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The map label for this gene is mutSB [H]

Identifier: 195977479

GI number: 195977479

Start: 354391

End: 356727

Strand: Direct

Name: mutSB [H]

Synonym: Sez_0334

Alternate gene names: 195977479

Gene position: 354391-356727 (Clockwise)

Preceding gene: 195977478

Following gene: 195977480

Centisome position: 17.51

GC content: 47.33

Gene sequence:

>2337_bases
ATGGAAAAAAAGATTTTAGAACAGTTAGAATTTGAAAAGGTTAAAGAGCAATTTTGGCCTTATTTACAGACAGAGCAGGG
GCAGCTAGAGCTTGACTTGTTGGAGCCTATTGCGAATAAAGACAAAATACAGGCTTACTTTACAGAGCTTGAGGAAATGG
CGGCTATTTTTGTAGAGCACCACCATTTTGCCTTGGGAGGGCTATCAGATGTCTCAGAAAGCATGCAGCGTTTGGATTTA
GAGGCAGATCTGAGCATTCAAGAGCTTTTAGAAGTCAAAAAGCTCCTGCAGGTGTCGGCAGAGGCCTGTCGTTTTTATGC
CGATTTGGAAAATGTTGATTTAGTTGCTCTAAAAGCACTCTTTGAAAAAATAGAGAGTTTTCCTAGCCTACAGGGGAGTC
TTCAGGCAATTAATGACGCAGGCTTTGTTGAAGGCTTTGCTAGTCCTGAGTTGGAGAGCATTCGTCGCCAGATATCAAAC
AAGGAACATGCCAGTCGTCAGCTCCTGCAGGATATCCTAAAAAAACAGGCAGCTTATTTGTCAGAGAGCCTGATTGCTAG
TCGTAACGGCCGAAGTGTCCTGCCTGTCAAAAACACCTATCGTCATAAAGTAGCAGGAGTTGTGCATGACATGTCAGCAT
CTGGCAGTACGGTCTACATTGAGCCTAGAGCGCTTGTAAGTCTCAATGAGGAGCTGACTCAGCTACAGACAGATGAACGC
CATGAGATTGGACGAATCTTGCATGAGCTGTCAGAGCAGCTGCGTCCCCATAGTCGATCTCTTAGGAATAACGCTTGGCT
ACTAGGTCACTTAGATCTTGTGAGAGCAAAATACCTTTATATGCAAGCCAAACAGGCAGCTGTGCCAGTGATTTCTGACG
ATAAAAGCTTACAGCTGCTCAATGCGCGCCACCCCTTGATTCAAAACCCTGTGGCAAATGACCTGCATTTTGCAAATGAT
CTAGCGGTAATTGTGATCACCGGTCCTAATACAGGTGGTAAGACCATCATGCTCAAAACCTTGGGGCTTGCTCAGGTGAT
GGCCCAGTCAGGTCTGCCTATTTTGGCTGACAAGGGCTCCAGGGTGGCAGTTTTTAATGGTATTTATGCTGATATTGGAG
ATGAGCAATCCATTGAGCAAAGCCTGTCTACCTTTTCCAGTCATATGACTCACATTGTTGAGATTCTCAAACAGGCAGAC
AGTGACAGCTTGATCCTCTTTGACGAGCTAGGAGCAGGGACTGACCCGCAGGAAGGAGCCAGCCTTGCTATGGCTATTTT
GGAGCAGCTGCGTCTGACCAATATCAAGACGATGGCCACCACCCATTACCCAGAGCTAAAGGCCTACGGGATTGAGACAG
CCTATGTTGAAAATGCCAGCATGGCCTTTGACAATGTCAGCCTAAAGCCTACTTACCGCTTTATGCAAGGAGTGCCTGGC
CGCTCAAACGCCTTTGACATTGCAAGACGATTAGGCTTGGCAGAGCATATCGTCAAGGAAGCTCAGGCAATGACCGCAAC
TAATCATGATGTCAATCGTATCATTGAGCAACTAGAGCAGCAAACGTTAGAAAGCCGCAAGCGTCTTGAACATATCAAGG
AGGTCGAGCAGGATAACCTCAAATTCAATCGTGCTGTTAAAAAGCTCTATAACGAATTCTCCCACGCCAAGGACAAGGAA
TTGGAAAAGGCAGCACTTGAAGCGCGTGAGATTGTGGATATGGCCTTGGCAGAAAGTGAGAGCATTTTAAGTCAGCTGCA
TGAAAAGGCAGAGCTAAAGCCGCACGAAATTATCGAAGCCAAGCATCGCCTAAAGCAGCTTGTGCCAGAGCAAAGCCTGT
CGCAAAATAAGGTGCTGAAAAAAGCGAAAAAATGGCGGGCTCCTCGTGTGGGTGATGATATCATTGTTACCGCCTATGGG
CAAAGAGGAACCTTGCTTGCCCAGCTTAAGGACAAGAGGTGGGAGGCTCAGGTTGGCCTGATCAAGTTGACCCTCAAGGA
AGACGAATTCAGCTTGGTTAAGCTAAAAGAAGAAGCGCAGCAGCCTAAGAAGAGGGCTGTCAAGGTCGTCAAAAAAGCAG
CTACAGGAAAAGGGCCGCGCGCTCGCTTGGACCTTCGAGGCAAGCGCTACGAGGAGGCCATGCAGGAACTAGATGCCTTT
ATCGACCAAGCCTTGCTTAACAACATGAGTCAGGTTGACATCATACATGGTATTGGTACAGGTGTTATACGTGAAGCGGT
CGGCAAGTACTTGCGACGCAACAAGCACGTCAAAAGCTTTGGCTATGCCCCGCAAAATGCCGGTGGATCAGGCTGTACCA
TAGCTAATCTAGGCTAA

