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The map label for this gene is clpC [H]

Identifier: 195977287

GI number: 195977287

Start: 151392

End: 153812

Strand: Direct

Name: clpC [H]

Synonym: Sez_0140

Alternate gene names: 195977287

Gene position: 151392-153812 (Clockwise)

Preceding gene: 195977286

Following gene: 195977288

Centisome position: 7.48

GC content: 44.32

Gene sequence:

>2421_bases
ATGCAAGACATTTTTAATCAGGCTCAATTTCAGGCAGAGCGCTTTGATAGTCCTTACCTTGAGACCTGGCACATTTTATT
AGCTATGGTAGCTGTTGATCATTCTTTAGCAGCCATGGTTTTAAGCGAATTTGAACGAAAGATCAGAGCTGAAGAGTATG
AGGCAGCTGCTATTTTAGCTATGGGAAAAAGTCCCAAGGAGGTGACTTCTGTCCAATTCAAGCCGCAATCCAAGGCCTTA
TCAGAAATACTAGCATTTGCTCATGCTATCTGTCAGGTCACCAATGAGCATGAGGTTGGCTCAGAGCATGTGCTTTTTGC
TATTTTGCTCAATCCGGACATTATGGCTAGTCGTCTATTAGAATTGGCAGGCTATAGGCTTAAGGATTCTGGCAAGGGAG
AGCCTAGGTTTGCGGATTTACGTAAGGCTATTGAGTTAAATGCCGGCTATAGTAAGGAAACCATTAAGGCGATTCATGAG
TTGCGTAAGCCTAAAAAGACGAAATCAGTAGGCACCTTTTCTGAAATGATGAAGCCACAGAGTACAGCTGGTGAGCTATC
AGACTTTACTAGAGACCTGACAGAGATGGCAAGACAGGGCTTGTTAGAGCCAGTTATCGGACGAGAAAAAGAGGTGTCAC
GTATGGTTCAGGTGCTCTGTCGTAAGACTAAAAATAATCCTGTTCTTGTTGGTGATGCGGGTGTTGGAAAAACTGCTCTA
GCTTATGGCTTGGCACAGCGTATTGCAAGCGGCGTGATTCCTTATGAATTACAGGACATGCGTGTCTTGGAGCTTGACAT
GATGAGTGTGGTTGCAGGTACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATCAACTCATTGACGATATTGAAGCAG
ATGGCAAAATCATCTTGTTTGTCGATGAGCTACATACCATTATGGGATCAGGAAGTGGTATTGACAGCACTCTTGATGCA
GCTAATATTCTAAAGCCAGCCCTTTCTCGCGGTACCCTGCATATGGTTGGCGCTACAACTCAAGAGGAATATCAAAAGCA
TATTGAAAAGGACGCAGCTCTTTCTCGTCGCTTTGCCAAGATATTGATTGAGGAGCCTAGTGTCGATGATGCTTATCAGA
TTTTGCTTGGCTTGAGGGCCTCCTATGAACAGTACCATAATGTAACAATCTCTGATAAAGCTGTTCATACTGCTGTGAAG
CTGGCCCAGCGCTACTTGACGAGTAAGCGGCTTCCAGATTCAGCGATTGATCTGCTTGATGAAGCTAGTGCGATGGTACA
AAGCATGGTTAAAAAGACGCAGCCTGACTTTATAACGCCGCTTGATCAAGCCCTGCTTGATGGTGATATGAGCAAGGTGT
CAGCCCTTTTAGCCAAAGAGGATAAGCAACCAAAGCTAAAACCAACAGCAGTTACTGAAGATGATATGTTACACACCTTA
AGCAAGCTATCAGGTATTCCCCTAGAAAAACTAACTCAGGCGGATAGTAAAAAATATCTGAATCTGGAAAAGGAATTGCA
TAAGCGTGTTGTTGGTCAGGAAATGGCTGTTTCTGCTATTGCACGAGCCATTCGTCGTAACCAGTCAGGCATTCGCACAG
GCAGGCGTCCGATTGGCTCCTTTATGTTTCTTGGTCCAACTGGTGTCGGAAAAACAGAGCTAGCAAAGGCCTTGGCCGAA
TTACTCTTTGATGATGAGTCAGCCCTTATTCGTTTTGATATGTCTGAGTACATGGAAAAATTTGCAGCCTCCCGTCTTAA
TGGGGCTCCTCCTGGCTATGTTGGCTATGATGAGGGAGGAGAGCTAACCGAAAAGGTTAGAAATAAGCCTTATGCCGTTC
TTCTTTTTGATGAGGTTGAAAAGGCTCACCCAGACATCTTTAATATCCTGCTGCAGGTCCTTGATGATGGTATGTTAACA
GATAGTCGTGGACGTAAGGTTGATTTTTCAAACACGATTATTATCATGACGAGCAACCTAGGAGCAACTGCTCTAAGAGA
TGATAAGACGGTTGGATTTGGCGCTAAAGCGATCGGTCATGACCATCAAGCAATGGAAAAGCGTATTTTAGAGGAATTGA
AAAAGGCTTATCGGCCTGAATTTATCAACAGAATTGATGAAAAGGTGGTCTTCCACAGCCTAACACAGGAAAACATGCGT
GATGTGGTCAAAATTATGGTTAAGCCGCTGATTGCAGCCTTGGCAGAAAAGCATATTAGCCTTAAGTTCCAGCCATCAGC
TCTCAAGTACTTGTCTGAAGCTGGTTACGATGTTGAAATGGGGGCTCGCCCACTTCGTCGCACCTTGCAAACAGAGGTTG
AGGACAGGTTAGCAGAATTAATGCTGTCAGGAGAGTTATCAAGCGGTCAAAGCCTCAAGATTGGTGTATCACATGGGAAG
TTAGCTTTTGATATTGCTTGA

