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The map label for this gene is fabF [H]

Identifier: 195977554

GI number: 195977554

Start: 439132

End: 440364

Strand: Direct

Name: fabF [H]

Synonym: Sez_0411

Alternate gene names: 195977554

Gene position: 439132-440364 (Clockwise)

Preceding gene: 195977553

Following gene: 195977555

Centisome position: 21.69

GC content: 44.85

Gene sequence:

>1233_bases
ATGACATTAAACAGAGTAGTTGTAACAGGTTATGGTGTGACTTCCCCAATTGGGCATACTCCAGAGGAGTTTTGGTCAAG
CTTAAAGGCAGGTCATATTGGTATTAAGCCTATCACAAAATTTGATACGAGTGACTTCGCTGTTAAGAATGCAGCAGAGA
TTCAGGATTTTCCATTTGATAAGTATTTTGTCAAAAAGGATCTAAATCGCTTTGACATGTATTCCTTGTATGCCTTATAT
GCTGCGACAGAGGCGGTTGAACATGCTGGCCTAGATATTGAAGCGATTGATTCTGACCGCTTTGGTGTTATTGTAGCGTC
TGGTATTGGAGGCATTCAAGAGATTGAAGAGCAGGTGATTCGGTTACATGAAAAAGGACCAAAGCGCGTTAAGCCGATGA
CTCTACCAAAGGCCTTGCCAAATATGGCGGCTGGTAATGTTGCCATGAAGCTGAATGCCCAAGGCGTATGTAAGTCAATC
AATACAGCCTGTGCCTCTTCAAACGATGCTATTGGCGATGCCTTTCGTACAATTAAGTTTGGTCTTCAAGATGTGATGAT
GGTTGGAGGATCAGAGGCAGCCATTACAAAATTTGCCATTGCGGGCTTCCAGAGCTTGACTGCCTTGTCAACAACTGAGG
ACCCAAGCCGCAGCTCTATTCCATTTGATAAGGATCGAAACGGCTTTATCATGGGTGAAGGCTCACGTATGCTTGTTTTG
GAAAGCTTAGAGCATGCTCAAAAGCGCGGTGCGACTATTTTAGCTGAGATTGTTGGCTACGGCAATACCTGTGACGCTTA
CCACATGACCTCACCACACCCAGAAGGACTTGGTGCTCGTAAGGCCATTAATCTAGCATTGCAGGAGGCTGGTATTGATG
CAGCAGCTATTGACTACGTGAATGCTCATGGCACCTCAACTCCTGCCAATGAAAAAGGAGAAAGTCAAGCTATCGTTGCA
GTGCTTGGCAAAGAGGTTCCTGTCTCATCAACCAAGTCCTTTACAGGCCACCTACTAGGGGCAGCTGGTGCTGTGGAAGC
TATTGCAACCATAGAAGCAATGCGGCATAATTATGTTCCAATGACAGCTGGGACAAAGGAGCTGTCAGACGACATTGAAG
CAAATGTTATTTTTGGACAAGGAAAAGAAGCCGATATTCGTTATGCCATTTCAAATACCTTTGGCTTTGGAGGTCATAAC
GCTGTATTAGCCTTTAAGCGTTGGGAGGATTAA

Upstream 100 bases:

>100_bases
TGCTCAGGCAGCAAGCTTCCTAGCTAGTCAGGATTATATTACTGGTCAGGTGCTTGCCATTGACGGCGGCATGACAATGC
AATAAAATAGAGGTACTAAA

Downstream 100 bases:

>100_bases
AATGAATATTCAAGAGATAAAGGATTTGATGGCACAGTTTGATGCTTCAAGCCTCCGCGAATTTTCATTCAAATCAAGTG
ATGGGGAGCTGTTATTTAGT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTLNRVVVTGYGVTSPIGHTPEEFWSSLKAGHIGIKPITKFDTSDFAVKNAAEIQDFPFDKYFVKKDLNRFDMYSLYALY
AATEAVEHAGLDIEAIDSDRFGVIVASGIGGIQEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMKLNAQGVCKSI
NTACASSNDAIGDAFRTIKFGLQDVMMVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSRMLVL
ESLEHAQKRGATILAEIVGYGNTCDAYHMTSPHPEGLGARKAINLALQEAGIDAAAIDYVNAHGTSTPANEKGESQAIVA
VLGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNYVPMTAGTKELSDDIEANVIFGQGKEADIRYAISNTFGFGGHN
AVLAFKRWED

