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The map label for this gene is norA [H]

Identifier: 195977466

GI number: 195977466

Start: 339788

End: 340987

Strand: Direct

Name: norA [H]

Synonym: Sez_0321

Alternate gene names: 195977466

Gene position: 339788-340987 (Clockwise)

Preceding gene: 195977463

Following gene: 195977467

Centisome position: 16.79

GC content: 45.08

Gene sequence:

>1200_bases
GTGGAAGATAAATTATTTAACAAGCATTTTGTAGGGATCACAGTATTAAATTTTATTGTGTATATGGTCTATTACTTGTT
TACGGTGATCATTGCCTTTGTTGCGACTAAGGAATTAGGGGCTAAGACCAGTGAGGCAGGTCTGGCGACAGGGATTTATA
TCCTAGGAACTCTGCTTGCGCGACTGATCTTTGGCAAGCAATTGGAGGTTTTGGGGCGACGATTAGTGCTAAGAGGCGGG
GCTATTTTTTACCTGTTGACCACCTTGGCTTACTTTTTCATGCCAACGATTGGCATGATGTATCTTGTCAGGCTGCTAAA
CGGCTTTGGCTATGGTGTTGTCTCAACAGCAACCAATACCATTGTGACTGCCTATATCCCAGCTAGAAAGCGTGGAGAGG
GGATCAATTTTTATGGCTTATCAACTAGTCTAGCAGCAGCTATTGGTCCTTTTGTGGGTACCTTTATGCTGGATAATCTG
CACATAGATTTTCGATTGATTATTGTCTTGTGTAGTGTCTTGATTGCAGTGGTTGTGGCGGGGGCTTTTGCCTTTCCTGT
GACAAATATTAGCCTTAACTCAGAGCAGCTAGCTAAAACAAAATCCTGGACGGTTGATAGCTTTATTGAACAGAAGGCTC
TGTTTATTACCCTCATTGCCTTTTTGATGGGGATTGCCTATGCGTCTGTGCTAGGCTTTCAAAAATTATACACAACAGAG
ATTCATTTAACGACGGTGGGAGCCTATTTCTTTGTGGTATATGCCTTGATCATTACGATCACACGACCTGCTATGGGACG
CTTGATGGACGTTAAGGGGGAGCAGTGGGTTCTTTATCCCAGCTATCTCTTTTTGGCGCTGGGGCTTTTCCTGCTTGGTA
GTGTGACAAGCAGCCTTCCCTATCTGCTTTCGGGTGCTTTGATAGGCTTTGGCTATGGAACCTTTATGTCCTGCGGACAG
GCTGCTTCTATCAAGGGTGTCGAAGAGCATCGCTTTAACACCGCTATGTCTACTTATATGATTGGGCTAGACCTGGGCTT
GGGGGCTGGACCTTATCTATTGGGACTCATCAAGGATATGCTTCTTGGGTCTGGTGTGCAGTCCTTTCGCCAATTGTTCT
GGCTAGCAGCGGTCATTCCAGTCGCCTGCGCAGTCATGTATTTCCTAAAGACACAAGCAAAGGCTATTGATAAAGGCTAA

Upstream 100 bases:

>100_bases
TAATGTCCTTTAATAGTATCACCTATATTATACCATTGAAATGGGGCCTTATCTGATTTTTTTGTAAAATGTTAATGAAA
TAGAGAGGAGCTCATTTTCA

Downstream 100 bases:

>100_bases
TCAACGAAAGGAGACAAAGATGATAAGCAAATATAAACGGATTCTGGCTGCTGTAGATGGCTCTTACGAATCAGAATTAG
CTGTTGAGAAGGCCATTAAT

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MEDKLFNKHFVGITVLNFIVYMVYYLFTVIIAFVATKELGAKTSEAGLATGIYILGTLLARLIFGKQLEVLGRRLVLRGG
AIFYLLTTLAYFFMPTIGMMYLVRLLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRLIIVLCSVLIAVVVAGAFAFPVTNISLNSEQLAKTKSWTVDSFIEQKALFITLIAFLMGIAYASVLGFQKLYTTE
IHLTTVGAYFFVVYALIITITRPAMGRLMDVKGEQWVLYPSYLFLALGLFLLGSVTSSLPYLLSGALIGFGYGTFMSCGQ
AASIKGVEEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDMLLGSGVQSFRQLFWLAAVIPVACAVMYFLKTQAKAIDKG

Sequences:

>Translated_399_residues
MEDKLFNKHFVGITVLNFIVYMVYYLFTVIIAFVATKELGAKTSEAGLATGIYILGTLLARLIFGKQLEVLGRRLVLRGG
AIFYLLTTLAYFFMPTIGMMYLVRLLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRLIIVLCSVLIAVVVAGAFAFPVTNISLNSEQLAKTKSWTVDSFIEQKALFITLIAFLMGIAYASVLGFQKLYTTE
IHLTTVGAYFFVVYALIITITRPAMGRLMDVKGEQWVLYPSYLFLALGLFLLGSVTSSLPYLLSGALIGFGYGTFMSCGQ
AASIKGVEEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDMLLGSGVQSFRQLFWLAAVIPVACAVMYFLKTQAKAIDKG
>Mature_399_residues
MEDKLFNKHFVGITVLNFIVYMVYYLFTVIIAFVATKELGAKTSEAGLATGIYILGTLLARLIFGKQLEVLGRRLVLRGG
AIFYLLTTLAYFFMPTIGMMYLVRLLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRLIIVLCSVLIAVVVAGAFAFPVTNISLNSEQLAKTKSWTVDSFIEQKALFITLIAFLMGIAYASVLGFQKLYTTE
IHLTTVGAYFFVVYALIITITRPAMGRLMDVKGEQWVLYPSYLFLALGLFLLGSVTSSLPYLLSGALIGFGYGTFMSCGQ
AASIKGVEEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDMLLGSGVQSFRQLFWLAAVIPVACAVMYFLKTQAKAIDKG

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43549; Mature: 43549

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]