Upstream 100 bases:

>100_bases
TGGGACATCAAGCACCAGAAATTCGTGCTCGTATGCTTTATCGCCTATTGCAACGAATTGATAGAAAGGGAAGCAATTAG
TGATGACTTATTCATTAAAG

Downstream 100 bases:

>100_bases
TGACTGATTGCTTGCTATTAAGTTAAGAGCTTTGAGAGGGTCTGAGACAAAGTTTCTCAGACTCTTTTTATCGTGTAGTG
ATGAAGTACCAGAATGAGAG

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MQDIFNQAQFQAERFDSPYLETWHILLAMVAVDHSLAAMVLSEFERKIRAEEYEAAAILAMGKSPKEVTSVQFKPQSKAL
SEILAFAHAICQVTNEHEVGSEHVLFAILLNPDIMASRLLELAGYRLKDSGKGEPRFADLRKAIELNAGYSKETIKAIHE
LRKPKKTKSVGTFSEMMKPQSTAGELSDFTRDLTEMARQGLLEPVIGREKEVSRMVQVLCRKTKNNPVLVGDAGVGKTAL
AYGLAQRIASGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQLIDDIEADGKIILFVDELHTIMGSGSGIDSTLDA
ANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPSVDDAYQILLGLRASYEQYHNVTISDKAVHTAVK
LAQRYLTSKRLPDSAIDLLDEASAMVQSMVKKTQPDFITPLDQALLDGDMSKVSALLAKEDKQPKLKPTAVTEDDMLHTL
SKLSGIPLEKLTQADSKKYLNLEKELHKRVVGQEMAVSAIARAIRRNQSGIRTGRRPIGSFMFLGPTGVGKTELAKALAE
LLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYAVLLFDEVEKAHPDIFNILLQVLDDGMLT
DSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKAIGHDHQAMEKRILEELKKAYRPEFINRIDEKVVFHSLTQENMR
DVVKIMVKPLIAALAEKHISLKFQPSALKYLSEAGYDVEMGARPLRRTLQTEVEDRLAELMLSGELSSGQSLKIGVSHGK
LAFDIA

Sequences:

>Translated_806_residues
MQDIFNQAQFQAERFDSPYLETWHILLAMVAVDHSLAAMVLSEFERKIRAEEYEAAAILAMGKSPKEVTSVQFKPQSKAL
SEILAFAHAICQVTNEHEVGSEHVLFAILLNPDIMASRLLELAGYRLKDSGKGEPRFADLRKAIELNAGYSKETIKAIHE
LRKPKKTKSVGTFSEMMKPQSTAGELSDFTRDLTEMARQGLLEPVIGREKEVSRMVQVLCRKTKNNPVLVGDAGVGKTAL
AYGLAQRIASGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQLIDDIEADGKIILFVDELHTIMGSGSGIDSTLDA
ANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPSVDDAYQILLGLRASYEQYHNVTISDKAVHTAVK
LAQRYLTSKRLPDSAIDLLDEASAMVQSMVKKTQPDFITPLDQALLDGDMSKVSALLAKEDKQPKLKPTAVTEDDMLHTL
SKLSGIPLEKLTQADSKKYLNLEKELHKRVVGQEMAVSAIARAIRRNQSGIRTGRRPIGSFMFLGPTGVGKTELAKALAE
LLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYAVLLFDEVEKAHPDIFNILLQVLDDGMLT
DSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKAIGHDHQAMEKRILEELKKAYRPEFINRIDEKVVFHSLTQENMR
DVVKIMVKPLIAALAEKHISLKFQPSALKYLSEAGYDVEMGARPLRRTLQTEVEDRLAELMLSGELSSGQSLKIGVSHGK
LAFDIA
>Mature_806_residues
MQDIFNQAQFQAERFDSPYLETWHILLAMVAVDHSLAAMVLSEFERKIRAEEYEAAAILAMGKSPKEVTSVQFKPQSKAL
SEILAFAHAICQVTNEHEVGSEHVLFAILLNPDIMASRLLELAGYRLKDSGKGEPRFADLRKAIELNAGYSKETIKAIHE
LRKPKKTKSVGTFSEMMKPQSTAGELSDFTRDLTEMARQGLLEPVIGREKEVSRMVQVLCRKTKNNPVLVGDAGVGKTAL
AYGLAQRIASGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQLIDDIEADGKIILFVDELHTIMGSGSGIDSTLDA
ANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPSVDDAYQILLGLRASYEQYHNVTISDKAVHTAVK
LAQRYLTSKRLPDSAIDLLDEASAMVQSMVKKTQPDFITPLDQALLDGDMSKVSALLAKEDKQPKLKPTAVTEDDMLHTL
SKLSGIPLEKLTQADSKKYLNLEKELHKRVVGQEMAVSAIARAIRRNQSGIRTGRRPIGSFMFLGPTGVGKTELAKALAE
LLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYAVLLFDEVEKAHPDIFNILLQVLDDGMLT
DSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKAIGHDHQAMEKRILEELKKAYRPEFINRIDEKVVFHSLTQENMR
DVVKIMVKPLIAALAEKHISLKFQPSALKYLSEAGYDVEMGARPLRRTLQTEVEDRLAELMLSGELSSGQSLKIGVSHGK
LAFDIA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=34.0694006309148, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1787109, Length=704, Percent_Identity=40.1988636363636, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1788943, Length=342, Percent_Identity=50.2923976608187, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6320464, Length=332, Percent_Identity=48.4939759036145, Blast_Score=330, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6323002, Length=334, Percent_Identity=41.0179640718563, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 89525; Mature: 89525