Sequences:

>Translated_410_residues
MTLNRVVVTGYGVTSPIGHTPEEFWSSLKAGHIGIKPITKFDTSDFAVKNAAEIQDFPFDKYFVKKDLNRFDMYSLYALY
AATEAVEHAGLDIEAIDSDRFGVIVASGIGGIQEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMKLNAQGVCKSI
NTACASSNDAIGDAFRTIKFGLQDVMMVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSRMLVL
ESLEHAQKRGATILAEIVGYGNTCDAYHMTSPHPEGLGARKAINLALQEAGIDAAAIDYVNAHGTSTPANEKGESQAIVA
VLGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNYVPMTAGTKELSDDIEANVIFGQGKEADIRYAISNTFGFGGHN
AVLAFKRWED
>Mature_409_residues
TLNRVVVTGYGVTSPIGHTPEEFWSSLKAGHIGIKPITKFDTSDFAVKNAAEIQDFPFDKYFVKKDLNRFDMYSLYALYA
ATEAVEHAGLDIEAIDSDRFGVIVASGIGGIQEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMKLNAQGVCKSIN
TACASSNDAIGDAFRTIKFGLQDVMMVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSRMLVLE
SLEHAQKRGATILAEIVGYGNTCDAYHMTSPHPEGLGARKAINLALQEAGIDAAAIDYVNAHGTSTPANEKGESQAIVAV
LGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNYVPMTAGTKELSDDIEANVIFGQGKEADIRYAISNTFGFGGHNA
VLAFKRWED

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=36.7788461538462, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=40.8163265306122, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI41872631, Length=436, Percent_Identity=23.6238532110092, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=44.6601941747573, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=35.0961538461538, Blast_Score=215, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=36.4734299516908, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=41.7624521072797, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17550940, Length=274, Percent_Identity=29.1970802919708, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212642053, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=38.4615384615385, Blast_Score=295, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=39.8081534772182, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221330659, Length=362, Percent_Identity=25.6906077348066, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920632, Length=362, Percent_Identity=25.6906077348066, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581345, Length=361, Percent_Identity=23.2686980609418, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43797; Mature: 43666

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNRVVVTGYGVTSPIGHTPEEFWSSLKAGHIGIKPITKFDTSDFAVKNAAEIQDFPFD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCH
KYFVKKDLNRFDMYSLYALYAATEAVEHAGLDIEAIDSDRFGVIVASGIGGIQEIEEQVI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
RLHEKGPKRVKPMTLPKALPNMAAGNVAMKLNAQGVCKSINTACASSNDAIGDAFRTIKF
HHHHCCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GLQDVMMVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSRMLVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEH
ESLEHAQKRGATILAEIVGYGNTCDAYHMTSPHPEGLGARKAINLALQEAGIDAAAIDYV
HHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEE
NAHGTSTPANEKGESQAIVAVLGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNYVP
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MTAGTKELSDDIEANVIFGQGKEADIRYAISNTFGFGGHNAVLAFKRWED
CCCCCHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TLNRVVVTGYGVTSPIGHTPEEFWSSLKAGHIGIKPITKFDTSDFAVKNAAEIQDFPFD
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCH
KYFVKKDLNRFDMYSLYALYAATEAVEHAGLDIEAIDSDRFGVIVASGIGGIQEIEEQVI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
RLHEKGPKRVKPMTLPKALPNMAAGNVAMKLNAQGVCKSINTACASSNDAIGDAFRTIKF
HHHHCCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GLQDVMMVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSRMLVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEH
ESLEHAQKRGATILAEIVGYGNTCDAYHMTSPHPEGLGARKAINLALQEAGIDAAAIDYV
HHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEE
NAHGTSTPANEKGESQAIVAVLGKEVPVSSTKSFTGHLLGAAGAVEAIATIEAMRHNYVP
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MTAGTKELSDDIEANVIFGQGKEADIRYAISNTFGFGGHNAVLAFKRWED
CCCCCHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]