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The map label for this gene is gor [H]

Identifier: 195977995

GI number: 195977995

Start: 909217

End: 910569

Strand: Direct

Name: gor [H]

Synonym: Sez_0867

Alternate gene names: 195977995

Gene position: 909217-910569 (Clockwise)

Preceding gene: 195977994

Following gene: 195977997

Centisome position: 44.92

GC content: 46.42

Gene sequence:

>1353_bases
ATGGCAATTCAGTATGATTATATTGTGATTGGTGGTGGGAGCGCTGGGATTGCCTCGGCGAATCGTGCAGCAATGTACGG
TGCTAAGGTCCTATTAGCTGAGGGCAAGGCTATTGGAGGAACCTGTGTTAATTTGGGCTGTGTGCCTAAAAAGGTCATGT
GGTATGGCGCACAGGTAGCAGAAACGATTCATACCTATGCGAAGGATTACGGGTTTACGGTGTTAGAGGATAGGTTTGAT
TTTAAAACCTTAAAAAGCAATCGTCAGGCCTATATTGACCGTATTCATGCCTCCTATGAGAAGGGCTTTGAGCATAATGG
GGTTGACCGTATCTATGATTATGCGCGATTTATTGATCAGCATACGGTTGACATTGCAGGTAAGACCTATACAGCCCCTC
ATATTTTAATCGCTACTGGTGGTCAGCCTATTTTTCCTGACATTGAAGGAGCTGAGCTGGGGATTAGCTCAGATGGCTTC
TTTGCCTTAGATGATATTCCAAAACGAACAGCGGTTGTCGGTGCTGGCTATATCGCTGTTGAGATTGCAGGAGTGCTCAA
TGCCTTAGGCTCTCAGACGGATTTGCTGGTTCGCTATGACAGGCCACTGAGGACCTTTGATCAGGATATTATTCAGGTTC
TGGTCGATGAGATGAAGGTACCTGGACCAAGGCTGCATACCAATGCCGATGTTACTAAGGTTACCAAGGCTAATGATGGC
TCTCTTCAAGTGCATTTGTCCGACGGTCGTAGGCTTGAAGTGGACCAAGTGATTTGGGCAATTGGCCGCAAGCCAAATGT
GACAGGCTTTGGCTTGGAGCATACAGGAGTTGAGCTGGATAAGAGGGGCTATATTGCTACTGATGCTTATGAAAACACGT
CTGTCGAGGGCATCTATGCTGTTGGTGATGTGAATGGAAAGCTTGCTTTGACCCCAGTTGCTGTCGCAGCAGGTCGTCGC
TTAGCAGAGCGTTTGTTTCATCATAAGGCCAATGAAAAGCTTGATTATGATAAGGTTGCGACGGTTGTCTTTAGCCATCC
GCCAATTGGTTCGATCGGCTTAACAGAAGAGGCAGCTATTCAAGCCTATGGGCAGGAGGCTGTTCGTGTCTATCAATCAC
AATTTACGTCTATGTATACAGCTATTACCAGTCACCGCCAGCCCTGTCTAATGAAATTGGTTGTTGCAGGAGAAGAAGAG
ACTGTCGTTGGTCTGCATGGAATTGGTTATGGCGTCGATGAGATGATTCAAGGCTTTGCTGTTGCCATTAAAATGGGGGC
TACTAAGGCTGATTTTGACAATACTGTTGCCATTCATCCCACAGGTGCTGAAGAGTTTGTTACCATGAGATAA

Upstream 100 bases:

>100_bases
TTATGTTATAGTCAAATGACAGTAGATTAAAATAAAGCAATAATGATAGCTTAATAACAAATCTATTGAGGCAAGCATTA
AGAGTAAAGGTGGTAAATTA

Downstream 100 bases:

>100_bases
TAGCACATGATAAAACACGATAACATGACAGTTCAGAGTTTATCTGAATTGTCTGTTATCGTGTTTTGTGTTATGGATTG
CTTGTACTGTTAGGAGCTGG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MAIQYDYIVIGGGSAGIASANRAAMYGAKVLLAEGKAIGGTCVNLGCVPKKVMWYGAQVAETIHTYAKDYGFTVLEDRFD
FKTLKSNRQAYIDRIHASYEKGFEHNGVDRIYDYARFIDQHTVDIAGKTYTAPHILIATGGQPIFPDIEGAELGISSDGF
FALDDIPKRTAVVGAGYIAVEIAGVLNALGSQTDLLVRYDRPLRTFDQDIIQVLVDEMKVPGPRLHTNADVTKVTKANDG
SLQVHLSDGRRLEVDQVIWAIGRKPNVTGFGLEHTGVELDKRGYIATDAYENTSVEGIYAVGDVNGKLALTPVAVAAGRR
LAERLFHHKANEKLDYDKVATVVFSHPPIGSIGLTEEAAIQAYGQEAVRVYQSQFTSMYTAITSHRQPCLMKLVVAGEEE
TVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGAEEFVTMR

Sequences:

>Translated_450_residues
MAIQYDYIVIGGGSAGIASANRAAMYGAKVLLAEGKAIGGTCVNLGCVPKKVMWYGAQVAETIHTYAKDYGFTVLEDRFD
FKTLKSNRQAYIDRIHASYEKGFEHNGVDRIYDYARFIDQHTVDIAGKTYTAPHILIATGGQPIFPDIEGAELGISSDGF
FALDDIPKRTAVVGAGYIAVEIAGVLNALGSQTDLLVRYDRPLRTFDQDIIQVLVDEMKVPGPRLHTNADVTKVTKANDG
SLQVHLSDGRRLEVDQVIWAIGRKPNVTGFGLEHTGVELDKRGYIATDAYENTSVEGIYAVGDVNGKLALTPVAVAAGRR
LAERLFHHKANEKLDYDKVATVVFSHPPIGSIGLTEEAAIQAYGQEAVRVYQSQFTSMYTAITSHRQPCLMKLVVAGEEE
TVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGAEEFVTMR
>Mature_449_residues
AIQYDYIVIGGGSAGIASANRAAMYGAKVLLAEGKAIGGTCVNLGCVPKKVMWYGAQVAETIHTYAKDYGFTVLEDRFDF
KTLKSNRQAYIDRIHASYEKGFEHNGVDRIYDYARFIDQHTVDIAGKTYTAPHILIATGGQPIFPDIEGAELGISSDGFF
ALDDIPKRTAVVGAGYIAVEIAGVLNALGSQTDLLVRYDRPLRTFDQDIIQVLVDEMKVPGPRLHTNADVTKVTKANDGS
LQVHLSDGRRLEVDQVIWAIGRKPNVTGFGLEHTGVELDKRGYIATDAYENTSVEGIYAVGDVNGKLALTPVAVAAGRRL
AERLFHHKANEKLDYDKVATVVFSHPPIGSIGLTEEAAIQAYGQEAVRVYQSQFTSMYTAITSHRQPCLMKLVVAGEEET
VVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=51.8438177874187, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=37.4727668845316, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=35.6043956043956, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=35.6043956043956, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=35.6043956043956, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=35.6043956043956, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=35.6043956043956, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=34.1719077568134, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI291045268, Length=477, Percent_Identity=30.8176100628931, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=29.0598290598291, Blast_Score=161, Evalue=9e-40,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=62.2222222222222, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=27.3730684326711, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=27.4725274725275, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=25.3863134657837, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=53.3333333333333, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=53.3333333333333, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=36.5750528541226, Blast_Score=300, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.9583333333333, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=27.4678111587983, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17559934, Length=186, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=49.4600431965443, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=27.8617710583153, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=23.6051502145923, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=39.9150743099788, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=39.9150743099788, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=39.9150743099788, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=38.3647798742138, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=26.5217391304348, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48839; Mature: 48708

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQYDYIVIGGGSAGIASANRAAMYGAKVLLAEGKAIGGTCVNLGCVPKKVMWYGAQVA
CEEEEEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ETIHTYAKDYGFTVLEDRFDFKTLKSNRQAYIDRIHASYEKGFEHNGVDRIYDYARFIDQ
HHHHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HTVDIAGKTYTAPHILIATGGQPIFPDIEGAELGISSDGFFALDDIPKRTAVVGAGYIAV
HEEEECCCEECCCEEEEEECCCCCCCCCCCCEECCCCCCCEEECCCCCCCEEEECCHHHH
EIAGVLNALGSQTDLLVRYDRPLRTFDQDIIQVLVDEMKVPGPRLHTNADVTKVTKANDG
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCC
SLQVHLSDGRRLEVDQVIWAIGRKPNVTGFGLEHTGVELDKRGYIATDAYENTSVEGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCEEEE
VGDVNGKLALTPVAVAAGRRLAERLFHHKANEKLDYDKVATVVFSHPPIGSIGLTEEAAI
EECCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHH
QAYGQEAVRVYQSQFTSMYTAITSHRQPCLMKLVVAGEEETVVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGAEEFVTMR
EEEEECCCCCCCCCEEEEECCCHHHCEECC
>Mature Secondary Structure 
AIQYDYIVIGGGSAGIASANRAAMYGAKVLLAEGKAIGGTCVNLGCVPKKVMWYGAQVA
EEEEEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ETIHTYAKDYGFTVLEDRFDFKTLKSNRQAYIDRIHASYEKGFEHNGVDRIYDYARFIDQ
HHHHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HTVDIAGKTYTAPHILIATGGQPIFPDIEGAELGISSDGFFALDDIPKRTAVVGAGYIAV
HEEEECCCEECCCEEEEEECCCCCCCCCCCCEECCCCCCCEEECCCCCCCEEEECCHHHH
EIAGVLNALGSQTDLLVRYDRPLRTFDQDIIQVLVDEMKVPGPRLHTNADVTKVTKANDG
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCC
SLQVHLSDGRRLEVDQVIWAIGRKPNVTGFGLEHTGVELDKRGYIATDAYENTSVEGIYA
EEEEEECCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCEEEE
VGDVNGKLALTPVAVAAGRRLAERLFHHKANEKLDYDKVATVVFSHPPIGSIGLTEEAAI
EECCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHH
QAYGQEAVRVYQSQFTSMYTAITSHRQPCLMKLVVAGEEETVVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGAEEFVTMR
EEEEECCCCCCCCCEEEEECCCHHHCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]