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The map label for this gene is fabD [H]

Identifier: 195977552

GI number: 195977552

Start: 437445

End: 438365

Strand: Direct

Name: fabD [H]

Synonym: Sez_0409

Alternate gene names: 195977552

Gene position: 437445-438365 (Clockwise)

Preceding gene: 195977551

Following gene: 195977553

Centisome position: 21.61

GC content: 46.15

Gene sequence:

>921_bases
ATGACAAAAACAGCCTTTTTATTTGCTGGTCAGGGAGCTCAGACACTAGGCATGACAAGAGATTTGTATGACCAACATGC
CATTGCTCGTGACACCTTTGATCAGGCTAGTCAGCTTTTAGGCTATGATTTACGCAAGCTCATTGATACTGACCAAGATC
GGTTGAACCAGACAGCCTACACGCAGCCAGCAATCTTAACCGCTTCAGTCTCTATTTACCGTATCTTAACCTCTTATGGG
GTTCACCCTGATATGGTGGCGGGGCTTTCTCTTGGAGAATATTCTGCCCTAGTCGCAGCAGGTGCTCTGAGCTTTGAGAC
AGCCCTAGAGCTAGTTGCTAAAAGGGGACGCTTTATGGAGGAGGCAGCGCCTGCTGGCTCTGGTAAGATGGTAGCTGTGA
TGAATACAGAGGCTAGGCTTATTGAGGAGGCTTGTCAAGAGGCTTCTTCGGTTGGTGTTGTGTCACCTGCTAACTATAAT
ACGCCAGGACAGATTGTTATTGGTGGGACAGCTGAGGCTGTCAATGCGGCACTTGAAATCTTAAAAGCAAAGGGAGTGAA
GCGTTTAATTCCGCTGAATGTCTCAGGACCTTTCCATACAGCACTTTTAGCGCCTGCTAGTCAAAGGTTGGCAGAGGAGC
TCAGCAAGATTCAATTTCAGGACTTTGATCTGCCACTGGTTGGAAATACAGAGGCTAAGGTCATGGAAAAGGATCGGATT
GCAGAATTATTGGCGCGTCAGGTCATGGAGCCTGTTCGTTTTTACGACAGTATTGATGTTATGAAGGCTAACGGTGTCAA
TCAGTTTGTTGAGATTGGCCCTGGCAGGGTTTTAACAGGCTTTATTAAAAAAATCGACAAAAAGCTGCTATGCAGCAGTG
TTGAAGATATGCCAAGCCTACAATTGTATTTGGGAAAATAG

Upstream 100 bases:

>100_bases
TATCTACTATGGCGCGGCAGCAGTGATTAGCCAAGAAGCTAAGCGCTGGCAAGCTCTTGCAGCTGATGACAAAAACGAAA
CGATATAATTAAGGAGAAGT

Downstream 100 bases:

>100_bases
GAGGGAATGCTAAGCTATGGAAATTAAAGGAAAAAACGTTTTTATCACAGGGTCAACAAGAGGCATTGGACTAGCAATGG
CTCATCAATTTGCAGGACTA

Product: malonyl CoA-acyl carrier protein transacylase FabD

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTKTAFLFAGQGAQTLGMTRDLYDQHAIARDTFDQASQLLGYDLRKLIDTDQDRLNQTAYTQPAILTASVSIYRILTSYG
VHPDMVAGLSLGEYSALVAAGALSFETALELVAKRGRFMEEAAPAGSGKMVAVMNTEARLIEEACQEASSVGVVSPANYN
TPGQIVIGGTAEAVNAALEILKAKGVKRLIPLNVSGPFHTALLAPASQRLAEELSKIQFQDFDLPLVGNTEAKVMEKDRI
AELLARQVMEPVRFYDSIDVMKANGVNQFVEIGPGRVLTGFIKKIDKKLLCSSVEDMPSLQLYLGK

Sequences:

>Translated_306_residues
MTKTAFLFAGQGAQTLGMTRDLYDQHAIARDTFDQASQLLGYDLRKLIDTDQDRLNQTAYTQPAILTASVSIYRILTSYG
VHPDMVAGLSLGEYSALVAAGALSFETALELVAKRGRFMEEAAPAGSGKMVAVMNTEARLIEEACQEASSVGVVSPANYN
TPGQIVIGGTAEAVNAALEILKAKGVKRLIPLNVSGPFHTALLAPASQRLAEELSKIQFQDFDLPLVGNTEAKVMEKDRI
AELLARQVMEPVRFYDSIDVMKANGVNQFVEIGPGRVLTGFIKKIDKKLLCSSVEDMPSLQLYLGK
>Mature_305_residues
TKTAFLFAGQGAQTLGMTRDLYDQHAIARDTFDQASQLLGYDLRKLIDTDQDRLNQTAYTQPAILTASVSIYRILTSYGV
HPDMVAGLSLGEYSALVAAGALSFETALELVAKRGRFMEEAAPAGSGKMVAVMNTEARLIEEACQEASSVGVVSPANYNT
PGQIVIGGTAEAVNAALEILKAKGVKRLIPLNVSGPFHTALLAPASQRLAEELSKIQFQDFDLPLVGNTEAKVMEKDRIA
ELLARQVMEPVRFYDSIDVMKANGVNQFVEIGPGRVLTGFIKKIDKKLLCSSVEDMPSLQLYLGK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=306, Percent_Identity=33.0065359477124, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1787334, Length=299, Percent_Identity=46.8227424749164, Blast_Score=251, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=31.740614334471, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=293, Percent_Identity=30.3754266211604, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24665753, Length=310, Percent_Identity=31.6129032258064, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221330659, Length=297, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19920632, Length=297, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33090; Mature: 32958

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAFLFAGQGAQTLGMTRDLYDQHAIARDTFDQASQLLGYDLRKLIDTDQDRLNQTAY
CCCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
TQPAILTASVSIYRILTSYGVHPDMVAGLSLGEYSALVAAGALSFETALELVAKRGRFME
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EAAPAGSGKMVAVMNTEARLIEEACQEASSVGVVSPANYNTPGQIVIGGTAEAVNAALEI
HHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHH
LKAKGVKRLIPLNVSGPFHTALLAPASQRLAEELSKIQFQDFDLPLVGNTEAKVMEKDRI
HHHCCCCEEEEECCCCCHHHHHHCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHH
AELLARQVMEPVRFYDSIDVMKANGVNQFVEIGPGRVLTGFIKKIDKKLLCSSVEDMPSL
HHHHHHHHHHHHHHHCCHHEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QLYLGK
EEEECC
>Mature Secondary Structure 
TKTAFLFAGQGAQTLGMTRDLYDQHAIARDTFDQASQLLGYDLRKLIDTDQDRLNQTAY
CCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
TQPAILTASVSIYRILTSYGVHPDMVAGLSLGEYSALVAAGALSFETALELVAKRGRFME
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EAAPAGSGKMVAVMNTEARLIEEACQEASSVGVVSPANYNTPGQIVIGGTAEAVNAALEI
HHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHH
LKAKGVKRLIPLNVSGPFHTALLAPASQRLAEELSKIQFQDFDLPLVGNTEAKVMEKDRI
HHHCCCCEEEEECCCCCHHHHHHCHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHH
AELLARQVMEPVRFYDSIDVMKANGVNQFVEIGPGRVLTGFIKKIDKKLLCSSVEDMPSL
HHHHHHHHHHHHHHHCCHHEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QLYLGK
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]