Upstream 100 bases:

>100_bases
GCAATTATGGGTAACTGCTATTCTTTGAGGTCAGAGTCTCTCTGGTCTCTTTTTGTTTAGTGTCCCACATTTTAAGTGAT
TTTTAGGTATAATAAGAACT

Downstream 100 bases:

>100_bases
TTGCTCCTCTTGGGTCAAAACAAAAGCCCCTTTTCTGTACTCAAGCTGATTGAGCCCTAGGTGACACAAGCGCCCCAAAG
AAAGCTACTGGGCGTGTTCC

Product: recombination inhibitory protein MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEHHHFALGGLSDVSESMQRLDL
EADLSIQELLEVKKLLQVSAEACRFYADLENVDLVALKALFEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISN
KEHASRQLLQDILKKQAAYLSESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQTDER
HEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQAAVPVISDDKSLQLLNARHPLIQNPVANDLHFAND
LAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGSRVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILKQAD
SDSLILFDELGAGTDPQEGASLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPG
RSNAFDIARRLGLAEHIVKEAQAMTATNHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNLKFNRAVKKLYNEFSHAKDKE
LEKAALEAREIVDMALAESESILSQLHEKAELKPHEIIEAKHRLKQLVPEQSLSQNKVLKKAKKWRAPRVGDDIIVTAYG
QRGTLLAQLKDKRWEAQVGLIKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAF
IDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG

Sequences:

>Translated_778_residues
MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEHHHFALGGLSDVSESMQRLDL
EADLSIQELLEVKKLLQVSAEACRFYADLENVDLVALKALFEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISN
KEHASRQLLQDILKKQAAYLSESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQTDER
HEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQAAVPVISDDKSLQLLNARHPLIQNPVANDLHFAND
LAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGSRVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILKQAD
SDSLILFDELGAGTDPQEGASLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPG
RSNAFDIARRLGLAEHIVKEAQAMTATNHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNLKFNRAVKKLYNEFSHAKDKE
LEKAALEAREIVDMALAESESILSQLHEKAELKPHEIIEAKHRLKQLVPEQSLSQNKVLKKAKKWRAPRVGDDIIVTAYG
QRGTLLAQLKDKRWEAQVGLIKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAF
IDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG
>Mature_778_residues
MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEHHHFALGGLSDVSESMQRLDL
EADLSIQELLEVKKLLQVSAEACRFYADLENVDLVALKALFEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISN
KEHASRQLLQDILKKQAAYLSESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQTDER
HEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQAAVPVISDDKSLQLLNARHPLIQNPVANDLHFAND
LAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGSRVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILKQAD
SDSLILFDELGAGTDPQEGASLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPG
RSNAFDIARRLGLAEHIVKEAQAMTATNHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNLKFNRAVKKLYNEFSHAKDKE
LEKAALEAREIVDMALAESESILSQLHEKAELKPHEIIEAKHRLKQLVPEQSLSQNKVLKKAKKWRAPRVGDDIIVTAYG
QRGTLLAQLKDKRWEAQVGLIKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAF
IDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=304, Percent_Identity=29.9342105263158, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI36949366, Length=327, Percent_Identity=27.217125382263, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4504191, Length=255, Percent_Identity=27.0588235294118, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4557761, Length=294, Percent_Identity=28.9115646258503, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI26638666, Length=269, Percent_Identity=27.1375464684015, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4505253, Length=269, Percent_Identity=27.1375464684015, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI26638664, Length=270, Percent_Identity=27.037037037037, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI262231786, Length=133, Percent_Identity=35.3383458646617, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1789089, Length=269, Percent_Identity=28.996282527881, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=335, Percent_Identity=24.4776119402985, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=376, Percent_Identity=23.6702127659574, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17508447, Length=197, Percent_Identity=26.3959390862944, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=328, Percent_Identity=25.3048780487805, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324482, Length=388, Percent_Identity=23.9690721649485, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319935, Length=221, Percent_Identity=29.8642533936652, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321109, Length=302, Percent_Identity=25.1655629139073, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320047, Length=293, Percent_Identity=24.5733788395904, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=237, Percent_Identity=24.0506329113924, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24584320, Length=291, Percent_Identity=28.8659793814433, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664545, Length=234, Percent_Identity=29.0598290598291, Blast_Score=92, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87174; Mature: 87174

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEH
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HHFALGGLSDVSESMQRLDLEADLSIQELLEVKKLLQVSAEACRFYADLENVDLVALKAL
HHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISNKEHASRQLLQDILKKQAAYL
HHHHHHCCCCCHHHHHHCCCHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQTDER
HHHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCHH
HEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQAAVPVISDDKSLQLL
HHHHHHHHHHHHHHCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCHHHH
NARHPLIQNPVANDLHFANDLAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGS
HCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEECCCC
RVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILKQADSDSLILFDELGAGTDPQEGA
EEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHH
SLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPG
HHHHHHHHHHHHHCHHHHHHCCCCCHHHCCCCHHEECCCHHHCCCCCCCHHHHHHCCCCC
RSNAFDIARRLGLAEHIVKEAQAMTATNHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KFNRAVKKLYNEFSHAKDKELEKAALEAREIVDMALAESESILSQLHEKAELKPHEIIEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KHRLKQLVPEQSLSQNKVLKKAKKWRAPRVGDDIIVTAYGQRGTLLAQLKDKRWEAQVGL
HHHHHHHCCHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCE
IKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAF
EEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHH
IDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure
MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEH
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HHFALGGLSDVSESMQRLDLEADLSIQELLEVKKLLQVSAEACRFYADLENVDLVALKAL
HHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISNKEHASRQLLQDILKKQAAYL
HHHHHHCCCCCHHHHHHCCCHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQTDER
HHHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCHH
HEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQAAVPVISDDKSLQLL
HHHHHHHHHHHHHHCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCHHHH
NARHPLIQNPVANDLHFANDLAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGS
HCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEECCCC
RVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILKQADSDSLILFDELGAGTDPQEGA
EEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHH
SLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPG
HHHHHHHHHHHHHCHHHHHHCCCCCHHHCCCCHHEECCCHHHCCCCCCCHHHHHHCCCCC
RSNAFDIARRLGLAEHIVKEAQAMTATNHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KFNRAVKKLYNEFSHAKDKELEKAALEAREIVDMALAESESILSQLHEKAELKPHEIIEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KHRLKQLVPEQSLSQNKVLKKAKKWRAPRVGDDIIVTAYGQRGTLLAQLKDKRWEAQVGL
HHHHHHHCCHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCE
IKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAF
EEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHH
IDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA