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The map label for this gene is szp [H]

Identifier: 195977938

GI number: 195977938

Start: 843000

End: 844133

Strand: Direct

Name: szp [H]

Synonym: Sez_0809

Alternate gene names: 195977938

Gene position: 843000-844133 (Clockwise)

Preceding gene: 195977937

Following gene: 195977940

Centisome position: 41.65

GC content: 46.65

Gene sequence:

>1134_bases
ATGGCAAAAAAAGAAATGAAGTTTTATCTTCGTAAATCGGCCTTTGGGCTAGCTTCAGTATCGGCAGCCTTGTTAGTTAG
CTCAGCAGTTGTCGCTGCAGATACAGCAGACTCAGCAGCTCCTGCGGTAACAGCTACTGTTAAGGATAGTTCAGCAGATA
AGGAAGCTACAGCATTAAAGGCAGAGGCAGACCTAGCTACTGCCAAAGCAGACCTAGCAGCAGCAGAAGCAGCAATCACA
GCTGCCAAGGCTGAATACGAGACAGCTCAAGCAGACCTAGCTACCGCTGATGCTACTATAGCAAGCCTTGAGCAAAAAAT
GGCTGAGTTAGAAAGCAAAATTCAAGAAAAGCAAAAAGAGCTAGAGGACATCATTCGTCAACAAGGCCCTGCTCATGCAG
CTATCGGTGGTCGTAATGGAGACGCTGACGCAGAACAATTAGATGAGCTAGCTGGTGAGGTTAGCCGAGCAAAAGCAGCT
CTTAAGGTTGAACTTCAAAAGGTCAAAGAAGAGTTAGAAGTAGCTAAAAGAGCTTATGCTGGTATCGAAGAAAGAAAACA
AGTAGCAGCAGCTAAGCTAGATGCAGCTAACAAGGCTTTTGCTGGAGTTGAAGAAAAGCATGCTCAAGCAATGGTTGCAT
TTGAAGAAGCATTCGCAGCATACAAGGAAGCTGTCAAGGCTGAATTGAAGGCAGCAGGTGCTAGCGACTTCTACACCAAG
AAGATTGACTCTGCCAACACAGTTGACGGTGTTAAGACACTCAGAGAAATGATCTTAGACTCAATTGCTAAGCCAGAGGT
TGAACCAGAGGCTAAGCCTGAACCTAAGCCAGAACCAAAACCTGAGCCAAAACCAGAACCAAAACCTGAGCCTAAGCCAG
AGCCAAAACCAGAACCTAAGCCTGAGCCTAAGCCAGAACCAAAACCAGAACCTAAGCCAAAACCTCAACCTAAACCAGCT
CCAGCTCCAAAACCTGAAGCTAAGAAGGAAGAGAAGAAAGCAGCGCCTAAGCAAGACGCCAACAAATTGCCATCAACAGG
TGAAGCTACAAATCCATTCTTCACCGCGGCAGCTCTTGCAGTTATGGCAGGTGCAGGCGTGGCTGCAGTGTCAACAAGAC
GCAAAGAAAACTAA

Upstream 100 bases:

>100_bases
TATTGATTTAATTGGCAATAACGTTTACAATAGAGGTATAATTATCTGCCGTTGATAATTAGGAGACATCATGTCTAGAT
AAAAACAAAAGGGGAATAAA

Downstream 100 bases:

>100_bases
GCCTTATACCCCAGTGGTAAAGCTTGAGCGAGAACAAGTTGTTCTCGCTTTTTTAGTGTCTTAAAAGCACCTATGCTTGC
TATAGGTGCTTGAAAAGATC

Product: M-like proptein Szp

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAKKEMKFYLRKSAFGLASVSAALLVSSAVVAADTADSAAPAVTATVKDSSADKEATALKAEADLATAKADLAAAEAAIT
AAKAEYETAQADLATADATIASLEQKMAELESKIQEKQKELEDIIRQQGPAHAAIGGRNGDADAEQLDELAGEVSRAKAA
LKVELQKVKEELEVAKRAYAGIEERKQVAAAKLDAANKAFAGVEEKHAQAMVAFEEAFAAYKEAVKAELKAAGASDFYTK
KIDSANTVDGVKTLREMILDSIAKPEVEPEAKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPKPQPKPA
PAPKPEAKKEEKKAAPKQDANKLPSTGEATNPFFTAAALAVMAGAGVAAVSTRRKEN