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIFNQAQFQAERFDSPYLETWHILLAMVAVDHSLAAMVLSEFERKIRAEEYEAAAILA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MGKSPKEVTSVQFKPQSKALSEILAFAHAICQVTNEHEVGSEHVLFAILLNPDIMASRLL
ECCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHH
ELAGYRLKDSGKGEPRFADLRKAIELNAGYSKETIKAIHELRKPKKTKSVGTFSEMMKPQ
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
STAGELSDFTRDLTEMARQGLLEPVIGREKEVSRMVQVLCRKTKNNPVLVGDAGVGKTAL
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
AYGLAQRIASGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQLIDDIEADGKIILF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEE
VDELHTIMGSGSGIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ILIEEPSVDDAYQILLGLRASYEQYHNVTISDKAVHTAVKLAQRYLTSKRLPDSAIDLLD
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EASAMVQSMVKKTQPDFITPLDQALLDGDMSKVSALLAKEDKQPKLKPTAVTEDDMLHTL
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SKLSGIPLEKLTQADSKKYLNLEKELHKRVVGQEMAVSAIARAIRRNQSGIRTGRRPIGS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
FMFLGPTGVGKTELAKALAELLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGG
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCC
ELTEKVRNKPYAVLLFDEVEKAHPDIFNILLQVLDDGMLTDSRGRKVDFSNTIIIMTSNL
HHHHHHCCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCC
GATALRDDKTVGFGAKAIGHDHQAMEKRILEELKKAYRPEFINRIDEKVVFHSLTQENMR
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
DVVKIMVKPLIAALAEKHISLKFQPSALKYLSEAGYDVEMGARPLRRTLQTEVEDRLAEL
HHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
MLSGELSSGQSLKIGVSHGKLAFDIA
HHHCCCCCCCEEEEEECCCCEEEECC
>Mature Secondary Structure
MQDIFNQAQFQAERFDSPYLETWHILLAMVAVDHSLAAMVLSEFERKIRAEEYEAAAILA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MGKSPKEVTSVQFKPQSKALSEILAFAHAICQVTNEHEVGSEHVLFAILLNPDIMASRLL
ECCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHH
ELAGYRLKDSGKGEPRFADLRKAIELNAGYSKETIKAIHELRKPKKTKSVGTFSEMMKPQ
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
STAGELSDFTRDLTEMARQGLLEPVIGREKEVSRMVQVLCRKTKNNPVLVGDAGVGKTAL
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
AYGLAQRIASGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQLIDDIEADGKIILF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEE
VDELHTIMGSGSGIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ILIEEPSVDDAYQILLGLRASYEQYHNVTISDKAVHTAVKLAQRYLTSKRLPDSAIDLLD
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EASAMVQSMVKKTQPDFITPLDQALLDGDMSKVSALLAKEDKQPKLKPTAVTEDDMLHTL
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SKLSGIPLEKLTQADSKKYLNLEKELHKRVVGQEMAVSAIARAIRRNQSGIRTGRRPIGS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
FMFLGPTGVGKTELAKALAELLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGG
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCC
ELTEKVRNKPYAVLLFDEVEKAHPDIFNILLQVLDDGMLTDSRGRKVDFSNTIIIMTSNL
HHHHHHCCCCEEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCC
GATALRDDKTVGFGAKAIGHDHQAMEKRILEELKKAYRPEFINRIDEKVVFHSLTQENMR
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
DVVKIMVKPLIAALAEKHISLKFQPSALKYLSEAGYDVEMGARPLRRTLQTEVEDRLAEL
HHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
MLSGELSSGQSLKIGVSHGKLAFDIA
HHHCCCCCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]