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The map label for this gene is purE [H]

Identifier: 195977187

GI number: 195977187

Start: 44103

End: 44591

Strand: Direct

Name: purE [H]

Synonym: Sez_0031

Alternate gene names: 195977187

Gene position: 44103-44591 (Clockwise)

Preceding gene: 195977186

Following gene: 195977188

Centisome position: 2.18

GC content: 49.28

Gene sequence:

>489_bases
ATGAAACCAATTATCTCTATCATCATGGGCTCAACATCTGACTGGGCTACCATGCAAAAAACCGCCGAAATCCTTGACCA
GTTTGGTCTTGCCTACGAAAAAAAAGTGATCTCTGCCCACCGCACACCGGACCTCATGTTCACGTACGCTGAGAAAGCAC
GCGAACGTGGTATTAAAATTATCATTGCTGGTGCTGGCGGAGCAGCTCATCTTCCTGGAATGGTCGCTGCAAAGACGACA
CTTCCTGTCATTGGTGTGCCTGTCAAATCGCGTGCTCTTAGTGGTCTTGATTCGCTGTATTCAATTGTGCAGATGCCAGG
TGGTGTGCCTGTAGCAACCATGGCCATTGGAGAGGCAGGAGCAATCAATGCAGCACTGACTGCCCTTCGGATCCTTTCAA
TTGAGGACGAAACAATCGCAGAGCAGCTCAGCCATTTCCACAAGGAACAAGGACGGATCGCAGAGGAGTCAACCAATGAG
CTTAACTAA

Upstream 100 bases:

>100_bases
TGAAAGACCTTGGGCTTTCAAGTTAGTCATGAGACACCTATGGTGGCTGCTGACGACCCCGCCACTTAAGAAAAGTATCA
AAAATCTTTAAGGAGAAAAT

Downstream 100 bases:

>100_bases
AACAATAGGTATTATCGGTGGTGGTCAGCTGGGGCAGATGATGGCGATTTCAGCCATTTACATGGGGCATAAGGTTATTA
CGCTGGATCCAACAGCAGAT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKPIISIIMGSTSDWATMQKTAEILDQFGLAYEKKVISAHRTPDLMFTYAEKARERGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAGAINAALTALRILSIEDETIAEQLSHFHKEQGRIAEESTNE
LN

Sequences:

>Translated_162_residues
MKPIISIIMGSTSDWATMQKTAEILDQFGLAYEKKVISAHRTPDLMFTYAEKARERGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAGAINAALTALRILSIEDETIAEQLSHFHKEQGRIAEESTNE
LN
>Mature_162_residues
MKPIISIIMGSTSDWATMQKTAEILDQFGLAYEKKVISAHRTPDLMFTYAEKARERGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAGAINAALTALRILSIEDETIAEQLSHFHKEQGRIAEESTNE
LN

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=146, Percent_Identity=60.2739726027397, Blast_Score=158, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=56, Blast_Score=163, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17214; Mature: 17214

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIISIIMGSTSDWATMQKTAEILDQFGLAYEKKVISAHRTPDLMFTYAEKARERGIKI
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAG
EEECCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AINAALTALRILSIEDETIAEQLSHFHKEQGRIAEESTNELN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKPIISIIMGSTSDWATMQKTAEILDQFGLAYEKKVISAHRTPDLMFTYAEKARERGIKI
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAG
EEECCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AINAALTALRILSIEDETIAEQLSHFHKEQGRIAEESTNELN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]