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The map label for this gene is galE [H]

Identifier: 195977978

GI number: 195977978

Start: 896013

End: 897032

Strand: Direct

Name: galE [H]

Synonym: Sez_0850

Alternate gene names: 195977978

Gene position: 896013-897032 (Clockwise)

Preceding gene: 195977977

Following gene: 195977979

Centisome position: 44.27

GC content: 42.06

Gene sequence:

>1020_bases
ATGTTAGGAAGTATTTTAGTTACTGGTGGTGCAGGCTATATTGGGTCACACACCTGTGTTGAGCTACTAGCTGCTGGCTA
TGACGTTGTTGTGATTGATAATTTGTGCAATTCAAATCCTAAAAGCCTAGCTGCTGTTGCTTCGATAGCTGGAAGAGAAG
TGACCTTTTATCAGGGGGATATTCGCGATCAACAGCTACTAACAGATATTTTCAGTAAGCATCCTATTGTGAGTGTCATT
CACTTTGCAGGTCTCAAAGCTGTTGGAGAGTCAAGCAGGATTCCACTTGATTACTATGACAATAATATCTCTGGCACATT
GACCTTACTAAAGGTAATGACAGCCTTTAATTGTAAAAAGATCATTTTTAGCTCCTCAGCAACGGTTTATGGAGATCCGC
ATACCGTTCCTATTTTAGAAACCTTTCCACTATCAGTGACCAATCCTTACGGTAGGACAAAGCTGATGCTAGAGGAGATT
TTCAAGGACCTCTATGCATCAGATAATGAGTGGCATATTGTATTGTTGAGGTATTTTAATCCTATCGGAGCTCATGAGTC
TGGTGATTTAGGAGAGGATCCTAAGGGCATACCTAACAACCTATTACCTTATGTTTCTCAGGTAGCTGTTGGTAAGCTGG
ATTGTGTTGGCGTTTTTGGTGATGATTATGAGACCAAGGACGGCACTGGCGTTAGAGATTATATCCATGTTGTTGATCTG
GCTAAAGGACACGTCGCTGCGCTTGCAAAGTTTGCTGAAGAGCCAAGCCTATCTATTTATAATTTAGGAACAGGTACAGG
CTATTCTGTGCTAGATATTATCGAAGCCTTTTCTCAGGTGGTTGGCAGGTCTATTCCTTACAAGATATTACCAAGGCGTC
AAGGAGACATCGCAGCCTGCTATGCTGATGCTAGCAAGGCTAAAAAAGAGCTTAACTGGACTGCAGAGTACGGCTTAGAA
AGGATGTGTACAGATACTTGGAGATGGCAAAGCAAGCACCCAAATGGTTATGAGGATTAA

Upstream 100 bases:

>100_bases
AATGCCTATCCAGATTTCTTTAACATGAAATGATAGATATACTTTTTGGGAGTAATCAGTTATAATATTAGTAACTATTA
GAAAGTCAGGTATATAATCG

Downstream 100 bases:

>100_bases
GGCATGGGCTGATGAATAATCAAGGCTGTCAAGAGCTTTCTTGGCAGCTGTCTTTTTATGAGAACGCAACTGTAACAGAA
CAGATAAAGCACTGTAAAAA

Product: UDP-glucose 4-epimerase GalE

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLGSILVTGGAGYIGSHTCVELLAAGYDVVVIDNLCNSNPKSLAAVASIAGREVTFYQGDIRDQQLLTDIFSKHPIVSVI
HFAGLKAVGESSRIPLDYYDNNISGTLTLLKVMTAFNCKKIIFSSSATVYGDPHTVPILETFPLSVTNPYGRTKLMLEEI
FKDLYASDNEWHIVLLRYFNPIGAHESGDLGEDPKGIPNNLLPYVSQVAVGKLDCVGVFGDDYETKDGTGVRDYIHVVDL
AKGHVAALAKFAEEPSLSIYNLGTGTGYSVLDIIEAFSQVVGRSIPYKILPRRQGDIAACYADASKAKKELNWTAEYGLE
RMCTDTWRWQSKHPNGYED

Sequences:

>Translated_339_residues
MLGSILVTGGAGYIGSHTCVELLAAGYDVVVIDNLCNSNPKSLAAVASIAGREVTFYQGDIRDQQLLTDIFSKHPIVSVI
HFAGLKAVGESSRIPLDYYDNNISGTLTLLKVMTAFNCKKIIFSSSATVYGDPHTVPILETFPLSVTNPYGRTKLMLEEI
FKDLYASDNEWHIVLLRYFNPIGAHESGDLGEDPKGIPNNLLPYVSQVAVGKLDCVGVFGDDYETKDGTGVRDYIHVVDL
AKGHVAALAKFAEEPSLSIYNLGTGTGYSVLDIIEAFSQVVGRSIPYKILPRRQGDIAACYADASKAKKELNWTAEYGLE
RMCTDTWRWQSKHPNGYED
>Mature_339_residues
MLGSILVTGGAGYIGSHTCVELLAAGYDVVVIDNLCNSNPKSLAAVASIAGREVTFYQGDIRDQQLLTDIFSKHPIVSVI
HFAGLKAVGESSRIPLDYYDNNISGTLTLLKVMTAFNCKKIIFSSSATVYGDPHTVPILETFPLSVTNPYGRTKLMLEEI
FKDLYASDNEWHIVLLRYFNPIGAHESGDLGEDPKGIPNNLLPYVSQVAVGKLDCVGVFGDDYETKDGTGVRDYIHVVDL
AKGHVAALAKFAEEPSLSIYNLGTGTGYSVLDIIEAFSQVVGRSIPYKILPRRQGDIAACYADASKAKKELNWTAEYGLE
RMCTDTWRWQSKHPNGYED

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=344, Percent_Identity=58.1395348837209, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI56118217, Length=344, Percent_Identity=58.1395348837209, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI189083684, Length=344, Percent_Identity=58.1395348837209, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI7657641, Length=286, Percent_Identity=26.5734265734266, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=23.6760124610592, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=58.0357142857143, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI48994969, Length=357, Percent_Identity=28.8515406162465, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788353, Length=356, Percent_Identity=26.685393258427, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982035, Length=343, Percent_Identity=52.4781341107872, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71982038, Length=345, Percent_Identity=52.1739130434783, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17568069, Length=330, Percent_Identity=24.5454545454545, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=53.0612244897959, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19923002, Length=345, Percent_Identity=55.0724637681159, Blast_Score=403, Evalue=1e-113,
Organism=Drosophila melanogaster, GI21356223, Length=321, Percent_Identity=23.6760124610592, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37099; Mature: 37099

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSILVTGGAGYIGSHTCVELLAAGYDVVVIDNLCNSNPKSLAAVASIAGREVTFYQGD
CCCCEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEEECC
IRDQQLLTDIFSKHPIVSVIHFAGLKAVGESSRIPLDYYDNNISGTLTLLKVMTAFNCKK
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCHH
IIFSSSATVYGDPHTVPILETFPLSVTNPYGRTKLMLEEIFKDLYASDNEWHIVLLRYFN
HEEECCCEEECCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECC
PIGAHESGDLGEDPKGIPNNLLPYVSQVAVGKLDCVGVFGDDYETKDGTGVRDYIHVVDL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKGHVAALAKFAEEPSLSIYNLGTGTGYSVLDIIEAFSQVVGRSIPYKILPRRQGDIAAC
CCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEE
YADASKAKKELNWTAEYGLERMCTDTWRWQSKHPNGYED
ECCHHHHHHHCCCHHHHCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLGSILVTGGAGYIGSHTCVELLAAGYDVVVIDNLCNSNPKSLAAVASIAGREVTFYQGD
CCCCEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEEECC
IRDQQLLTDIFSKHPIVSVIHFAGLKAVGESSRIPLDYYDNNISGTLTLLKVMTAFNCKK
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCHH
IIFSSSATVYGDPHTVPILETFPLSVTNPYGRTKLMLEEIFKDLYASDNEWHIVLLRYFN
HEEECCCEEECCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECC
PIGAHESGDLGEDPKGIPNNLLPYVSQVAVGKLDCVGVFGDDYETKDGTGVRDYIHVVDL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKGHVAALAKFAEEPSLSIYNLGTGTGYSVLDIIEAFSQVVGRSIPYKILPRRQGDIAAC
CCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEE
YADASKAKKELNWTAEYGLERMCTDTWRWQSKHPNGYED
ECCHHHHHHHCCCHHHHCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]