| Definition | Streptococcus equi subsp. zooepidemicus MGCS10565, complete genome. |
|---|---|
| Accession | NC_011134 |
| Length | 2,024,171 |
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The map label for this gene is idnO [C]
Identifier: 195977825
GI number: 195977825
Start: 717634
End: 718473
Strand: Direct
Name: idnO [C]
Synonym: Sez_0691
Alternate gene names: 195977825
Gene position: 717634-718473 (Clockwise)
Preceding gene: 195977824
Following gene: 195977826
Centisome position: 35.45
GC content: 45.71
Gene sequence:
>840_bases ATGAGTCGAGTTATTGAATTTAAGGACAAGGTTGTTGTGATCACAGGAGCTGGCGGTGTCCTTTGTGGCAGTATGGCAAA GGCATTTGCAAAAGCAGGGGCTAAGGTGGCACTGTTGGACCTTAACCAAGAGGCGGCACAGGCCTTTGTTGATGATATTG AGGCAGAGGGGGGCATTGCAAGGGCCTATCAGGCAAATGTATTGTCTAAAGAAAACCTAGAGGCCGTTCGTCAGGCAGTT TTAGCAGATTTTGGTCCAGCAGATATTTTAGTGAATGGTGCTGGCGGAAACAGCCCTAAGGCAACAACGGATAATGAGTT TCACGACACGAGCCTGCCAGAGGATACAAAAACCTTCTTTGATCTTGATGAAGCAGGTATCAGCTTTGTCTTTAATTTAA ACTATTTAGGAACCTTGCTGCCGACACAGGTCTTTGCTCAGGATATGGTTGGTCGTAAGGGGGCAAATATTATTAACATT TCTTCAATGAATGCCTTTACGCCATTAACAAAGATTCCAGCCTATTCTGGAGCTAAGGCAGCTATTTCCAACTTTACCCA GTGGCTGGCTGTTCACTTCTCTAAGGTTGGTATTCGTTGTAACGCTATTGCCCCTGGCTTTTTGGTAACCAATCAAAACC GTAGTCTCCTTTTTACAGAGGACGGACAGCCGACTGCTCGCGCTGAAAAAATTCTGAAGAATACACCAATGGGACGCTTT GGTGAGGCAGAAGAATTAATTGGAGGCCTCTTTTTCTTGGCTGATGAGCAATCTGCTTCCTTTGTGAACGGAGTTGTTCT CCCGATTGACGGCGGCTTTGCAGCTTATTCAGGCGTTTAA
Upstream 100 bases:
>100_bases TTAATGGGCTTTATGAGGCTAATATGCGTGCAGCTGGAAAGACACCAGATTTTGGTATTACTGTAAAAACAGTTGGAGAT AAATAGAAAAGGGGCATGAG
Downstream 100 bases:
>100_bases GCTAAAACATAAACCACTTGAGAACTCAAACTGCAATGCCTCAAGTGGTTTTTCTATTGTGACAGCTTGCTTTGTAGCCA AGATGTCATTAATAAAGGTA
Product: D-mannonate oxidoreductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 279; Mature: 278
Protein sequence:
>279_residues MSRVIEFKDKVVVITGAGGVLCGSMAKAFAKAGAKVALLDLNQEAAQAFVDDIEAEGGIARAYQANVLSKENLEAVRQAV LADFGPADILVNGAGGNSPKATTDNEFHDTSLPEDTKTFFDLDEAGISFVFNLNYLGTLLPTQVFAQDMVGRKGANIINI SSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFLVTNQNRSLLFTEDGQPTARAEKILKNTPMGRF GEAEELIGGLFFLADEQSASFVNGVVLPIDGGFAAYSGV
Sequences:
>Translated_279_residues MSRVIEFKDKVVVITGAGGVLCGSMAKAFAKAGAKVALLDLNQEAAQAFVDDIEAEGGIARAYQANVLSKENLEAVRQAV LADFGPADILVNGAGGNSPKATTDNEFHDTSLPEDTKTFFDLDEAGISFVFNLNYLGTLLPTQVFAQDMVGRKGANIINI SSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFLVTNQNRSLLFTEDGQPTARAEKILKNTPMGRF GEAEELIGGLFFLADEQSASFVNGVVLPIDGGFAAYSGV >Mature_278_residues SRVIEFKDKVVVITGAGGVLCGSMAKAFAKAGAKVALLDLNQEAAQAFVDDIEAEGGIARAYQANVLSKENLEAVRQAVL ADFGPADILVNGAGGNSPKATTDNEFHDTSLPEDTKTFFDLDEAGISFVFNLNYLGTLLPTQVFAQDMVGRKGANIINIS SMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFLVTNQNRSLLFTEDGQPTARAEKILKNTPMGRFG EAEELIGGLFFLADEQSASFVNGVVLPIDGGFAAYSGV
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=265, Percent_Identity=26.4150943396226, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI15277342, Length=278, Percent_Identity=29.136690647482, Blast_Score=92, Evalue=8e-19, Organism=Homo sapiens, GI66933014, Length=268, Percent_Identity=31.3432835820896, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=24.6323529411765, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI59889578, Length=247, Percent_Identity=27.9352226720648, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI7705925, Length=272, Percent_Identity=24.6323529411765, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI31542939, Length=243, Percent_Identity=29.2181069958848, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI10190704, Length=273, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI4503301, Length=268, Percent_Identity=28.3582089552239, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=27.4881516587678, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI19923817, Length=280, Percent_Identity=25, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1790717, Length=273, Percent_Identity=30.4029304029304, Blast_Score=117, Evalue=6e-28, Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=31.3432835820896, Blast_Score=111, Evalue=5e-26, Organism=Escherichia coli, GI1789208, Length=270, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1787335, Length=269, Percent_Identity=30.1115241635688, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=27.7153558052434, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=28.8389513108614, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1788459, Length=266, Percent_Identity=27.0676691729323, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1786812, Length=274, Percent_Identity=28.1021897810219, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI1789378, Length=273, Percent_Identity=29.3040293040293, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI2367175, Length=268, Percent_Identity=27.6119402985075, Blast_Score=73, Evalue=2e-14, Organism=Caenorhabditis