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The map label for this gene is alr [H]

Identifier: 195977262

GI number: 195977262

Start: 123518

End: 124576

Strand: Direct

Name: alr [H]

Synonym: Sez_0111

Alternate gene names: 195977262

Gene position: 123518-124576 (Clockwise)

Preceding gene: 195977261

Following gene: 195977263

Centisome position: 6.1

GC content: 41.83

Gene sequence:

>1059_bases
GTGATTGAATTGATGACGAAAGAGAGCCAGAAAGTCACTGACAGCCTCAATACCTCTGTGGTAAGCCTGTTACAATACTG
CTTTGCCATAATGGTTATTGTTATTCATAGCGGTAGGCTGTTTCAGTATGAGCCGCTGCATTTCTTTTTGAAAAGCTTTT
TAGGAAGAATGGCAGTGCCTTATTTTCTTATTTGTACCGCCTTTTTTCTAAAAGGTCGCCTTAGAGAGGCGAATCGGGAA
AAGCAGTACTTCAAGCAAATGCTAAAAACCTATTTGTTTTGGTCTTTGATTTACTTCCCTTATGCTTATGCTTTTTTTGA
GTCGCTTCATCTGCCCAAGCATTATCTTCCCCTTGGCTTGTGTTTAGCCCTTGGTTATTTTGGGATGTGCTATCATCTGT
GGTATATTCCTGCTTTATTGCTGGGGTGGGTGCTTGTTCAGCTTTCTCTGAAGACTTTTGGTCAGAAGGTAACGCTCATC
ATAGTGGCGGGCTTGTATTTACTAGGGAGTATGGAAACCTATTCTCATTTTTTAAGCTCGACGCCTTTTGAGCCTTTGCT
GACAGGCTACATGCACATTTTTCAAACAAGTCGTAATGGTATTTTTTACACCCCTGCCTATCTTTGTGCGGGCTGCTTGC
TTTATGATCATTTTTCCTCGGTGCTTTTTTCTCAGCGGTATATGAAAAAAGCGGCTCTTTGTCTGACCTTATTGACCTTG
GAAAGCCTGCTTATTTACCATCATCAGGGTCTGGATAAAAATTTCTTCTTGCTTTCTGCGCTGTTTACTACCTTTTTATT
CAACGCTAGTGTTCGTACCAGCCTTCTGTCTAAATATTCTTTAGCTAAATTAAAAAAGCTAAGCTATTATTATTTTTTCT
TGCACCCAATGTTTATTGAATCCTCACTATTTCTGCTAAAGCCCTACCAGCTTGCCCCTGCCACAAAAGGAAAACTGGTC
TTTCTCATGACCCTGCTGGCTACCCATCTTTGCTCAGAGGGGCTTATGCTGCTGGTGCGTTCCCAAGCTCATGCCAAGGC
CTATCTGAGAAGGCAGTGA

Upstream 100 bases:

>100_bases
ATTGGTTGTATTACGCTATAATAAAAACAACATTAATCAAAATGAGATACAAATGCGATAAATACTAAAAGTTATACGTA
TATTAATCTCTTAAAAGAAA

Downstream 100 bases:

>100_bases
GCAGATGTTTTTTAAAAATATCTTTCTTCGGCTATAATAGGCAATAGAGGAAATGAGAACATGTATCAAGTGATTGAAAT
GTATGGAGACTGGGAGCCTT

Product: alanine racemase Alr

Products: NA

Alternate protein names: Vancomycin C-type resistance protein VanT [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MIELMTKESQKVTDSLNTSVVSLLQYCFAIMVIVIHSGRLFQYEPLHFFLKSFLGRMAVPYFLICTAFFLKGRLREANRE
KQYFKQMLKTYLFWSLIYFPYAYAFFESLHLPKHYLPLGLCLALGYFGMCYHLWYIPALLLGWVLVQLSLKTFGQKVTLI
IVAGLYLLGSMETYSHFLSSTPFEPLLTGYMHIFQTSRNGIFYTPAYLCAGCLLYDHFSSVLFSQRYMKKAALCLTLLTL
ESLLIYHHQGLDKNFFLLSALFTTFLFNASVRTSLLSKYSLAKLKKLSYYYFFLHPMFIESSLFLLKPYQLAPATKGKLV
FLMTLLATHLCSEGLMLLVRSQAHAKAYLRRQ

Sequences:

>Translated_352_residues
MIELMTKESQKVTDSLNTSVVSLLQYCFAIMVIVIHSGRLFQYEPLHFFLKSFLGRMAVPYFLICTAFFLKGRLREANRE
KQYFKQMLKTYLFWSLIYFPYAYAFFESLHLPKHYLPLGLCLALGYFGMCYHLWYIPALLLGWVLVQLSLKTFGQKVTLI
IVAGLYLLGSMETYSHFLSSTPFEPLLTGYMHIFQTSRNGIFYTPAYLCAGCLLYDHFSSVLFSQRYMKKAALCLTLLTL
ESLLIYHHQGLDKNFFLLSALFTTFLFNASVRTSLLSKYSLAKLKKLSYYYFFLHPMFIESSLFLLKPYQLAPATKGKLV
FLMTLLATHLCSEGLMLLVRSQAHAKAYLRRQ
>Mature_352_residues
MIELMTKESQKVTDSLNTSVVSLLQYCFAIMVIVIHSGRLFQYEPLHFFLKSFLGRMAVPYFLICTAFFLKGRLREANRE
KQYFKQMLKTYLFWSLIYFPYAYAFFESLHLPKHYLPLGLCLALGYFGMCYHLWYIPALLLGWVLVQLSLKTFGQKVTLI
IVAGLYLLGSMETYSHFLSSTPFEPLLTGYMHIFQTSRNGIFYTPAYLCAGCLLYDHFSSVLFSQRYMKKAALCLTLLTL
ESLLIYHHQGLDKNFFLLSALFTTFLFNASVRTSLLSKYSLAKLKKLSYYYFFLHPMFIESSLFLLKPYQLAPATKGKLV
FLMTLLATHLCSEGLMLLVRSQAHAKAYLRRQ

Specific function: Provides D-serine and D-alanine required for cell wall biosynthesis. Necessary for vancomycin resistance in E.gallinarum [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the alanine racemase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002656
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- InterPro:   IPR011248 [H]

Pfam domain/function: PF01757 Acyl_transf_3; PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 40858; Mature: 40858

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELMTKESQKVTDSLNTSVVSLLQYCFAIMVIVIHSGRLFQYEPLHFFLKSFLGRMAVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHH
YFLICTAFFLKGRLREANREKQYFKQMLKTYLFWSLIYFPYAYAFFESLHLPKHYLPLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
CLALGYFGMCYHLWYIPALLLGWVLVQLSLKTFGQKVTLIIVAGLYLLGSMETYSHFLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHC
TPFEPLLTGYMHIFQTSRNGIFYTPAYLCAGCLLYDHFSSVLFSQRYMKKAALCLTLLTL
CCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLLIYHHQGLDKNFFLLSALFTTFLFNASVRTSLLSKYSLAKLKKLSYYYFFLHPMFIE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLFLLKPYQLAPATKGKLVFLMTLLATHLCSEGLMLLVRSQAHAKAYLRRQ
CCHHEECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIELMTKESQKVTDSLNTSVVSLLQYCFAIMVIVIHSGRLFQYEPLHFFLKSFLGRMAVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHH
YFLICTAFFLKGRLREANREKQYFKQMLKTYLFWSLIYFPYAYAFFESLHLPKHYLPLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
CLALGYFGMCYHLWYIPALLLGWVLVQLSLKTFGQKVTLIIVAGLYLLGSMETYSHFLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHC
TPFEPLLTGYMHIFQTSRNGIFYTPAYLCAGCLLYDHFSSVLFSQRYMKKAALCLTLLTL
CCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLLIYHHQGLDKNFFLLSALFTTFLFNASVRTSLLSKYSLAKLKKLSYYYFFLHPMFIE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLFLLKPYQLAPATKGKLVFLMTLLATHLCSEGLMLLVRSQAHAKAYLRRQ
CCHHEECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10209740; 10878136 [H]