Sequences:

>Translated_377_residues
MAKKEMKFYLRKSAFGLASVSAALLVSSAVVAADTADSAAPAVTATVKDSSADKEATALKAEADLATAKADLAAAEAAIT
AAKAEYETAQADLATADATIASLEQKMAELESKIQEKQKELEDIIRQQGPAHAAIGGRNGDADAEQLDELAGEVSRAKAA
LKVELQKVKEELEVAKRAYAGIEERKQVAAAKLDAANKAFAGVEEKHAQAMVAFEEAFAAYKEAVKAELKAAGASDFYTK
KIDSANTVDGVKTLREMILDSIAKPEVEPEAKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPKPQPKPA
PAPKPEAKKEEKKAAPKQDANKLPSTGEATNPFFTAAALAVMAGAGVAAVSTRRKEN
>Mature_376_residues
AKKEMKFYLRKSAFGLASVSAALLVSSAVVAADTADSAAPAVTATVKDSSADKEATALKAEADLATAKADLAAAEAAITA
AKAEYETAQADLATADATIASLEQKMAELESKIQEKQKELEDIIRQQGPAHAAIGGRNGDADAEQLDELAGEVSRAKAAL
KVELQKVKEELEVAKRAYAGIEERKQVAAAKLDAANKAFAGVEEKHAQAMVAFEEAFAAYKEAVKAELKAAGASDFYTKK
IDSANTVDGVKTLREMILDSIAKPEVEPEAKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPEPKPKPQPKPAP
APKPEAKKEEKKAAPKQDANKLPSTGEATNPFFTAAALAVMAGAGVAAVSTRRKEN

Specific function: Mediates the attachment of S.pyogenes to skin epithelial cells through the binding of the human membrane cofactor protein CD46. Also binds to the factor H and factor H-like protein 1. These interactions could contribute to the fact that the M6 protein pro

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the M protein family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR019948
- InterPro:   IPR019950
- InterPro:   IPR019931
- InterPro:   IPR001899 [H]

Pfam domain/function: PF00746 Gram_pos_anchor; PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 39749; Mature: 39618

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50847 GRAM_POS_ANCHORING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKEMKFYLRKSAFGLASVSAALLVSSAVVAADTADSAAPAVTATVKDSSADKEATALK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHH
AEADLATAKADLAAAEAAITAAKAEYETAQADLATADATIASLEQKMAELESKIQEKQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDIIRQQGPAHAAIGGRNGDADAEQLDELAGEVSRAKAALKVELQKVKEELEVAKRAYA
HHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIEERKQVAAAKLDAANKAFAGVEEKHAQAMVAFEEAFAAYKEAVKAELKAAGASDFYTK
CHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KIDSANTVDGVKTLREMILDSIAKPEVEPEAKPEPKPEPKPEPKPEPKPEPKPEPKPEPK
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPKPEPKPEPKPKPQPKPAPAPKPEAKKEEKKAAPKQDANKLPSTGEATNPFFTAAALA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHH
VMAGAGVAAVSTRRKEN
HHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
AKKEMKFYLRKSAFGLASVSAALLVSSAVVAADTADSAAPAVTATVKDSSADKEATALK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHH
AEADLATAKADLAAAEAAITAAKAEYETAQADLATADATIASLEQKMAELESKIQEKQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDIIRQQGPAHAAIGGRNGDADAEQLDELAGEVSRAKAALKVELQKVKEELEVAKRAYA
HHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIEERKQVAAAKLDAANKAFAGVEEKHAQAMVAFEEAFAAYKEAVKAELKAAGASDFYTK
CHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KIDSANTVDGVKTLREMILDSIAKPEVEPEAKPEPKPEPKPEPKPEPKPEPKPEPKPEPK
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPKPEPKPEPKPKPQPKPAPAPKPEAKKEEKKAAPKQDANKLPSTGEATNPFFTAAALA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHH
VMAGAGVAAVSTRRKEN
HHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA