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The map label for this gene is trxA [H]

Identifier: 195977482

GI number: 195977482

Start: 358568

End: 358882

Strand: Direct

Name: trxA [H]

Synonym: Sez_0337

Alternate gene names: 195977482

Gene position: 358568-358882 (Clockwise)

Preceding gene: 195977480

Following gene: 195977485

Centisome position: 17.71

GC content: 44.44

Gene sequence:

>315_bases
ATGGCACATATCGTAACAGATGCAACATTTGAAGCAGAAACTAATGAAGGCCTAGTCCTTGTGGACTTTTGGGCAACCTG
GTGCGGCCCTTGCTTAATGCAAGCGCCAATCCTTGATCAATTAGCAGCAGAAATTGACGAAGCTGAGCTTAAGATTGTCA
AGCTAGATGTTGATGACAATCCCAATACTGCTCAACAATTTGGCATTATGTCTATCCCAACCCTGCTGTTCAAAAAGGAC
GGTAAGGTTGTCAAGCAGGTAGCAGGCGTCCATACCAAGGATCAAATCAAGGCGATCGTAGCAGAATTAAGCTAA

Upstream 100 bases:

>100_bases
TTTTCTTAAATCATAAGACCGAGGTCTTCGTATCAGATTCTTGCATTATCAGTCGTTTTCCCCTAAAATAGGCTTATAAA
CTATAAGAACGGAGATTACA

Downstream 100 bases:

>100_bases
AGCAACAAGCCAACAGCCTCTTAGAAGGACAGCAAGCCTCAAGAGCTGCTGTTGGTTGTATGACCAAAAAAAGATTGAAG
ACCTAATAAGCTGTGTCTTC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAHIVTDATFEAETNEGLVLVDFWATWCGPCLMQAPILDQLAAEIDEAELKIVKLDVDDNPNTAQQFGIMSIPTLLFKKD
GKVVKQVAGVHTKDQIKAIVAELS

Sequences:

>Translated_104_residues
MAHIVTDATFEAETNEGLVLVDFWATWCGPCLMQAPILDQLAAEIDEAELKIVKLDVDDNPNTAQQFGIMSIPTLLFKKD
GKVVKQVAGVHTKDQIKAIVAELS
>Mature_103_residues
AHIVTDATFEAETNEGLVLVDFWATWCGPCLMQAPILDQLAAEIDEAELKIVKLDVDDNPNTAQQFGIMSIPTLLFKKDG
KVVKQVAGVHTKDQIKAIVAELS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=89, Percent_Identity=34.8314606741573, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=47.3684210526316, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1788936, Length=75, Percent_Identity=40, Blast_Score=66, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=44.8717948717949, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=42.8571428571429, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=77, Percent_Identity=37.6623376623377, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=79, Percent_Identity=43.0379746835443, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=79, Percent_Identity=32.9113924050633, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11366; Mature: 11235

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIVTDATFEAETNEGLVLVDFWATWCGPCLMQAPILDQLAAEIDEAELKIVKLDVDDN
CCEECCCCEEECCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCC
PNTAQQFGIMSIPTLLFKKDGKVVKQVAGVHTKDQIKAIVAELS
CCHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AHIVTDATFEAETNEGLVLVDFWATWCGPCLMQAPILDQLAAEIDEAELKIVKLDVDDN
CEECCCCEEECCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCC
PNTAQQFGIMSIPTLLFKKDGKVVKQVAGVHTKDQIKAIVAELS
CCHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]