGCTCCAGATGAAAACTTTGTTGGCTACACCAACCGATACGCTATGGCAGTTTGGACCGGTTATAAAAACCG
TATGACGCCAATTTATGGCTACAGCCTAGAAATTGCTTCTCATGTTTATCGCAATATGATCAGCTATCTCACTGGTGGCT
ACAGCGAGGATTGGACCATGCCAAGCGGGCTCTATCGCAGCGGCGGCTTCCTCTACCTAAGTGGTACCTATACAAACAGC
AGTGATTATACAAGCTCTGTCTACAACAACCTCTACGGTAATAACAGCTCATCTTCAAGCCAATCCTCAGACGAGGATAC
AACTGAAGACAGCCACACAGAAGCAAACGACAGCACAACGTCATCATCAGAGCAGCATTCAAGCTCCACCGATGATAAGA
AAACCAACTGA

Upstream 100 bases:

>100_bases
ATTATAGAACAAAAATTTTTAGGCGGTGATTACAATTAACAATCCAAAAATCCTTAAATTCCTGAAGTATACATTAGGTG
CTATCCTTAGCCTTATCATT

Downstream 100 bases:

>100_bases
CAACAAAACCCTGGCTCAAGTGTTCTGAACCAGGGTTTTTAATTATTGGCTCTATCATTTCTGTAGTGGGTAACTCCACC
TCGGAGATTATAGGGCTTTT

Product: multimodular transpeptidase-transglycosylase; penicillin-binding protein 1A PonA

Products: NA

Alternate protein names: PBP-1A [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTITLGGLLFAYYISSAPKLSEAQLKSTNSSLVYDGNNHLIADLGSEKRENVTADSIPINLVNAIISIEDKRFFNHRGVD
LYRILGAAFHNLTSKTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQMERKYTKQEILTFYINKVYMGNGNYG
MLTAAKAYYGKDLKDLSYAQLALLAGIPQAPSQYDPYTQPETAQSRRNIVLQQMYAEKNITKAEYEAAIATPISEGLQPL
QQRASYPKYMDNYLKQVIEQVKAETNKDIFTSGLKVYTNIIPEAQKRLYDIYNSEDYVYYPDADFQVASTVIDVTNGHVI
AQLGGRNQDTNVSFGTNQAVLTDRDWGSTMKPITDYGPAIESGAYNSTAQTTNDSVYYWPGTHTQLYNWDRRYYGWMTIQ
AALMQSRNVPAVRALEAAGLSYAQSFLSDLGINYPEMHYSNAISSNNSSSDSKYGASSEKMAAAYAAFANGGLYYKPQYV
NKIEFSDGTSKVIENKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSNYTDEELAQIVETHGLSPDYV
GTMAPDENFVGYTNRYAMAVWTGYKNRMTPIYGYSLEIASHVYRNMISYLTGGYSEDWTMPSGLYRSGGFLYLSGTYTNS
SDYTSSVYNNLYGNNSSSSSQSSDEDTTEDSHTEANDSTTSSSEQHSSSTDDKKTN

Sequences:

>Translated_696_residues
MTITLGGLLFAYYISSAPKLSEAQLKSTNSSLVYDGNNHLIADLGSEKRENVTADSIPINLVNAIISIEDKRFFNHRGVD
LYRILGAAFHNLTSKTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQMERKYTKQEILTFYINKVYMGNGNYG
MLTAAKAYYGKDLKDLSYAQLALLAGIPQAPSQYDPYTQPETAQSRRNIVLQQMYAEKNITKAEYEAAIATPISEGLQPL
QQRASYPKYMDNYLKQVIEQVKAETNKDIFTSGLKVYTNIIPEAQKRLYDIYNSEDYVYYPDADFQVASTVIDVTNGHVI
AQLGGRNQDTNVSFGTNQAVLTDRDWGSTMKPITDYGPAIESGAYNSTAQTTNDSVYYWPGTHTQLYNWDRRYYGWMTIQ
AALMQSRNVPAVRALEAAGLSYAQSFLSDLGINYPEMHYSNAISSNNSSSDSKYGASSEKMAAAYAAFANGGLYYKPQYV
NKIEFSDGTSKVIENKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSNYTDEELAQIVETHGLSPDYV
GTMAPDENFVGYTNRYAMAVWTGYKNRMTPIYGYSLEIASHVYRNMISYLTGGYSEDWTMPSGLYRSGGFLYLSGTYTNS
SDYTSSVYNNLYGNNSSSSSQSSDEDTTEDSHTEANDSTTSSSEQHSSSTDDKKTN
>Mature_695_residues
TITLGGLLFAYYISSAPKLSEAQLKSTNSSLVYDGNNHLIADLGSEKRENVTADSIPINLVNAIISIEDKRFFNHRGVDL
YRILGAAFHNLTSKTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQMERKYTKQEILTFYINKVYMGNGNYGM
LTAAKAYYGKDLKDLSYAQLALLAGIPQAPSQYDPYTQPETAQSRRNIVLQQMYAEKNITKAEYEAAIATPISEGLQPLQ
QRASYPKYMDNYLKQVIEQVKAETNKDIFTSGLKVYTNIIPEAQKRLYDIYNSEDYVYYPDADFQVASTVIDVTNGHVIA
QLGGRNQDTNVSFGTNQAVLTDRDWGSTMKPITDYGPAIESGAYNSTAQTTNDSVYYWPGTHTQLYNWDRRYYGWMTIQA
ALMQSRNVPAVRALEAAGLSYAQSFLSDLGINYPEMHYSNAISSNNSSSDSKYGASSEKMAAAYAAFANGGLYYKPQYVN
KIEFSDGTSKVIENKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSNYTDEELAQIVETHGLSPDYVG
TMAPDENFVGYTNRYAMAVWTGYKNRMTPIYGYSLEIASHVYRNMISYLTGGYSEDWTMPSGLYRSGGFLYLSGTYTNSS
DYTSSVYNNLYGNNSSSSSQSSDEDTTEDSHTEANDSTTSSSEQHSSSTDDKKTN

Specific function: Cell wall formation [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=612, Percent_Identity=28.5947712418301, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI87082258, Length=377, Percent_Identity=30.5039787798408, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786343, Length=525, Percent_Identity=30.2857142857143, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789601, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 77282; Mature: 77151

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITLGGLLFAYYISSAPKLSEAQLKSTNSSLVYDGNNHLIADLGSEKRENVTADSIPIN
CEEEHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCEEEEECCCCHHCCCCCCCCHHH
LVNAIISIEDKRFFNHRGVDLYRILGAAFHNLTSKTTQGGSTLDQQLIKLAYFSTNESDQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHH
TLKRKAQEVWLALQMERKYTKQEILTFYINKVYMGNGNYGMLTAAKAYYGKDLKDLSYAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEHHHHHCCCHHHHHHHH
LALLAGIPQAPSQYDPYTQPETAQSRRNIVLQQMYAEKNITKAEYEAAIATPISEGLQPL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHH
QQRASYPKYMDNYLKQVIEQVKAETNKDIFTSGLKVYTNIIPEAQKRLYDIYNSEDYVYY
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
PDADFQVASTVIDVTNGHVIAQLGGRNQDTNVSFGTNQAVLTDRDWGSTMKPITDYGPAI
CCCCCEEHHHEEECCCCEEEEEECCCCCCCCEECCCCCEEEEECCCCCCCCCHHHCCCCC
ESGAYNSTAQTTNDSVYYWPGTHTQLYNWDRRYYGWMTIQAALMQSRNVPAVRALEAAGL
CCCCCCCCCCCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SYAQSFLSDLGINYPEMHYSNAISSNNSSSDSKYGASSEKMAAAYAAFANGGLYYKPQYV
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCHHC
NKIEFSDGTSKVIENKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSN
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCCCCCC
YTDEELAQIVETHGLSPDYVGTMAPDENFVGYTNRYAMAVWTGYKNRMTPIYGYSLEIAS
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHH
HVYRNMISYLTGGYSEDWTMPSGLYRSGGFLYLSGTYTNSSDYTSSVYNNLYGNNSSSSS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
QSSDEDTTEDSHTEANDSTTSSSEQHSSSTDDKKTN
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC
>Mature Secondary Structure 
TITLGGLLFAYYISSAPKLSEAQLKSTNSSLVYDGNNHLIADLGSEKRENVTADSIPIN
EEEHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCEEEEECCCCHHCCCCCCCCHHH
LVNAIISIEDKRFFNHRGVDLYRILGAAFHNLTSKTTQGGSTLDQQLIKLAYFSTNESDQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHH
TLKRKAQEVWLALQMERKYTKQEILTFYINKVYMGNGNYGMLTAAKAYYGKDLKDLSYAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEHHHHHCCCHHHHHHHH
LALLAGIPQAPSQYDPYTQPETAQSRRNIVLQQMYAEKNITKAEYEAAIATPISEGLQPL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHH
QQRASYPKYMDNYLKQVIEQVKAETNKDIFTSGLKVYTNIIPEAQKRLYDIYNSEDYVYY
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
PDADFQVASTVIDVTNGHVIAQLGGRNQDTNVSFGTNQAVLTDRDWGSTMKPITDYGPAI
CCCCCEEHHHEEECCCCEEEEEECCCCCCCCEECCCCCEEEEECCCCCCCCCHHHCCCCC
ESGAYNSTAQTTNDSVYYWPGTHTQLYNWDRRYYGWMTIQAALMQSRNVPAVRALEAAGL
CCCCCCCCCCCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SYAQSFLSDLGINYPEMHYSNAISSNNSSSDSKYGASSEKMAAAYAAFANGGLYYKPQYV
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCHHC
NKIEFSDGTSKVIENKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSN
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCCCCCC
YTDEELAQIVETHGLSPDYVGTMAPDENFVGYTNRYAMAVWTGYKNRMTPIYGYSLEIAS
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHH
HVYRNMISYLTGGYSEDWTMPSGLYRSGGFLYLSGTYTNSSDYTSSVYNNLYGNNSSSSS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
QSSDEDTTEDSHTEANDSTTSSSEQHSSSTDDKKTN
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396576; 11463916 [H]