elegans, GI115534694, Length=270, Percent_Identity=27.4074074074074, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17560150, Length=278, Percent_Identity=28.4172661870504, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17559104, Length=285, Percent_Identity=27.0175438596491, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI71994600, Length=272, Percent_Identity=27.2058823529412, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=28.3687943262411, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI71994604, Length=267, Percent_Identity=26.2172284644195, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI25147288, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536025, Length=268, Percent_Identity=28.3582089552239, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=25, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17562910, Length=281, Percent_Identity=27.7580071174377, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17563726, Length=283, Percent_Identity=26.1484098939929, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17560676, Length=273, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI72000259, Length=281, Percent_Identity=25.6227758007117, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538480, Length=281, Percent_Identity=28.4697508896797, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17560220, Length=285, Percent_Identity=27.3684210526316, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17565030, Length=289, Percent_Identity=28.0276816608997, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17551412, Length=288, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI193204405, Length=291, Percent_Identity=28.1786941580756, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17538486, Length=281, Percent_Identity=27.0462633451957, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17562904, Length=286, Percent_Identity=25.5244755244755, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17560332, Length=285, Percent_Identity=28.7719298245614, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17561272, Length=252, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17538182, Length=211, Percent_Identity=34.5971563981043, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17544670, Length=285, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17536651, Length=271, Percent_Identity=27.6752767527675, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17562908, Length=280, Percent_Identity=25, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17562906, Length=280, Percent_Identity=24.2857142857143, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17508895, Length=205, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=210, Percent_Identity=32.3809523809524, Blast_Score=73, Evalue=5e-14, Organism=Saccharomyces cerevisiae, GI6324126, Length=271, Percent_Identity=25.4612546125461, Blast_Score=69, Evalue=9e-13, Organism=Drosophila melanogaster, GI23397609, Length=271, Percent_Identity=30.2583025830258, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI28571526, Length=277, Percent_Identity=31.0469314079422, Blast_Score=110, Evalue=8e-25, Organism=Drosophila melanogaster, GI21357041, Length=272, Percent_Identity=31.25, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI24639444, Length=267, Percent_Identity=31.4606741573034, Blast_Score=102, Evalue=4e-22, Organism=Drosophila melanogaster, GI24644339, Length=278, Percent_Identity=29.4964028776978, Blast_Score=95, Evalue=7e-20, Organism=Drosophila melanogaster, GI24644337, Length=270, Percent_Identity=32.2222222222222, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24643142, Length=267, Percent_Identity=28.8389513108614, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI21355319, Length=266, Percent_Identity=24.0601503759398, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24640492, Length=176, Percent_Identity=28.4090909090909, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24649181, Length=251, Percent_Identity=27.4900398406374, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI21355631, Length=235, Percent_Identity=24.6808510638298, Blast_Score=65, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 29509; Mature: 29378
Theoretical pI: Translated: 4.62; Mature: 4.62
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRVIEFKDKVVVITGAGGVLCGSMAKAFAKAGAKVALLDLNQEAAQAFVDDIEAEGGIA CCCCEEECCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEE RAYQANVLSKENLEAVRQAVLADFGPADILVNGAGGNSPKATTDNEFHDTSLPEDTKTFF HHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH DLDEAGISFVFNLNYLGTLLPTQVFAQDMVGRKGANIINISSMNAFTPLTKIPAYSGAKA CCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCHHH AISNFTQWLAVHFSKVGIRCNAIAPGFLVTNQNRSLLFTEDGQPTARAEKILKNTPMGRF HHHHHHHHHHHHHHHHCEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCC GEAEELIGGLFFLADEQSASFVNGVVLPIDGGFAAYSGV CCHHHHHCEEEEEECCCCCHHHCCEEEEECCCCHHCCCC >Mature Secondary Structure SRVIEFKDKVVVITGAGGVLCGSMAKAFAKAGAKVALLDLNQEAAQAFVDDIEAEGGIA CCCEEECCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEE RAYQANVLSKENLEAVRQAVLADFGPADILVNGAGGNSPKATTDNEFHDTSLPEDTKTFF HHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH DLDEAGISFVFNLNYLGTLLPTQVFAQDMVGRKGANIINISSMNAFTPLTKIPAYSGAKA CCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCHHH AISNFTQWLAVHFSKVGIRCNAIAPGFLVTNQNRSLLFTEDGQPTARAEKILKNTPMGRF HHHHHHHHHHHHHHHHCEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCC GEAEELIGGLFFLADEQSASFVNGVVLPIDGGFAAYSGV CCHHHHHCEEEEEECCCCCHHHCCEEEEECCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} 0.02 {NADP+}} 20 {D-gluconate}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7542800; 10675023 [H]