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The map label for this gene is glmU [H]

Identifier: 195977349

GI number: 195977349

Start: 222202

End: 223581

Strand: Direct

Name: glmU [H]

Synonym: Sez_0202

Alternate gene names: 195977349

Gene position: 222202-223581 (Clockwise)

Preceding gene: 195977348

Following gene: 195977350

Centisome position: 10.98

GC content: 50.58

Gene sequence:

>1380_bases
ATGAAAAACTACGCCATTATCCTAGCAGCTGGAAAGGGAACGCGCATGAAGTCAGCGCTTCCCAAGGTGCTGCACAAGGT
ATCAGGCCTAAGCATGCTGGAGCATGTCCTCAAGAGTGTCTCAGCCCTAGCCCCTCAAAAGCAGCTCACAGTGATCGGTC
ATCAGGCAGAGCAGGTGCGTGCTGTCCTAGGAGAGCAATCGCTAACAGTGGTGCAAGAGGAGCAGCTAGGGACAGGCCAT
GCAGTCATGATGGCAGAAGAGGAGCTATCTGGCTTAGAGGGGCAAACCCTAGTGATTGCAGGTGACACCCCCTTGATCAG
AGGAGAAAGCCTCAAGGCTCTGCTAGACTATCATATCAGAGAAAAGAATGTGGCAACCATTCTCACAGCCAATGCCAAGG
ATCCCTTTGGCTATGGACGAATCATTCGCAATGCAGCAGGAGAGGTGGTCAACATCGTTGAGCAAAAGGATGCTAATGAG
GCAGAGCAAGAGGTCAAGGAGATCAACACAGGGACTTATATCTTTGACAATAAGCGCCTTTTTGAGGCTCTAAAGCATCT
CACGACTGATAATGCCCAAGGGGAGTACTACCTAACCGATGTGATCAGTATTTTCAAGGCTGGCCAAGAAAGGGTTGGCG
CTTACCTGCTGAAGGACTTTGATGAGAGCCTAGGGGTTAATGATCGCTTAGCTCTAGCCCAGGCCGAGGTGATTATGCAA
GAGCGGATCAACAGGCAGCACATGCTTAATGGGGTGACCCTGCAAAACCCGGCAGCTACCTATATTGAAAGCAGTGTAGA
GATTGCACCAGACGTCTTGATTGAAGCCAATGTGACCTTAAAGGGACAGACTAGAATTGGCAGCAGAAGTGTCATAAGCA
ATGGGAGCTATATCCTTGATTCGAGGCTTGGTGAGGGTGTAGTGGTTAGCCAGTCGGTGATTGAGGCTTCAGTCTTAGCA
GATGGAGTGACAGTAGGGCCATATGCACACATTCGCCCGGACTCCCAGCTCGATGAGTGTGTTCATATTGGGAACTTTGT
AGAGGTTAAGGGGTCTCATCTAGGGGCCAATACCAAGGCAGGGCATTTGACTTACCTGGGGAATGCCGAGATTGGCTCAG
AGGTTAACATTGGTGCAGGAAGCATTACGGTTAATTATGATGGTCAACGGAAATACCAGACAGTGATTGGCGATCACGCT
TTTATTGGGAGTCATTCGACTTTGATAGCTCCGGTAGAGGTTGGGGAGAATGCTTTAACAGCAGCAGGGTCTACGATAGC
CCAGTCAGTGCCGGCAGACAGTGTGGCTATAGGGCGCAGCCGTCAGGTGGTGAAGGAAGGCTATGCCAAGAGGCTGCCGC
ACCACCCAAATCAAGCCTAA

Upstream 100 bases:

>100_bases
GGATTGGTATCTCACTTTTTAGGCTGACTTGTATTAATACCAAAAGCCAAAACTAGGCAGATAAGCATAAGGAATTAGAT
TAAAAATAAGGAACCAAAAC

Downstream 100 bases:

>100_bases
TCGCTCAACCAAAAGAGGCAGGTGAGAAAACCTAGGCCATTAAAAAAGCTTTTGAAAAGAGATGATTATCGGGTAGCTAG
GAGTAGCCACCTGTTTCTTA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase / glucosamine-1-phosphate N-acetyltransferase protein GlmU

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKNYAIILAAGKGTRMKSALPKVLHKVSGLSMLEHVLKSVSALAPQKQLTVIGHQAEQVRAVLGEQSLTVVQEEQLGTGH
AVMMAEEELSGLEGQTLVIAGDTPLIRGESLKALLDYHIREKNVATILTANAKDPFGYGRIIRNAAGEVVNIVEQKDANE
AEQEVKEINTGTYIFDNKRLFEALKHLTTDNAQGEYYLTDVISIFKAGQERVGAYLLKDFDESLGVNDRLALAQAEVIMQ
ERINRQHMLNGVTLQNPAATYIESSVEIAPDVLIEANVTLKGQTRIGSRSVISNGSYILDSRLGEGVVVSQSVIEASVLA
DGVTVGPYAHIRPDSQLDECVHIGNFVEVKGSHLGANTKAGHLTYLGNAEIGSEVNIGAGSITVNYDGQRKYQTVIGDHA
FIGSHSTLIAPVEVGENALTAAGSTIAQSVPADSVAIGRSRQVVKEGYAKRLPHHPNQA

Sequences:

>Translated_459_residues
MKNYAIILAAGKGTRMKSALPKVLHKVSGLSMLEHVLKSVSALAPQKQLTVIGHQAEQVRAVLGEQSLTVVQEEQLGTGH
AVMMAEEELSGLEGQTLVIAGDTPLIRGESLKALLDYHIREKNVATILTANAKDPFGYGRIIRNAAGEVVNIVEQKDANE
AEQEVKEINTGTYIFDNKRLFEALKHLTTDNAQGEYYLTDVISIFKAGQERVGAYLLKDFDESLGVNDRLALAQAEVIMQ
ERINRQHMLNGVTLQNPAATYIESSVEIAPDVLIEANVTLKGQTRIGSRSVISNGSYILDSRLGEGVVVSQSVIEASVLA
DGVTVGPYAHIRPDSQLDECVHIGNFVEVKGSHLGANTKAGHLTYLGNAEIGSEVNIGAGSITVNYDGQRKYQTVIGDHA
FIGSHSTLIAPVEVGENALTAAGSTIAQSVPADSVAIGRSRQVVKEGYAKRLPHHPNQA
>Mature_459_residues
MKNYAIILAAGKGTRMKSALPKVLHKVSGLSMLEHVLKSVSALAPQKQLTVIGHQAEQVRAVLGEQSLTVVQEEQLGTGH
AVMMAEEELSGLEGQTLVIAGDTPLIRGESLKALLDYHIREKNVATILTANAKDPFGYGRIIRNAAGEVVNIVEQKDANE
AEQEVKEINTGTYIFDNKRLFEALKHLTTDNAQGEYYLTDVISIFKAGQERVGAYLLKDFDESLGVNDRLALAQAEVIMQ
ERINRQHMLNGVTLQNPAATYIESSVEIAPDVLIEANVTLKGQTRIGSRSVISNGSYILDSRLGEGVVVSQSVIEASVLA
DGVTVGPYAHIRPDSQLDECVHIGNFVEVKGSHLGANTKAGHLTYLGNAEIGSEVNIGAGSITVNYDGQRKYQTVIGDHA
FIGSHSTLIAPVEVGENALTAAGSTIAQSVPADSVAIGRSRQVVKEGYAKRLPHHPNQA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=448, Percent_Identity=42.6339285714286, Blast_Score=338, Evalue=6e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49267; Mature: 49267

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYAIILAAGKGTRMKSALPKVLHKVSGLSMLEHVLKSVSALAPQKQLTVIGHQAEQVR
CCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
AVLGEQSLTVVQEEQLGTGHAVMMAEEELSGLEGQTLVIAGDTPLIRGESLKALLDYHIR
HHHCCCCEEEEEHHHCCCCEEEEEEHHHHCCCCCCEEEEECCCCEECCCHHHHHHHHHHC
EKNVATILTANAKDPFGYGRIIRNAAGEVVNIVEQKDANEAEQEVKEINTGTYIFDNKRL
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHHH
FEALKHLTTDNAQGEYYLTDVISIFKAGQERVGAYLLKDFDESLGVNDRLALAQAEVIMQ
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ERINRQHMLNGVTLQNPAATYIESSVEIAPDVLIEANVTLKGQTRIGSRSVISNGSYILD
HHHCHHHHHCCCEECCCHHHHHHCCCCCCCCEEEEECEEEECCCCCCCCCEECCCCEEEE
SRLGEGVVVSQSVIEASVLADGVTVGPYAHIRPDSQLDECVHIGNFVEVKGSHLGANTKA
CCCCCCEEEHHHHHHHHHHHCCCEECCEEEECCCHHHHHHHHCCCEEEECCCCCCCCCCC
GHLTYLGNAEIGSEVNIGAGSITVNYDGQRKYQTVIGDHAFIGSHSTLIAPVEVGENALT
CEEEEECCCCCCCEEECCCCEEEEEECCCCHHHHHHCCCEEECCCCEEEEEEECCCCHHH
AAGSTIAQSVPADSVAIGRSRQVVKEGYAKRLPHHPNQA
HCCHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNYAIILAAGKGTRMKSALPKVLHKVSGLSMLEHVLKSVSALAPQKQLTVIGHQAEQVR
CCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
AVLGEQSLTVVQEEQLGTGHAVMMAEEELSGLEGQTLVIAGDTPLIRGESLKALLDYHIR
HHHCCCCEEEEEHHHCCCCEEEEEEHHHHCCCCCCEEEEECCCCEECCCHHHHHHHHHHC
EKNVATILTANAKDPFGYGRIIRNAAGEVVNIVEQKDANEAEQEVKEINTGTYIFDNKRL
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHHH
FEALKHLTTDNAQGEYYLTDVISIFKAGQERVGAYLLKDFDESLGVNDRLALAQAEVIMQ
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ERINRQHMLNGVTLQNPAATYIESSVEIAPDVLIEANVTLKGQTRIGSRSVISNGSYILD
HHHCHHHHHCCCEECCCHHHHHHCCCCCCCCEEEEECEEEECCCCCCCCCEECCCCEEEE
SRLGEGVVVSQSVIEASVLADGVTVGPYAHIRPDSQLDECVHIGNFVEVKGSHLGANTKA
CCCCCCEEEHHHHHHHHHHHCCCEECCEEEECCCHHHHHHHHCCCEEEECCCCCCCCCCC
GHLTYLGNAEIGSEVNIGAGSITVNYDGQRKYQTVIGDHAFIGSHSTLIAPVEVGENALT
CEEEEECCCCCCCEEECCCCEEEEEECCCCHHHHHHCCCEEECCCCEEEEEEECCCCHHH
AAGSTIAQSVPADSVAIGRSRQVVKEGYAKRLPHHPNQA
HCCHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA