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The map label for this gene is gap [H]

Identifier: 195977417

GI number: 195977417

Start: 291899

End: 292909

Strand: Direct

Name: gap [H]

Synonym: Sez_0270

Alternate gene names: 195977417

Gene position: 291899-292909 (Clockwise)

Preceding gene: 195977415

Following gene: 195977418

Centisome position: 14.42

GC content: 41.44

Gene sequence:

>1011_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTCGGTCGTATCGGTCGTCTTGCGTTCCGTCTTATCCAAAATGTAGAAGGTGT
TGAAGTAACTCGCATCAACGACTTGACAGATCCAGCGATGTTAGCACATCTTTTGAAATATGATTCAACTCAAGGACGCT
TTGATGGCGACGTTGAAGTAGTAGAAGGTGGATTTAACGTTAACGGTAAATTTGTTAAGGTTTCTGCTGAAGCTAACCCT
GAAAACATTGACTGGGCTTCACAAGAAGTAGATATCGTTTTGGAAGCAACTGGTTTCTTCGCTTCAAAAGCTGGTGCTGA
AAAGCACTTACATGCTAATGGTGCTAAGAAGGTTGTTATCACTGCTCCTGGTGGAAACGATGTTAAAACTGTTGTTTTCA
ACACTAACCACGAAATTCTGGATGGTACTGAAACAGTTATCTCAGGTGCTTCATGTACAACTAACTGTCTTGCACCAATG
GCTAAAGTTCTTCAAGACCAATTTGGTGTTGTTGAAGGATTGATGACAACTATCCATGGTTACACTGGTGACCAAATGAC
TCTTGATGCACCACACCGTAAGGGTGATTTCCGTCGCGCACGTGCTGCAGCTGTGAACATTGTTCCTAACTCAACTGGTG
CTGCAAAAGCTATCGGCCTTGTTATTCCAGAGCTTAATGGTAAGCTTGACGGTGCTGCACAACGTGTTCCAGTTCCAACA
GGATCTGTTACTGAATTAGTATCTGTACTTGAAAAAGAAGTTACAGCTGACGAAGTGAATGCTGCAATGAAGGCTGCTGC
AAACGATAGCTTTGGTTACACTGAAGATCAAATCGTATCAAGCGACGTTGTAGGTATCCACTATGGTTCATTGTTTGATG
CAACTCAAACTAAGGTATTGACAGTTGACGGTAAACAATTGGTTAAAACTGTTTCATGGTATGACAACGAAATGTCATAC
ACTGCTCAGCTTGTTCGTACACTTGAGTACTTTGCAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
AGGGTTGTTGCAGGAATCTGCAAGTTAATCTTTTCACAATAGGCAGGGATTAATCCCTTTAATAATAATTCTTTTGATTT
TCATAAGGAGGAAATCACTA

Downstream 100 bases:

>100_bases
TGACTAGAGGGCCTAGTTTACCTAGGCTCTTTTTTGTGTCATGATAAAGGTTGCTTATCCCTCATTGGCTAGCTTATTGC
TGAACTTGCACTTAGGCTTA

Product: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase / plasmin(ogen) receptor

Products: NA

Alternate protein names: GAPDH; Plasmin receptor; Plasminogen-binding protein [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVVKVGINGFGRIGRLAFRLIQNVEGVEVTRINDLTDPAMLAHLLKYDSTQGRFDGDVEVVEGGFNVNGKFVKVSAEANP
ENIDWASQEVDIVLEATGFFASKAGAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHEILDGTETVISGASCTTNCLAPM
AKVLQDQFGVVEGLMTTIHGYTGDQMTLDAPHRKGDFRRARAAAVNIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVSVLEKEVTADEVNAAMKAAANDSFGYTEDQIVSSDVVGIHYGSLFDATQTKVLTVDGKQLVKTVSWYDNEMSY
TAQLVRTLEYFAKIAK

Sequences:

>Translated_336_residues
MVVKVGINGFGRIGRLAFRLIQNVEGVEVTRINDLTDPAMLAHLLKYDSTQGRFDGDVEVVEGGFNVNGKFVKVSAEANP
ENIDWASQEVDIVLEATGFFASKAGAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHEILDGTETVISGASCTTNCLAPM
AKVLQDQFGVVEGLMTTIHGYTGDQMTLDAPHRKGDFRRARAAAVNIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVSVLEKEVTADEVNAAMKAAANDSFGYTEDQIVSSDVVGIHYGSLFDATQTKVLTVDGKQLVKTVSWYDNEMSY
TAQLVRTLEYFAKIAK
>Mature_336_residues
MVVKVGINGFGRIGRLAFRLIQNVEGVEVTRINDLTDPAMLAHLLKYDSTQGRFDGDVEVVEGGFNVNGKFVKVSAEANP
ENIDWASQEVDIVLEATGFFASKAGAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHEILDGTETVISGASCTTNCLAPM
AKVLQDQFGVVEGLMTTIHGYTGDQMTLDAPHRKGDFRRARAAAVNIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVSVLEKEVTADEVNAAMKAAANDSFGYTEDQIVSSDVVGIHYGSLFDATQTKVLTVDGKQLVKTVSWYDNEMSY
TAQLVRTLEYFAKIAK

Specific function: Also binds human plasminogen [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=335, Percent_Identity=44.7761194029851, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI7657116, Length=332, Percent_Identity=43.9759036144578, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1788079, Length=337, Percent_Identity=49.8516320474777, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1789295, Length=343, Percent_Identity=38.4839650145773, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=46.4705882352941, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=46.4705882352941, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=45.8823529411765, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=45.8823529411765, Blast_Score=264, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6322409, Length=337, Percent_Identity=45.6973293768546, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6321631, Length=337, Percent_Identity=46.8842729970326, Blast_Score=280, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6322468, Length=337, Percent_Identity=46.5875370919881, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI17933600, Length=334, Percent_Identity=45.8083832335329, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI18110149, Length=334, Percent_Identity=45.8083832335329, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI85725000, Length=334, Percent_Identity=45.5089820359281, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI22023983, Length=334, Percent_Identity=45.5089820359281, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=43.202416918429, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35889; Mature: 35889

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLAFRLIQNVEGVEVTRINDLTDPAMLAHLLKYDSTQGRFDGDVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEE
VEGGFNVNGKFVKVSAEANPENIDWASQEVDIVLEATGFFASKAGAEKHLHANGAKKVVI
EECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEECCCCCEEEE
TAPGGNDVKTVVFNTNHEILDGTETVISGASCTTNCLAPMAKVLQDQFGVVEGLMTTIHG
ECCCCCCEEEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTGDQMTLDAPHRKGDFRRARAAAVNIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
CCCCEEEECCCCCCCHHHHHHEEEEEEEECCCCCHHEEEEEEECCCCCCCCCCCCCCCCC
GSVTELVSVLEKEVTADEVNAAMKAAANDSFGYTEDQIVSSDVVGIHYGSLFDATQTKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCEECCCCEEEE
TVDGKQLVKTVSWYDNEMSYTAQLVRTLEYFAKIAK
EECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLAFRLIQNVEGVEVTRINDLTDPAMLAHLLKYDSTQGRFDGDVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEE
VEGGFNVNGKFVKVSAEANPENIDWASQEVDIVLEATGFFASKAGAEKHLHANGAKKVVI
EECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEECCCCCEEEE
TAPGGNDVKTVVFNTNHEILDGTETVISGASCTTNCLAPMAKVLQDQFGVVEGLMTTIHG
ECCCCCCEEEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTGDQMTLDAPHRKGDFRRARAAAVNIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
CCCCEEEECCCCCCCHHHHHHEEEEEEEECCCCCHHEEEEEEECCCCCCCCCCCCCCCCC
GSVTELVSVLEKEVTADEVNAAMKAAANDSFGYTEDQIVSSDVVGIHYGSLFDATQTKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCEECCCCEEEE
TVDGKQLVKTVSWYDNEMSYTAQLVRTLEYFAKIAK
EECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8706717 [H]