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The map label for this gene is cysK [H]

Identifier: 195978651

GI number: 195978651

Start: 1597222

End: 1598148

Strand: Direct

Name: cysK [H]

Synonym: Sez_1549

Alternate gene names: 195978651

Gene position: 1597222-1598148 (Clockwise)

Preceding gene: 195978650

Following gene: 195978652

Centisome position: 78.91

GC content: 45.95

Gene sequence:

>927_bases
ATGTCAAAGTTATATCACAACATTACAGAGTTGGTTGGTAAAACCCCTATCATTAAATTGAGAAATACCAGTCCAGAGGA
GGCTGCCGATATTTATGTCAAGCTAGAGGCTTTTAATCCAGGCTCCTCAGTCAAGGACCGCATCGCACTTGCAATGATTG
AAGCTGCTGAGAAAGCAGACATGATCAAGCCAGGTGATACAATCGTTGAGCCAACCAGTGGCAATACAGGGATTGGCTTA
TCCTGGGTTGGGGCTGCAAAAGGCTACCGAGTGCTTATTGTAATGCCTGAGACAATGAGTATTGAAAGACGTCAAATCAT
TCAGGCTTATGGAGCAGAGCTTGTTTTAACCCCGGGTAGTGATGGGATGAAAGGTGCGATTGCTAAAGCAGAAGAGATTG
CCAGAGAGACCGGTGCTTGGATGCCCTCGCAATTTGACAATCCTGCCAATCCCAAGGTTCATGAAGAGACAACAGGGCAA
GAAATTATCGCGGTTTTTGGAGAAAAAGGACTTGATGCCTTTGTTTCTGGTGTGGGAACTGGTGGCACTATTTCTGGCGT
TGCGCATGCCTTAAAGGCTGTTAATCCTGATATTTCTATCTATGCTGTGGAAGCAGATGAATCTGCCGTCTTATCTGGTG
AAGAGTCTTCTCCGCACAAGATTCAAGGGATTTCAGCTGGCTTTATCCCAAATACCTTAGATACAAAGGCCTATGACCAC
ATCATTCGAGTAGCGTCAGAGGCTGCCCTTGCCACTGCTCGGTCAATCGGGGCTAAGGAGGGCTTTCTTGTAGGCATTTC
TTCTGGAGCCGCTGTTTATGCTGCTATTGAAGCCGCTAAGGAGCTTGGAAAAGGTAAAAAGGTCTTAGCTATATTACCAG
ATAATGGTGAGCGGTACCTGTCTACTGCCCTTTATCAGTTTGATTAG

Upstream 100 bases:

>100_bases
TTTATCACTATGATAGTAAATGGCTATTTTACTTTGTCGATTATTGGCTATATACTTTTATATAAGCATGTATTGATACA
AGGATAAAAAAGGAGGACCT

Downstream 100 bases:

>100_bases
AATAATCATATAAGCACCAGCCCTAGCAGCTAGAATAAGCTTTCAAGCATAAATCATCGCTCTTACTTAGTCACCATTAA
AGGCCAGTCAGCTAGCATAT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSKLYHNITELVGKTPIIKLRNTSPEEAADIYVKLEAFNPGSSVKDRIALAMIEAAEKADMIKPGDTIVEPTSGNTGIGL
SWVGAAKGYRVLIVMPETMSIERRQIIQAYGAELVLTPGSDGMKGAIAKAEEIARETGAWMPSQFDNPANPKVHEETTGQ
EIIAVFGEKGLDAFVSGVGTGGTISGVAHALKAVNPDISIYAVEADESAVLSGEESSPHKIQGISAGFIPNTLDTKAYDH
IIRVASEAALATARSIGAKEGFLVGISSGAAVYAAIEAAKELGKGKKVLAILPDNGERYLSTALYQFD

Sequences:

>Translated_308_residues
MSKLYHNITELVGKTPIIKLRNTSPEEAADIYVKLEAFNPGSSVKDRIALAMIEAAEKADMIKPGDTIVEPTSGNTGIGL
SWVGAAKGYRVLIVMPETMSIERRQIIQAYGAELVLTPGSDGMKGAIAKAEEIARETGAWMPSQFDNPANPKVHEETTGQ
EIIAVFGEKGLDAFVSGVGTGGTISGVAHALKAVNPDISIYAVEADESAVLSGEESSPHKIQGISAGFIPNTLDTKAYDH
IIRVASEAALATARSIGAKEGFLVGISSGAAVYAAIEAAKELGKGKKVLAILPDNGERYLSTALYQFD
>Mature_307_residues
SKLYHNITELVGKTPIIKLRNTSPEEAADIYVKLEAFNPGSSVKDRIALAMIEAAEKADMIKPGDTIVEPTSGNTGIGLS
WVGAAKGYRVLIVMPETMSIERRQIIQAYGAELVLTPGSDGMKGAIAKAEEIARETGAWMPSQFDNPANPKVHEETTGQE
IIAVFGEKGLDAFVSGVGTGGTISGVAHALKAVNPDISIYAVEADESAVLSGEESSPHKIQGISAGFIPNTLDTKAYDHI
IRVASEAALATARSIGAKEGFLVGISSGAAVYAAIEAAKELGKGKKVLAILPDNGERYLSTALYQFD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=39.297124600639, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=39.297124600639, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=39.297124600639, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI11345492, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=49.0506329113924, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=38.9261744966443, Blast_Score=214, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=48, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=49.3421052631579, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=46.4882943143813, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=46.5986394557823, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=44.9180327868852, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=37.6582278481013, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=44.6009389671362, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=36.0128617363344, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=43.9655172413793, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=24.0853658536585, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=38.9937106918239, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.1288343558282, Blast_Score=125, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24643623, Length=306, Percent_Identity=37.9084967320261, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI20129101, Length=306, Percent_Identity=37.9084967320261, Blast_Score=188, Evalue=4e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32387; Mature: 32256

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLYHNITELVGKTPIIKLRNTSPEEAADIYVKLEAFNPGSSVKDRIALAMIEAAEKAD
CCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
MIKPGDTIVEPTSGNTGIGLSWVGAAKGYRVLIVMPETMSIERRQIIQAYGAELVLTPGS
CCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
DGMKGAIAKAEEIARETGAWMPSQFDNPANPKVHEETTGQEIIAVFGEKGLDAFVSGVGT
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHCCCC
GGTISGVAHALKAVNPDISIYAVEADESAVLSGEESSPHKIQGISAGFIPNTLDTKAYDH
CCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCEEECEECCCCCCCCCHHHHHH
IIRVASEAALATARSIGAKEGFLVGISSGAAVYAAIEAAKELGKGKKVLAILPDNGERYL
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
STALYQFD
HHHHEECC
>Mature Secondary Structure 
SKLYHNITELVGKTPIIKLRNTSPEEAADIYVKLEAFNPGSSVKDRIALAMIEAAEKAD
CHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
MIKPGDTIVEPTSGNTGIGLSWVGAAKGYRVLIVMPETMSIERRQIIQAYGAELVLTPGS
CCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
DGMKGAIAKAEEIARETGAWMPSQFDNPANPKVHEETTGQEIIAVFGEKGLDAFVSGVGT
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHCCCC
GGTISGVAHALKAVNPDISIYAVEADESAVLSGEESSPHKIQGISAGFIPNTLDTKAYDH
CCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCEEECEECCCCCCCCCHHHHHH
IIRVASEAALATARSIGAKEGFLVGISSGAAVYAAIEAAKELGKGKKVLAILPDNGERYL
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
STALYQFD
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA